[Federal Register Volume 71, Number 177 (Wednesday, September 13, 2006)]
[Notices]
[Pages 54086-54087]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-15151]


=======================================================================
-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[60Day-06-0641]


Proposed Data Collections Submitted for Public Comment and 
Recommendations

    In compliance with the requirement of Section 3506(c)(2)(A) of the 
Paperwork Reduction Act of 1995 for opportunity for public comment on 
proposed data collection projects, the Centers for Disease Control and 
Prevention (CDC) will publish periodic summaries of proposed projects. 
To request more information on the proposed projects or to obtain a 
copy of the data collection plans and instruments, call 404-639-5960 
and send comments to Seleda Perryman, CDC Assistant Reports Clearance 
Officer, 1600 Clifton Road, MS-D74, Atlanta, GA 30333 or send an e-mail 
to [email protected].
    Comments are invited on: (a) Whether the proposed collection of 
information is necessary for the proper performance of the functions of 
the agency, including whether the information shall have practical 
utility; (b) the accuracy of the agency's estimate of the burden of the 
proposed collection of information; (c) ways to enhance the quality, 
utility, and clarity of the information to be collected; and (d) ways 
to minimize the burden of the collection of information on respondents, 
including through the use of automated collection techniques or other 
forms of information technology. Written comments should be received 
within 60 days of this notice.

Proposed Project

    Descriptive Epidemiology of Missed or Delayed Diagnoses for 
Conditions Detected by Newborn Screening--(OMB No. 0920-0641)--
Extension-National Center for Environmental Health (NCEH), Centers for 
Disease Control and Prevention (CDC).

Background and Brief Description

    Every State in the United States and Washington, DC, has a public 
health program to test newborn babies for congenital metabolic and 
other disorders through laboratory testing of dried blood spots. These 
programs screen for between 4 and 36 different conditions including 
phenylketonuria (PKU) and congenital hypothroidism, with testing 
performed in both state laboratories and private laboratories 
contracted by state health departments. The screening process or system 
is broader than the state public health newborn screening program, 
which is composed only of the laboratory and follow-up personnel. It 
involves the collection of blood from a newborn, analysis of the sample 
in a screening laboratory, follow-up of abnormal results, confirmatory 
testing and diagnostic work-up. Parents, hospitals, medical providers 
including primary care providers and specialists, state laboratory and 
follow-up personnel, advocates, as well as other partners such as local 
health departments, police, child protection workers, and courts play 
important roles in this process. Most children born with metabolic 
disease are identified in a timely manner and within the parameters 
defined by the newborn screening system of each State. These children 
are referred for diagnosis and treatment. However, some cases are not 
detected at all or the detection comes too late to prevent harm. These 
``missed cases'' often result in severe morbidity such as mental 
retardation or death.
    In this project, we will update and expand a previous 
epidemiological study of missed cases of two disorders published in 
1986. We will assess the number of cases of each disorder missed, the 
reasons for the miss and legal outcomes, if any. The reasons for the 
miss will be tabulated according to which step or steps of the 
screening process it occurred. Data will be collected by asking state 
public health laboratory directors, newborn screening laboratory 
managers, follow-up coordinators, specialists at metabolic clinics and 
parent groups with an interest in newborn screening for information 
regarding missed cases. An estimated 100 subjects will be requested to 
complete a short questionnaire that asks for information regarding the 
details of any missed cases of which they are aware.
    The survey will highlight procedures and actions taken by States 
and other participants in newborn screening systems to identify causes 
of missed cases and to modify policies and procedures to prevent or 
minimize recurrences. The information gleaned from this study may be 
used to help craft changes in the screening protocols that will make 
the process more organized and efficient and less likely to fail an 
affected child. Further, it is not clear that there is a systematic 
assessment of missed cases on a population basis; this project will 
seek to identify procedures for routine surveillance of missed cases. 
There are no costs to respondents except their time to participate in 
the survey.

                                        Estimated Annualized Burden Hours
----------------------------------------------------------------------------------------------------------------
                                                                     Number of    Average burden
                   Respondents                       Number of     responses per   per response    Total burden
                                                    respondents     respondent      (in hours)        (hours)
----------------------------------------------------------------------------------------------------------------
State laboratory directors, screening laboratory             100               1           10/60              17
 managers, follow-up coordinators, metabolic
 clinic specialists, and parent groups..........
----------------------------------------------------------------------------------------------------------------



[[Page 54087]]

    Dated: September 7, 2006.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. E6-15151 Filed 9-12-06; 8:45 am]
BILLING CODE 4163-18-P