[Federal Register Volume 71, Number 52 (Friday, March 17, 2006)]
[Notices]
[Pages 13852-13853]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-3916]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[60Day-06-06AW]


Proposed Data Collections Submitted for Public Comment and 
Recommendations

    In compliance with the requirement of section 3506(c)(2)(A) of the 
Paperwork Reduction Act of 1995 for opportunity for public comment on 
proposed data collection projects, the Centers for Disease Control and 
Prevention (CDC) will publish periodic summaries of proposed projects. 
To request more information on the proposed projects or to obtain a 
copy of the data collection plans and instruments, call 404-639-5960 
and send comments to Seleda Perryman, CDC Assistant Reports Clearance 
Officer, 1600 Clifton Road, MS-D74, Atlanta, GA 30333 or send an e-mail 
to [email protected].
    Comments are invited on: (a) Whether the proposed collection of 
information is necessary for the proper performance of the functions of 
the agency, including whether the information shall have practical 
utility; (b) the accuracy of the agency's estimate of the burden of the 
proposed collection of information; (c) ways to enhance the quality, 
utility, and clarity of the information to be collected; and (d) ways 
to minimize the burden of the collection of information on respondents, 
including through the use of automated collection techniques

[[Page 13853]]

or other forms of information technology. Written comments should be 
received within 60 days of this notice.

Proposed Project

    Supplement to the National Birth Defects Prevention Study: 
Qualitative Assessment of the Attitudes Mothers Have Toward Collecting 
Biological Specimens on their Infants and Young Children to Study Risk 
Factors for Birth Defects and Preterm Delivery--New--National Center on 
Birth Defects and Developmental Disabilities (NCBDDD), Centers for 
Disease Control and Prevention (CDC).

Background and Brief Description

    National Center on Birth Defects and Developmental Disabilities 
(NCBDDD), Centers for Disease Control and Prevention (CDC), has been 
conducting the National Birth Defects Prevention Study (NBDPS) 
(OMB 0920-0010) since 1997. The NBDPS is a case-control study 
of major birth defects that includes cases identified from existing 
birth defect surveillance registries in nine states, including 
metropolitan Atlanta. Control infants are randomly selected from birth 
certificates or birth hospital records. Mothers of case and control 
infants are interviewed using a computer-assisted telephone interview. 
Parents are asked to collect cheek cells from themselves and their 
infants for DNA testing. Information gathered from both the interviews 
and the DNA specimens will be used to study independent genetic and 
environmental factors as well as gene-environment interactions for a 
broad range of carefully classified birth defects.
    This proposed supplement to the National Birth Defects Prevention 
Study will use qualitative research to provide data on the barriers to 
participation in the collection of biological specimens by mothers on 
themselves, their infants, and young children. It is costly to 
implement the collection of biological specimens into an interview/
questionnaire-based study. However, an ever-increasing number of 
studies include the examination of environmental and genetic 
interactions to help medical and public health professional's better 
target appropriate interventions. A critical component for studies of 
gene variants is the collection of biological specimens. Participation 
and non-participation in the collection of biological specimens is not 
fully understood. We will conduct multiple well-designed focus groups 
to assess the attitudes of both mothers who participated and mothers 
who did not participate in the collection of biological specimens to 
increase the effectiveness of these studies. This information will be 
useful to many groups at the CDC who are currently collecting 
biological specimens from infants and their families but with less than 
optimal response rates and those who are working to implement studies 
that include the use of biological specimens.
    Scientists from the National Birth Defects Prevention Study in 
NCBDDD, the Pregnancy Risk Assessment Monitoring System (PRAMS) in 
National Center for Chronic Disease Prevention and Health Promotion 
(NCCDPHP), and Office of Genomics and Disease Prevention (OGDP) have 
received Collaborative Initiative intramural funding to conduct focus 
groups aimed at gaining insight into the barriers and motivations women 
have for participating in the collection of biological specimens. Among 
the three collaborating Centers within the Coordinating Center for 
Health Promotion, NCBDDD's National Birth Defects Prevention Study 
provides a unique opportunity for exploring the barriers and 
motivations toward collection of genetic material. This focus group 
project will recruit mothers who participated in the maternal interview 
for the NBDPS. There are no costs to the respondents other than their 
time to participate in the survey.

                                           Estimated Annualized Burden
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                                                                                 Average burden/
                   Instrument                       Number of     Frequency of    response (in    Annual burden
                                                   respondents      response         hours)           hours
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Telephone Contact..............................              90               1            5/60              7.5
Focus Group Discussion.........................              45               1               2             90
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    Dated: March 12, 2006.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. E6-3916 Filed 3-16-06; 8:45 am]
BILLING CODE 4163-18-P