[Federal Register Volume 71, Number 44 (Tuesday, March 7, 2006)]
[Notices]
[Pages 11418-11419]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E6-3189]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[30Day-06-0010]


Agency Forms Undergoing Paperwork Reduction Act Review

    The Centers for Disease Control and Prevention (CDC) publishes a 
list of information collection requests under review by the Office of 
Management and Budget (OMB) in compliance with the Paperwork Reduction 
Act (44 U.S.C. Chapter 35). To request a copy of these requests, call 
the CDC Reports Clearance Officer at (404) 639-5960 or send an e-mail 
to [email protected]. Send written comments to CDC Desk Officer, Office of 
Management and Budget, Washington, DC or by fax to (202) 395-6974. 
Written comments should be received within 30 days of this notice.

Proposed Project

    The National Birth Defects Prevention Study (OMB 0920-0010)--
Extension--National Center on Birth Defects and Developmental 
Disabilities (NCBDDD), Centers for Disease Control and Prevention 
(CDC).

Background and Brief Description

    The National Birth Defects Prevention Study has been monitoring the 
occurrence of serious birth defects and genetic diseases in Atlanta 
since 1967 through the Metropolitan Atlanta Congenital Defects Program 
(MACDP). The MACDP is a population-based surveillance system for birth 
defects in the 5 counties of Metropolitan Atlanta. Its primary purpose 
is to describe the spatial and temporal patterns of birth defects 
occurrence and serve as an early warning system for new teratogens. 
From 1993 to 1996, DBDDD conducted the Birth Defects Risk Factor 
Surveillance (BDRFS) study, a case-control study of risk factors for 
selected birth defects. Infants with birth defects were identified 
through MACDP and maternal interviews, and clinical/laboratory tests 
were conducted on approximately 300 cases and 100 controls per year. 
Controls were selected from among normal births in the same population. 
In 1997 the BDRFS became the National Birth Defects Prevention Study 
(NBDPS). The major components of the study did not change.
    The NBDPS is a case-control study of major birth defects that 
includes cases identified from existing birth defect surveillance 
registries in ten states (including metropolitan Atlanta). Control 
infants are randomly selected from birth certificates or birth hospital

[[Page 11419]]

records. Mothers of case and control infants are interviewed using a 
computer-assisted telephone interview. Parents are asked to collect 
cheek cells from themselves and their infants for DNA testing. 
Information gathered from both the interviews and the DNA specimens 
will be used to study independent genetic and environmental factors as 
well as gene-environment interactions for a broad range of carefully 
classified birth defects.
    The program is requesting approval for an additional three years. 
There is no cost to the respondent other than their time. The total 
estimated annualized burden hours are 600.

                                        Estimated Annualized Burden Hours
----------------------------------------------------------------------------------------------------------------
                                                                                                  Average burden/
                           Instrument                                Number of     Frequency of    response  (in
                                                                    respondents      response         hours)
----------------------------------------------------------------------------------------------------------------
NBDPS case/control interview....................................             400               1               1
Biologic specimen collection....................................           1,200               1           10/60
----------------------------------------------------------------------------------------------------------------


    Dated: February 27, 2006.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and 
Prevention.
[FR Doc. E6-3189 Filed 3-6-06; 8:45 am]
BILLING CODE 4163-18-P