[Federal Register Volume 70, Number 216 (Wednesday, November 9, 2005)]
[Notices]
[Pages 68069-68070]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-22320]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP); Liaison and Scientific Review 
Office; Meeting of the Scientific Advisory Committee on Alternative 
Toxicological Methods (SACATM)

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH), HHS.

ACTION: Meeting announcement and request for comment.

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SUMMARY: Pursuant to section 10(a) of the Federal Advisory Committee 
Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of a 
meeting of the SACATM on December 12, 2005. The meeting is scheduled 
from 8:30 a.m. to adjournment (~5 p.m.) and is open to the public with 
attendance limited only by the space available. SACATM advises the 
Interagency Coordinating Committee on the Validation of Alternative 
Methods (ICCVAM), the NTP Interagency Center for the Evaluation of 
Alternative Toxicological Methods (NICEATM), and the Director of the 
NIEHS regarding statutorily mandated duties of ICCVAM and activities of 
NICEATM. SACATM provides advice on priorities and activities related to 
the development, validation, scientific review, regulatory acceptance, 
implementation, and national and international harmonization of new, 
revised, and alternative toxicological test methods. Additional 
information about SACATM, including the charter, roster, and records of 
past meetings can be found at http://ntp.niehs.nih.gov/ see ``Advisory 
Board & Committees.''

DATES: The SACATM meeting will be held on December 12, 2005. All 
individuals who plan to attend are encouraged to register online at the 
NTP Web site by December 5, 2005, at http://ntp.niehs.nih.gov/ select 
``Advisory Boards & Committees.'' In order to facilitate planning for 
this meeting, persons wishing to make an oral presentation are asked to 
notify the Executive Secretary for SACTAM via online registration, 
phone, or e-mail by December 5, 2005, (see ADDRESSES below). Written 
comments should also be received by December 5, 2005, to enable review 
by SACATM and NTP staff prior to the meeting.

ADDESSES: The SACATM meeting will be held at the Hilton Alexandria Old 
Town, 1767 King Street, Alexandria, VA 22314. Public comments and other 
correspondence should be directed to Dr. Kristina Thayer, Executive 
Secretary for SACATM (NTP Liaison and Scientific Review Office, NIEHS, 
P.O. Box 12233, MD A3-01, Research Triangle Park, NC 27709; telephone: 
919-541-5021, fax: 919-541-0295; or e-mail: [email protected]). 
Persons needing special assistance, such as sign language 
interpretation or other reasonable accommodation in order to attend, 
should contact 919-541-2475 voice, 919-541-4644 TTY (text telephone), 
through the Federal TTY Relay System at 800-877-8339, or by e-mail to 
[email protected]. Requests should be made at least 7 days in 
advance of the event.

SUPPLEMENTARY INFORMATION:

Preliminary Agenda and Availability of Meeting Materials

    A preliminary agenda is provided below. Additional background 
material will be posted on the NTP Web site as available at http://ntp.niehs.nih.gov/ see ``Advisory Board & Committees'' or available 
upon request (see ADDRESSES above). Following the meeting, summary 
minutes will be prepared and available at this Web site and upon 
request.
    Preliminary Agenda, Scientific Advisory Committee on Alternative 
Toxicological Methods, December 12, 2005, Hilton Alexandria Old Town, 
1767 King Street, Alexandria, VA 22314.
    8:30 a.m.
     Call to Order, Introductions, and Recognition of Retiring 
Members.
     NICEATM and ICCVAM Update.
     Overview of the May 2005 Ocular Toxicity Scientific 
Symposia.
    [cir] Mechanisms of Chemically-Induced Ocular Injury and Recovery.
    [cir] Reducing Pain and Distress in Ocular Safety Testing.
     Performance Characteristics of the In Vivo Ocular 
Irritancy Test.
    [cir] Public Comment.
     ICCVAM Evaluation of In Vitro Methods to Identify Ocular 
Sever Irritants and Corrosives: Report from the Expert Panel 
(Presentation).
    [cir] Bovine Corneal Opacity and Permeability (BCOP) Assay.
    [cir] Isolated Chicken Eye (ICE) Assay.
    [cir] Isolated Rabbit Eye (IRE) Assay.
    [cir] Hen's Egg Test--Chorion Allantoic Membrane (HET-CAM) Assay.
    [cir] Reference Chemicals.
    12 p.m.
    LUNCH BREAK.
    1 p.m.
     ICCVAM Evaluation of In Vitro Methods to Identify Ocular 
Severe Irritants and Corrosives: Report from the Expert Panel 
Continued.
    [cir] Public Comment.
     ICCVAM Nominations.
    [cir] Public Comment.
     ICCVAM-NICEATM-ECVAM Workshop on Validation Principles and 
Approaches for Toxicogenomic-based Method.
    [cir] Public Comment.
     ECVAM Update.
     SACATM General Discussion.
    ~5 p.m.
    ADJOURN.

Request for Comments

    Public input at this meeting is invited and time is set aside for 
the presentation of public comments. Each organization is allowed one 
time slot per public comment period. At least 7 minutes will be 
allotted to each speaker, and if time permits, may be extended to 10 
minutes. Registration for oral comments will also be available on-site, 
although time allowed for presentation by on-site registrants may be 
less than that for pre-registered speakers and will be determined by 
the number of persons who register at the meeting.
    Persons registering to make oral comments are asked, if possible, 
to send a copy of their statement to the Executive Secretary for SACATM 
(see ADDRESSES above) by December 5, 2005, to enable review by SACATM 
and NIEHS/NTP staff prior to the meeting. Written statements can 
supplement and may expand the oral presentation. If registering on-site 
and reading from written text, please bring 40 copies of the statement 
for distribution and to supplement the record. Written comments 
received in response to this notice will be posted on the NTP Web site. 
Persons submitting written comments should include their name, 
affiliation, mailing address, phone, fax, e-mail, and sponsoring 
organization (if any) with the document.

Background Information on SACATM

    The SACATM was established January 9, 2002, to fulfill section 3(d) 
of Public Law 106-545, the ICCVAM Authorization Act of 2000 [42 U.S.C. 
285l-3(d)] and is composed of scientists from the public and private 
sectors (Federal Register: March 13, 2002: Vol. 67, No. 49, page 
11358). The SACATM provides advice to the Director of the NIEHS, 
ICCVAM, and NICEATM regarding statutorily mandated duties of ICCVAM and 
activities of NICEATM. Additional information about SACATM,

[[Page 68070]]

including the charter, roster, and records of past meetings can be 
found at http://ntp.niehs.nih.gov/ see ``Advisory Board & Committees.'' 
Information about NICEATM and ICCVAM activities can be found at the 
NICEATM/ICCVAM Web site (http://iccvam.niehs.nih.gov) or by contacting 
the Director of NICEATM, Dr. William Stokes (telephone: 919-541-2384, 
or E-mail: [email protected]).

    Dated: October 26, 2005.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.
[FR Doc. 05-22320 Filed 11-8-05; 8:45 am]
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