[Federal Register Volume 70, Number 150 (Friday, August 5, 2005)]
[Notices]
[Pages 45404-45406]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-15539]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Toxicology Program (NTP); Liaison and Scientific Review 
Office; Meeting of the NTP Board of Scientific Counselors Technical 
Reports Review Subcommittee

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH).

ACTION: Meeting announcement and request for comments.

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SUMMARY: Pursuant to Public Law 92-463, notice is hereby given of a 
meeting of the NTP Board of Scientific Counselors Technical Reports 
Review Subcommittee (TRR Subcommittee). The primary agenda topic is the 
peer review of the findings and conclusions of ten draft NTP Technical 
Reports (TR) of rodent toxicology and carcinogenicity studies conducted 
by the NTP (see Preliminary Agenda below). TRR Subcommittee meeting is 
open to the public with time scheduled for oral public comment. The NTP 
also invites written comments on any draft technical report discussed 
at the meeting. The TRR Subcommittee deliberations on the draft 
technical reports will be reported to the NTP Board of Scientific 
Counselors (NTP Board) at a future date.

[[Page 45405]]


DATES: The TRR Subcommittee meeting will be held on September 27-28, 
2005. Written comments should be received by September 13, 2005, to 
enable review by the TRR Subcommittee and NIEHS/NTP staff prior to the 
meeting. Individuals wishing to make oral public comments are asked to 
contact Dr. Barbara Shane (see FOR FURTHER INFORMATION CONTACT below) 
by September 13, 2005, and if possible, also to send a copy of the 
statement or talking points at that time. Persons needing special 
assistance, such as sign language interpretation, or other reasonable 
accommodation in order to attend, are asked to notify Dr. Shane at 
least 7 business days prior to the meeting (see FOR FURTHER INFORMATION 
CONTACT below).

ADDRESSES: The TRR Subcommittee meeting will be held in the Rodbell 
Auditorium, Rall Building at the NIEHS, 111 T. W. Alexander Drive, 
Research Triangle Park, NC 27709. A copy of the preliminary agenda, 
committee roster, and any additional information, when available, will 
be posted on the NTP Web site (http://ntp.niehs.nih.gov/ select 
``Advisory Boards and Committees'') and provided upon request from the 
NTP (see FOR FURTHER INFORMATION CONTACT below).

FOR FURTHER INFORMATION CONTACT: Public comments and any other 
correspondence should be submitted to Dr. Barbara Shane, Executive 
Secretary for the NTP Board (NTP Liaison and Scientific Review Office, 
NIEHS, P.O. Box 12233, MD A3-01, Research Triangle Park, NC 27709; 
telephone: 919-541-4253, fax: 919-541-0295; or e-mail: 
[email protected]).

SUPPLEMENTARY INFORMATION:

Background

    The primary agenda topic is the peer review of the findings and 
conclusions of ten draft NTP Technical Reports (TR) of rodent 
toxicology and carcinogenicity studies conducted by the NTP (see 
Preliminary Agenda below). Five of the reports are on studies with 
conventional strains of rats and mice (TR 523, TR 534, TR 535, TR 537, 
TR 538); four reports are on studies performed in genetically modified 
models (GMM) including Tg.AC hemizygous and p53 haploinsufficient mice 
(GMM 5, GMM 6, GMM 10 and GMM 11), and one study is with Crl:SKH-1 
hairless mice (TR 524). There will also be a presentation on background 
seizures in the F344/N rats used by the NTP.

Attendance and Registration

    The meeting is scheduled for September 27-28, 2005, from 8:30 a.m. 
to adjournment and is open to the public with attendance limited only 
by the space available. Individuals who plan to attend are encouraged 
to register online at the NTP Web site by September 13, 2005, at http://ntp.niehs.nih.gov/ select ``Advisory Boards and Committees'' to 
facilitate access to the NIEHS campus. Please note that a photo ID is 
required to access the NIEHS campus. The NTP is making plans to 
videocast the meeting through the Internet at http://www.niehs.nih.gov/external/video.htm.

Availability of Meeting Materials

    A copy of the preliminary agenda, committee roster, and any 
additional information, when available, will be posted on the NTP Web 
site (http://ntp.niehs.nih.gov/ select ``Advisory Boards and 
Committees'') or may be requested in hardcopy from the NTP (see FOR 
FURTHER INFORMATION CONTACT above). Following the meeting, summary 
minutes will be prepared and made available on the NTP Web site.

Request for Comments

    Public input at this meeting is invited and time is set aside for 
the presentation of public comments on any draft technical report. Each 
organization is allowed one time slot per agenda topic. At least 7 
minutes will be allotted to each speaker, and if time permits, may be 
extended to 10 minutes. Registration for oral comments will also be 
available on-site, although time allowed for presentation by on-site 
registrants may be less than that for pre-registered speakers and will 
be determined by the number of persons who register at the meeting.
    Persons registering to make oral comments are asked, if possible, 
to send a copy of their statement to Dr. Shane (see FOR FURTHER 
INFORMATION CONTACT above) by September 13, 2005, to enable review by 
the TRR Subcommittee and NIEHS/NTP staff prior to the meeting. Written 
statements can supplement and may expand the oral presentation. If 
registering on-site and reading from written text, please bring 40 
copies of the statement for distribution to the TRR Subcommittee and 
NIEHS/NTP staff and to supplement the record. Written comments received 
in response to this notice will be posted on the NTP website. Persons 
submitting written comments should include their name, affiliation, 
mailing address, phone, fax, e-mail, and sponsoring organization (if 
any) with the document.

Background Information on the NTP Board of Scientific Counselors

    The NTP Board is a technical advisory body comprised of scientists 
from the public and private sectors who provide primary scientific 
oversight to the overall program and its centers. Specifically, the NTP 
Board advises the NTP on matters of scientific program content, both 
present and future, and conducts periodic review of the program for the 
purposes of determining and advising on the scientific merit of its 
activities and their overall scientific quality. The TRR Subcommittee 
is at standing subcommittee of the NTP Board. NTP Board members are 
selected from recognized authorities knowledgeable in fields, such as 
toxicology, pharmacology, pathology, biochemistry, epidemiology, risk 
assessment, carcinogenesis, mutagenesis, molecular biology, behavioral 
toxicology and neurotoxicology, immunotoxicology, reproductive 
toxicology or teratology, and biostatistics. The NTP strives for 
equitable geographic distribution and minority and female 
representation on the NTP Board. Its members are invited to serve 
overlapping terms of up to four years. NTP Board meetings are held 
annually or biannually.

    Dated: July 28, 2005.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.

Preliminary Agenda

    National Toxicology Program (NTP) Board of Scientific Counselors, 
Technical Reports Review Subcommittee Meeting, September 27-28, 2005, 
Rodbell Auditorium, Rall Building, National Institute of Environmental 
Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC.

NTP Technical Reports (TR) Scheduled for Review

 TR 524: [alpha]- and [beta]-Hydroxy acids (glycolic and 
salicylic acids, respectively) in combination with solar light (CAS 
Nos. 79-14-1 and 69-72-7, respectively)
    [cir] Used in many cosmetic formulations for the treatment of skin 
conditions including acne, ichthyosis, actnic keratosis, warts and 
psoriasis
 TR 537: Dibromoacetic acid) (CAS No. 631-64-1)
    [cir] Water disinfection by-product
 GMM 11: Dichloroacetic acid (CAS No. 79-43-6)
    [cir] Water disinfection by-product

[[Page 45406]]

 GMM 5: Bromodichloromethane (CAS No 75-27-4)
    [cir] Water disinfection by-product
 GMM 6: Sodium bromate (CAS No. 7789-38-0)
    [cir] Water disinfection by-product
 TR 534: Divinylbenzene (high purity) (CAS No. 1321-74-0)
    [cir] Used in production of vinyl polymers
 TR 538: Methyl-isobutyl ketone (CAS No. 108-10-1)
    [cir] Denaturant in rubbing alcohol, solvent for paints, used in 
industrial extraction processes, dry cleaning preparations and in 
synthetic reactions
 TR 523: Diisopropylcarbodiimide (CAS No. 693-13-0)
    [cir] Reagent for peptide synthesis, chemical intermediate and used 
in preparation of coatings
 GMM 10: Diisopropylcarbodiimide (CAS No. 693-13-0)
    [cir] Reagent for peptide synthesis, chemical intermediate and used 
in preparation of coatings
 TR 535 4-Methylmidazole (822-36-6)
    [cir] Used in manufacture of pharmaceuticals, dyes, agricultural 
chemicals and rubber

Other Topics

 Background Seizures Observed in F344/N Rats
[FR Doc. 05-15539 Filed 8-4-05; 8:45 am]
BILLING CODE 4140-01-P