[Federal Register Volume 70, Number 79 (Tuesday, April 26, 2005)]
[Notices]
[Page 21435]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-8299]



[[Page 21435]]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Nitroxides as Protectors 
Against Oxidative Stress

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

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SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), 
Department of Health and Human Services, is contemplating the grant of 
an exclusive license worldwide to practice the invention embodied in 
U.S. Patent 5,792,775, issued on August 11, 1998, entitled ``Nitroxides 
as Protectors Against Oxidative Stress,'' to Mitos, Inc. having a place 
of business in the State of California. The field of use may be limited 
to therapeutics for the treatment and/or protection of tissue damage 
caused by ionization radiation. The United States of America is the 
assignee of the patent rights in this invention. This announcement is 
the first notice to grant an exclusive license to this technology.

DATES: Only written comments and/or application for a license which are 
received by the NIH Office of Technology Transfer on or before June 27, 
2005 will be considered.

ADDRESSES: Requests for a copy of the patent, inquiries, comments and 
other materials relating to the contemplated license should be directed 
to: Pradeep Ghosh, J.D., Ph.D., M.B.A., Technology Licensing 
Specialist, Office of Technology Transfer, National Institutes of 
Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852-3804; 
telephone: (301) 435-5282; Facsimile: (301) 402-0220; e-mail: 
[email protected].]

SUPPLEMENTARY INFORMATION: This technology relates to to the use of a 
biologically compatible composition containing an effective amount of a 
metal independent nitroxide compound as an antioxidant capable of 
protecting cells, tissues, organs, and whole organisms against 
deleterious effects of harmful oxygen-derived species generated during 
oxidative stress induced by ionizing radiations. Nitroxides are low 
molecular weight molecules and easily soluble in aqueous solutions. 
They are active within the biological pH range of 5-8, non-toxic at 
effective concentrations and can be easily attached to several organic 
molecules that may facilitate targeting of the molecules to specific 
organs or organelles. These properties of nitroxides make them ideal 
for treatment and protection of radiation induced cellular and tissue 
damages.
    The prospective exclusive license will be royalty-bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. 
The prospective exclusive license may be granted unless, within 60 days 
from the date of this published Notice, NIH receives written evidence 
and argument that establishes that the grant of the license would not 
be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7.
    Properly filed competing applications for a license filed in 
response to this notice will be treated as objections to the 
contemplated license. Comments and objections submitted in response to 
this notice will not be made available for public inspection, and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: April 18, 2005.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 05-8299 Filed 4-25-05; 8:45 am]
BILLING CODE 4140-01-P