[Federal Register Volume 70, Number 52 (Friday, March 18, 2005)]
[Notices]
[Pages 13183-13184]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-5328]


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DEPARTMENT OF DEFENSE

Department of the Army


Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Concerning Trifluoromethylepinephrine 
Compounds and Methods of Making and Using Thereof

AGENCY: Department of the Army, DoD.

ACTION: Notice.

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SUMMARY: In accordance with 37 CFR 404.6 and 404.7, announcement is 
made of the availability for licensing of U.S. Patent No. 6,825,382 
entitled ``Trifluoromethylepinephrine Compounds and Methods of Making 
and Using Thereof,'' issued November 30, 2004. Foreign rights are also 
available (PCT/US03/05976). The United States Government, as 
represented by the Secretary of the Army, has rights in this invention.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Command Judge Advocate, MCMR-ZA-J, 504 Scott Street, Fort 
Detrick, Frederick, MD 21702-5012.

FOR FURTHER INFORMATION CONTACT: For patent issues, Ms. Elizabeth 
Arwine, Patent Attorney, (301) 619-7808. For licensing issues, Dr. Paul 
Mele, Office of Research & Technology Assessment, (301) 619-6664, both 
at telefax (301) 619-5034.

SUPPLEMENTARY INFORMATION: Disclosed herein are 
trifluoromethylepinephrine compounds having the following structural 
forumula (I):
[GRAPHIC] [TIFF OMITTED] TN18MR05.004

Wherein R\1\--R\5\ are each independently selected from the group 
consisting of H, alkyl, alkoxyl, aryl, heteroaryl, cycloalkyl, 
heterocycloalkyl, acyl, thioacyl, suffonyl mercapto, alkylthio, 
carboxy, amino, alkylamino dialkylamino, carbamoyl, arylthio, and 
heteroarylthio; wherein X, Y, and Z are each independently selected 
from the group consisting of H or trifluoromethyl with the proviso that 
at least one of which is trifluoromethyl. Also disclosed are 
pharmaceutical compositions comprising the trifluoromethylepinephrine 
compounds and methods of making and using thereof. Novel

[[Page 13184]]

trifluoromethylepinephrine intermediates are also disclosed.

Brenda S. Bowen,
Army Federal Register Liaison Officer.
FR Doc. 05-5328 Filed 3-17-05; 8:45 am]
BILLING CODE 3710-08-M