[Federal Register Volume 70, Number 23 (Friday, February 4, 2005)]
[Notices]
[Pages 6023-6024]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 05-2127]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Proposed Collection; Comment Request; Physical Activity and Its 
Components In Relation To Plasma Inflammatory Markers of Cancer Risks 
Among Chinese Adults

SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of 
the Paperwork Reduction Act of 1995, for opportunity for public comment 
on proposed data collection projects, the National Cancer Institute 
(NCI), the National Institutes of Health (NIH) will publish periodic 
summaries of proposed projects to be submitted to the Office of 
Management and Budget (OMB) for review and approval.

Proposed Collection

    Title: Physical Activity And Its Components In Relation To Plasma 
Inflammatory Markers Of Cancer Risks Among Chinese Adults.
    Type of Information Collection Request: NEW.
    Need and Use of Information Collection: The specific objectives of 
the current study are to: (1) Develop a comprehensive physical activity 
questionnaire that includes standardized questions about all types of 
physical activity (e.g., recreational, household, occupational, and 
transportation), and all parameters of physical activity (e.g., 
frequency, intensity; and duration in hours per week; (2) to assess the 
validity and reliability of this comprehensive physical activity 
questionnaire and the currently used baseline physical activity 
questionnaire in two existing study cohorts using objective measures of 
physical activity/physical fitness (activity monitors and step test), 
and; (3) to evaluate whether types and parameters of physical activity 
are associated with circulating levels of specific inflammatory markers 
that have been linked to cancer risk, independent of body mass and 
other potentially confounding variables. The specific markers are C-
reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor 
necrosis factor alpha (TNF-'').
    The findings of this study will contribute to research in several 
important ways. They will allow the collection of objective physical 
activity measurements using activity monitors within a population with 
a wide range of between-person variation in physical activity; add to 
our understanding of the relationship of individual types of physical 
activity (e.g., recreational, household, occupational, and 
transportation), and parameters of physical activity (e.g., frequency, 
intensity, and duration in hours per week) to cancer outcomes; allow 
the use of physical activity information together with detailed, 
prospectively collected information regarding other lifestyle factors, 
such as diet and body mass, factors that are highly correlated with 
physical activity and also represent strong independent determinants of 
inflammatory mediator production, and; should the anticipated 
associations be found, the current study will likely stimulate future 
studies aimed at independently and jointly evaluating physical activity 
and chronic low-grade systemic inflammation in relation to cancer of 
several sites.
    Frequency of Response: Once a month during a twelve-month period.
    Affected Public: Approximately 600 men and women from a current 
cohort study among 75,000 women and 73,000 men and residing in 
Shanghai, China who agree to participate in this study.
    Type of Respondents: Adult men and women aged 40 to 70 years old 
who are residents of Shanghai, China and current participants in 
another ongoing study. The annual reporting burden is as follows:
    Estimated Number of Respondents: 600.
    Estimates of Respondent Hour Burden and Annualized Cost to 
Respondents:

----------------------------------------------------------------------------------------------------------------
                                     Survey                                       Average burden
      Type of respondents        instruments per     Number of     Frequency of      hours per     Total annual
                                   respondents     participants      response        response       hour burden
----------------------------------------------------------------------------------------------------------------
Adults (40-70 yrs old)........  Physical                     600               2             0.5             600
                                 Activity
                                 Questionnaire.
                                7-Day Physical               600               4             1.4            3360
                                 Activity Record.
                                1-Week Physical              600              12            0.25            1800
                                 Activity Recall.
                               -------------------
    TOTAL.....................  ................             600  ..............  ..............           5,760
----------------------------------------------------------------------------------------------------------------

    There are no Capital Costs to report. There are no Operating or 
Maintenance Costs to report.
    Request for Comments: Written comments and/or suggestions from the 
public and affected agencies are invited on one or more of the 
following points: (1) Whether the proposed collection of information is 
necessary for the proper performance of the function of the agency, 
including whether the information will have practical utility; (2) The 
accuracy of the agency's estimate of the burden of the proposed 
collection of information, including the validity of the methodology 
and assumptions used; (3) Ways to enhance the quality, utility, and 
clarity of the information to be collected; and (4) Ways to minimize 
the burden of the collection of information on those who are to 
respond, including the use of appropriate automated, electronic, 
mechanical, or other technological collection techniques or other forms 
of information technology.

FOR FURTHER INFORMATION CONTACT: To request more information on the 
proposed project or to obtain a copy of the data collection plans and 
instruments, contact Michael F. Leitzmann, M.D., Dr. P.H., Nutritional 
Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 
National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., EPS-MSC 
7232, Bethesda, MD, 20892, U.S.A. or call non-toll-free number 301-402-
3491 or E-mail your request, including your address to: 
[email protected].
    Comments Due Date: Comments regarding this information collection 
are best assured of having their full effect if received within 60 days 
of the date of this publication.


[[Page 6024]]


    Dated: January 25, 2005.
Rachelle Ragland-Greene,
NCI Project Clearance Liaison, National Institutes of Health.
[FR Doc. 05-2127 Filed 2-3-05; 8:45 am]
BILLING CODE 4140-01-P