[Federal Register Volume 69, Number 157 (Monday, August 16, 2004)]
[Notices]
[Pages 50390-50391]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 04-18621]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: (301) 496-7057; fax: (301) 402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Multivariate Profiling of Complex Biological Regulatory Pathways

Kevin Gardner et al. (NCI)
U.S. Patent Application No. 10/822,140 filed 12 Apr 2004 (DHHS 
Reference No. E-127-2003/0-US-02)
Licensing Contact: Cristina Thalhammer-Reyero; (301) 435-4507; 
[email protected].

    This invention is in the general area of methods for high-
throughput profiling of transcriptional targets. More particularly, it 
can be described as systems and methods for generating and analyzing 
multi-factorial biological response profiles, using a transcriptional 
approach that profiles the activation of multiple transcriptional 
targets against combinatorial arrays of signal transducing agents and 
therapeutic drugs. Cellular behavior in response to changes in its 
environment is controlled through extracellular events that are 
biochemically ``transduced'' at the cell membrane, and through a series 
of molecular signaling pathways converge in the nucleus to influence 
the combination of transcription factor binding sites that control the 
activation of targeted genes. Most of those promoter or regulatory 
regions of gene loci have a modular structure that is bound by two or 
more different transcriptional factors in a highly cooperative fashion. 
Accordingly, it is the nature of the surrounding regulatory elements or 
``promoter context'' that combine to determine how genes are 
transcriptionally regulated. Currently there are very few techniques 
that provide a clear picture of the level of signal integration that 
must occur at these transcriptional targets.
    The technology is further described in Targeting Combinatorial 
Transcriptional Complex Assembly at Specific Modules within the 
Interleukin-2 Promoter by the Immunosuppressant SB203580 by James L. 
Smith, Irene Collins, G. V. R. Chandramouli, Wayne G. Butscher, Elena 
Zaitseva, Wendy J. Freebern, Cynthia M. Haggerty, Victoria Doseeva, and 
Kevin Gardner. J. Biol. Chem., Oct 2003; 278: 41034--41046).

Resonant Structure for Spatial and Spectral-Spatial Imaging of Free 
Radical Spin Probes Using Radiofrequency Time Domain Electron 
Paramagnetic Resonance Spectroscopy

Nallathamb Devasahayam et al. (NCI) U.S. Patent 6,573,720 issued 03 Jun 
2003 (DHHS Reference No. E-166-1997/0-US-07); European, Japanese, 
Canadian and Australian rights are also pending

[[Page 50391]]

Licensing Contact: Michael Shmilovich; (301) 435-5019; 
[email protected].

    Available for licensing and commercial development is a radio-
frequency coil design suitable for detecting time domain electron 
paramagnetic resonance responses from spin probes after pulsed 
excitation using radio-frequency irradiation (60-400 MHz). The coil is 
configured in an array of numerous surface coils of appropriate 
diameters connected in a parallel configuration with appropriate 
spacing between individual surface coils to form a volume type 
resonator. The design can accommodate and irradiate objects of varying 
dimensions, such as living objects, containing free radical spin probes 
and induce an EPR signal which can also be recovered by the resonator. 
Such a resonator has the capability of facilitating the enhanced 
dissipation of noise to thermal noise levels associated with the input 
power from the radio-frequency pulse, and recovering weak and rapidly 
decaying free induction decays. In addition, the lowering of the Q 
values by over-coupling, instead of resistively damping provides 
enhanced B1 fields thereby increasing the sensitivity of detection of 
the resonance signals after pulsed excitation.

    Dated: August 2, 2004.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 04-18621 Filed 8-13-04; 8:45 am]
BILLING CODE 4140-01-P