[Federal Register Volume 69, Number 98 (Thursday, May 20, 2004)]
[Notices]
[Page 29137]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 04-11437]


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ENVIRONMENTAL PROTECTION AGENCY

[FRL-7665-5]


Peer Consultation Workshop on Physiologically-Based 
Pharmacokinetic Modeling of Trichloroethylene and Its Metabolites

AGENCY: Environmental Protection Agency.

ACTION: Notice of a peer consultation workshop and public meeting.

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SUMMARY: The U.S. Air Force (USAF) and the U.S. Environmental 
Protection Agency (EPA) are jointly announcing that Toxicology 
Excellence for Risk Assessment (TERA), under contract to the USAF, will 
convene a panel of experts and organize and conduct a peer consultation 
workshop to discuss physiologically-based pharmacokinetic (PBPK) 
modeling of trichloroethylene (TCE) and its metabolites. The public is 
invited to attend this workshop.

DATES: The one-day peer consultation workshop will be held on June 29, 
2004, from 8 a.m. to 4:30 p.m.

ADDRESSES: The peer consultation workshop will be held at Marriott 
Kingsgate Conference Center at the University of Cincinnati, 
Cincinnati, OH. TERA, under contract to the USAF, is organizing, 
convening, and conducting the peer consultation workshop. To attend the 
workshop as an observer, register by sending an e-mail to Patricia 
Nance at [email protected]. If you wish to make comments available to 
panel for consideration, please provide them to TERA before June 18, 
2004. You can also call Patricia Nance at 513-542-7475 ext. 25, or send 
a facsimile to 513-542-7487. The availability of the draft workgroup 
document will be announced on the TERA Web site at http://www.tera.org/vera/TCEwelcome.htm.

FOR FURTHER INFORMATION CONTACT: For more information on the workshop, 
contact Dr. Jay Zhao, TERA; telephone: 513-542-7475 ext. 16; facsimile: 
513-542-7487; or e-mail: [email protected]. Additional information on this 
joint USAF-EPA effort, including workshop information, registration, 
and logistics, will be available on the TERA Web page at http://www.tera.org/vera/TCEwelcome.htm. The USAF contact for this project is 
Dr. Brian Howard; telephone: (210) 536-4548; facsimile: (210) 536-1130 
or e-mail: [email protected]. The EPA contact for this project 
is Dr. Weihsueh Chiu; telephone: (202) 564-7789; facsimile: (202) 565-
0079; or e-mail: [email protected].

SUPPLEMENTARY INFORMATION:

Background Information

    The USAF and EPA are announcing a public peer consultation workshop 
to discuss physiologically-based pharmacokinetic (PBPK) modeling of 
trichloroethylene (TCE) and its metabolites. A joint USAF-EPA 
workgroup, with support from TERA under contract to the USAF, has been 
working to develop a harmonized PBPK model for TCE and its metabolites 
based on the most recent science and data. The joint USAF-EPA 
workgroup's efforts will be summarized in a draft document that will be 
the basis of the peer consultation, and which will be made available to 
the public several weeks before the workshop. The workgroup will 
consider advice obtained from the peer consultation in revising and 
calibrating its harmonized PBPK model, and in developing its final 
report. The results of this joint USAF-EPA project will serve as 
important input to ongoing TCE risk assessment activities, including a 
planned multi-agency consultation with the National Academy of Sciences 
on TCE science issues as well as EPA's revised TCE human health risk 
assessment.

    Dated: May 13, 2004.
Peter W. Preuss,
Director, National Center for Environmental Assessment.
[FR Doc. 04-11437 Filed 5-19-04; 8:45 am]
BILLING CODE 6560-50-P