[Federal Register Volume 69, Number 62 (Wednesday, March 31, 2004)]
[Notices]
[Page 16902]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 04-7193]


-----------------------------------------------------------------------

DEPARTMENT OF DEFENSE

Department of the Army


Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application Concerning Artemisinins With 
Improved Stability and Bioavailability for Therapeutic Drug Development 
and Application

AGENCY: Department of the Army, DoD.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: In accordance with 37 CFR 404.6 and 404.7, announcement is 
made of the availability for licensing of U.S. Patent Application No. 
10/376,387 entitled ``Artemisinins with Improved Stability and 
Bioavailability for Therapeutic Drug Development and Application,'' 
filed February 27, 2003. Foreign rights are also available (PCT/US03/
06283). The United States Government, as represented by the Secretary 
of the Army, has rights in this invention.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick, 
Frederick, MD 21702-5012.

FOR FURTHER INFORMATION CONTACT: For patent issues, Ms. Elizabeth 
Arwine, Patent Attorney, (301) 619-7808. For licensing issues, Dr. Paul 
Mele, Office of Research & Technology Assessment, (301) 619-6664, both 
at telefax (301) 619-5034.

SUPPLEMENTARY INFORMATION: A stable form of artemisinin wherein an 
artelinic acid or artesunic acid is complexed with cyclodextrin 
analogs, preferably, [beta]-cyclodextrin. The complexed cyclodextrin 
artemisinin formulation shields the peroxide portion of the artemisinin 
backbone from hydrolytic decomposition rendering it stable in solution. 
Artelinic acid and cyclodextrin are placed into contact with one 
another to yield a 2:1 molecular species. Artesunic acid and 
cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin 
artemisinin formulation is effective for the treatment of malaria and 
is stable in solution for long periods of time.

Brenda S. Bowen,
Alternate Army Federal Register Liaison Officer.
[FR Doc. 04-7193 Filed 3-30-04; 8:45 am]
BILLING CODE 3710-08-M