[Federal Register Volume 68, Number 189 (Tuesday, September 30, 2003)]
[Notices]
[Pages 56296-56298]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 03-24671]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention


Candidate Chemicals for Possible Inclusion in Future Releases of 
the National Report on Human Exposure to Environmental Chemicals

AGENCY: Centers for Disease Control and Prevention (CDC), Health and 
Human Services (HHS).

ACTION: On Monday, October 7, 2002, CDC published final selection 
criteria and solicited nominations for chemicals or categories of 
chemicals for analytical development and inclusion in future releases 
of the National Report on Human Exposure to Environmental Chemicals 
(the ``Report''). (See 67 FR, p. 62477-8, October 7, 2002.) 
Subsequently, the nominated chemicals were published on CDC's Web site, 
http://www.cdc.gov/exposurereport. CDC now provides the list of 
candidate chemicals by priority groups that may be included in future 
releases of the ``Report.'' Using the selection criteria and the 
weighting factors described in the above-mentioned notice, an expert 
panel of outside reviewers and scientists at CDC's National Center for 
Environmental Health, Division of Laboratory Sciences, scored nominated 
individual chemicals or categories of chemicals. On the basis of their 
final point score, chemicals were placed in one of five priority 
groups. Listing these chemicals or categories of chemicals in priority 
groups does not imply that CDC has determined that exposure to them 
causes adverse human health effects. The nominations enabled CDC to 
learn which chemicals or categories concerned the public and the 
scientific community. Chemicals in the priority groups are listed in 
alphabetical order. Chemicals in Group 1 are more likely, but not 
guaranteed, to appear in future releases of the ``Report'' than are 
chemicals in the remaining groups. In addition to appearing in the 
Federal Register, the list of candidate chemicals will appear on CDC's 
Web site at http://www.cdc.gov/exposurereport/candidatechemicals. CDC 
will publish additional notices in the Federal Register as needed to 
keep the public abreast of progress.

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Candidate Chemicals in Priority Groups

Group 1 [in alphabetical order]

1,3-Butadiene
1-Decanesulfonic acid, 1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10, 10, 10-
heneicosafluoro, ammonium salt
Aldicarb
Benzo[a]pyrene
Dichlorvos (DDVP)
Diesel exhaust
Dimethoate
Ethylene dibromide
Fonofos
Formaldehyde
Isodrin
Mancozeb
Manganese
Methyl bromide
N-methyl perfluorooctanesulfonamidoacetate (M570)
Octabromodiphenyl ether (OBDE)
Oxamyl
Pentabromodiphenyl ether (PeBDE)--congeners include BDE 82, 116, and 
119
Perfluorinated carboxylic acid metabolites of telomer alcohol or 
telomer acrylate (n = 3)
Perfluorobutane sulfonate (PFBS)

[[Page 56297]]

Perfluorooctanoic acid fluoride
Perfluorooctanoic acid (PFOA) ammonium salt*
PFOA ethyl ester
PFOA free acid
PFOA methyl ester
PFOA potassium salt*
PFOA silver salt*
PFOA sodium salt*
Perfluorooctane sulfonate (PFOS) ammonium salt*
PFOS diethanolamine salt*
PFOS lithium salt*
PFOS potassium salt*
Phorate
Phosmet
trans Fatty acids
*PFOA and PFOS measured as a consequence of exposure to any PFOA or 
PFOS salt.

Group 2 [in alphabetical order]

2,2',4,4'-Tetrachlorobiphenyl (PCB 47)
2,3,4,4',5-Pentachlorobiphenyl (PCB 114) 2',3,4,4',6-
Pentachlorobiphenyl (PCB 123)
Acetaldehyde
Acrolein
Amitrole
Anthracene
Benzo[j,k]-fluorene
Bifenthrin
Butylate
(Carboxymethylamino) methylphosphonic acid (Glyphosate)
Chromium (speciated and total)
Diaminochlorotriazine
Lambda cyhalothrin
Methomyl
Mevinphos
Molinate
N-methyl-N-ethylnitrosamine
N-nitrosodibutylamine
N-nitrosodiethanolamine
N-nitrosodiethylamine
N-nitroso-dimethylamine (NDMA)
N-nitrosodiphenylamine
N-nitrosodipropylamine
Pebulate
Pendimethalin
Pentachloronitrobenzene
Perchlorate
Perfluorodecanesulfonate (PFDS) ammonium salt
Perfluorooctanesulfonamidoacetate (M556)
Propazine
Selenium (speciated and total)
Simizine
Thiram
Tin (speciated and total)
Triclosan
Trifluralin

Group 3 [in alphabetical order]

4,4'-Dichlorobiphenyl (PCB 15)
2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl (PCB 207)
2,2',3,3',4,4',6-Heptachlorobiphenyl (PCB 171)
2,2',3,3',4,4',6,6'-Octachlorobiphenyl (PCB 197)
2,2',3,3',5,5'-Hexachlorobiphenyl (PCB 133)
2,2',3,4,4,'5-Hexachlorobiphenyl (PCB 137)
2,2',3,4,4',5,6'-Heptachlorobiphenyl (PCB 182)
2,2',3,4,4',5,6-Heptachlorobiphenyl (PCB 191)
2,2',3,4,4',5,6,6'-Octachlorobiphenyl (PCB 204)
2,2',3,4,4',6,6'-Heptachlorobiphenyl (PCB 184)
2,2',3,4,4',6-Hexachlorobiphenyl (PCB 139)
2,2',3,4,4',6'-Hexachlorobiphenyl (PCB 140)
2,2',3,4,4'-Pentachlorobiphenyl (PCB 85)
2,2',4,4',5,6'-Hexachlorobiphenyl (PCB 154)
2,2',4',4',6-Pentachlorobiphenyl (PCB 100)
2,3,3',4,4',5,5',6-Octachlorobiphenyl (PCB 205)
2,3,3',4,4',5,6-Heptachlorobiphenyl (PCB 190)
2,3,3',4',5,6'-Hexachlorobiphenyl (PCB 163)
2,3,3',5,5',6-Hexachlorobiphenyl (PCB 165)
2,3,4,4',5,6-Hexachlorobiphenyl (PCB 166)
2,3,4,4',5',6-Hexachlorobiphenyl (PCB 168)
2,3,4,4',6-Pentachlorobiphenyl (PCB 119)
2,4,4',6-Tetrachlorobiphenyl (PCB 75)
3,3',5,5'-Tetrachlorobiphenyl (PCB 80)
3,4,4'-Trichlorobiphenyl (PCB 37)
Acephthene
Aluminum
Desethyl atrazine
Desisopropyl atrazine
Fenbuconazole
Methiocarb
Pentylphenol
PFOS-related compounds (n = 11; a heterogeneous group)
Radon

Group 4 [in alphabetical order]

Acenaphthylene
Benzo[g,h,i]pyrene
Butachlor
Desethyl S-atrazine
Desisopropyl S-atrazine
Fluoroalkyl ethers (n = 6)
Fluoroalkyl iodides (n = 3)
Formetanate
Gamma, omega-perfluoroalkyl alcohols (n = 3)
3-chloro-4(dichloromethyl)5-hydroxy-2(5H)furanone (MX)
Other phased-out PFCs related to PFOS chemistries (n = 13)
Perfluorinated carboxylic acid metabolites of telomer alcohol or 
telomer acrylate (n = 3)
Perfluorinated chemicals not assigned to a structural class (n = 2)
Perfluorinated homologues of PFOS and PFOA (n = 2)
Perfluorinated quaternary ammonium chemicals (n = 2)
Perfluoroalkanes (n = 3)
Perfluoroalkyl acids and salts (n = 6)
Perfluoroalkyl alcohols (n = 4)
Perfluoroalkyl carboxylic acid fluorides (n = 2)
Perfluoroalkyl esters (n = 5)
Perfluoroalkyl iodides (n = 6)
Perfluoroalkyl sulfonamides (n = 10)
Perfluoroalkyl sulfonates (n = 75)
Perfluoroalkyl sulfonyl fluorides (n = 4)
Perfluoroglycol acid fluorides (n = 5)
Primicarb
Propiconazole
Propylparaben
Strontium
Tebuconazole
Thiodicarb
Triadimefon
Ziram

Group 5 [in Alphabetical Order]

1,2,4-Trizole
Acetamiprid
Acetochlor ethane sulfonic acid
Acetochlor oxanilic acid
Alachlor ethane sulfonic acid
Alachlor oxanilic acid
Butylparaben
Cerium
Copper
Dimethenamid
Dimethenamid ethane sulfonic acid
Dimethenamid oxanilic acid
Ethylparaben
Hexachlorocyclopentadiene (HCCPD)
Iron
Lanthanum
lmidacloprid
lmidazolinone herbicides (e.g., imazapyr, imazethapyr, imazaquin)
Methylparaben
Metolachlor ethane sulfonic acid
Metolachlor oxanilic acid
Myclobutanil
Nickel
Perfluorinated compounds that the U.S. Food and Drug Administration 
has approved as indirect food additives (n = 16)
Perfluoroalkyl acids and salts (n = 2)
Scandium
Silver
Sulfonyl urea herbicides (e.g., nicosulfuron, chlorsulfuron, 
triasulfuron)
Tellurium
Thiamethoxam
Triazole actic acid
Triazole aniline
Vanadium

    Some chemicals that were nominated appeared in the second 
``Report,'' which was published in January 2003. In addition, other 
chemicals or groups of chemicals that were already scheduled for 
inclusion in either the third or fourth release of the ``Report'' were 
not reviewed by the external expert panel and thus do not appear on the 
priority list. Chemicals or chemical categories that were included in 
the second ``Report,'' as well as those already slated for inclusion in 
future ``Reports,'' are listed below.

Nominated Chemicals or Chemical Categories Already Measured in the 
Second ``Report''

Metals

Cadmium
Lead
Mercury (inorganic and total)

Tobacco Smoke

Cotinine

Polyaromatic Hydrocarbons (PAHs)

Naphthalene (as the metabolites 1- and 2-naphthol)

Organochlorine Pesticides

Chlordane (as the metabolite oxychlordane)
4,4'-DDE (p,p'-DDE)
4,4'-DDT (p,p'-DDT)
Heptachlor (as the metabolite heptachlor epoxide)
Heptachlor epoxide
Hexachlorobenzene
Lindane (gamma HCH)
Mirex

[[Page 56298]]

1,2,4-Trichlorobenzene (as the metabolite 2,4,5-trichlorophenol)

Organophosphate Pesticides

Chlorpyrifos (as the metabolite 3,5,6-trichloro-2-pyridinol)

Phenols

ortho-Phenylphenol

N-Methyl Carbamates

Carbaryl (as the metabolite 1-naphthol)
Carbofuran (as the metabolite carbofuranphenol)
Propoxur (as the metabolite 2-isopropoxyphenol)
Alachlor (as the metabolite alachlor mercapturate)

Triazines

Atrazine (as the metabolite atrazine mercapturate)

Other Herbicides

2,4-Dichlorophenoxyacetic acid (2,4-D)

Polychlorinated Biphenyls (PCBs)

PCB numbers 52, 66, 81, 99, 101, 105, 118, 126, 128, 138, 146, 153, 
156, 157, 167, 169, 170, 180, and 183

Nominated Chemicals or Chemical Categories Already Planned for 
Inclusion in Future ``Reports''

Metals

Arsenic (speciated and total)
Methyl mercury

Volatile Organic Compounds (VOCs)

Benzene
1,1,1-Trichloroethane
1,2-Dichlorobenzene
Carbon tetrachloride
Chloroform
Ethylene dichloride
Perchloroethylene
Toluene
Xylenes (o, m, p-isomers)

Polybrominated Compounds

Polybrominated biphenyls (PBBs)
Polybrominated diphenyl ethers (PBDEs)
Tetrabromodiphenyl ether (TeBDE)
Pentabromodiphenyl ether (PeBDE)
Heptabromodiphenyl ether (HpBDE)
Decabromodiphenyl ether (DeBDE)
Hexabromocyclododecane (HBCD)
Tetrabromobisphenol A (TBBP-A)

Organochlorine Pesticides

alpha Hexachlorocyclohexane (HCH)
Aldrin (as the metabolite endrin)
4,4'-DDD (p,p'-DDD; DDD)
Dieldrin
Endosulfan
Endrin
Methoxychlor
Octachlorostyrene
Pentachlorobenzene (as the metabolite pentachlorophenol)
Toxaphene

Chloroacetanilides

Acetochlor (as the metabolite acetochlor mercapturate)
Metolachlor (as the metabolite metolachlor mercapturate)

Phenols

Bisphenol A
Nonylphenol
Octylphenol

Dithiocarbamates

Ethylenethiourea

Pyrethrins and Pyrethroids

Cyfluthrin
Cypermethrin
Deltamethrin
Esfenvalerate
Fenvalerate
Permethrin

Perfluorinated Compounds

Perfluorohexanoic sulfonic acid (PFHS)
Perfluorooctane sulfonate (PFOS), including nominated salt forms
Perfluorooctanoic acid (PFOA), including nominated salt forms

Organophosphate Pesticides

Acephate
Azinophos-methyl (also as dialkyl phosphate metabolites)
Coumaphos (also as dialkyl phosphate metabolites)
Methamidophos

Polychlorinated Biphenyls (PCBs)

PCB numbers 77, 87, 151, 158, 189, 194, 195, 169, 203, 206, and 209


ADDRESSES: Address all correspondence related to this notice to Dorothy 
Sussman, CDC, National Center for Environmental Health, Division of 
Laboratory Sciences, Mail Stop F-20, 4770 Buford Highway, Atlanta, 
Georgia 30341.

SUPPLEMENTARY INFORMATION: CDC publishes the ``Report'' under the 
authorities 42 U.S.C. 241 and 42 U.S.C. 242k. The ``Report'' provides 
an ongoing assessment using biomonitoring of the exposure of the 
noninstitutionalized, U.S. civilian population to environmental 
chemicals. Biomonitoring assesses human exposure to chemicals by 
measuring the chemicals or their breakdown products in human specimens 
such as blood or urine. For the ``Report,'' an environmental chemical 
means a chemical compound or chemical element present in air, water, 
soil, dust, food, or other environmental medium. The ``Report'' 
provides exposure information about participants in an ongoing national 
survey known as the National Health and Nutrition Examination Survey 
(NHANES). This survey is conducted by CDC's National Center for Health 
Statistics; biomonitoring measurements are conducted by CDC's National 
Center for Environmental Health. The first ``Report,'' published in 
March 2001, gave information about levels of 27 chemicals in the U.S. 
population. The second ``Report,'' published in January 2003, provided 
data on 116 chemicals, including expanded data on the 27 in the first 
``Report,'' and was the most extensive assessment ever of the exposure 
of the U.S. population to environmental chemicals. The ``Report'' can 
be obtained in the following ways: Access http://www.cdc.gov/exposurereport; e-mail [email protected]; or telephone 1-866-670-6052.
    Current plans are to release future reports of exposure of the U.S. 
population that cover 2-year periods (e.g., 2001-2002; 2003-2004; 2005-
2006) and that will include data on more chemicals than the 116 listed 
in the second ``Report.'' Over time, CDC will be able to track trends 
in exposure levels. Future releases also may include additional 
exposure information for special exposure populations (e.g., children, 
women of childbearing age, elderly people) from studies examining 
localized or point sources and from studies of adverse health effects 
resulting from exposure to varying levels of environmental chemicals.
    The Director, Management Analysis and Services Office, has been 
delegated the authority to sign Federal Register notices pertaining to 
announcements of meetings and other committee management activities for 
both the CDC and ATSDR.

    Dated: September 24, 2003.
Alvin Hall,
Director, Management Analysis and Services Office, Centers for Disease 
Control and Prevention.
[FR Doc. 03-24671 Filed 9-29-03; 8:45 am]
BILLING CODE 4163-18-P