[Federal Register Volume 68, Number 78 (Wednesday, April 23, 2003)]
[Notices]
[Pages 19991-19994]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 03-9746]


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ENVIRONMENTAL PROTECTION AGENCY

[OPP-2003-0129; FRL-7303-1]


Fluoxastrobin; Notice of Filing a Pesticide Petition to Establish 
a Tolerance for a Certain Pesticide Chemical in or on Food

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: This notice announces the initial filing of a pesticide 
petition proposing the establishment of regulations for residues of a 
certain pesticide chemical in or on various food commodities.

DATES: Comments, identified by docket ID number OPP-2003-0129, must be 
received on or before May 23, 2003.

ADDRESSES: Comments may be submitted electronically, by mail, or 
through hand delivery/courier. Follow the detailed instructions as 
provided in Unit I. of the SUPPLEMENTARY INFORMATION.

FOR FURTHER INFORMATION CONTACT: Dennis McNeilly, Registration Division 
(7505C), Office of Pesticide Programs, Environmental Protection Agency, 
1200 Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone 
number: (703) 308-6742; e-mail address: [email protected].

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does This Action Apply to Me?

    You may be potentially affected by this action if you are an 
agricultural producer, food manufacturer, or pesticide manufacturer. 
Potentially affected entities may include, but are not limited to:
    [sbull] Crop production (NAICS 111)
    [sbull] Animal production (NAICS 112)
    [sbull] Food manufacturing (NAICS 311)
    [sbull] Pesticide manufacturing (NAICS 32532)
    This listing is not intended to be exhaustive, but rather provides 
a guide for readers regarding entities likely to be affected by this 
action. Other types of entities not listed in this unit could also be 
affected. The North American Industrial Classification System (NAICS) 
codes have been provided to assist you and others in determining 
whether this action might apply to certain entities. If you have any 
questions regarding the applicability of this action to a particular 
entity, consult the person listed under FOR FURTHER INFORMATION 
CONTACT.

B. How Can I Get Copies of This Document and Other Related Information?

    1. Docket. EPA has established an official public docket for this 
action under docket identification (ID) number OPP-2003-0129. The 
official public docket consists of the documents specifically 
referenced in this action, any public comments received, and other 
information related to this action. Although a part of the official 
docket, the public docket does not include Confidential Business 
Information (CBI) or other information whose disclosure is restricted 
by statute. The official public docket is the collection of materials 
that is available for public viewing at the Public Information and 
Records Integrity Branch (PIRIB), Rm. 119, Crystal Mall 2, 
1921 Jefferson Davis Hwy., Arlington, VA. This docket facility is open 
from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal 
holidays. The docket telephone number is (703) 305-5805.
    2. Electronic access. You may access this Federal Register document 
electronically through the EPA Internet under the ``Federal Register'' 
listings at http://www.epa.gov/fedrgstr.
    An electronic version of the public docket is available through 
EPA's electronic public docket and comment system, EPA Dockets. You may 
use EPA Dockets at http://www.epa.gov/edocket/ to submit or view public 
comments, access the index listing of the contents of the official 
public docket, and to access those documents in the public docket that 
are available electronically. Although not all docket materials may be 
available electronically, you may still access any of the publicly 
available docket materials through the docket facility identified in 
Unit I.B.1. Once in the system, select ``search,'' then key in the 
appropriate docket ID number.
    Certain types of information will not be placed in the EPA Dockets. 
Information claimed as CBI and other information whose disclosure is 
restricted by statute, which is not included in the official public 
docket, will not be available for public viewing in EPA's electronic 
public docket. EPA's policy is that copyrighted material will not be 
placed in EPA's electronic public docket but will be available only in 
printed, paper form in the official public docket. To the extent 
feasible, publicly available docket materials will be made available in 
EPA's electronic public docket. When a document is selected from the 
index list in EPA Dockets, the system will identify whether the 
document is available for viewing in EPA's electronic public docket. 
Although not all docket materials may be available electronically, you 
may still access any of the publicly available docket materials through 
the docket facility identified in Unit I.B. EPA intends to work towards 
providing electronic access to all of the publicly available docket 
materials through EPA's electronic public docket.
    For public commenters, it is important to note that EPA's policy is 
that public comments, whether submitted electronically or in paper, 
will be made available for public viewing in EPA's electronic public 
docket as EPA receives them and without change, unless the comment 
contains copyrighted material, CBI, or other information whose 
disclosure is restricted by statute. When EPA identifies a comment 
containing copyrighted material, EPA will provide a reference to that 
material in the version of the comment that is placed in EPA's 
electronic public docket. The entire printed comment, including the 
copyrighted material, will be available in the public docket.
    Public comments submitted on computer disks that are mailed or 
delivered to the docket will be transferred to EPA's electronic public

[[Page 19992]]

docket. Public comments that are mailed or delivered to the docket will 
be scanned and placed in EPA's electronic public docket. Where 
practical, physical objects will be photographed, and the photograph 
will be placed in EPA's electronic public docket along with a brief 
description written by the docket staff.

C. How and To Whom Do I Submit Comments?

    You may submit comments electronically, by mail, or through hand 
delivery/courier. To ensure proper receipt by EPA, identify the 
appropriate docket ID number in the subject line on the first page of 
your comment. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the close of the 
comment period will be marked ``late.'' EPA is not required to consider 
these late comments. If you wish to submit CBI or information that is 
otherwise protected by statute, please follow the instructions in Unit 
I.D. Do not use EPA Dockets or e-mail to submit CBI or information 
protected by statute.
    1. Electronically. If you submit an electronic comment as 
prescribed in this unit, EPA recommends that you include your name, 
mailing address, and an e-mail address or other contact information in 
the body of your comment. Also include this contact information on the 
outside of any disk or CD ROM you submit, and in any cover letter 
accompanying the disk or CD ROM. This ensures that you can be 
identified as the submitter of the comment and allows EPA to contact 
you in case EPA cannot read your comment due to technical difficulties 
or needs further information on the substance of your comment. EPA's 
policy is that EPA will not edit your comment, and any identifying or 
contact information provided in the body of a comment will be included 
as part of the comment that is placed in the official public docket, 
and made available in EPA's electronic public docket. If EPA cannot 
read your comment due to technical difficulties and cannot contact you 
for clarification, EPA may not be able to consider your comment.
    i. EPA Dockets. Your use of EPA's electronic public docket to 
submit comments to EPA electronically is EPA's preferred method for 
receiving comments. Go directly to EPA Dockets at http://www.epa.gov/edocket, and follow the online instructions for submitting comments. 
Once in the system, select ``search,'' and then key in docket ID number 
OPP-2003-0129. The system is an ``anonymous access'' system, which 
means EPA will not know your identity, e-mail address, or other contact 
information unless you provide it in the body of your comment.
    ii. E-mail. Comments may be sent by e-mail to [email protected], 
Attention: Docket ID Number OPP-2003-0129. In contrast to EPA's 
electronic public docket, EPA's e-mail system is not an ``anonymous 
access'' system. If you send an e-mail comment directly to the docket 
without going through EPA's electronic public docket, EPA's e-mail 
system automatically captures your e-mail address. E-mail addresses 
that are automatically captured by EPA's e-mail system are included as 
part of the comment that is placed in the official public docket, and 
made available in EPA's electronic public docket.
    iii. Disk or CD ROM. You may submit comments on a disk or CD ROM 
that you mail to the mailing address identified in Unit I.C.2. These 
electronic submissions will be accepted in WordPerfect or ASCII file 
format. Avoid the use of special characters and any form of encryption.
    2. By mail. Send your comments to: Public Information and Records 
Integrity Branch (PIRIB) (7502C), Office of Pesticide Programs (OPP), 
Environmental Protection Agency, 1200 Pennsylvania Ave., NW., 
Washington, DC 20460-0001, Attention: Docket ID Number OPP-2003-0129.
    3. By hand delivery or courier. Deliver your comments to: Public 
Information and Records Integrity Branch (PIRIB), Office of Pesticide 
Programs (OPP), Environmental Protection Agency, Rm. 119, Crystal Mall 
2, 1921 Jefferson Davis Hwy., Arlington, VA, Attention: Docket 
ID Number OPP-2003-0129. Such deliveries are only accepted during the 
docket's normal hours of operation as identified in Unit I.B.1.

D. How Should I Submit CBI to the Agency?

    Do not submit information that you consider to be CBI 
electronically through EPA's electronic public docket or by e-mail. You 
may claim information that you submit to EPA as CBI by marking any part 
or all of that information as CBI (if you submit CBI on disk or CD ROM, 
mark the outside of the disk or CD ROM as CBI and then identify 
electronically within the disk or CD ROM the specific information that 
is CBI). Information so marked will not be disclosed except in 
accordance with procedures set forth in 40 CFR part 2.
    In addition to one complete version of the comment that includes 
any information claimed as CBI, a copy of the comment that does not 
contain the information claimed as CBI must be submitted for inclusion 
in the public docket and EPA's electronic public docket. If you submit 
the copy that does not contain CBI on disk or CD ROM, mark the outside 
of the disk or CD ROM clearly that it does not contain CBI. Information 
not marked as CBI will be included in the public docket and EPA's 
electronic public docket without prior notice. If you have any 
questions about CBI or the procedures for claiming CBI, please consult 
the person listed under FOR FURTHER INFORMATION CONTACT.

E. What Should I Consider as I Prepare My Comments for EPA?

    You may find the following suggestions helpful for preparing your 
comments:
    1. Explain your views as clearly as possible.
    2. Describe any assumptions that you used.
    3. Provide copies of any technical information and/or data you used 
that support your views.
    4. If you estimate potential burden or costs, explain how you 
arrived at the estimate that you provide.
    5. Provide specific examples to illustrate your concerns.
    6. Make sure to submit your comments by the deadline in this 
notice.
    7. To ensure proper receipt by EPA, be sure to identify the docket 
ID number assigned to this action in the subject line on the first page 
of your response. You may also provide the name, date, and Federal 
Register citation.

II. What Action is the Agency Taking?

     EPA has received a pesticide petition as follows proposing the 
establishment and/or amendment of regulations for residues of a certain 
pesticide chemical in or on various food commodities under section 408 
of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a. 
EPA has determined that this petition contains data or information 
regarding the elements set forth in FFDCA section 408(d)(2); however, 
EPA has not fully evaluated the sufficiency of the submitted data at 
this time or whether the data support granting of the petition. 
Additional data may be needed before EPA rules on the petition.

List of Subjects

    Environmental protection, Agricultural commodities, Feed additives, 
Food additives, Pesticides and pests, Reporting and recordkeeping 
requirements.


[[Page 19993]]


    Dated: April 15, 2003.
 Debra Edwards,
Director, Registration Division, Office of Pesticide Programs.

Summary of Petition

    The petitioner summary of the pesticide petition is printed below 
as required by FFDCA section 408(d)(3). The summary of the petition was 
prepared by the petitioner and represents the view of the petitioner. 
The petition summary announces the availability of a description of the 
analytical methods available to EPA for the detection and measurement 
of the pesticide chemical residues or an explanation of why no such 
method is needed.

Bayer CropScience

PP 3F6556

    EPA has received a pesticide petition (3F6556) from Bayer 
CropScience, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709 
proposing, pursuant to section 408(d) of the Federal Food, Drug, and 
Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180 by 
establishing a tolerance for residues of fluoxastrobin; 2-[[6-(2-
chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl (5,6-dihydro-1,4,2-
dioxazin-3-yl)methanone-O-methyloxime in or on the raw agricultural 
commodities (RACs) alfalfa, forage at 0.05 parts per million (ppm), 
alfalfa, hay at 1.0 ppm, cotton, gin byproducts at 0.02 ppm, grain, 
cereal, forage at 0.10 ppm, grain, cereal, hay at 0.10 ppm, grain, 
cereal, straw at 0.10 ppm, grain, cereal, stover at 0.10 ppm, grass, 
forage at 0.10 ppm, grass, hay at 0.50 ppm, legume, seed at 0.01 ppm, 
legume, forage at 0.05 ppm, legume, hay at 0.05 ppm, peanut at 0.01 
ppm, peanut, hay at 20 ppm, peanut, refined oil at 0.10 ppm, tomato, 
paste at 2.0 ppm, vegetable, fruiting, group at 1.0 ppm, vegetable, 
leafy, petioles, except brassica, subgroup at 5.0 ppm, and vegetable, 
tuberous and corm, subgroup at 0.01 ppm. Fluoxastrobin; 2-[[6-(2-
chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl (5,6-dihydro-1,4,2-
dioxazin-3-yl)methanone-O-methyloxime, and its phenoxy-
hydroxypyrimidine metabolite; 6-(2-chlorophenoxy)-5-fluoro-4-
pyrimidinol in or on the RACs cattle, fat at 0.10 ppm, cattle, meat at 
0.05 ppm, cattle, meat byproducts at 0.20 ppm, milk at 0.01 ppm, and 
milk, fat at 0.10 ppm. EPA has determined that the petition contains 
data or information regarding the elements set forth in section 
408(d)(2) of the FFDCA; however, EPA has not fully evaluated the 
sufficiency of the submitted data at this time or whether the data 
support granting of the petition. Additional data may be needed before 
EPA rules on the petition.

A. Residue Chemistry

    1. Plant metabolism. The metabolism of fluoxastrobin in plants is 
adequately understood. Studies have been conducted to delineate the 
metabolism of radiolabeled fluoxastrobin in peanut, tomato, spring 
wheat, and various representative rotational crops, all showing similar 
results. The residue of concern is parent fluoxastrobin (sum of E and Z 
isomers).
    2. Analytical method. Adequate analytical methodology using liquid 
chromatography/mass spectrometer/mass spectromer (LC/MS/MS) detection 
is available for enforcement purposes.
    3. Magnitude of residues. Complete residue data exists for 
fluoxastrobin on these crops and crop groupings. Magnitude of residue 
trials were conducted on peanut, potato, celery, tomato, pepper, and 
the rotational crops of alfalfa, cotton, cereal grains (corn, rice, 
sorghum and wheat), soybeans, other legume vegetables, and grasses. A 
cattle feeding study was performed in order to determine residues in 
meat and milk commodities. The data support the proposed tolerances.

B. Toxicological Profile

    1. Acute toxicity. Oral and dermal lethal dose (LD)50 
values were >2,000 milligrams/kilogram bodyweight (mg/kg) (bwt). 
Inhalation lethal concentrations (LC)50 values were >4,998 
milligrams/meters (mg/m\3\) air. Fluoxastrobin technical was not 
irritating to rabbit skin, was moderately irritating to eyes in 
rabbits, and was non-sensitizing dermally in the Magnusson/Kligman 
maximization test in guinea pigs. Acute toxicity studies for 
fluoxastrobin support an overall Toxicity Category III.
    2. Genotoxicity. Several genotoxicity tests were conducted to test 
for point-mutagenic activity, chromosome aberration in vitro and in 
vivo, and for DNA repair. All tests conducted were negative, indicating 
no evidence of mutagenic or genotoxic potential.
    3. Reproductive and developmental toxicity. An oral developmental 
toxicity study in rat did not reveal any evidence of teratogenic 
potential. The maternal no observed adverse effect level (NOAEL) was 
300 mg/kg and the developmental NOAEL was 1,000 mg/kg bwt/day. An oral 
developmental toxicity study in rabbits demonstrated a maternal NOAEL 
of 25 mg/kg bwt/day, a developmental NOAEL of 100 mg/kg bwt/day and did 
not reveal any teratogenic potential. A 2-generation study in rats, 
with a parental toxicity NOAEL of 73.7 mg/kg bwt/day for males and 86.7 
mg/kg bwt/day for females, did not reveal evidence of a primary 
reproductive toxicity potential. The reproductive NOAEL was 763.6 mg/kg 
bwt/day for males and 806.5 mg/kg bwt/day in females.
    4. Subchronic toxicity. A subchronic toxicity feeding study with 
rats over 90 days demonstrated a NOAEL of 7.3 and 18.3 mg/kg bwt/day 
for males and females, respectively, based on reduced body weights and 
alterations in several urinary tract-related clinical chemistry 
parameters, at the higher dose levels. In a subchronic feeding study in 
mice over 14 weeks, a NOAEL was not established based on decreased 
alanine aminotransferase (ALAT) and increased absolute and relative 
liver weights at the low dose level (21.7 and 35.3 mg/kg bwt/day for 
males and females respectively). A 14-week feeding study in dogs 
demonstrated a NOAEL of 3.0 mg/kg bwt/day based on decreased body 
weights and food consumption, and liver effects (enzyme induction, 
increased liver weights, cytoplasmic change), and thyroid effects 
(decreased T3)
    5. Chronic toxicity. A 24-month chronic/oncogenicity feeding study 
in rats demonstrated a NOAEL of 53.0 and 35.2 mg/kg bwt/day for males 
and females, respectively. An oncogenicity study in the mouse revealed 
a NOAEL of 18.5 and 29.5 mg/kg bwt/day for males and females, 
respectively based on liver effects. There was no indication in the rat 
or mouse for an oncogenic effect of fluoxastrobin. A 1-year feeding 
study with dogs demonstrated a NOAEL of 1.7 and 1.5 mg/kg bwt/day for 
males and females, respectively based on decreased body weights and 
slight liver effects (increased alkaline phosphatase (Aph) and liver 
weights).
    6. Animal metabolism. Metabolism and pharmacokinetic studies in the 
rats, lactating goats, and laying hens demonstrate that fluoxastrobin 
residues are rapidly absorbed, metabolized, and eliminated. There was 
no evidence of accumulation of residues in any tissues or organs. The 
metabolic pattern was always complex and numerous metabolites were 
identified. The main metabolic reactions, however, are very comparable 
for all tested animal species and most metabolites were present at low 
levels. Based on the available metabolism data, fluoxastrobin and 
phenoxy-hydroxypyrimidine are the proposed residues of concern in 
animals.
    7. Metabolite toxicology. The residues of concern are fluoxastrobin 
its

[[Page 19994]]

phenoxy-hydroxypyrimidine metabolite. This metabolite was investigated 
for acute oral toxicity and point mutagenic activity in a bacterial 
reverse mutation assay. The phenoxy-hydroxypyrimidine metabolite did 
not show mutagenic activity in the reverse mutation assay and the oral 
LD50 was >300 <500 mg/kg body weight.
    8. Endocrine disruption. There is no evidence to suggest that 
fluoxastrobin has any primary endocrine disruptive potential. 
Reproductive and developmental findings provided no evidence of an 
enhanced sensitivity of the young.

C. Aggregate Exposure

    1. Dietary exposure--i. Food. Acute and chronic dietary analyses 
were conducted to estimate exposure to potential fluoxastrobin residues 
in/on the following crops and crop groups: celery, fruiting vegetables, 
peanuts, and potatoes. Rotational crops included in the analysis are 
alfalfa, grasses, legume vegetables, foliage of legume vegetables, 
cereal grains, and cotton. Tier I analysis were conducted for both the 
acute and chronic scenarios using the Dietary Exposure Evaluation Model 
(DEEM) (Exponent, Inc.) software. The acute dietary exposure estimates 
at the 95\th\ percentile of exposure for the U.S. population was 1.4% 
of the acute reference dose (RfD). The population subgroup with the 
highest exposure was children 1 to 6 at 2.7% of the acute RfD. Chronic 
dietary exposure estimates from potential residues of fluoxastrobin for 
the U.S. population was 6.5% of the chronic RfD. The subpopulation with 
the highest exposure was children 1 to 6 with 12.7% of the chronic RfD 
used. Tier I assessments use tolerance residue values and 100% crop 
treated. These can be considered very conservative values.
    ii. Drinking water. EPA's Standard Operating Procedure (SOP) for 
Drinking Water Exposure and Risk Assessments was used to perform the 
drinking water analysis for fluoxastrobin. This SOP utilizes a variety 
of tools to conduct drinking water assessment. These tools include 
water models such as Screening Concentration in Groundwater (SCI-GROW), 
Generic Estimate Exposure Concentration (GENEEC), Pesticide Root Zone 
Model-Exposure Analysis Modeling Systems (PRZM/EXAMS), and monitoring 
data. If monitoring data are not available then the models are used to 
predict potential residues in surface water and ground water. In the 
case of fluoxastrobin, monitoring data do not exist, therefore, PRZMS/
EXAMS and SCI-GROW models were used to estimate a drinking water 
residue. The calculated drinking water levels of comparison (DWLOC) for 
acute and chronic exposures for all adults and children exceed the 
modeled fluoxastrobin drinking water estimated concentrations (DWECs). 
The acute DWLOC values are 8,624 parts per billion (ppb) for adults and 
2,433 ppb for children. The worst-case DWEC for acute scenarios is 
calculated to be 58 ppb using the PRZMS/EXAMS surface water model. The 
chronic DWLOC values are 491 ppb for adults and 131 ppb for children. 
The DWEC for the worst-case chronic scenario is 28 ppb PRZM/EXAMS.
    2. Non-dietary exposure. Residential (non-dietary) exposure is 
limited to post-application exposure of fluoxastrobin from professional 
applications to residential turf and golf courses. Using the very 
conservative EPA SOPs for residential exposure a margin of exposure 
(MOE) of 7,143 was calculated for the youth golfer scenario. Adult and 
toddler reentry to treated turf MOEs were 784 and 468 respectively.
    Aggregate exposure considers all exposures from food, drinking 
water, and residential uses together. Probabilistic models and methods 
as well as refined data for these scenarios are under development. In 
the interim, as a screening level analysis a worst-case deterministic 
calculation can be considered. For fluoxastrobin this would consist of 
a child (1 to 6) who has a chronic dietary exposure to potential 
residues in food and also plays on a maximally treated lawn (after 4 
applications) on a particular day. The childs lawn exposure includes 
estimates of dermal exposure and oral exposure from hand to mouth, 
object to mouth and soil ingestion SOP scenarios. The childs estimated 
dose from the lawn exposure is 0.0194 mg/kg bwt/day. The child 1 to 6 
chronic dietary exposure estimate is 0.001907 mg/kg bwt/day. The total 
dose for a child 1 to 6 with this worst-case exposure is 0.0213 mg/kg 
bwt/day or 8.5% of the acute RfD. The resulting aggregate acute DWLOC 
is 2,287 ppb still well above the acute DWEC of 58 ppb. Total adult 
exposure (average dietary and dermal lawn) is 0.004804 mg/kg bwt/day or 
1.9% of the acute RfD. The resulting aggregate acute DWLOC for adults 
is 17,164 ppb.

D. Cumulative Effects

    Fluoxastrobin is a novel strobilurin analog. Bayer will submit 
information, if necessary, for EPA to consider concerning potential 
cumulative effects of fluoxastrobin consistent with the schedule 
established by EPA in the Federal Register of August 4, 1997 (62 FR 
42020) (FRL-5734-6), and other EPA publications pursuant to the Food 
Quality Protection Act (FQPA).

E. Safety Determination

    1. U.S. population. Using the conservative assumptions described 
above, based on the completeness and reliability of the toxicity data 
it is concluded that aggregate exposure to the proposed uses of 
fluoxastrobin will utilize at most 1.9% of the RfD for the U.S. 
population, and is likely to be much less as more realistic data and 
models are developed. EPA generally has no concern for exposures below 
100% of the RfD because the RfD represents the level at or below which 
daily aggregate exposure over a lifetime will not pose appreciable 
risks to human health. DWLOC based on this exposure are much greater 
than conservative estimated concentrations, and would be expected to be 
well below the 100% level, if they occur at all. Therefore, there is a 
reasonable certainty that no harm will occur to the U.S. population 
from aggregate exposure to fluoxastrobin.
    2. Infants and children. Consideration of the toxicology data base 
as described above leads to no additional concerns for infants and 
children. Therefore the FQPA safety factor can be established at 1X. 
Using the conservative exposure assumptions described in the exposure 
section above, the percent of the RfD that will be used for short-term 
aggregate exposure to residues of fluoxastrobin will be 8.5% for 
children 1 to 6 (the most highly exposed sub-group). This value is 
based on a worst-case aggregate exposure calculation of a child 1 to 6 
who has a background dietary exposure to potential residues and plays 
on a maximally treated lawn. As in the adult situation, DWLOC are much 
higher than the worst-case DWECs and would be expected to use well 
below 100% of the RfD, if they occur at all. Therefore, there is a 
reasonable certainty that no harm will occur to infants and children 
from aggregate exposure to residues of fluoxastrobin.

F. International Tolerances

    Codex maximum residue levels are not yet established for 
fluoxastrobin.
[FR Doc. 03-9746 Filed 4-22-03; 8:45 am]
BILLING CODE 6560-50-S