[Federal Register Volume 68, Number 38 (Wednesday, February 26, 2003)]
[Notices]
[Pages 8976-8988]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 03-4522]



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Part III





Environmental Protection Agency





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Fifty-First Report of the TSCA Interagency Testing Committee to the 
Administrator, Receipt of Report and Request for Comments; Notice

  Federal Register / Vol. 68, No. 38 / Wednesday, February 26, 2003 / 
Notices  

[[Page 8976]]


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ENVIRONMENTAL PROTECTION AGENCY

[OPPT-2002-0075; FRL-7285-7]


Fifty-First Report of the TSCA Interagency Testing Committee to 
the Administrator; Receipt of Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing 
Committee (ITC) transmitted its 51\st\ ITC Report to the Administrator 
of the United States Environmental Protection Agency on November 26, 
2002. In the 51\st\ ITC Report, which is included in this notice, the 
ITC is adding 43 vanadium compounds to its Priority Testing List and 
removing 39 chemicals from the Priority Testing List.
    The ITC is asking EPA to add 43 vanadium compounds to the TSCA 
section 8(a) Preliminary Assessment Information Reporting (PAIR) rule 
and rescinding its requests to add 2 chemicals to the TSCA section 8(a) 
PAIR rule and 36 chemicals to the TSCA section 8(d) Health and Safety 
Data Reporting rule.
    The ITC continues to request voluntary information submissions 
directly from trade organizations, producers, and importers, while 
working to improve the utility of the Voluntary Information Submissions 
Innovative Online Network (VISION) and Voluntary Information 
Submissions Policy (VISP).

DATES: Comments, identified by docket ID number OPPT-2002-0075, must be 
received on or before March 28, 2003.

ADDRESSES: Comments may be submitted electronically, by mail, or 
through hand delivery/courier. Follow the detailed instructions as 
provided in Unit I. of the SUPPLEMENTARY INFORMATION.

FOR FURTHER INFORMATION CONTACT: For general information contact: 
Barbara Cunningham, Acting Director, Environmental Assistance Division 
(7408M), Office of Pollution Prevention and Toxics, Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-
0001; telephone number: (202) 554-1404; e-mail address: [email protected].
    For technical information contact: John D. Walker, ITC Executive 
Director (7401M), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460-0001; telephone number: (202) 564-7526; 
fax: (202) 564-7528; e-mail address: [email protected].

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?

    This notice is directed to the public in general. It may, however, 
be of particular interest to you if you manufacture (defined by statute 
to include import) and/or process TSCA-covered chemicals and you may be 
identified under the North American Industrial Classification System 
(NAICS) codes 325 (Chemical Manufacturing) and 32411(Petroleum 
Refineries). Because this notice is directed to the general public and 
other entities may also be interested, the Agency has not attempted to 
describe all the specific entities that may be interested in this 
action. If you have any questions regarding the applicability of this 
action to a particular entity, consult the technical person listed 
under FOR FURTHER INFORMATION CONTACT.

B. How Can I Get Copies of this Document and Other Related Information?

    1. Docket. EPA has established an official public docket for this 
action under docket identification (ID) number OPPT-2002-0075. The 
official public docket consists of the documents specifically 
referenced in this action, any public comments received, and other 
information related to this action. Although a part of the official 
docket, the public docket does not include Confidential Business 
Information (CBI) or other information whose disclosure is restricted 
by statute. The official public docket is the collection of materials 
that is available for public viewing at the EPA Docket Center, Rm. 
B102-Reading Room, EPA West, 1301 Constitution Ave., NW., Washington, 
DC. The EPA Docket Center is open from 8:30 a.m. to 4:30 p.m., Monday 
through Friday, excluding legal holidays. The EPA Docket Center Reading 
Room telephone number is (202) 566-1744 and the telephone number for 
the OPPT Docket, which is located in EPA Docket Center, is (202) 566-
0280.
    2. Electronic access. You may access this Federal Register document 
electronically through the EPA Internet under the ``Federal Register'' 
listings at http://www.epa.gov/fedrgstr/.
    An electronic version of the public docket is available through 
EPA's electronic public docket and comment system, EPA Dockets. You may 
use EPA Dockets at http://www.epa.gov/edocket/ to submit or view public 
comments, access the index listing of the contents of the official 
public docket, and to access those documents in the public docket that 
are available electronically. Although not all docket materials may be 
available electronically, you may still access any of the publicly 
available docket materials through the docket facility identified in 
Unit I.B.1. Once in the system, select ``search,'' then key in the 
appropriate docket ID number.
    Certain types of information will not be placed in the EPA Dockets. 
Information claimed as CBI and other information whose disclosure is 
restricted by statute, which is not included in the official public 
docket, will not be available for public viewing in EPA's electronic 
public docket. EPA's policy is that copyrighted material will not be 
placed in EPA's electronic public docket but will be available only in 
printed, paper form in the official public docket. To the extent 
feasible, publicly available docket materials will be made available in 
EPA's electronic public docket. When a document is selected from the 
index list in EPA Dockets, the system will identify whether the 
document is available for viewing in EPA's electronic public docket. 
Although not all docket materials may be available electronically, you 
may still access any of the publicly available docket materials through 
the docket facility identified in Unit I.B.1. EPA intends to work 
towards providing electronic access to all of the publicly available 
docket materials through EPA's electronic public docket.
    For public commenters, it is important to note that EPA's policy is 
that public comments, whether submitted electronically or in paper, 
will be made available for public viewing in EPA's electronic public 
docket as EPA receives them and without change, unless the comment 
contains copyrighted material, CBI, or other information whose 
disclosure is restricted by statute. When EPA identifies a comment 
containing copyrighted material, EPA will provide a reference to that 
material in the version of the comment that is placed in EPA's 
electronic public docket. The entire printed comment, including the 
copyrighted material, will be available in the public docket.
    Public comments submitted on computer disks that are mailed or 
delivered to the docket will be transferred to EPA's electronic public 
docket. Public comments that are mailed or delivered to the docket will 
be scanned and placed in EPA's electronic public docket. Where 
practical, physical objects will be photographed, and the photograph 
will be placed in EPA's electronic public docket along with a

[[Page 8977]]

brief description written by the docket staff.

C. How and To Whom Do I Submit Comments?

    You may submit comments electronically, by mail, or through hand 
delivery/courier. To ensure proper receipt by EPA, identify the 
appropriate docket ID number in the subject line on the first page of 
your comment. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the close of the 
comment period will be marked ``late.'' EPA is not required to consider 
these late comments. If you wish to submit CBI or information that is 
otherwise protected by statute, please follow the instructions in Unit 
I.D. Do not use EPA Dockets or e-mail to submit CBI or information 
protected by statute.
    1. Electronically. If you submit an electronic comment as 
prescribed in this unit, EPA recommends that you include your name, 
mailing address, and an e-mail address or other contact information in 
the body of your comment. Also include this contact information on the 
outside of any disk or CD ROM you submit, and in any cover letter 
accompanying the disk or CD ROM. This ensures that you can be 
identified as the submitter of the comment and allows EPA to contact 
you in case EPA cannot read your comment due to technical difficulties 
or needs further information on the substance of your comment. EPA's 
policy is that EPA will not edit your comment, and any identifying or 
contact information provided in the body of a comment will be included 
as part of the comment that is placed in the official public docket, 
and made available in EPA's electronic public docket. If EPA cannot 
read your comment due to technical difficulties and cannot contact you 
for clarification, EPA may not be able to consider your comment.
    i. EPA Dockets. Your use of EPA's electronic public docket to 
submit comments to EPA electronically is EPA's preferred method for 
receiving comments. Go directly to EPA Dockets at http://www.epa.gov/edocket, and follow the online instructions for submitting comments. 
Once in the system, select ``search,'' and then key in docket ID number 
OPPT-2002-0075. The system is an ``anonymous access'' system, which 
means EPA will not know your identity, e-mail address, or other contact 
information unless you provide it in the body of your comment.
    ii. E-mail. Comments may be sent by e-mail to [email protected], 
Attention: Docket ID Number OPPT-2002-0075. In contrast to EPA's 
electronic public docket, EPA's e-mail system is not an ``anonymous 
access'' system. If you send an e-mail comment directly to the docket 
without going through EPA's electronic public docket, EPA's e-mail 
system automatically captures your e-mail address. E-mail addresses 
that are automatically captured by EPA's e-mail system are included as 
part of the comment that is placed in the official public docket, and 
made available in EPA's electronic public docket.
    iii. Disk or CD ROM. You may submit comments on a disk or CD ROM 
that you mail to the mailing address identified in Unit I.C.2. These 
electronic submissions will be accepted in WordPerfect or ASCII file 
format. Avoid the use of special characters and any form of encryption.
    2. By mail. Send your comments to: Document Control Office (7407M), 
Office of Pollution Prevention and Toxics (OPPT), Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-
0001.
    3. By hand delivery or courier. Deliver your comments to: OPPT 
Document Control Office (DCO) in EPA East Building Rm. 6428, 1201 
Constitution Ave., NW., Washington, DC. Attention: Docket ID Number 
OPPT-2002-0075. The DCO is open from 8 a.m. to 4 p.m., Monday through 
Friday, excluding legal holidays. The telephone number for the DCO is 
(202) 564-8930.

D. How Should I Submit CBI To the Agency?

    Do not submit information that you consider to be CBI 
electronically through EPA's electronic public docket or by e-mail. You 
may claim information that you submit to EPA as CBI by marking any part 
or all of that information as CBI (if you submit CBI on disk or CD ROM, 
mark the outside of the disk or CD ROM as CBI and then identify 
electronically within the disk or CD ROM the specific information that 
is CBI). Information so marked will not be disclosed except in 
accordance with procedures set forth in 40 CFR part 2.
    In addition to one complete version of the comment that includes 
any information claimed as CBI, a copy of the comment that does not 
contain the information claimed as CBI must be submitted for inclusion 
in the public docket and EPA's electronic public docket. If you submit 
the copy that does not contain CBI on disk or CD ROM, mark the outside 
of the disk or CD ROM clearly that it does not contain CBI. Information 
not marked as CBI will be included in the public docket and EPA's 
electronic public docket without prior notice. If you have any 
questions about CBI or the procedures for claiming CBI, please consult 
the technical person listed under FOR FURTHER INFORMATION CONTACT.

E. What Should I Consider as I Prepare My Comments for EPA?

    We invite you to provide your views on the various options we 
propose, new approaches we have not considered, the potential impacts 
of the various options (including possible unintended consequences), 
and any data or information that you would like the Agency to consider 
during the development of the final action. You may find the following 
suggestions helpful for preparing your comments:
    1. Explain your views as clearly as possible.
    2. Describe any assumptions that you used.
    3. Provide copies of any technical information and/or data you used 
that support your views.
    4. If you estimate potential burden or costs, explain how you 
arrived at the estimate that you provide.
    5. Provide specific examples to illustrate your concerns.
    6. Offer alternative ways to improve the notice or collection 
activity.
    7. Make sure to submit your comments by the deadline in this 
notice.
    8. To ensure proper receipt by EPA, be sure to identify the docket 
ID number assigned to this action in the subject line on the first page 
of your response. You may also provide the name, date, and Federal 
Register citation.

II. Background

    The Toxic Substances Control Act (TSCA) (15 U.S.C. 260l et seq.) 
authorizes the Administrator of the EPA to promulgate regulations under 
section 4(a) of TSCA requiring testing of chemicals and chemical 
mixtures in order to develop data relevant to determining the risks 
that such chemicals and chemical mixtures may present to health or the 
environment. Section 4(e) of TSCA established the ITC to recommend 
chemicals and chemical mixtures to the Administrator of the EPA for 
priority testing consideration. Section 4(e) of TSCA directs the ITC to 
revise the TSCA section 4(e) Priority Testing List at least every 6 
months.

A. The 51th ITC Report

    The 51th ITC Report was transmitted to the EPA's Administrator on 
November 26, 2002, and is included in this notice. In the 51\st\ ITC 
Report, the ITC:
    1. Adds 43 vanadium compounds to its Priority Testing List and 
removes

[[Page 8978]]

thiophenol, 7 alkylphenols and alkylphenol ethoxylates, 3 Degradation 
Effects Bioconcentration Information Testing Strategies (DEBITS) 
chemicals, and 28 indium chemicals from the Priority Testing List.
    2. Asks EPA to add 43 vanadium compounds to the TSCA section 8(a) 
PAIR rule and rescinds its request to add 3H-pyrazol-3-one, 5-((2-
chloro-5-nitrophenyl)amino)-2,4-dihydro-2- (2,4,6-trichlorophenyl)- 
(CAS No. 30707-68-7) and phenol, 4,4'-[2,2,2-trifluoro-1-
(trifluoromethyl)ethylidene]bis- (CAS No. 1478-61-1) to the TSCA 
section 8(a) PAIR rule.
    3. Rescinds its request to EPA to add 8 nonylphenol polyethoxylate 
degradation products and 28 indium compounds to the TSCA section 8(d) 
Health and Safety Data Reporting rule.
    4. Continues to request voluntary information submissions directly 
from trade organizations, producers, and importers, while working to 
improve the utility of VISION and VISP.

B. Status of the Priority Testing List

    The current TSCA 4(e) Priority Testing List as of November 2002 can 
be found in Table 1 of the 51\st\ ITC Report, which is included in this 
notice.

List of Subjects

    Environmental protection, Chemicals, Hazardous substances.


    Dated: February 19, 2003.
Wardner G. Penberthy,
Acting Director, Chemical Control Division, Office of Pollution 
Prevention and Toxics.



Fifty-First Report of the TSCA Interagency Testing Committee to the 
Administrator, U.S. Environmental Protection Agency

Table of Contents

Summary

The TSCA Section 4(e) Priority Testing List (November 2002)

I. Background
II. TSCA Section 8 Reporting
A. TSCA Section 8 Reporting Rules
B. ITC's Use of TSCA Section 8 and Other Information
C. Previous and New Requests to Add Chemicals to TSCA Section 8(a) PAIR 
Rule
D. Rescinding Requests to Add Chemicals to TSCA Section 8(a) PAIR Rules
E. Previous Requests to Add Chemicals to TSCA Section 8(d) HaSDR Rules
F. Rescinding Requests to Add Chemicals to TSCA Section 8(d) HaSDR 
Rules
III. ITC's Activities During this Reporting Period (May to November 
2002)
A. Voluntary Information Submissions
B. DEBITS
IV. Revisions to the TSCA Section 4(e) Priority Testing List
A. Chemicals Added to the Priority Testing List: Vanadium Compounds
B. Chemicals Removed From the Priority Testing List
1. Thiophenol.
2. Seven alkylphenols and alkylphenol ethoxylates.
3. DEBITS 1 chemical.
4. Indium compounds.
V. References
VI. TSCA Interagency Testing Committee

Summary

    In this 51\st\ Report, the ITC is adding 43 vanadium compounds to 
the Priority Testing List. The ITC is removing thiophenol, 7 
alkylphenols and alkylphenol ethoxylates, 3 Degradation Effects 
Bioconcentration Information Testing Strategies (DEBITS) chemicals, and 
28 indium chemicals from the Priority Testing List.
    The ITC is asking the United States Environmental Protection Agency 
(USEPA) to add 43 vanadium compounds to the Toxic Substances Control 
Act (TSCA) section 8(a) Preliminary Assessment Information Reporting 
(PAIR) rule and rescinding its request to add 3H-pyrazol-3-one, 5-((2-
chloro-5-nitrophenyl)amino)-2,4-dihydro-2- (2,4,6-trichlorophenyl)- 
(CAS No. 30707-68-7) and phenol, 4,4'-[2,2,2-trifluoro-1-
(trifluoromethyl)ethylidene]bis- (CAS No. 1478-61-1) to the TSCA 
section 8(a) PAIR rule. The ITC is rescinding its request to USEPA to 
add 8 nonylphenol polyethoxylate degradation products, and 28 indium 
compounds to the TSCA section 8(d) Health and Safety Data Reporting 
(HaSDR) rule.
    The ITC will continue to request voluntary information submissions 
directly from trade organizations, producers, and importers, while 
working to improve the utility of the Voluntary Information Submissions 
Innovative Online Network (VISION) and Voluntary Information 
Submissions Policy (VISP).
    The revised TSCA section 4(e) Priority Testing List follows as 
Table 1.


                      Table 1.--The TSCA Section 4(e) Priority Testing List (November 2002)
----------------------------------------------------------------------------------------------------------------
             ITC Report                         Date              Chemical name/Group             Action
----------------------------------------------------------------------------------------------------------------
31                                    January 1993             13 Chemicals with         Designated
                                                                insufficient dermal
                                                                absorption rate data
-------------------------------------
32                                    May 1993                 16 Chemicals with         Designated
                                                                insufficient dermal
                                                                absorption rate data
-------------------------------------
35                                    November 1994            4 Chemicals with          Designated
                                                                insufficient dermal
                                                                absorption rate data
-------------------------------------
37                                    November 1995            2 Alkylphenols            Recommended
-------------------------------------
41                                    November 1997            1 Alkylphenol             Recommended
-------------------------------------
42                                    May 1998                 3-Amino-5-mercapto-1,2,4- Recommended
                                                                triazole
-------------------------------------
42                                    May 1998                 Glycoluril                Recommended
-------------------------------------
47                                    November 2000            9 Indium compounds        Recommended
-------------------------------------
48                                    May 2001                 Benzenamine, 3-chloro-    Recommended
                                                                2,6-dinitro-N,N-
                                                                dipropyl-4-
                                                                (trifluoromethyl)-
-------------------------------------

[[Page 8979]]

 
49                                    November 2001            Stannane, dimethylbis[(1- Recommended
                                                                oxoneodecyl)oxy]-
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50                                    May 2002                 Benzene, 1,3,5-tribromo-  Recommended
                                                                2-(2-propenyloxy)-
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50                                    May 2002                 1-Triazene, 1,3-diphenyl- Recommended
 
-------------------------------------
51                                    November 2002            43 Vanadium compounds     Recommended
----------------------------------------------------------------------------------------------------------------

I. Background

    The ITC was established by section 4(e) of TSCA ``to make 
recommendations to the Administrator respecting the chemical substances 
and mixtures to which the Administrator should give priority 
consideration for the promulgation of a rule for testing under section 
4(a).... At least every six months ..., the Committee shall make such 
revisions to the Priority Testing List as it determines to be necessary 
and transmit them to the Administrator together with the Committee's 
reasons for the revisions'' (Public Law 94-469, 90 Stat. 2003 et seq., 
15 U.S.C. 2601 et seq.). Since its creation in 1976, the ITC has 
submitted 50 semi-annual (May and November) Reports to the USEPA 
Administrator transmitting the Priority Testing List and its revisions. 
ITC Reports are available from the ITC's web site (http://www.epa.gov/opptintr/itc) within a few days of submission to the Administrator and 
from http://www.epa.gov/fedrgstr after publication in the Federal 
Register. The ITC meets monthly and produces its revisions to the 
Priority Testing List with administrative and technical support from 
the ITC Staff and ITC Members and their U.S. Government organizations 
and contract support provided by USEPA. ITC Members and Staff are 
listed at the end of this report.

II. TSCA Section 8 Reporting

A. TSCA Section 8 Reporting Rules

    Following receipt of the ITC's Report (and the revised Priority 
Testing List) by the USEPA Administrator, the USEPA's Office of 
Pollution Prevention and Toxics (OPPT) appends the chemicals added to 
the Priority Testing List to TSCA section 8(a) PAIR and TSCA section 
8(d) HaSDR rules. The PAIR rule requires producers and importers of 
Chemical Abstract Service (CAS)-numbered chemicals added to the 
Priority Testing List to submit production and exposure reports (http://www.epa.gov/opptintr/chemtest/pairform.pdf). The HaSDR rule requires 
producers, importers, and processors of all chemicals (including those 
with no CAS numbers) added to the Priority Testing List to submit 
unpublished health and safety studies under TSCA section 8(d) that must 
be in compliance with the revised HaSDR rule (Ref. 1). All submissions 
must be received by USEPA within 90 days of the reporting rules Federal 
Register publication date. The reporting rules are automatically 
promulgated by OPPT unless otherwise requested by the ITC.

B. ITC's Use of TSCA Section 8 and Other Information

    The ITC reviews the TSCA section 8(a) PAIR rule reports, TSCA 
section 8(d) HaSDR rule studies, and other information that becomes 
available after the ITC adds chemicals to the Priority Testing List. 
Other information includes TSCA section 4(a) and 4(d) studies, TSCA 
section 8(c) submissions, TSCA section 8(e) ``substantial risk'' 
notices, ``For Your Information'' (FYI) submissions, unpublished data 
submitted to and from U.S. Government organizations represented on the 
ITC, published papers, as well as use, exposure, effects, and 
persistence data that are voluntarily submitted to the ITC by 
manufacturers, importers, processors, and users of chemicals 
recommended by the ITC. The ITC reviews this information and determines 
if data needs should be revised, if chemicals should be removed from 
the Priority Testing List or if recommendations should be changed to 
designations. To avoid duplicate reporting, the ITC carefully 
coordinates its information solicitations and reporting requirements 
with other national and international testing programs, e.g., the 
National Toxicology Program (NTP) (http://ntp-server.niehs.nih.gov/), 
the Organization for Economic Cooperation and Development (OECD) 
Screening Information Data Set (SIDS) Program (http://www.oecd.org), 
and the USEPA's High Production Volume (HPV) Challenge Program (http://www.epa.gov/opptintr/chemrtk/volchall.htm).

C. Previous and New Requests to Add Chemicals to TSCA Section 8(a) PAIR 
Rules

    The ITC has requested in previous reports that USEPA add the 
following chemicals to the TSCA section 8(a) PAIR rules: Benzenamine, 
3-chloro-2,6-dinitro-N,N-dipropyl-4- (trifluoromethyl)- (CAS No. 29091-
20-1) (48\th\ Report, Ref. 2); stannane, dimethylbis[(1-
oxoneodecyl)oxy]- (CAS No. 68928-76-7) (49\th\ Report, Ref. 3); and 
benzene, 1,3,5-tribromo-2-(2-propenyloxy)- (CAS No. 3278-89-5) and 1-
triazene, 1,3-diphenyl- (CAS No.136-35-6) (50\th\ Report, Ref. 4).
    The ITC requests that USEPA add the 43 vanadium compounds described 
in this 51\st\ Report to the TSCA section 8(a) PAIR rule.

D. Rescinding Requests to Add Chemicals to TSCA Section 8(a) PAIR Rules

    The ITC is rescinding its 48\th\ Report (Ref. 2) request to add 3H-
pyrazol-3-one, 5-[(2-chloro-5-nitrophenyl)amino]-2,4- dihydro-2- 
(2,4,6-trichlorophenyl)- (CAS No. 30707-68-7) to the TSCA section 8(a) 
PAIR rule because of decreasing production volume trends from 1990 to 
the present. The ITC is also rescinding its 48\th\ Report (Ref. 2) 
request to add phenol, 4,4'-[2,2,2-trifluoro-1-
(trifluoromethyl)ethylidene]bis- (CAS No. 1478-61-1) to the TSCA 
section 8(a) PAIR rule because the ITC has learned that the predicted 
bioconcentration factor (BCF) of 500 is below the BCF threshold 
currently considered for action by USEPA under its Persistent, 
Bioaccumulative and Toxic (PBT) Chemical Program (http://www.epa.gov/opptintr/pbt).

E. Previous Requests to Add Chemicals to TSCA Section 8(d) HaSDR Rules

    The ITC has requested in previous reports to the USEPA Adminstrator 
that the following chemicals be added to TSCA section 8(d) HaSDR rules: 
3H-1,2,4-triazole-3-thione, 5-amino-1,2-dihydro- (3-amino-5-mercapto-
1,2,4-triazole) (CAS No. 16691-43-3) and imidazo[4,5-d]imidazole-
2,5(1H,3H)-dione, tetrahydro- (glycoluril) (CAS No.

[[Page 8980]]

496-46-8) (42\nd\ Report, Ref. 5); 9 indium compounds (47\th\ Report, 
Ref. 6); benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-4- 
(trifluoromethyl)- (CAS No. 29091-20-1) (48\th\ Report, Ref. 2); 
stannane, dimethylbis[(1-oxoneodecyl)oxy]- (CAS No. 68928-76-7) (49\th\ 
Report, Ref. 3); and benzene, 1,3,5-tribromo-2-(2-propenyloxy)- (CAS 
No. 3278-89-5) and 1-triazene, 1,3-diphenyl- (CAS No.136-35-6) (50\th\ 
Report, Ref. 4). At this time, the ITC is requesting that USEPA not add 
vanadium compounds to the TSCA section 8(d) HaSDR rule to allow 
producers and importers of vanadium compounds an opportunity to 
voluntarily provide the information requested in section IV.A.3. of 
this report.
    For 3H-1,2,4-triazole-3-thione, 5-amino-1,2-dihydro- (3-amino-5-
mercapto-1,2,4-triazole) and imidazo[4,5-d]imidazole-2,5-(1H,3H)-dione, 
tetrahydro- (glycoluril), the ITC requests that the TSCA section 8(d) 
HaSDR rule require the submission of pharmacokinetics, subchronic 
toxicity, immunotoxicity, genotoxicity, carcinogenicity, reproductive 
effects and developmental toxicity, and ecological effects studies. 
Only studies for which 3-amino-5-mercapto-1,2,4-triazole or glycoluril 
is = 90% of the test substance by weight should be 
submitted.
    For the 9 indium compounds remaining on the Priority Testing List, 
the ITC requests that the TSCA section 8(d) HaSDR rule require the 
submission of pharmacokinetics, genotoxicity, subchronic and chronic 
toxicity, and reproductive effects and developmental toxicity studies. 
Only studies where indium compounds are = 90% of the test 
substance by weight should be submitted.
    For benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-4- 
(trifluoromethyl)-, the ITC requests that the TSCA section 8(d) HaSDR 
rule require the submission of biodegradation, bioconcentration, 
pharmacokinetics, subchronic toxicity, mutagenicity, reproductive 
effects and developmental toxicity, carcinogenicity, and ecological 
effects studies. Only studies where benzenamine, 3-chloro-2,6-dinitro-
N,N-dipropyl-4- (trifluoromethyl)- is = 90% of the test 
substance by weight should be submitted.
    For stannane, dimethylbis[(1-oxoneodecyl)oxy]-, the ITC requests 
that the TSCA section 8(d) HaSDR rule require the submission of 
hydrolysis, biodegradation, bioconcentration, pharmacokinetics, 
subchronic toxicity, mutagenicity, neurotoxicity, reproductive effects 
and developmental toxicity, carcinogenicity, and ecological effects 
studies. Only studies where stannane, dimethylbis[(1-oxoneodecyl)oxy]- 
is = 90% of the test substance by weight should be 
submitted.
    For benzene, 1,3,5-tribromo-2-(2-propenyloxy)-, the ITC requests 
that the TSCA section 8(d) HaSDR rule require the submission of 
biodegradation, bioconcentration, pharmacokinetics, subchronic 
toxicity, neurotoxicity, reproductive effects and developmental 
toxicity, carcinogenicity, and ecological effects studies. Only studies 
where benzene, 1,3,5-tribromo-2-(2-propenyloxy)- is = 90% of 
the test substance by weight should be submitted.
    For 1-triazene, 1,3-diphenyl-, the ITC requests that the TSCA 
section 8(d) HaSDR rule require the submission of pharmacokinetics, 
genotoxicity, subchronic and chronic toxicity, reproductive effects and 
developmental toxicity studies. Only studies where 1-triazene, 1,3-
diphenyl- is = 90% of the test substance by weight should be 
submitted.

F. Rescinding Requests to Add Chemicals to TSCA Section 8(d) HaSDR 
Rules

    The ITC is rescinding its request to USEPA to add 8 nonylphenol 
polyethoxylate degradation products and 28 indium compounds to the TSCA 
section 8(d) HaSDR rule. The request to add 8 nonylphenol 
polyethoxylate degradation products to the TSCA section 8(d) HaSDR rule 
is being rescinded because the ITC learned that they are not 
commercially produced (Table 2 of this unit). Data on the 8 nonylphenol 
polyethoxylate degradation products were summarized in the 46\th\ 
Report (Ref. 7). The ITC is rescinding its request to add 28 indium 
compounds to the TSCA section 8(d) HaSDR rule because no PAIR reports 
were submitted for these chemicals in response to the July 26, 2001, 
PAIR rule (1,000 pound reporting threshold) (Ref. 8). Data on the 
indium compounds were summarized in the 47\th\ Report (Ref. 6).


  Table 2.--Nonylphenol Polyethoxylate (NPE) Degradation Products Being
                 Removed From the Priority Testing List
------------------------------------------------------------------------
                                         Nonylphenol polyethoxylate
              CAS No.                        degradation product
------------------------------------------------------------------------
104-35-8                            4-nonylphenol ethoxylate (NP1EO)
-----------------------------------
20427-84-3                          4-nonylphenol diethoxylate (NP2EO)
-----------------------------------
51437-95-7                          4-nonylphenol triethoxylate (NP3EO)
-----------------------------------
7311-27-5                           4-nonylphenol tetraethoxylate
                                     (NP4EO)
-----------------------------------
3115-49-9                           4-nonylphenoxy acetic acid (NP1EC)
-----------------------------------
106807-78-7                         4-nonylphenoxy ethoxy acetic acid
                                     (NP2EC)
-----------------------------------
108149-59-3                         4-nonylphenoxy diethoxy acetic acid
                                     (NP3EC)
-----------------------------------
184007-22-5                         4-nonylphenoxy triethoxy acetic acid
                                     (NP4EC)
------------------------------------------------------------------------



[[Page 8981]]

III. ITC's Activities During this Reporting Period (May to November 
2002)

A. Voluntary Information Submissions

    To promote more efficient use of information submission resources, 
the ITC developed the VISP and the VISION. The VISP is described in the 
ITC's 41\st\ Report (Ref. 9), while the VISION is described in the 
ITC's 42\nd\ Report (Ref. 5). The ITC developed the VISP and VISION as 
tools to provide a more cost-effective method for chemical producers, 
importers, processors, and users of ITC-recommended chemicals to 
provide voluntary information. Except for a few industries, the ITC 
received voluntary information submissions through the VISION on < 15% 
of the chemicals for which voluntary information was solicited. The ITC 
has not yet determined the reasons for the apparent low utilization of 
the VISION. In its 50\th\ Report (Ref. 4), the ITC requested comments 
on procedures that could be implemented to make the VISION or other 
procedures for submitting voluntary information more effective.
    The American Chemistry Council (ACC) provided an explanation of the 
chemical industry's limited participation in the VISION (Ref. 10). The 
ACC expressed concerns about the need to protect Confidential Business 
Information (CBI), the problems associated with soliciting voluntary 
submissions on non-HPV chemicals, the potential non-existence of 
specific data being requested by the ITC, and the resources required to 
submit studies in portable document format (PDF).
    To supplement the efforts to obtain studies in PDF through the 
VISION, the ITC Staff has been contacting the producers and importers 
of ITC-recommended chemicals to obtain voluntary information 
submissions. These efforts were highly successful for the chemicals 
identified through DEBITS. The ITC Staff will continue to contact the 
producers and importers of ITC-recommended chemicals to obtain 
voluntary information submissions as it continues its efforts to 
improve the utility of the VISP and VISION.
    During this reporting period, the ITC acknowledges the voluntary 
information submissions from the following organizations: 3M 
Corporation; Albemarle Corporation; Amfine Chemical Corporation; 
Alkylphenol & Ethoxylates Research Council; Akzo Nobel Chemicals, Inc.; 
BASF Corporation; Bayer Corporation; Biddle Sawyer Corporation; Canon 
USA, Inc.; Ciba Specialty Chemicals Corporation; Cognis Corporation; 
Crompton Corporation; E.I. duPont de Nemours and Company; Eastman 
Chemical Company; ExxonMobil Corporation; Great Lakes Chemical Company; 
Hercules, Inc.; Lonza, Inc.; Lubrizol Corporation; Magruder Color 
Company; Noveon, Inc.; Schenectady International, Inc.; Society of 
Plastics Industry; and Strucktol Company.
    Following the transmittal of this 51\st\ Report to the USEPA 
Administrator, the ITC Staff will contact the producers and importers 
of the 9 indium compounds remaining on the Priority Testing List to 
obtain the following information to adequately access the extent and 
degree of exposure and potential hazard associated with indium 
compounds:
    1. Recent non-CBI estimates of annual production or importation 
volume trends.
    2. Use information, including percentages of production or 
importation that are associated with different uses.
    3. Estimates of the number of workers and concentrations of indium 
compounds to which workers may be exposed during manufacture or 
processing including smelting processes, leaching processes, recovery 
of scrap material, deposition of film coatings, soldering, and 
production of electrical components including, but not limited to 
semiconductors.

B. DEBITS

    In its 45\th\ through 50\th\ Reports (Refs. 2-4, 6, 7, and 11), the 
ITC described its strategies to screen and evaluate chemicals with 
persistence and bioconcentration potential. These activities are 
referred to as DEBITS. DEBITS provides a means to prioritize chemicals 
for information reporting and testing based on degradation and 
bioconcentration potential and availability of effects data. For DEBITS 
1, the ITC used criteria to screen 12,685 chemicals and ultimately 
review 458, the disposition of which was described in the 45\th\ 
through 50\th\ Reports (Refs. 2-4, 6, 7, and 11). As a result of 
implementing DEBITS 1, the Priority Testing List contains three 
chemicals with persistence and bioconcentration potential that the 
USEPA may consider for its PBT Program: Benzenamine, 3-chloro-2,6-
dinitro-N,N-dipropyl-4- (trifluoromethyl)-; stannane, dimethylbis[(1-
oxoneodecyl)oxy]-; and benzene, 1,3,5-tribromo-2-(2-propenyloxy)-.
    DEBITS 2 started with 8,511 chemicals with production volumes > 
10,000 lbs reported to USEPA in response to the 1998 Inventory Update 
Rule (IUR). From these 8,511 chemicals, 30 non-HPV chemicals were 
identified that had 1998 production volumes > 50,000 lbs, predicted 
biodegradation half-lives > 2 months and predicted bioconcentration 
factors > 1,000. The ITC contacted manufacturers and importers of these 
30 DEBITS 2 chemicals to solicit voluntary information on production 
and uses, and unpublished toxicity data. The ITC received production 
and use information for 22 DEBITS 2 chemicals and unpublished toxicity 
studies for 13 DEBITS 2 chemicals. After reviewing this and other 
available information the ITC deferred the 30 DEBITS 2 chemicals for 
information reporting rules. A brief rationale for deferring each 
DEBITS 2 chemical is given in Table 3 of this unit.

        Table 3.--Rationales for Deferring 30 DEBITS 2 Chemicals
------------------------------------------------------------------------
            CAS No.                 Chemical name          Rationale
------------------------------------------------------------------------
118-74-1                         Benzene, hexachloro- Not domestically
                                                       produced or
                                                       imported
--------------------------------
128-69-8                         Perylo[3,4-cd:9,10-  Potential low
                                  c'd']dipyran-        bioavailability
                                  1,3,8,10-tetrone
--------------------------------
133-14-2                         Peroxide, bis(2,4-   Low exposure
                                  dichlorobenzoyl)     potential from
                                                       use
--------------------------------
423-50-7                         1-Hexanesulfonyl     Perfluorinated
                                  fluoride,            chemical referred
                                  1,1,2,2,3,3,4,4,5,   to USEPA
                                  5,6,6,6-
                                  tridecafluoro-
--------------------------------
509-34-2                         Spiro[isobenzofuran- Not domestically
                                  1(3H),9'-            produced or
                                  [9H]xanthen]-3-      imported
                                  one, 3',6'-
                                  bis(diethylamino)-
--------------------------------

[[Page 8982]]

 
678-39-7                         1-Decanol,           Perfluorinated
                                  3,3,4,4,5,5,6,6,7,   chemical referred
                                  7,8,8,9,9,10,10,10-  to USEPA
                                  heptadecafluoro-
--------------------------------
3006-86-8                        Peroxide,            Low exposure
                                  cyclohexylidenebis   potential from
                                  [(1,1-               use
                                  dimethylethyl)
--------------------------------
3864-99-1                        Phenol, 2-(5-chloro- Adequate toxicity
                                  2H-benzotriazol-2-   studies available
                                  yl)-4,6-bis(1,1-
                                  dimethylethyl)-
--------------------------------
4051-63-2                        [1,1'-Bianthracene]- Potential low
                                  9,9',10,10'-         bioavailability
                                  tetrone, 4,4'-
                                  diamino-
--------------------------------
4162-45-2                        Ethanol, 2,2'-[(1-   Not domestically
                                  methylethylidene)b   produced or
                                  is[(2,6-dibromo-     imported
                                  4,1-
                                  phenylene)oxy]]bis-
 
--------------------------------
&qd rt;13417-01-1                1-                   Perfluorinated
                                  Octanesulfonamide,   chemical referred
                                  N-[3-                to USEPA
                                  (dimethylamino)pro
                                  pyl]-
                                  1,1,2,2,3,3,4,4,5,
                                  5,6,6,7,7,8,8,8-
                                  heptadecafluoro-
--------------------------------
15667-10-4                       Peroxide,            Low exposure
                                  cyclohexylidenebis   potential from
                                  [(1,1-               use
                                  dimethylpropyl)
--------------------------------
16090-14-5                       Ethanesulfonyl       Perfluorinated
                                  fluoride, 2-[1-      chemical referred
                                  [difluoro[(trifluo   to USEPA
                                  roethenyl)oxy]meth
                                  yl]-1,2,2,2-
                                  tetrafluoroethoxy]-
                                  1,1,2,2-
                                  tetrafluoro-
--------------------------------
25637-99-4                       Cyclododecane,       Included in OECD
                                  hexabromo- (HBCD)    Risk Assessment
                                                       of brominated
                                                       flame retardants
                                                       and specific
                                                       isomer of HBCD
                                                       previously
                                                       designated in
                                                       ITC's 25\th\
                                                       Report (Ref. 12)
--------------------------------
29512-49-0                       Spiro[isobenzofuran- Not domestically
                                  1(3H),9'-            produced or
                                  [9H]xanthen]-3-      imported
                                  one, 6'-
                                  (diethylamino)-3'-
                                  methyl-2'-
                                  (phenylamino)-
--------------------------------
31148-95-5                       1-                   Low exposure
                                  Phenanthrenecarbon   potential from
                                  itrile,              use
                                  1,2,3,4,4a,9,10,10
                                  a-octahydro-1,4a-
                                  dimethyl-7-(1-
                                  methylethyl)-,
                                  (1R,4aS,10aR)-
--------------------------------
40567-16-6                       Butanoyl chloride,   Low exposure
                                  2-[2,4-bis(1,1-      potential from
                                  dimethylpropyl)phe   use
                                  noxy]-
--------------------------------
41556-26-7                       Decanedioic acid,    Low measured BCF
                                  bis(1,2,2,6,6-
                                  pentamethyl-4-
                                  piperidinyl) ester
--------------------------------
50598-28-2                       1-                   Perfluorinated
                                  Hexanesulfonamide,   chemical referred
                                  N-[3-                to USEPA
                                  (dimethylamino)pro
                                  pyl]-
                                  1,1,2,2,3,3,4,4,5,
                                  5,6,6,6-
                                  tridecafluoro-
--------------------------------
51461-11-1                       Butanamide, N-(3-    Not domestically
                                  amino-4-             produced or
                                  chlorophenyl)-4-     imported
                                  [2,4-bis(1,1-
                                  dimethylpropyl)phe
                                  noxy]-
--------------------------------
51772-35-1                       1-Naphthalenamine,   Low exposure
                                  N-[(1,1,3,3-         potential from
                                  tetramethylbutyl)p   use
                                  henyl]-
--------------------------------
58798-47-3                       3H-Indolium, 2-[[(4- Not domestically
                                  methoxyphenyl)meth   produced or
                                  ylhydrazono]methyl   imported
                                  ]-1,3,3-trimethyl-
                                  , acetate
--------------------------------
64022-61-3                       1,2,3,4-             Low exposure
                                  Butanetetracarboxy   potential from
                                  lic acid,            use
                                  tetrakis(2,2,6,6-
                                  tetramethyl-4-
                                  piperidinyl) ester
--------------------------------
67584-57-0                       2-Propenoic acid, 2- Perfluorinated
                                  [methyl[(tridecafl   chemical referred
                                  uorohexyl)sulfonyl   to USEPA
                                  ]amino]ethyl ester
--------------------------------
68259-36-9                       1-Naphthalenamine,   Low measured BCF
                                  N-phenyl-ar-
                                  (1,1,3,3-
                                  tetramethylbutyl)-
--------------------------------
68555-73-7                       1-                   Perfluorinated
                                  Heptanesulfonamide   chemical referred
                                  , N-ethyl-           to USEPA
                                  1,1,2,2,3,3,4,4,5,
                                  5,6,6,7,7,7-
                                  pentadecafluoro-N-
                                  (2-hydroxyethyl)-
--------------------------------
68555-76-0                       1-                   Perfluorinated
                                  Heptanesulfonamide   chemical referred
                                  ,                    to USEPA
                                  1,1,2,2,3,3,4,4,5,
                                  5,6,6,7,7,7-
                                  pentadecafluoro-N-
                                  (2-hydroxyethyl)-N-
                                  methyl-
--------------------------------
72869-85-3                       Chromate(1-),        Low exposure
                                  bis[3,5-bis(1,1-     potential from
                                  dimethylethyl)-2-    use
                                  (hydroxy-
                                  .kappa.O)benzoato(
                                  2-)-.kappa.O]-,
                                  hydrogen, (T-4)-
--------------------------------

[[Page 8983]]

 
75627-12-2                       Xanthylium, 3,6-     Potential low
                                  bis(ethylamino)-9-   bioavailability
                                  [2-
                                  (methoxycarbonyl)p
                                  henyl]-2,7-
                                  dimethyl-,
                                  molybdatesilicate
--------------------------------
106246-33-7                      Benzenamine, 4,4'-   Low exposure
                                  methylenebis[3-      potential from
                                  chloro-2,6-diethyl-  use
 
------------------------------------------------------------------------

IV. Revisions to the TSCA Section 4(e) Priority Testing List

A. Chemicals Added to the Priority Testing List: Vanadium Compounds

    1. Recommendation. Forty-three vanadium compounds are being added 
to the Priority Testing List to obtain importation, production, use, 
exposure, and health effects information to meet U.S. Government data 
needs (Table 4 of this unit). These compounds were identified by 
searching reference sources and chemical databases maintained by 
agencies in the United States and Canada. The ITC believes the list of 
vanadium compounds in Table 4 of this unit includes those most likely 
to be in current use. Toxicological effects of vanadium compounds were 
recently summarized by the International Program on Chemical Safety 
under the auspices of the World Health Organization (WHO) (Ref. 13).


  Table 4.--Vanadium Compounds Being Added to the Priority Testing List
------------------------------------------------------------------------
              CAS No.                        Vanadium compounds
------------------------------------------------------------------------
1314-34-7                           Vanadium oxide (V2O3) [Vanadium
                                     trioxide]
-----------------------------------
1314-62-1                           Vanadium oxide (V2O5) [Vanadium
                                     pentoxide]
-----------------------------------
1686-22-2                           Vanadium, triethoxyoxo-, (T-4)-
                                     [Triethyl orthovanadate]
-----------------------------------
3153-26-2                           Vanadium, oxobis (2,4-pentanedionato-
                                     .kappa.O,.kappa.O')-, (SP-5-21)-
-----------------------------------
5588-84-1                           Vanadium, oxotris(2-propanolato)-,
                                     (T-4)- [Vanadium triisopropoxide
                                     oxide]
-----------------------------------
7440-62-2                           Vanadium
-----------------------------------
7632-51-1                           Vanadium chloride (VCl4), (T-4)-
                                     [Vanadium tetrachloride]
-----------------------------------
7718-98-1                           Vanadium chloride (VCl3) [Vanadium
                                     trichloride]
-----------------------------------
7727-18-6                           Vanadium, trichlorooxo-, (T-4)-
                                     [Vanadium oxytrichloride]
-----------------------------------
7803-55-6                           Vanadate (VO31-), ammonium [Ammonium
                                     metavanadate]
-----------------------------------
10049-16-8                          Vanadium fluoride (VF4) [Vanadium
                                     tetrafluoride]
-----------------------------------
10213-09-9                          Vanadium, dichlorooxo- [Vanadyl
                                     dichloride]
-----------------------------------
10580-52-6                          Vanadium chloride (VCl2) [Vanadium
                                     dichloride]
-----------------------------------
11099-11-9                          Vanadium oxide [Polyvanadic acid]
-----------------------------------
11115-67-6                          Ammonium vanadium oxide
-----------------------------------
11130-21-5                          Vanadium carbide
-----------------------------------
12007-37-3                          Vanadium boride (VB2)
-----------------------------------
12035-98-2                          Vanadium oxide (VO)
-----------------------------------
12036-21-4                          Vanadium oxide (VO2)
-----------------------------------
12070-10-9                          Vanadium carbide (VC)
-----------------------------------
12083-48-6                          Vanadium, dichlorobis (.eta.5-2,4-
                                     cyclopentadien-1-yl)-
-----------------------------------
12166-27-7                          Vanadium sulfide (VS)
-----------------------------------
12439-96-2                          Vanadium, oxo[sulfato(2-)-kappa.O]-,
                                     pentahydrate [Vanadyl sulfate
                                     (VOSO4), pentahydrate]
-----------------------------------
12604-58-9                          Vanadium alloy, base, V,C,Fe
                                     (Ferrovanadium)
-----------------------------------
13470-26-3                          Vanadium bromide (VBr3)
-----------------------------------
13476-99-8                          Vanadium, tris(2,4-pentanedionato-
                                     .kappa.O,.kappa.O')-, (OC-6-11)-
                                     [Vanadium tris(acetylacetonate)]
-----------------------------------

[[Page 8984]]

 
13497-94-4                          Silver vanadium oxide (AgVO3)
-----------------------------------
13517-26-5                          Sodium vanadium oxide (Na4V2O7)
                                     [Sodium pyrovanadate]
-----------------------------------
13718-26-8                          Vanadate (VO31-), sodium [Sodium
                                     metavanadate]
-----------------------------------
13721-39-6                          Sodium vanadium oxide (Na3VO4)
                                     [Sodium orthovanadate]
-----------------------------------
13769-43-2                          Vanadate (VO31-), potassium
                                     [Potassium metavanadate]
-----------------------------------
13930-88-6                          Vanadium, oxo[29H,31H-
                                     phthalocyaninato(2-)-
                                     .kappa.N29,.kappa.N30,.kappa.N31,.k
                                     appa.N32]-, (SP-5-12)-
-----------------------------------
14059-33-7                          Bismuth vanadium oxide (BiVO4)
-----------------------------------
19120-62-8                          Vanadium, tris(2-methyl-1-
                                     propanolato)oxo-, (T-4)- [Isobutyl
                                     orthovanadate]
-----------------------------------
24646-85-3                          Vanadium nitride (VN)
-----------------------------------
27774-13-6                          Vanadium, oxo[sulfato(2-)-.kappa.O]-
                                     [Vanadyl sulfate]
-----------------------------------
30486-37-4                          Vanadium hydroxide oxide (V(OH)2O)
-----------------------------------
39455-80-6                          Ammonium sodium vanadium oxide
-----------------------------------
53801-77-7                          Bismuth vanadium oxide
-----------------------------------
65232-89-5                          Vanadium hydroxide oxide phosphate
-----------------------------------
68130-18-7                          Vanadium hydroxide oxide phosphate
                                     (V6(OH)3O3(PO4)7)
-----------------------------------
68815-09-8                          Naphthenic acids, vanadium salts
-----------------------------------
68990-29-4                          Balsams, copaiba, sulfurized,
                                     vanadium salts
------------------------------------------------------------------------


    2. Rationale for recommendation. Long-term inhalation exposure to 
vanadium pentoxide increased the incidence of lung tumors in male and 
female mice. As a result, vanadium pentoxide and other vanadium 
compounds may be potentially carcinogenic to humans. Existing 
occupational exposure limits for vanadium dusts were primarily 
developed to protect workers from irritation and acute pulmonary 
effects and may not be sufficiently protective against an increased 
risk of lung cancer.
    3. Information needs. The ITC needs:
    i. Recent non-CBI estimates of annual production or importation 
volume data and trends, and use information, including percentages of 
production or importation that are associated with different uses.
    ii. Estimates of the number of humans and concentrations of 
vanadium chemicals to which humans may be exposed in each relevant 
manufacturing or processing scenario.
    iii. Health effects data including pharmacokinetics, genotoxicity, 
subchronic toxicity, reproductive and developmental toxicity, and any 
human data from occupationally exposed workers.
The ITC seeks this information in order to adequately assess the extent 
and degree of exposure and potential hazard associated with the various 
forms of vanadium.
    4. Supporting information. Vanadium is widely distributed in low 
amounts as a constituent of mineral ores and crude petroleum deposits. 
The U.S. consumption of vanadium compounds was reported to be 3,210 
metric tons in 2001 (Ref. 14). The majority of vanadium was utilized as 
an alloying agent in the steel industry or in the production of 
ferrovanadium and other metal alloys. A smaller portion of vanadium was 
used as industrial catalysts and in the production of pesticides, dyes, 
inks, and pigments. More recent applications of vanadium compounds are 
thought to include manufacture of semiconductors, vanadate glasses, and 
electro-optical switches. There were over 5,000 potentially exposed 
workers reported in the National Occupational Exposure Survey conducted 
between 1980 and 1983. Vanadium exposure has been found in over 300 
personal air samples reported in OSHA's Integrated Management 
Information System since 1995. Worker exposures are known to occur 
during manufacture and handling of vanadium containing materials, such 
as welding operations or during cleaning of oil-fired furnaces and 
boilers. General population exposure to vanadium most likely occurs 
through ingestion of food-bearing soil residue and inhaled air in areas 
with high levels of residual fuel oil consumption (Ref. 15).
    For vanadium pentoxide and most vanadium dusts and fumes, NIOSH's 
Recommended Exposure Limit (REL) is a ceiling value of 0.05 milligram/
meter cubed (mg/m\3\). The American Council of Government Industrial 
Hygienists (ACGIH) threshold limit value (TLV) for vanadium pentoxide 
is 0.05 mg/m\3\ as an 8-hour time weighted average. OSHA's Permissible 
Exposure Limit (PEL) is a 0.1 mg/m\3\ ceiling for vanadium pentoxide 
fumes and a 0.5 mg/m\3\ ceiling for respirable dust. These occupational 
exposure limits were developed to protect against respiratory tract 
irritation and acute pulmonary effects and may not be adequate against 
an increased risk of lung cancer.
    In a 2-year inhalation study, NTP found clear evidence of 
carcinogenic activity of vanadium pentoxide (CAS No. 1314-62-1) in male 
and female

[[Page 8985]]

B6C3F1 mice (http://ntp-server.niehs.nih.gov/htdocs/LT-studies/tr507.html). The incidence of benign and malignant neoplasms was 
increased in the lungs of the experimental animals at doses of 1, 2, 
and 4 mg/m\3\. There was also some lesser evidence of increased lung 
tumor incidence in male and female rats at similar exposure levels. 
Exposures to vanadium pentoxide caused a spectrum of nonneoplastic 
lesions in the respiratory tracts of rats and mice, including 
epithelial hyperplasia, inflammation and fibrosis. The NTP report 
raises concerns for other vanadium chemicals and their potential health 
effects.

B. Chemicals Removed From the Priority Testing List

    1. Thiophenol. Thiophenol (CAS No. 108-98-5) was designated in the 
ITC's 28\th\Report (Ref. 16) because there was a low confidence in the 
Reference Dose (RfD) and no Reference Concentration (RfC). The USEPA's 
RfC/RfD Workgroup requested that the ITC review health effects data for 
thiophenol and recommend health effects testing that would increase the 
confidence in the RfD and provide a RfC. Since thiophenol was 
designated, the ITC has learned that it is not currently produced in 
the United States, that the NTP has conducted developmental toxicity 
(Refs. 17 and 18) and reproductive effects (Ref. 19) studies, and that 
Japan is developing a SIDS dossier. Thiophenol is being removed from 
the Priority Testing List because it is no longer produced and the ITC 
anticipates the SIDS dossier will address the testing data needs 
recommended by the ITC.
    2. Seven alkylphenols and alkylphenol ethoxylates. The ITC is 
continuing to review data on the alkylphenols and alkylphenol 
ethoxylates that were recommended in ITC Reports 37 (Ref. 20), 39 (Ref. 
21), and 41 (Ref. 9). For these chemicals the ITC has reviewed the PAIR 
reports submitted by producers and voluntary information provided by 
the Alkylphenol & Ethoxylates Research Council (APERC). At this time 
the ITC is removing from the Priority Testing List 4 alkylphenols from 
the 37th Report (Ref. 20) 1 nonylphenol ethoxylate from the 39\th\ 
Report (Ref. 21) and 2 alkylphenols from the 41st Report (Ref. 9) 
(Table 5 of this unit).


         Table 5.--Alkylphenols and Alkylphenol Ethoxylates Being Removed From the Priority Testing List
----------------------------------------------------------------------------------------------------------------
             ITC Report                       CAS No.                Chemical name        Rationale for removal
----------------------------------------------------------------------------------------------------------------
37                                    80-46-6                  Phenol, 4-(1,1-           Sponsored in HPV
                                                                dimethylpropyl)-          Challenge Program
-------------------------------------
37                                    88-18-6                  Phenol, 2-(1,1-           Sponsored in HPV
                                                                dimethylethyl)-           Challenge Program
-------------------------------------
37                                    1806-26-4                Phenol, 4-octyl-          No longer used by APERC
                                                                                          Members
-------------------------------------
37                                    25154-52-3               Phenol, nonyl-            Not commercially
                                                                                          available
-------------------------------------
39                                    27986-36-3               Ethanol, 2-               \1\
                                                                (nonylphenoxy)-
-------------------------------------
41                                    1987-50-4                Phenol, 4-heptyl-         \2\
-------------------------------------
41                                    72624-02-3               Phenol, heptyl derivs.    Sponsored in HPV
                                                                                          Challenge Program
----------------------------------------------------------------------------------------------------------------
\1\ Ethanol, 2-(nonylphenoxy)- (CAS No. 27986-36-3) is likely to be degraded in the environment to branched 4-
  nonylphenol (CAS No. 84852-15-3); data developed from testing branched 4-nonylphenol (CAS No. 84852-15-3) in
  response to the HPV Challenge Program may be used to predict toxicity of 2-(nonylphenoxy)ethanol.
\2\ The ITC learned that there is only a single product being sold and purchased as heptylphenol (phenol, heptyl
  derivs., CAS No. 72624-02-3). CAS No. 1987-50-4 for Phenol, 4-heptyl- denotes a linear structure of the C7
  chain and was previously used and reported on the IUR though it is not the most appropriate CAS number for the
  commercial heptylphenol product.


    There are 2 alkylphenols from the 37\th\ Report (Ref. 20) and 1 
alkylphenol from the 41\st\ Report (Ref. 9) remaining on the Priority 
Testing List (Table 6 of this unit).


      Table 6.--Alkylphenols Remaining on the Priority Testing List
------------------------------------------------------------------------
          ITC Report                 CAS No.           Chemical name
------------------------------------------------------------------------
37                              98-54-4            Phenol, 4-(1,1-
                                                    dimethylethyl)-
-------------------------------
37                              84852-15-3         Phenol, 4-nonyl-,
                                                    branched
-------------------------------
41                              140-66-9           Phenol, 4-(1,1,3,3-
                                                    tetramethylbutyl)-
------------------------------------------------------------------------


For phenol, 4-(1,1-dimethylethyl)- (CAS No. 98-54-4), the ITC 
anticipates reviewing the SIDS dossier and the ongoing reproductive 
effects study. For phenol, 4-(1,1,3,3-tetramethylbutyl)- (CAS No. 140-
66-9) and phenol, 4-nonyl-, branched (CAS No. 84852-15-3), the ITC 
anticipates receiving amphibian toxicity data, avian reproductive 
effects data, and fish reproductive effects data.
    3. DEBITS 1 chemical. 3H-Pyrazol-3-one, 5-((2-chloro-5- 
nitrophenyl)amino)-2,4-dihydro-2-(2,4,6-trichlorophenyl)- is being 
removed from the Priority Testing List because of decreasing production 
volume trends from 1990 to the present. Phenol, 4,4'-[2,2,2-trifluoro-
1-(trifluoromethyl)ethylidene]bis- is being removed from the Priority 
Testing List because the ITC has learned that the predicted BCF of 
approximately 500 is not sufficient to be considered by USEPA's PBT 
Program. Pentachlorothiophenol (CAS No. 133-49-3) is being removed from 
the Priority Testing List because of low exposure potential from 
current use.

[[Page 8986]]

    4. Indium compounds. Twenty-eight indium compounds are being 
removed from the Priority Testing List because no production or 
importation data were submitted to USEPA in response to the July 26, 
2001, PAIR rule (Ref. 8) (Table 7 of this unit).


 Table 7.--Indium Compounds Being Removed From the Priority Testing List
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
923-34-2                            Indium, triethyl-
-----------------------------------
1303-11-3                           Indium arsenide (InAs)
-----------------------------------
1312-41-0                           Antimony, compd. with indium (1:1)
-----------------------------------
1312-45-4                           Indium telluride (In2Te3)
-----------------------------------
4194-69-8                           1,2,3-Propanetricarboxylic acid, 2-
                                     hydroxy-, indium(3+) salt
-----------------------------------
7783-52-0                           Indium fluoride (InF3)
-----------------------------------
12018-95-0                          Copper indium selenide (CuInSe2)
-----------------------------------
12030-14-7                          Indium sulfide (InS)
-----------------------------------
12030-24-9                          Indium sulfide (In2S3)
-----------------------------------
12056-07-4                          Indium selenide (In2Se3)
-----------------------------------
12672-70-7                          Indium chloride
-----------------------------------
12672-71-8                          Indium oxide
-----------------------------------
13510-35-5                          Indium iodide (InI3)
-----------------------------------
13770-61-1                          Nitric acid, indium(3+) salt
-----------------------------------
13966-94-4                          Indium iodide (InI)
-----------------------------------
14166-78-0                          Indium fluoride (InF3), trihydrate
-----------------------------------
14280-53-6                          Indium bromide (InBr)
-----------------------------------
14405-45-9                          Indium, tris(2,4-pentanedionato-
                                     .kappa.O,.kappa.O')-, (OC-6-11)-
-----------------------------------
25617-98-5                          Indium nitride (InN)
-----------------------------------
55326-87-9                          Indium hydroxide
-----------------------------------
71243-84-0                          Indium tin oxide (In1.69Sn0.15O2.85)
-----------------------------------
13465-09-3                          Indium bromide (InBr3)
-----------------------------------
13465-10-6                          Indium chloride (InCl)
-----------------------------------
13709-93-8                          Boric acid (H3BO3), indium(3+) salt
                                     (1:1)
-----------------------------------
27765-48-6                          Borate(1-), tetrafluoro-, indium(3+)
                                     (3:1)
-----------------------------------
66027-94-9                          Indium, hydroxybis(trifluoroacetato-
                                     .kappa.O)-
-----------------------------------
67816-06-2                          Hexanoic acid, 2-ethyl-, indium(3+)
                                     salt
-----------------------------------
68310-35-0                          Neodecanoic acid, indium(3+) salt
------------------------------------------------------------------------


    With these actions, there are nine indium compounds remaining on 
the Priority Testing List (Table 8 of this unit). Indium phosphide 
remains on the Priority Testing List due to carcinogenicity concerns 
based on experimental animal studies (Ref. 22). The other eight indium 
compounds remain on the Priority Testing List because PAIR reports were 
submitted for these chemicals and the ITC needs health effects data 
(see section II.E. of this report).


    Table 8.--Indium Compounds Remaining on the Priority Testing List
------------------------------------------------------------------------
             CAS No.                          Chemical name
-----------------------------------------------------------------------
1312-43-2                          Indium oxide (In2O3)
----------------------------------

[[Page 8987]]

 
7440-74-6                          Indium
----------------------------------
10025-82-8                         Indium chloride (InCl3)
----------------------------------
13464-82-9                         Sulfuric acid, indium(3+) salt
                                    (3:2)
----------------------------------
20661-21-6                         Indium hydroxide (In(OH)3)
----------------------------------
25114-58-3                         Acetic acid, indium(3+) salt
----------------------------------
22398-80-7                         Indium phosphide (InP)
----------------------------------
17906-67-7                         Indium tin oxide
----------------------------------
66027-93-8                         Sulfamic acid, indium(3+) salt
------------------------------------------------------------------------

V. References

    1. USEPA. 1998. Revisions to Reporting Regulations Under TSCA 
Section 8(d) (63 FR 15765, April 1, 1998) (FRL-5750-4). Available 
online at: http://www.epa.gov/fedrgstr/.
    2. ITC. 2001. Forty-Eighth Report of the ITC. Federal Register (66 
FR 51276, October 5, 2001) (FRL-6786-7). Available online at: http://www.epa.gov/fedrgstr/.
    3. ITC. 2001. Forty-Ninth Report of the ITC. Federal Register (67 
FR 10298, March 6, 2002) (FRL-6820-8). Available online at: http://www.epa.gov/fedrgstr/.
    4. ITC. 2001. Fiftieth Report of the ITC. Federal Register (67 FR 
49530, July 30, 2002) (FRL-7183-7). Available online at: http://www.epa.gov/fedrgstr/.
    5. ITC. 1998. Forty-Second Report of the ITC. Federal Register (63 
FR 42554, August 7, 1998) (FRL-5797-8). Available online at: http://www.epa.gov/fedrgstr/.
    6. ITC. 2001. Forty-Seven Report of the ITC. Federal Register (66 
FR 17768 April 3, 2001) (FRL-6763-6). Available online at: http://www.epa.gov/fedrgstr/.
    7. ITC. 2000. Forty-Sixth Report of the ITC. Federal Register (65 
FR 75552 December 1, 2000) (FRL-6594-7). Available online at: http://www.epa.gov/fedrgstr/.
    8. USEPA. 2001. Preliminary Assessment Information Reporting; 
Addition of Certain Chemicals (66 FR 38955, July 26, 2001) (FRL-6783-
6). Available online at: http://www.epa.gov/fedrgstr/.
    9. ITC. 1998. Forty-First Report of the ITC. Federal Register (63 
FR 17658, April 9, 1998) (FRL-5773-5). Available online at: http://www.epa.gov/fedrgstr/.
    10. ACC. 2002. Comments on 50\th\ TSCA Interagency Testing 
Committee Report. Docket ID Number OPPT-2002-0026 (67 FR 45929, July 
30, 2002). September 13, 2002 letter from the American Chemistry 
Council, Arlington, VA.
    11. ITC. 2000. Forty-Fifth Report of the ITC. Federal Register (65 
FR 75544, December 1, 2000) (FRL-6399-5). Available online at: http://www.epa.gov/fedrgstr/.
    12. ITC. 1989. Twenty-Fifth Report of the ITC, Receipt of Report 
and Request for Comments Regarding Priority Testing List of Chemicals. 
Federal Register (54 FR 51114, December 12, 1989). Available online at: 
http://www.epa.gov/fedrgstr/EPA-TOX/pre1994/hisindex.htmToxic 
Substances Control Act (TSCA) Interagency Testing Committee (ITC) 
Reports.
    13. WHO. 2001. Vanadium Pentoxide and Other Inorganic Vanadium 
Compounds. Concise International Chemical Assessment Document 29. World 
Health Organization, Geneva, Switzerland. Available online at: http://www.inchem.org/documents/cicads/cicads/cicad29.htm.
    14. Reese, Robert G., Jr. 2001. Vanadium. The Mineral Yearbook--
Minerals and Metals. Available online at: (http://minerals.usgs.gov/minerals/pubs/commodity/vanadium/700401.pdf).
    15. ATSDR. 1992. Toxicological Profile of Vanadium. Available 
online at: http://www.atsdr.cdc.gov/toxprofiles/tp58.html.
    16. ITC. 1991. Twenty-Eighth Report of the ITC, Receipt of Report 
and Request for Comments Regarding Priority List of Chemicals. Federal 
Register (56 FR 41212, August 19, 1991). Available online at: http://
www.epa.gov/fedrgstr/EPA-TOX/pre1994/hisindex.htmToxic 
Substances Control Act (TSCA) Interagency Testing Committee (ITC) 
Reports.
    17. NTP. 1994. Developmental Toxicity of Thiophenol (CAS No. 108-
98-5) in Sprague-Dawley (CD[reg]) Rats. NTIS PB94-155009. 
Available online at: http://ntp-server.niehs.nih.gov/htdocs/TT-studies/TER92133.html.
    18. NTP. 1994. Developmental Toxicity of Thiophenol (CAS No. 108-
98-5) in New Zealand White Rabbits. NTIS PB94-201183 . 
Available online at: http://ntp-server.niehs.nih.gov/htdocs/TT-studies/TER92134.html.
    19. NTP. 1996. Reproductive Toxicity of Thiophenol II (CAS No: 108-
98-5) Administered by Gavage to Sprague-Dawley Rats. National 
Toxicology Program. NTIS PB96-211735. Available online at: 
http://ntp-server.niehs.nih.gov/htdocs/RT-studies/RACB94001.html.
    20. ITC. 1996. Thirty-Seventh Report of the ITC. Federal Register 
(61 FR 4188, February 2, 1996) (FRL-4991-6). Available online at: 
http://www.epa.gov/fedrgstr/.
    21. ITC. 1997. Thirty-Ninth Report of the ITC. Federal Register (62 
FR 8578, February 25, 1997) (FRL-5580-9). Available online at: http://www.epa.gov/fedrgstr/.
    22. NTP. 2001. Toxicology and carcinogenesis studies of indium 
phosphide (CAS No. 22398-80-7) in F344/Nrats and B6C3F1 mice 
(inhalation studies). National Toxicology Program Technical Report. 
2001 July; 499:1-4433 (http://ehp.niehs.nih.gov/ntp/members/tr499/tr499-full.pdf).

VI. TSCA Interagency Testing Committee

    Statutory Organizations and Their Representatives

    Council on Environmental Quality
     Vacant

    Department of Commerce

     National Institute of Standards and Technology
     Robert Huie, Member

[[Page 8988]]

     Barbara C. Levin, Alternate

     National Oceanographic and Atmospheric Administration
     Thomas P. O'Connor, Member
     Teri Rowles, Alternate

    Environmental Protection Agency
     Gerry Brown, Member
     Paul Campanella, Alternate

    National Cancer Institute
     Alan Poland, Member
     David Longfellow, Alternate

    National Institute of Environmental Health Sciences
     Scott Masten, Member, Chair
     William Eastin, Alternate

    National Institute for Occupational Safety and Health
     Mark Toraason, Member, Vice Chair
     Dennis W. Lynch, Alternate

    National Science Foundation
     Marge Cavanaugh, Member

    Occupational Safety and Health Administration
     Val H. Schaeffer, Member
     Lyn Penniman, Alternate

    Liaison Organizations and Their Representatives
    Agency for Toxic Substances and Disease Registry
     William Cibulas, Member
     Daphne Moffett, Alternate

    Consumer Product Safety Commission
     Treye Thomas, Member
     Jacqueline Ferrante, Alternate

    Department of Agriculture
     Clifford P. Rice, Member
     Laurau L. McConnell, Alternate

    Department of Defense
     Barbara Larcom, Member
     Kenneth Still, Alternate
     Jos[eacute] Centeno, Alternate

    Department of the Interior
     Barnett A. Rattner, Member

    Food and Drug Administration
     David Hatten, Member

    National Library of Medicine
     Vera W. Hudson, Member

    National Toxicology Program
     NIEHS, FDA, and NIOSH Members

    Technical Support Contractor
     Syracuse Research Corporation

    ITC Staff
     John D. Walker, Director
     Norma S. L. Williams, Executive Assistant

TSCA Interagency Testing Committee, Office of Pollution Prevention and 
Toxics (7401M), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460-0001; telephone number: (202) 564-7527; 
fax number: (202) 564-7528; e-mail address: [email protected]; 
url: http://www.epa.gov/opptintr/itc.
[FR Doc. 03-4522 Filed 2-25-03; 8:45 am]
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