[Federal Register Volume 68, Number 24 (Wednesday, February 5, 2003)]
[Notices]
[Page 5909]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 03-2624]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: ``Spatially and Temporal 
Control of Gene Expression Protein Promoter in Combination with Local 
Heat''

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

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SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR 404.7(a)(1)(i), that the National Institutes of Health, Department 
of Health and Human Services, is contemplating the grant of an 
exclusive license to practice the inventions embodied in International 
Patent Application No. PCT/US97/15270, entitled ``Spatially and 
Temporal Control of Gene Expression Protein Promoter in Combination 
with Local Heat,'' to Celsion Corporation, a US company with 
headquarters in Maryland.
    The prospective exclusive license territory may be worldwide and 
the field of use may be limited to gene-based therapeutics for the 
treatment of cancer.

DATES: Only written comments and/or license applications which are 
received by the National Institutes of Health on or before April 7, 
2003 will be considered.

ADDRESSES: Requests for copies of the patent, inquiries, comments and 
other materials relating to the contemplated exclusive license should 
be directed to: Matthew B. Kiser, Technology Licensing Specialist, 
Office of Technology Transfer, National Institutes of Health, 6011 
Executive Boulevard, Suite 325, Rockville, MD 20852-3804. Telephone: 
(301) 435-5236; Facsimile (301) 402-0220; E-mail [email protected].

SUPPLEMENTARY INFORMATION: International Patent Application No. PCT/
US97/15270 relates to the spatial and temporal control of exogenous 
gene expression in genetically engineered cells and organisms. In 
particular, it discloses the use of heat inducible promoters, such as 
the promoter of heat shock genes to control the expression of exogenous 
genes. It further relates to the use of focused ultrasound to heat 
cells that contain therapeutic genes under the control of heat shock 
promoters, thereby inducing the expression of therapeutic genes.
    The prospective exclusive license will be royalty-bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. 
The prospective exclusive license may be granted unless within sixty 
(60) days from the date of this published notice, the NIH receives 
written evidence and argument that establish that the grant of the 
license would not be consistent with the requirements of 35 U.S.C. 209 
and 37 CFR 404.7.
    Applications for a license in the field of use filed in response to 
this notice will be treated as objections to the grant of the 
contemplated exclusive license. Comments and objections submitted to 
this notice will not be made available for public inspection and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: January 28, 2003.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer.
[FR Doc. 03-2624 Filed 2-4-03; 8:45 am]
BILLING CODE 4140-01-P