[Federal Register Volume 67, Number 135 (Monday, July 15, 2002)]
[Notices]
[Pages 46536-46537]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-17655]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Heatlh Service


National Toxicology Program; National Toxicology Program Board of 
Scientific Counselors Technical Reports Review Subcommittee Meeting; 
Review of Draft NTP Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the National Toxicology Program (NTP) Board of Scientific 
Counselors Technical Reports Review Subcommittee on September 5 and 6, 
2002, in the Rodbell Auditorium, Rall Building, South Campus, National 
Institute of Environmental Health Sciences (NIEHS), 111 T.W. Alexander 
Drive, Research Triangle Park, North Carolina. The meeting will begin 
at 8:30 a.m. each day.

Agenda

    The primary agenda topic is the peer review of seven draft 
Technical Reports (TR) of rodent toxicology and carcinogenesis studies 
conducted by the NTP. The reports are listed in the table below in the 
tentative order of their review for each day. The NTP Technical Reports 
will be reviewed over two days: reports numbered TR 510 to TR 514 on 
September 5 and reports numbered TR 516 and TR 517 on September 6. 
There will also be brief presentations on September 6 concerning the 
use of transgenic models in carcinogenic hazard identification and NTP 
studies.
    The agenda and roster of subcommittee members will be available 
prior to the meeting on the NTP Web home page at http://ntp-server.niehs.nih.gov and upon request to the NTP Executive Secretary, 
Dr. Mary S. Wolfe, P.O. Box 12233, 111 T.W. Alexander Dr., MD A3-01, 
Research Triangle Park, NC 27709, T: 919-541-0295; e-mail: 
[email protected]. Following the meeting, summary minutes will be 
available on the NTP Web home page and in hard copy upon request to the 
Executive Secretary. Plans are also underway for making this meeting 
available for viewing on the Internet (http://www.niehs.nih.gov/external/video.htm).
    The NTP Board of Scientific Counselors Technical Reports Review 
Subcommittee meeting is open to the public. Attendance at this meeting 
is limited only by the space available. Individuals who plan to attend 
are asked to register with the NTP Executive Secretary (see contact 
information above). The names of those registered to attend will be 
given to the NIEHS Security Office in order to gain access to the 
campus. Persons attending who have not pre-registered may be asked to 
provide pertinent information about the meeting, i.e., title or host of 
meeting before gaining access to the campus. All visitors (whether or 
not you are pre-registered) will need to be prepared to show 2 forms of 
identification (ID), i.e., driver's license and one of the following: 
company ID, government ID, or university ID. Also, those planning to 
attend who need special assistance are asked to notify the NTP 
Executive Secretary in advance of the meeting (see contact information 
above).

Draft Reports Available for Public Review and Comment

    Approximately five weeks prior to the meeting, the draft reports 
will be available for public review, free of charge, through the 
Environmental Health Perspectives (EHP) at http://ehp.niehs.nih.gov/. 
Printed copies can be obtained, as available, from Central Data 
Management (CDM), NIEHS, 111 T.W. Alexander Dr., P.O. Box 12233, MD EC-
03, Research Triangle Park, NC 27709, t: 919-541-3419, fax: 919-541-
3687, e-mail: [email protected].
    Comments on any of the NTP Technical Reports are welcome. Time will 
be provided at the meeting for public comment on each of the reports 
under review. In order to facilitate planning for the meeting, persons 
requesting time for an oral presentation on a particular report are 
asked to notify the Executive Secretary at 919-541-0530, fax: 919-541-
0295, e-mail: [email protected]. Persons registering to submit 
comments are asked to provide a written copy of their statement to the 
Executive Secretary on or before August 28, 2002, to enable review by 
the Subcommittee and NTP staff prior to the meeting. Written statements 
can supplement and may expand the oral presentation or may be submitted 
in lieu of an oral presentation. Each submitter is asked to provide 
his/her name, affiliation, mailing address, phone, fax, e-mail, and 
supporting organization (if any). Each speaker will be allotted at 
least seven minutes and, if time permits, up ten minutes for 
presentation of oral comments. Each organization is allowed one time 
slot per report being reviewed. Registration for making public comments 
will also be available on-site. If registering on-site to speak and 
read comments from printed copy, the speaker is asked to provide 25 
copies of the statement. These copies will be distributed to the 
Subcommittee and NTP staff and will supplement the record.

Request for Additional Information

    The NTP would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing or planned studies as well as 
current production data, human exposure information, and use patterns 
for any of the chemicals listed in this announcement. Please send this 
information to CDM at the address given above. CDM will forward the 
information to the appropriate NTP staff scientist.

NTP Technical and Toxicity Report Series

    The NTP conducts toxicology and carcinogenesis studies of agents of 
public health concern. Any scientist, organization, or member of the 
public may nominate a chemical for NTP testing. Details about the 
nomination process are available on the NTP Web site (http://ntp-server.niehs.nih.gov). The results of short-term rodent toxicology 
studies are published in the NTP Toxicity Report series. Longer-term 
studies, generally, rodent carcinogenicity studies, are published in 
the NTP Technical Report series. Study abstracts for all reports are 
available at the NTP Web site under NTP Study Information. Hard copies 
and PDF files of published reports can be obtained through subscription 
to the EHP (http://ehp.niehs.nih.gov/ or 1-800-315-3010).

[[Page 46537]]

NTP Board of Scientific Counselors

    The Board is a technical advisory body composed of scientists from 
the public and private sectors who provide primary scientific oversight 
and peer review to the NTP. Specifically, the Board advises the NTP on 
matters of scientific program content, both present and future, and 
conducts periodic review of the program for the purpose of determining 
and advising on the scientific merit of its activities and overall 
scientific quality. The Technical Reports Review Subcommittee of the 
Board provides scientific peer review of the findings and conclusions 
of NTP Technical Reports. The Report on Carcinogens Subcommittee of the 
Board provides scientific peer review of nominations to the Report on 
Carcinogens, a Congressionally mandated listing of agents known or 
reasonably anticipated to be human carcinogens.
    The Board's members are selected from recognized authorities 
knowledgeable in fields such as toxicology, pharmacology, pathology, 
biochemistry, epidemiology, risk assessment, carcinogenesis, 
mutagenesis, molecular biology, behavioral and neurotoxicology, 
immunotoxicology, reproductive toxicology or teratology, and 
biostatistics. The NTP strives for equitable geographic distribution 
and minority and female representation on the Board.

    Dated: July 5, 2002.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.

 Technical Reports Tentatively Scheduled for Review by the NTP Board of Scientific Counselors Technical Reports
                                   Review Subcommittee on September 5-6, 2002
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                                                                                     Route & exposure     Review
         Chemical CAS No.                 Report No.             Primary uses             levels          order
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September 5, 2002:
    Dipropylene glycol, 25265-71-8  TR 511................  A component of air     Two-year exposure           1
                                                             and room fresheners,   via drinking water:
                                                             household cleansers,   2,500, 10,000, or
                                                             cosmetic               40,000 ppm to male
                                                             formulations, auto     and female F344/N
                                                             paints, and            rats and 10,000,
                                                             antifreeze.            20,000, or 40,000
                                                                                    ppm to male and
                                                                                    female B6C3F1 mice.
    Elmiron, 37319-17-8...........  TR 512................  Used in treatment of   Two-year exposure by        2
                                                             thrombosis and         gavage in deionized
                                                             hyperlipidemia and     water: 14, 42, or
                                                             for relief of          126 mg/kg body
                                                             urinary bladder pain   weight to male F344/
                                                             associated with        N rats; 28, 84, or
                                                             interstitial           252 mg/kg to female
                                                             cystitis.              F344/N rats; 56,
                                                                                    168, or 504 mg/kg
                                                                                    to male and female
                                                                                    B6C3F1 mice.
    Decalin, 91-17-8..............  TR 513................  An industrial solvent  Two-year inhalation         3
                                                             for fats, resins,      exposure (25, 100,
                                                             oils, waxes, and       or 400 ppm in air)
                                                             naphthalene; a         to male and female
                                                             substitute for         F344/N rats and
                                                             turpentine; a          B6C3F1 mice.
                                                             constituent of motor
                                                             fuels and lubricants.
    Urethane + ethanol, 51-79-6,    TR 510................  Urethane is a by-      Two-year drinking           4
     64-17-5.                                                product of             water exposures of
                                                             fermentation and       10, 30, or 90 ppm
                                                             occurs in breads and   urethane in 0,
                                                             alcoholic beverages.   2.5%, or 5% ethanol
                                                             The effect of          mixtures to male
                                                             urethane was studied   and female B6C3F1
                                                             in combination with    mice.
                                                             alcohol (ethanol).
    Cinnamaldehyde, 14371-10-9....  TR 514................  A flavoring and        Two-year exposure of        5
                                                             fragrance              microencapsulated
                                                             ingredient; the        chemical in feed
                                                             primary component of   (1,000, 2,100, or
                                                             cinnamon oil.          4,100 ppm) to male
                                                                                    and female F344/N
                                                                                    rats and B6C3F1
                                                                                    mice.
September 6, 2002:
    Trimethylolpropane              TR 516................  A representative       Six-month dermal            6
     triacrylate, 15625-89-5.                                multifunctional        applications (0.75,
                                                             acrylate used in       1.5, 3, 6, or 12 mg/
                                                             photocurable inks      kg body weight) to
                                                             and coatings,          male and female
                                                             acrylic glues, paper   Tg.AC hemizygous
                                                             and wood               mice.
                                                             impregnates, wire
                                                             and cable extrusion,
                                                             and polymer-concrete
                                                             composites.
    Pentaerythritol triacrylate,    TR 517................  Representative         Six-month dermal            7
     3524-68-3.                                              multifunctional        applications (0.75,
                                                             acrylate used in       1.5, 3, 6, or 12 mg/
                                                             photocurable inks      kg body weight) to
                                                             and coatings and as    male and female
                                                             an ingredient of       Tg.AC hemizygous
                                                             acrylic glues,         mice.
                                                             adhesives, and
                                                             sealants.
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[FR Doc. 02-17655 Filed 7-12-02; 8:45 am]
BILLING CODE 4140-01-P