[Federal Register Volume 67, Number 129 (Friday, July 5, 2002)]
[Notices]
[Page 44808]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-16884]


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DEPARTMENT OF DEFENSE

Department of the Army


Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application Concerning Assay for Detecting, 
Measuring, and Monitoring the Activities and Concentrations of Proteins 
and Methods of Use Thereof

AGENCY: Department of the Army, DOD.

ACTION: Notice.

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SUMMARY: In accordance with 37 CFR 404.6 and 404.7, announcement is 
made of the availability for licensing of U.S. Patent Application No. 
09/848,370 entitled ``Assay for Detecting, Measuring, and Monitoring 
the Activities and Concentrations of Proteins and Methods of Use 
Thereof,'' filed May 4, 2001. Foreign rights are also available (PCT/
US01/14444). The United States Government, as represented by the 
Secretary of the Army has rights in this invention.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick, 
Frederick, MD 21702-5012.

FOR FURTHER INFORMATION CONTACT: For patent issues, Ms. Elizabeth 
Arwine, Patent Attorney, (301) 619-7808. For licensing issues, Dr. Paul 
Mele, Office of Research & Technology Assessment, (301) 619-6664, both 
at telefax (301) 619-5034.

SUPPLEMENTARY INFORMATION: As assay for detecting, measuring, or 
monitoring the activity of concentration of at least two proteins that 
have similar or overlapping properties is disclosed. The assay 
comprises first determining the sensitivity coefficients of the 
substrates for each of the proteins in which the concentrations are to 
be determined. This method may be used for detecting, measuring, or 
monitoring the activity and concentration of AChE, BChE, or both in a 
test sample which test sample may be whole and unprocessed blood or 
tissue. Also disclosed are methods of using the assay to detect a 
subject's exposure to an agent which affects cholinesterase, determine 
the efficacy or progress of a treatment, determine the amount of 
protection provided against exposure to an agent which affects 
cholinesterase, or both, screen a subject for having a drug sensitivity 
or a particular disease, detect a change in red blood cell count of a 
subject, determine whether a candidate compound affects cholinesterase. 
Also disclosed are devices and kits for detecting, measuring, or 
monitoring the activities and concentrations of AChE, BChE, or both.

Luz D. Ortiz,
Army Federal Register Liaison Officer.
[FR Doc. 02-16884 Filed 7-3-02; 8:45 am]
BILLING CODE 3710-08-M