[Federal Register Volume 67, Number 106 (Monday, June 3, 2002)]
[Notices]
[Pages 38280-38281]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-13767]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-182]


Availability of Draft Guidance Manual and Draft Interaction 
Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice of availability.

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SUMMARY: This notice announces the availability of a draft guidance 
manual and six draft interaction profiles prepared by ATSDR for review 
and comment.

DATES: To ensure consideration, comments on these draft documents must 
be received on or before September 2, 2002. Comments received after the 
close of the public comment period will be considered at the discretion 
of ATSDR based upon what is deemed to be in the best interest of the 
general public.

ADDRESSES: Requests for copies of the draft interaction profiles should 
be sent to the attention of Ms. Franchetta Stephens, Division of 
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop 
E-29, 1600 Clifton Road, NE, Atlanta, Georgia 30333.
    Requests for the draft interaction profiles must be in writing, and 
must specifically identify the interaction profile(s) that you wish to 
receive. The documents will be primarily available in electronic Adobe 
Acrobat (pdf) files. If you do not have a computer, you can ask for a 
hard copy. ATSDR reserves the right to provide only one copy of each 
profile requested, free of charge. In case of extended distribution 
delays, requestors will be notified.
    Interaction profiles and the guidance manual will also be available 
on ATSDR's Web site at http://www.atsdr.cdc.gov.
    Written comments and other data submitted in response to this 
notice and the draft interaction profiles or draft guidance document 
should bear the docket control number ATSDR-182. Send one copy of all 
comments and three copies of all supporting documents to Dr. Hana Pohl, 
ATSDR, Division of Toxicology, Mailstop E-29, 1600 Clifton Road, 
Atlanta, Georgia 30333 by the end of the comment period. Because all 
public comments regarding ATSDR interaction profiles and the guidance 
manual are available for public inspection after they are published in 
final, no confidential business information or other confidential 
information should be submitted in response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Franchetta Stephens, Division of 
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop 
E-29, 1600 Clifton Road, NE, Atlanta, Georgia 30333, telephone (888) 
422-8737 or (404) 498-0720.

SUPPLEMENTARY INFORMATION: The Comprehensive Environmental Response, 
Compensation, and Liability Act of 1980 (CERCLA) mandates that the 
Agency for Toxic Substances and Disease Registry (ATSDR) shall assess 
whether adequate information on health effects is available for the 
priority hazardous substances. Where such information is not available 
or under development, ATSDR shall, in cooperation with the National 
Toxicology Program, initiate a program of research to determine these 
health effects. The Act further directs that where feasible, ATSDR 
shall develop methods to determine the health effects of substances in 
combination with other substances with which they are commonly found. 
The Food Quality Protection Act (FQPA) of 1996 requires that factors to 
be considered in establishing, modifying, or revoking tolerances for 
pesticide chemical residues shall include the available information 
concerning the cumulative effects of substances that have a common 
mechanism of toxicity, and combined exposure levels to the substance 
and other related substances. The FQPA requires that the Administrator 
of the Environmental Protection Agency consult with the Secretary of 
the Department of Health and Human Services (which includes ATSDR) in 
implementing some of the provisions of the act.
    To carry out these legislative mandates, ATSDR has developed a 
chemical mixtures program. As part of

[[Page 38281]]

the mixtures program, ATSDR developed a guidance manual that outlines 
the latest methods for mixtures health assessment. In addition, a 
series of documents called interaction profiles are being developed for 
certain priority mixtures that are of special concern to ATSDR. The 
purpose of an interaction profile is to evaluate data on the toxicology 
of the ``whole'' priority mixture (if available) and on the joint toxic 
action of the chemicals in the mixture in order to recommend approaches 
for the exposure-based assessment of the potential hazard to public 
health.
    Although key studies for each of the mixtures were considered 
during the profile development process, this Federal Register notice 
seeks to solicit any additional studies, particularly unpublished data 
and ongoing studies, which will be evaluated for possible addition to 
the profiles now or in the future.
    The following draft documents will be available to the public on or 
about, June 1, 2002.
Document 1
    Guidance manual for the assessment of joint toxic action of 
chemical mixtures.
Document 2
    Interaction profiles for persistent chemicals found in fish. 
Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene, 
dichlorodiphenyl dichloroethane (p,p'-DDE), methyl mercury, and 
polychlorinated biphenyls (PCBs).
Document 3
    Interaction profiles for persistent chemicals found in breast milk. 
Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene, 
dichlorodiphenyl dichloroethane (p,p'-DDE), methyl mercury, and 
polychlorinated biphenyls (PCBs).
Document 4
    Interaction profile for 1,1,1-trichloroethane, 1,1-dichloroethane, 
trichloroethylene, and tetrachloroethylene.
Document 5
    Interaction profile for benzene, ethylbenzene, toluene, and xylenes 
(BTEX).
Document 6
    Interaction profile for arsenic, cadmium, chromium, and lead.
Document 7
    Interaction profile for copper, lead, manganese, and zinc.

    All documents issued as ``Drafts for Public Comment'' represent 
ATSDR's best efforts to provide important toxicological information on 
interactions of priority hazardous substances. We are seeking public 
comments and additional information which may be used to supplement 
these documents. ATSDR remains committed to providing a public comment 
period for these documents as a means to best serve public health and 
our clients.

    Dated: May 24, 2002.
Georgi Jones,
Director, Office of Policy and External Affairs, Agency for Toxic 
Substances and Disease Registry.
[FR Doc. 02-13767 Filed 5-31-02; 8:45 am]
BILLING CODE 4310-70-P