[Federal Register Volume 67, Number 48 (Tuesday, March 12, 2002)]
[Notices]
[Page 11106]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-5903]


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DEPARTMENT OF DEFENSE

Department of the Army


Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application Concerning High-Throughput Assays 
for the Proteolytic Activities of Clostridial Neurotoxins

AGENCY: Department of the Army, DoD.

ACTION: Notice.

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SUMMARY: In accordance with 37 CFR 404.6, announcement is made of the 
availability for licensing of U.S. Patent Application No. 09/962,260 
entitled ``High Throughput Assays for the Proteolytic Activities of 
Clostridial Neurotoxins'' filed September 25, 2001. Foreign rights are 
also available (PCT/US01/30188). The United States Government as 
represented by the Secretary of the Army has rights in this invention.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick, 
Frederick, Maryland 21702-5012.

FOR FURTHER INFORMATION CONTACT: For patent issues, Ms. Elizabeth 
Arwine, Patent Attorney, (301) 619-7808. For licensing issues, Dr. Paul 
Mele, Office of Research & Technology Assessment, (301) 619-6664, both 
at telefax (301) 619-5034.

SUPPLEMENTARY INFORMATION: In this application are described substrates 
for high-throughput assays of clostridial neurotoxin proteolytic 
activities. Two types of substrates are described for use in assays for 
the proteolytic activities of clostridial neurotoxins: (1) Modified 
peptides or proteins that can serve as FRET substrates and (2) modified 
peptides or proteins that can serve as immobilized substrates. In both 
types a fluorescent molecules is present in the substrate, eliminating 
the requirement for the addition of a fluorigenic reagent. The assays 
described can be readily adapted for use in automated or robotic 
systems.

Luz D. Ortiz,
Army Federal Register Liaison Officer.
[FR Doc. 02-5903 Filed 1-11-02; 8:45 am]
BILLING CODE 3710-08-M