[Federal Register Volume 67, Number 44 (Wednesday, March 6, 2002)]
[Notices]
[Pages 10298-10307]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-5317]



[[Page 10297]]

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Part III





Environmental Protection Agency





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Forty-Ninth Report of the TSCA Interagency Testing Committee to the 
Administrator of the Environmental Protection Agency; Receipt of Report 
and Request for Comments; Notice

  Federal Register / Vol. 67 , No. 44 / Wednesday, March 6, 2002 / 
Notices  

[[Page 10298]]


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ENVIRONMENTAL PROTECTION AGENCY

[OPPTS-41057; FRL-6820-8]


Forty-Ninth Report of the TSCA Interagency Testing Committee to 
the Administrator of the Environmental Protection Agency; Receipt of 
Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing 
Committee (ITC) transmitted its Forty-Ninth Report to the Administrator 
of EPA on November 27, 2001. In the 49\th\ ITC Report, which is 
included with this notice, the ITC rescinds its request to EPA to add 8 
nonylphenol polyethoxylate degradation products to the TSCA section 
8(a) Preliminary Assessment Information Reporting (PAIR) rule, adds 
stannane, dimethylbis[(1-oxoneodecyl)oxy]- (CAS No. 68928-76-7) to the 
Priority Testing List and solicits voluntary information on this 
chemical under the Voluntary Information Submission Policy (VISP) as 
part of the ITC's ongoing effort to evaluate chemicals with potential 
to persist and bioconcentrate. The ITC also solicits voluntary 
information on 17 perfluorinated alcohols, esters, iodides, acids, and 
salts that are considered by the ITC to be possible replacement 
chemicals for perfluorooctylsufonates. Finally, the ITC removes 5 
siloxanes from the Priority Testing List as a result of a successful 
dialogue with the Silicones Environmental Health and Safety Council 
(SEHSC) and implementation of an EPA-SEHSC Product Stewardship Program.

DATES: Comments, identified by docket control number OPPTS-41057, must 
be received on or before April 5, 2002.

ADDRESSES: Comments may be submitted by mail, electronically, or in 
person. Please follow the detailed instructions for each method as 
provided in Unit I. of the SUPPLEMENTARY INFORMATION. To ensure proper 
receipt by EPA, it is imperative that you identify docket control 
number OPPTS-41057 in the subject line on the first page of your 
response.

FOR FURTHER INFORMATION CONTACT: For general information contact: 
Barbara Cunningham, Acting Director, Environmental Assistance Division 
(7408M), Office of Pollution Prevention and Toxics, Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; 
telephone numbers: (202) 554-1404; e-mail address: [email protected]. -
    For technical information contact: John D. Walker, ITC Executive 
Director (7401M), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460; telephone number: (202) 564-7526; fax: 
(202) 564-7528; e-mail address: [email protected].

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me? -

    This notice is directed to the public in general. It may, however, 
be of particular interest to you if you manufacture (defined by statute 
to include import) and/or process TSCA-covered chemicals and you may be 
identified by the North American Industrial Classification System 
(NAICS) codes 325 and 32411. Because this notice is directed to the 
general public and other entities may also be interested, the Agency 
has not attempted to describe all the specific entities that may be 
interested in this action. If you have any questions regarding the 
applicability of this action to a particular entity, consult the 
technical person listed under FOR FURTHER INFORMATION CONTACT.

B. How Can I Get Additional Information, Including Copies of this 
Document or Other Related Documents? -

    1. Electronically. You may obtain electronic copies of this 
document, and certain other related documents that might be available 
electronically, from the EPA Internet Home Page at http://www.epa.gov/. 
To access this document, on the Home Page select ``Laws and 
Regulations,'' ``Regulations and Proposed Rules,'' and then look up the 
entry for this document under the ``Federal Register--Environmental 
Documents.'' You can also go directly to the Federal Register listings 
at http://www.epa.gov/fedrgstr/. -
    You may also access additional information about the ITC and the 
TSCA testing program through the web site for the Office of Prevention, 
Pesticides and Toxic Substances (OPPTS) at http://www.epa.gov/opptsfrs/home/opptsim.htm/, or go directly to the ITC home page at http://www.epa.gov/opptintr/itc/.
    2. In person. The Agency has established an official record for 
this action under docket control number OPPTS-41057. The official 
record consists of the documents specifically referenced in this 
action, any public comments received during an applicable comment 
period, and other information related to this action, including any 
information claimed as Confidential Business Information (CBI). This 
official record includes the documents that are physically located in 
the docket, as well as the documents that are referenced in those 
documents. The public version of the official record does not include 
any information claimed as CBI. The public version of the official 
record, which includes printed, paper versions of any electronic 
comments submitted during an applicable comment period, is available 
for inspection in the TSCA Nonconfidential Information Center, North 
East Mall Rm. B-607, Waterside Mall, 401 M St., SW., Washington, DC. 
The Center is open from noon to 4 p.m., Monday through Friday, 
excluding legal holidays. The telephone number for the Center is (202) 
260-7099.

C. How and to Whom Do I Submit Comments? -

    You may submit comments through the mail, in person, or 
electronically. To ensure proper receipt by EPA, it is imperative that 
you identify docket control number OPPTS-41057 in the subject line on 
the first page of your response. -
    1. By mail. Submit your comments to: Document Control Office 
(7407M), Office of Pollution Prevention and Toxics (OPPT), 
Environmental Protection Agency, 1200 Pennsylvania Ave., NW., 
Washington, DC 20460. -
    2. In person or by courier. Deliver your comments to: OPPT Document 
Control Office (DCO) in EPA East Building Rm. 6428, 1201 Constitution 
Ave., NW., Washington, DC. The DCO is open from 8 a.m. to 4 p.m., 
Monday through Friday, excluding legal holidays. The telephone number 
for the DCO is (202) 564-8930. -
    3. Electronically. You may submit your comments electronically by 
e-mail to: [email protected], or mail your computer disk to the address 
identified above. Do not submit any information electronically that you 
consider to be CBI. Electronic comments must be submitted as an ASCII 
file avoiding the use of special characters and any form of encryption. 
Comments and data will also be accepted on standard disks in 
WordPerfect 6.1/8.0 or ASCII file format. All comments in electronic 
form must be identified by docket control number OPPTS-41057. 
Electronic comments may also be filed online at many Federal Depository 
Libraries.

D. How Should I Handle CBI Information that I Want to Submit to the 
Agency? -

    Do not submit any information electronically that you consider to 
be

[[Page 10299]]

CBI. You may claim information that you submit to EPA in response to 
this document as CBI by marking any part or all of that information as 
CBI. Information so marked will not be disclosed except in accordance 
with procedures set forth in 40 CFR part 2. In addition to one complete 
version of the comment that includes any information claimed as CBI, a 
copy of the comment that does not contain the information claimed as 
CBI must be submitted for inclusion in the public version of the 
official record. Information not marked confidential will be included 
in the public version of the official record without prior notice. If 
you have any questions about CBI or the procedures for claiming CBI, 
please consult the technical person listed under FOR FURTHER 
INFORMATION CONTACT.

E. What Should I Consider as I Prepare My Comments for EPA? -

    We invite you to provide your views and comments on the 49\th\ ITC 
Report. You may find the following suggestions helpful for preparing 
your comments: -- -
    1. Explain your views as clearly as possible. -
    2. Describe any assumptions that you used. -
    3. Provide copies of any technical information and/or data you used 
that support your views. -
    4. Provide specific examples to illustrate your concerns. -
    5. Offer alternatives for improvement. -
    6. To ensure proper receipt by EPA, be sure to identify the docket 
control number assigned to this action in the subject line on the first 
page of your response. You may also provide the name, date, and Federal 
Register citation.

II. Background-

    The Toxic Substances Control Act (TSCA) (15 U.S.C. 2601 et seq.) 
authorizes the Administrator of the EPA to promulgate regulations under 
TSCA section 4(a) requiring testing of chemicals and chemical groups in 
order to develop data relevant to determining the risks that such 
chemicals and chemical groups may present to health or the environment. 
Section 4(e) of TSCA established the ITC to recommend chemicals and 
chemical groups to the Administrator of the EPA for priority testing 
consideration. Section 4(e) of TSCA directs the ITC to revise the TSCA 
section 4(e)Priority Testing List at least every 6 months.

A. The 49\th\ ITC Report

    The 49\th\ ITC Report was transmitted to EPA's Administrator on 
November 27, 2001, and is included in this notice.
    In the 49\th\ ITC Report, the ITC:
    1. Rescinds its request to EPA to add 8 nonylphenol polyethoxylate 
degradation products to the TSCA section 8(a) PAIR rule.
    2. Adds stannane, dimethylbis[(1-oxoneodecyl)oxy]- (CAS No. 68928-
76-7) to the Priority Testing List and solicits voluntary information 
on this chemical under VISP as part of the ITC's ongoing effort to 
evaluate chemicals with potential to persist and bioconcentrate.
    3. Solicits voluntary information on 17 perfluorinated alcohols, 
esters, iodides, acids, and salts that are considered by the ITC to be 
possible replacement chemicals for perfluorooctylsufonates.
    4. Removes 5 siloxanes from the Priority Testing List as a result 
of a successful dialogue with the SEHSC and implementation of an EPA-
SEHSC Product Stewardship Program.

B. Status of the Priority Testing List

    The current TSCA 4(e) Priority Testing List as of November 2001 can 
be found in Table 1 of the 49\th\ ITC Report which is included in this 
notice.

List of Subjects -

    Environmental protection, Chemicals, Hazardous substances.


    Dated: February 26, 2002.
Charles M. Auer,
Director, Chemical Control Division, Office of Pollution Prevention and 
Toxics.

Forty-Ninth Report of the TSCA Interagency Testing Committee to the 
Administrator, U.S. Environmental Protection Agency

Table of Contents

Summary

I. Background
II. TSCA Section 8 Reporting
A. TSCA Section 8 Reporting Rules
B. ITC's Use of TSCA Section 8 and Other Information
C. Promoting More Efficient Use of Information Submission Resources
D. Coordinating Information Requests
E. Requests to Promulgate TSCA Section 8(a) Preliminary Assessment 
Information Reporting (PAIR) and Section 8(d) Health and Safety Data 
Reporting (HaSDR) Rules
III. ITC's Activities During this Reporting Period (May to October 
2001)
A. Continued Review of Degradation Effects Bioconcentration Information 
Testing Strategies (DEBITS) Chemicals
B. Information Solicitations: Perfluorinated Alcohols, Esters, Iodides, 
Acids, and Salts
IV. Revisions to the TSCA Section 4(e) Priority Testing List
A. Chemicals Added to the Priority Testing List: Stannane, 
dimethylbis[(1-oxoneodecyl)oxy]-
B. Chemicals Removed From the Priority Testing List: Siloxanes
V. References
VI. The TSCA Interagency Testing Committee

SUMMARY

    This is the 49\th\ Report of the TSCA Interagency Testing Committee 
(ITC) to the Administrator of the U.S. Environmental Protection Agency 
(EPA). In this Report, the ITC is rescinding its request to the EPA to 
add 8 nonylphenol polyethoxylate degradation products to the TSCA 
section 8(a) Preliminary Assessment Information Reporting (PAIR) rule. 
The ITC is adding stannane, dimethylbis[(1-oxoneodecyl)oxy]- to the 
Priority Testing List and soliciting voluntary information under the 
Voluntary Information Submission Policy (VISP) as part of the ongoing 
effort to evaluate chemicals with potential to persist and 
bioconcentrate. The ITC is also soliciting voluntary information on 
perfluorinated alcohols, esters, iodides, acids and salts that are 
considered possible replacement chemicals for perfluorooctylsufonates 
(PFOS). The ITC is removing 5 siloxanes from the Priority Testing List 
as a result of a successful dialogue with the Silicones Environmental 
Health and Safety Council (SEHSC) and implementation of a EPA-SEHSC 
Product Stewardship Program. The revised TSCA section 4(e) Priority 
Testing List follows as Table 1.


[[Page 10300]]



                      Table 1.--The TSCA Section 4(e) Priority Testing List (November 2001)
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             Report No.                         Date                Chemical/Group                Action
----------------------------------------------------------------------------------------------------------------
28..................................  May 1991...............  Chemicals with low        Designated
                                                                confidence reference
                                                                dose (RfD).
                                                                 Acetone...............
                                                                 Thiophenol............
31..................................  January 1993...........  13 Chemicals with         Designated
                                                                insufficient dermal
                                                                absorption rate data.
32..................................  May 1993...............  16 Chemicals with         Designated
                                                                insufficient dermal
                                                                absorption rate data.
35..................................  November 1994..........  4 Chemicals with          Designated
                                                                insufficient dermal
                                                                absorption rate data.
37..................................  November 1995..........  12 Alkylphenols and       Recommended
                                                                alkylphenol ethoxylates.
39..................................  November 1996..........  8 Nonylphenol             Recommended
                                                                ethoxylates.
41..................................  November 1997..........  7 Alkylphenols and        Recommended
                                                                alkylphenol ethoxylates.
42..................................  May 1998...............  3-Amino-5-mercapto-1,2,4- Recommended
                                                                triazole.
42..................................  May 1998...............  Glycoluril..............  Recommended
46..................................  May 2000...............  8 Nonylphenol             Recommended
                                                                polyethoxylate
                                                                degradation products.
47..................................  November 2000..........  37 Indium chemicals.....  Recommended
47..................................  November 2000..........  Pentachlorothiophenol...  Recommended
47..................................  November 2000..........  Tetrachloropyrocatechol.  Recommended
47..................................  November 2000..........  p-Toluidine, 5-chloro-    Recommended
                                                                .alpha.,.alpha.,.alpha.-
                                                                trifluoro-2-nitro-N-
                                                                phenyl.
47..................................  November 2000..........  Benzoic acid, 3-[2-       Recommended
                                                                chloro-4-
                                                                (trifluoromethyl)phenox
                                                                y]-, 2-ethoxy-1-methyl-
                                                                2-oxoethyl ester.
47..................................  November 2000..........  3 Chloroalkenes.........  Recommended
48..................................  May 2001...............  5 Chlorinated             Recommended
                                                                trihalomethyl pyridines.
48..................................  May 2001...............  2 Trihaloethylidene       Recommended
                                                                bisbenzenes.
48..................................  May 2001...............  3-Chlorotrifluralin.....  Recommended
48..................................  May 2001...............  4                         Recommended
                                                                Trichlorophenyldihydrop
                                                                yrazols.
49..................................  November 2001..........  Stannane, dimethylbis[(1- Recommended
                                                                oxoneodecyl)oxy]-.
----------------------------------------------------------------------------------------------------------------

I. Background

    The ITC was established by section 4(e) of TSCA ``to make 
recommendations to the Administrator respecting the chemical substances 
and mixtures to which the Administrator should give priority 
consideration for the promulgation of a rule for testing under section 
4(a).... At least every six months ..., the Committee shall make such 
revisions to the Priority Testing List as it determines to be necessary 
and transmit them to the Administrator together with the Committee's 
reasons for the revisions'' (Public Law 94-469, 90 Stat. 2003 et seq., 
15 U.S.C. 2601 et seq.). Since its creation in 1976, the ITC has 
submitted 48 semi-annual (May and November) reports to the EPA 
Administrator transmitting the Priority Testing List and its revisions. 
ITC reports are available from the ITC's web site (http://www.epa.gov/opptintr/itc) within a few days of submission to the Administrator and 
from http://www.epa.gov/fedrgstr after publication in the Federal 
Register. The ITC meets monthly and produces its revisions to the 
Priority Testing List with administrative and technical support from 
the ITC Staff, ITC Members and their U.S. Government organizations, and 
contract support provided by EPA. ITC Members and Staff are listed at 
the end of this Report.

II. TSCA Section 8 Reporting

A. TSCA Section 8 Reporting Rules

    Following receipt of the ITC's Report (and the revised Priority 
Testing List) by the EPA Administrator, the EPA's Office of Pollution 
Prevention and Toxics (OPPT) promulgates TSCA section 8(a) PAIR and 
TSCA section 8(d) Health and Safety Data Reporting (HaSDR) rules for 
chemicals added to the Priority Testing List. The PAIR rule requires 
producers and importers of Chemical Abstract Service (CAS)-numbered 
chemicals added to the Priority Testing List to submit production and 
exposure reports under TSCA section 8(a). The HaSDR rule requires 
producers, importers and processors of all chemicals (including those 
with no CAS numbers) added to the Priority Testing List to submit 
unpublished health and safety studies under TSCA section 8(d) that must 
be in compliance with the revised HaSDR rule (63 FR 15765, April 1, 
1998) (FRL-5750-4). All submissions must be received by the EPA within 
90 days of the reporting rules Federal Register publication date. The 
reporting rules are automatically promulgated by OPPT unless otherwise 
requested by the ITC. It is an ITC policy, for most chemicals that are 
added to the Priority Testing List, to delay automatic promulgation of 
HaSDR rules to allow voluntary submission of studies of specific 
interest (see Unit II.C. of this Report for further details).

B. ITC's Use of TSCA Section 8 and Other Information

    The ITC reviews the TSCA section 8(a) PAIR rule reports, TSCA 
section 8(d) HaSDR rule studies and other information that becomes 
available after the ITC adds chemicals to the Priority Testing List. 
Other information includes: TSCA section 4(a) and 4(d) studies; TSCA 
section 8(c) submissions; TSCA section 8(e) ``substantial risk'' 
notices; ``For Your Information'' (FYI) submissions; ITC voluntary 
submissions; unpublished data submitted to and from U.S. Government 
organizations represented on the ITC; and published papers, as well as 
use, exposure, effects, and persistence data that are voluntarily 
submitted to the ITC by manufacturers, importers, processors, and users 
of chemicals recommended by the ITC. The ITC reviews this information 
and determines if data needs should be revised, if chemicals should be 
removed from the Priority Testing List or if recommendations should be 
changed to designations.

C. Promoting More Efficient Use of Information Submission Resources

    To promote more efficient use of information submission resources, 
the ITC developed the Voluntary Information Submissions Policy (VISP). 
The VISP provides examples of data needed by ITC Member U.S. Government 
organizations, examples of studies that should not be submitted, the 
milestones for submitting information, guidelines for using the TSCA 
Electronic HaSDR Form and instructions for electronically submitting 
full studies. The TSCA Electronic HaSDR Form can be used to provide 
information electronically on ITC voluntary submissions, TSCA section 
8(d) studies, FYI submissions, and TSCA section 8(e) studies. VISP is

[[Page 10301]]

described in the ITC's 41\st\ Report (63 FR 17658, April 9, 1998) (FRL-
5773-5) and is accessible through the world wide web (http://www.epa.gov/opptintr/itc/visp.htm). To facilitate the implementation of 
VISP, the ITC developed the Voluntary Information Submissions 
Innovative Online Network (VISION). VISION is described in the ITC's 
42\nd\ Report (63 FR 42554, August 7, 1998) (FRL-5797-8) and is 
accessible through the world wide web (http://www.epa.gov/opptintr/itc/vision.htm). VISION includes the VISP and links to the TSCA Electronic 
HaSDR Form (http://www.epa.gov/opptintr/.er/hasd.htm) including revised 
section 3.2 of the TSCA Electronic HaSD Reporting Form to provide more 
use and exposure information (see the ITC's 46\th\ Report for details; 
65 FR 75552, December 1, 2000) (FRL-6594-7).
    The ITC requests that chemical producers, importers, processors, 
and users provide information electronically via VISION on chemicals 
for which the ITC is soliciting voluntary information. To enhance 
visibility, the ITC will be adding all chemicals to the Priority 
Testing List for which it is soliciting voluntary information. If the 
ITC does not receive voluntary information submissions to meet its data 
needs according to the procedures in VISP, the ITC may then request 
that EPA promulgate the appropriate TSCA sections 8(a) and 8(d) 
reporting rules to determine if there are unpublished data to meet 
those needs. The ITC requests that those companies responding to a TSCA 
section 8(d) HaSDR rule, provide data by using the TSCA Electronic 
HaSDR Form.

D. Coordinating Information Requests

    To avoid duplicate reporting, the ITC carefully coordinates its 
information solicitations and reporting requirements with other 
national and international testing programs, e.g., the National 
Toxicology Program, the Organization for Economic Cooperation and 
Development (OECD) Screening Information Data Set (SIDS) program and 
the EPA's High Production Volume (HPV) Challenge. The ITC is currently 
focusing its efforts on persistent non-HPV chemicals that have exposure 
potential, but few, if any, publicly available ecological or health 
effects data. The ITC is working with the EPA's Persistent 
Bioaccumulative Toxics (PBT), Endocrine Disruption and 
perfluoroctylsulfonate chemicals workgroups to identify data-poor, 
potentially toxic chemicals to complement the objectives of those 
programs.

E. Requests to Promulgate TSCA Section 8(a) Preliminary Assessment 
Information Reporting (PAIR) and Section 8(d) (HaSDR) Rules

    In its 47\th\ Report, the ITC asked the EPA to add 8 nonylphenol 
polyethoxylate degradation products to the TSCA section 8(a) PAIR rule 
(66 FR 17768, April 4, 2001) (FRL-6763-6). Since that Report the ITC 
has obtained additional information on these chemicals from the EPA and 
the Alkylphenols & Ethoxylates Research Council (APERC).
    At this time, the ITC is rescinding its request to add 8 
nonylphenol polyethoxylate degradation products to the TSCA section 
8(a) PAIR rule, because:
    1. No production or importation volumes for any of the 8 
nonylphenol polyethoxylate degradation products were reported to EPA in 
response to the 1986, 1990, 1994, or 1998 Inventory Update Rules (IURs) 
and
    2. A November 14, 2000, letter from APERC stated that none of the 8 
nonylphenol polyethoxylate degradation products have been or are being 
manufactured or processed for commercial purposes (Ref . 1, APERC, 
2000). The 8 nonylphenol polyethoxylate degradation products are listed 
in Table 2.


 Table 2.--Nonylphenol Polyethoxylate Degradation Products for which the
ITC is Rescinding its Request for Addition to the TSCA Section 8(a) PAIR
                                  Rule
------------------------------------------------------------------------
                                         Nonylphenol polyethoxylate
              CAS No.                       degradation products
------------------------------------------------------------------------
104-35-8..........................  4-nonylphenol ethoxylate (NP1EO);
                                     Ethanol, 2-(4-nonylphenoxy)-*
20427-84-3........................  4-nonylphenol diethoxylate (NP2EO);
                                     Ethanol, 2-[2-(4-
                                     nonylphenoxy)ethoxy]-
51437-95-7........................  4-nonylphenol triethoxylate (NP3EO);
                                     Ethanol, 2-[2-[2-(4-
                                     nonylphenoxy)ethoxy]ethoxy]-
7311-27-5.........................  4-nonylphenol tetraethoxylate
                                     (NP4EO); Ethanol, 2-[2-[2-[2-(4-
                                     nonylphenoxy)ethoxy]ethoxy]ethoxy]-
3115-49-9.........................  4-nonylphenoxy acetic acid (NP1EC);
                                     Acetic acid, (4-nonylphenoxy)-
106807-78-7.......................  4-nonylphenoxy ethoxy acetic acid
                                     (NP2EC); Acetic acid, [2-(4-
                                     nonylphenoxy)-ethoxy]-
108149-59-3.......................  4-nonylphenoxy diethoxy acetic acid
                                     (NP3EC); Acetic acid, [2-[4-
                                     nonylphenoxy)ethoxy]ethoxy]-
184007-22-5.......................  4-nonylphenoxy triethoxy acetic acid
                                     (NP4EC); Acetic acid, [2-[2-[2-(4-
                                     nonylphenoxy)ethoxy]ethoxy]ethoxy]-
 
------------------------------------------------------------------------
\*\ Names following the semicolon are TSCA-preferred names.


    At this time, the ITC is requesting that EPA not promulgate a TSCA 
section 8(d) HaSDR rule for stannane, dimethylbis[(1-oxoneodecyl)oxy]-. 
The ITC is making this request to allow ORTEP and the producers, 
importers, processors, and users of stannane, dimethylbis [(1-
oxoneodecyl)oxy]- an opportunity to voluntarily provide the requested 
information (see Units III. and IV. of this Report).

III. ITC's Activities During this Reporting Period (May to October 
2001)

A. Continued Review of Degradation Effects Bioconcentration Information 
Testing Strategies (DEBITS) Chemicals

    In its 45\th\ through 48\th\ Reports, the ITC described its 
strategies to screen and evaluate chemicals with persistence and 
bioconcentration potential. These activities are referred to as DEBITS. 
DEBITS provides a means to prioritize chemicals for information 
reporting and testing based on degradation and bioconcentration 
potential and availability of effects data.
    During this reporting period, the ITC continued to implement DEBITS 
by reviewing moderate production volume (MPV) chemicals (production or 
importation volumes between 100,000 and 1,000,000 pounds) with 
estimated or measured bioconcentration factors (BCFs) > 250 and 
structurally related non-MPV chemicals. The ITC reviewed 95 chemicals 
during this reporting period including 48 chemicals for which 
information was solicited from manufacturers and trade associations 
(Table 3).


[[Page 10302]]



   Table 3.--DEBITS Chemicals for Which Information was Solicited From
    Manufacturers and Trade Associations During this Reporting Period
------------------------------------------------------------------------
            CAS No.                 Chemical name      Structural class
------------------------------------------------------------------------
61260-55-7                       1,2-Bis((2,2,6,6-    2,2,6,6-
                                  tetramethyl-         Tetramethylpiperi
                                  piperidin-4-         dines
                                  yl)aminoethyl)etha
                                  ne.
82919-37-7.....................  Decanedioic acid,    2,2,6,6-
                                  methyl 1,2,2,6,6-    Tetramethylpiperi
                                  pentamethyl-4-       dines
                                  piperidinyl ester.
110843-97-5....................  1,5-                 2,2,6,6-
                                  Dioxaspiro[5.5]und   Tetramethylpiperi
                                  ecane-3,3-           dines
                                  dicarboxylic acid,
                                  bis(2,2,6,6-
                                  tetramethyl-4-
                                  piperidinyl) ester.
1552-42-7......................  6-(Dimethylamino)-   3,3-
                                  3,3-bis(4-           Diphenylisobenzof
                                  (dimethylamino)phe   uranones
                                  nyl)-1(3H)-
                                  isobenzofuranone.
52830-74-7.....................  6-(Dimethylamino)-3- 3,3-
                                  (4-                  Diphenylisobenzof
                                  (dimethylamino)phe   uranones
                                  nyl)-1(3H)-
                                  Isobenzofuranone,
                                  3-(2,4-
                                  bis(dimethylamino)
                                  phenyl-.
15715-19-2.....................  Quino [2,3-b]        6,13-
                                  acridine-7,14-       Dihydroquinacrido
                                  dione, 4,11-         nes
                                  dichloro-5,6,12,13-
                                  tetrahydro-.
51085-07-5.....................  Quino[2,3-           6,13-
                                  b]acridine-7,14-     Dihydroquinacrido
                                  dione, 2,9-          nes
                                  dichloro-5,6,12,13-
                                  tetrahydro-.
81-33-4........................  Anthra[2,1,9-        Anthra[2,1,9-
                                  def:6,5,10-          def:6,5,10-
                                  d'e'f']diisoquinol   d'e'f']diisoquino
                                  ine-                 line-1,3,8,10
                                  1,3,8,10(2H,9H)-     (2H,9H)-tetrones
                                  tetrone.
5521-31-3......................  Anthra[2,1,9-        Anthra[2,1,9-
                                  def:6,5,10-          def:6,5,10-
                                  d'e'f']diisoquinol   d'e'f']diisoquino
                                  ine-                 line-1,3,8,10
                                  1,3,8,10(2H,9H)-     (2H,9H)-tetrones
                                  tetrone, 2,9-
                                  dimethyl-.
6424-77-7......................  Anthra[2,1,9-        Anthra[2,1,9-
                                  def:6,5,10-          def:6,5,10-
                                  d'e'f']diisoquinol   d'e'f']diisoquino
                                  ine-                 line-1,3,8,10
                                  1,3,8,10(2H,9H)-     (2H,9H)-tetrones
                                  tetrone, 2,9-bis(4-
                                  methoxyphenyl)-.
67923-45-9.....................  Thiocyanic acid,     Anthra[2,1,9-
                                  (1,3,8,10-           def:6,5,10-
                                  tetrahydro-          d'e'f']diisoquino
                                  1,3,8,10-            line-1,3,8,10
                                  tetraoxoanthra       (2H,9H)-tetrones
                                  (2,1,9-def:6,5,10-
                                  d'e'f')diisoquinol
                                  ine-2,9-diyl)di-
                                  3,1-phenylene
                                  ester.
2716-10-1......................  Benzenamine, 4,4'-   Bis[(4-
                                  [1,4-                aminophenyl)methy
                                  phenylenebis(1-      l]benzenes
                                  methylethylidene)]
                                  bis-.
25834-80-4.....................  2,4-Bis[(4-          Bis[(4-
                                  aminophenyl)methyl   aminophenyl)methy
                                  ]benzenamine.        l]benzenes
2379-74-0......................  Benzo[b]thiophen-    Bisindolones and
                                  3(2H)-one, 6-        Bisbenzothiopheno
                                  chloro-2-(6-chloro-  nes
                                  4-methyl-3-
                                  oxobenzo[b]thien-
                                  2(3H)-ylidene)-4-
                                  methyl-.
85702-64-3.....................  3H-Indol-3-one, 5,7- Bisindolones and
                                  dibromo-2-(5-bromo-  Bisbenzothiopheno
                                  7-chloro-1,3-        nes
                                  dihydro-3-oxo-2H-
                                  indol-2-ylidene)-
                                  1,2-dihydro-.
82-68-8........................  Pentachloronitroben  Halo nitrobenzenes
                                  zene.                (chloronitrobenze
                                                       nes)
29091-09-6.....................  2,4-Dichloro-3,5-    Halo nitrobenzenes
                                  dinitrobenzotriflu   (chloronitrobenze
                                  oride.               nes)
121-17-5.......................  Benzene, 1-chloro-2- Halo nitrobenzenes
                                  nitro-4-             (trihalomethylnit
                                  (trifluoromethyl)-.  robenzenes)
6379-46-0......................  Benzene, 2,3,4-      Halo nitrobenzenes
                                  trichloro-1,5-       (trihalomethylnit
                                  dinitro-.            robenzenes)
319-84-6.......................  alpha-               Halogenated
                                  Hexachlorocyclohex   cyclohexanes
                                  ane.
30554-72-4.....................  Cyclohexane,         Halogenated
                                  tetrabromodichloro-  cyclohexanes
                                  .
30554-73-5.....................  Cyclohexane,         Halogenated
                                  tribromotrichloro-.  cyclohexanes
68258-90-2.....................  Heptachlorocyclopen  Halogenated
                                  tane.                cyclopentanes
68258-91-3.....................  Hexachlorocyclopent  Halogenated
                                  ane.                 cyclopentanes
91-78-1........................  s-Triazine,          Hexahydrotriazines
                                  hexahydro-1,3,5-
                                  triphenyl-.
6281-14-7......................  1,3,5-               Hexahydrotriazines
                                  Tricyclohexylhexah
                                  ydro-s-triazine.
68083-44-3.....................  1,3,5-Triazine,      Hexahydrotriazines
                                  hexahydro-1,3,5-
                                  tris(2-
                                  methylphenyl)-,
                                  trihydrochloride.
5915-41-3......................  2-tert-Butylamino-4- N-(1,1-
                                  chloro-6-            Dimethylethyl)-N'-
                                  ethylamino-s-        ethyl-1,3,5-
                                  triazine.            triazine-2,4-
                                                       diamines
33693-04-8.....................  N-(1,1-              N-(1,1-
                                  dimethylethyl)-N'-   Dimethylethyl)-N'-
                                  ethyl-6-methoxy-     ethyl-1,3,5-
                                  1,3,5-triazine-2,4-  triazine-2,4-
                                  diamine.             diamines
20749-68-2.....................  12H-Phthaloperin-12- Phthaloperinone
                                  one, 8,9,10,11-      Type Compounds
                                  tetrachloro-.
68296-59-3.....................  7H-Benzimidazo[2,1-  Phthaloperinone
                                  a]benz[de]isoquino   Type Compounds
                                  lin-7-one, 9(or
                                  10)-methoxy-.
980-26-7.......................  2,9-                 Quinacridones
                                  Dimethylquinacrido
                                  ne.
1047-16-1......................  5,12-                Quinacridones
                                  Dihydroquino[2,3-
                                  b]acridine-7,14-
                                  dione.
3089-16-5......................  Quino [2,3-b]        Quinacridones
                                  acridine-7,14-
                                  dione, 4,11-
                                  dichloro-5,12-
                                  dihydro-.
3089-17-6......................  Quino[2,3-           Quinacridones
                                  b]acridine-7,14-
                                  dione, 2,9-
                                  dichloro-5,12-
                                  dihydro-.
68-36-0........................  Benzene, 1,4-        Simple
                                  bis(trichloromethy   polyhalomethylben
                                  l)-.                 zenes
328-84-7.......................  Benzene, 1,2-        Simple
                                  dichloro-4-          polyhalomethylben
                                  (trifluoromethyl)-.  zenes
5216-25-1......................  4-                   Simple
                                  Chlorobenzotrichlo   polyhalomethylben
                                  ride.                zenes
25641-99-0.....................  1,2-                 Simple
                                  Bis(dichloromethyl   polyhalomethylben
                                  )benzene.            zenes
30359-53-6.....................  Benzene, 1-(2,2,2-   Simple
                                  trichloroethyl)-3-   polyhalomethylben
                                  (trifluoromethyl).   zenes
78068-85-6.....................  2-Chloro-1-fluoro-4- Simple
                                  (trifluoromethyl)b   polyhalomethylben
                                  enzene.              zenes
467-63-0.......................  Benzenemethanol, 4-  Tris(aminoaryl)met
                                  (dimethylamino)-     hanes
                                  alpha,alpha-bis[4-
                                  (dimethylamino)phe
                                  nyl]-.
603-48-5.......................  Benzenamine,         Tris(aminoaryl)met
                                  4,4',4''-            hanes
                                  methylidynetris
                                  [N,N-dimethyl-.
65294-17-9.....................  Methylium, tris[4-   Tris(aminoaryl)met
                                  (dimethylamino)phe   hanes
                                  nyl]-, salt with 3-
                                  [[4-
                                  (phenylamino)pheny
                                  l]azo]benzenesulfo
                                  nic acid (1:1).

[[Page 10303]]

 
68155-73-7.....................  Benzenesulfonic      Tris(aminoaryl)met
                                  acid, 2-[bis[4-      hanes
                                  [ethyl[(3-
                                  sulfophenyl)methyl
                                  ]amino]phenyl]meth
                                  yl].
71173-64-3.....................  Methylium, bis-[4-   Tris(aminoaryl)met
                                  (dimethylamino)      hanes
                                  phenyl][4-[(2-
                                  hydroxyethyl)amino
                                  ] phenyl]-.
515-03-7.......................  Sclareol
68928-76-7.....................  Stannane,
                                  dimethylbis[(1-
                                  oxoneodecyl)oxy]-
------------------------------------------------------------------------


    The ITC reviewed information on the chemicals in Table 3 from the 
Color Pigments Manufacturers Association (CPMA) and the Ecological and 
Toxicological Association of Dyes and Organic Pigments Manufacturers 
(ETAD) and the companies that were previously or are currently 
manufacturing these chemicals. The ITC learned that many low production 
volume (LPV) chemicals (production/importation volumes between 10,000 
and 100,000 pounds) were no longer produced or imported. Some of the 
chemicals are still produced but only used as chemical intermediates. 
Because of limited production or use, the ITC is not requesting 
additional information for 46 of these 48 chemicals, at this time.
    However, the ITC is continuing to review information for 2 of these 
48 chemicals, 2,9-dimethylquinacridone or quino[2,3-b]acridine-7,14-
dione, 5,12-dihydro-2,9-dimethyl- (CAS No. 980-26-7) and stannane, 
dimethylbis[(1-oxoneodecyl)oxy]- (CAS No. 68928-76-7) (Table 3). The 
ITC requested additional information on 2,9-dimethylquinacridone from 
CPMA and ETAD and is adding stannane, dimethylbis[(1-oxoneodecyl)oxy]- 
to the Priority Testing List (see Unit IV. of this Report).
    The ITC reviewed 47 other chemicals satisfying the DEBITS criteria 
listed in the 45\th\ ITC Report published in the Federal Register of 
December 1, 2000 (65 FR 75544) (FRL-6399-5). It was determined that 
there is a substantial amount of health and ecological effects data 
available for 6 chemicals (Table 4). There is testing being planned 
under EPA's HPV Challenge or the OECD SIDS program for 5 chemicals 
(Table 5). There was no production or importation volumes reported to 
EPA in response to the 1998 IUR for 36 chemicals with bioconcentration 
potential (Table 6). The ITC is not requesting additional information 
on these 47 chemicals, at this time.


        Table 4.--DEBITS Chemicals with Substantial Effects Data
------------------------------------------------------------------------
            CAS No.                 Chemical name      Structural class
------------------------------------------------------------------------
101-14-4.......................  Benzenamine, 4,4'-   Bis(3-chloro-4-
                                  methylenebis [2-     aminophenyl)s
                                  chloro-.
91-94--1.......................  Benzidine, 3,3'-     Bis(3-chloro-4-
                                  dichloro-.           aminophenyl)s
1330-38-7......................  Copper, [dihydrogen  Copper
                                  phthalocyaninedisu   phthalocyanines
                                  lfonato(2-)]-,
                                  disodium salt.
147-14-8.......................  Copper               Copper
                                  phthalocyanine.      phthalocyanines
3380-34-5......................  5-Chloro-2-(2,4-
                                  dichlorophenoxy)ph
                                  enol (Triclosan)
129-00-0.......................  Pyrene
------------------------------------------------------------------------



   Table 5.--DEBITS Chemicals in the EPA's HPV Challenge or the (OECD)
                             (SIDS) Program
------------------------------------------------------------------------
            CAS No.                 Chemical name      Structural class
------------------------------------------------------------------------
7328-97-4......................  Oxirane,2,2',2'',2'  Glycidyl ethers
                                  ''-[1,2-
                                  ethanediylidenetet
                                  rakis (4,1-
                                  phenyleneoxymethyl
                                  ene)]tetrakis-.
6472-82-8......................  Acetamide, N-        Spiro[isobenzofura
                                  [(3.beta.,4.beta.,   n-1(3H),9'-
                                  5.alpha.,16.alpha.   [9H]xanthen]-3-
                                  ,20S)-16-            ones
                                  (acetyloxy)-3-
                                  (dimethylamino)-4-
                                  (hydroxymethyl)-
                                  4,14-dimethyl-9,19-
                                  cylcopregn-6-en-20-
                                  yl]-N-methyl-.
632-79-1.......................  Tetrabromophthalic   1,2-Dicarboxy-
                                  anhydride.           3,4,5,6-
                                                       tetrahalobenzenes
117-08-8.......................  Tetrachlorophthalic  1,2-Dicarboxy-
                                  anhydride.           3,4,5,6-
                                                       tetrahalobenzenes
3468-63-1......................  1-[(2,4-             1-
                                  Dinitrophenyl)azo]-  [(Dinitrophenyl)a
                                  2-naphthalenol.      zo]-2-
                                                       naphthalenols
------------------------------------------------------------------------



   Table 6.--DEBITS Chemicals with Bioconcentration Potential, but no
  Production or Importation Volumes Reported to EPA in Response to the
                                1998 IUR
------------------------------------------------------------------------
            CAS No.                 Chemical name      Structural class
------------------------------------------------------------------------
25357-79-3.....................  Tetrabromophthalic   1,2-Dicarboxy-
                                  acid disodium salt.  3,4,5,6
                                                       tetrahalobenzenes
59756-57-9.....................  2-Propanone, 1-      1-Phenyl-3-
                                  phenyl-3- 3-         (trifluoromethyl)
                                  [trifluoromethyl)p   phenyl-2-
                                  henyl] -.            propanones
89768 -05 -8...................  Benzenebutanenitril  1-Phenyl-3-
                                  e, .beta.-oxo-       (trifluoromethyl)
                                  .alpha.-phenyl-3-    phenyl-2-
                                  (trifluoromethyl)-.  propanones
147-82-0.......................  2,4,6-               2,6-
                                  Tribromoaniline.     Dibromoanilines

[[Page 10304]]

 
92484-07-6.....................  2-Butenediamide,     2,6-
                                  N,N'-bis(2,4,6-      Dibromoanilines
                                  tribromophenyl)-,
                                  (E)-.
6372-69-6......................  Phenothiazin-5-ium,  3,7-
                                  3,7-                 Bis(dimethylamino
                                  bis(dimethylamino)-  )pheno(thia or
                                  , chloride, compd.   oxa)zin-5-ium
                                  with zinc chloride
                                  (ZnCl2).
345-92-6.......................  Bis(4-               4,4'-Substituted
                                  fluorophenyl)metha   benzophenones
                                  none.
81-42-5........................  1,4-Diamino-2,3-     Diaminoanthraquino
                                  dichloro-9,10-       nes
                                  anthracenedione.
81-49-2........................  1-Amino-2,4-dibromo- Diaminoanthraquino
                                  9,10-                nes
                                  anthracenedione.
3443-90-1......................  Benzenesulfonic      Diaminoanthraquino
                                  acid, 2,2'-[(9,10-   nes
                                  dihydro-9-10-dioxo-
                                  1,4-
                                  anthracenediyl)dii
                                  mino]bis(5-methyl-.
6397-02-0......................  2-                   Diaminoanthraquino
                                  Anthracenesulfonic   nes
                                  acid, 1-amino-9,10-
                                  dihydro-9,10-dioxo-
                                  4-[(2,4,6-
                                  trimethylphenyl)am
                                  ino]-, monosodium
                                  salt.
68227-79-2.....................  Benzenesulfonic      Diaminoanthraquino
                                  acid, 2-[[9,10-      nes
                                  dihydro-4-[(4-
                                  methylphenyl)amino
                                  ]-9,10-dioxo-1-
                                  anthracenyl]
                                  amino]-5-methyl-,
                                  monoammonium salt.
68834-02-6.....................  2-                   Diaminoanthraquino
                                  Anthracenesulfonic   nes
                                  acid, 1-amino-4-
                                  [[4-[[(4-
                                  methylphenyl)sulfo
                                  nyl]oxy]phenyl]ami
                                  no]- 9,10-dihydro-
                                  9,10-dioxo.
6130-72-9......................  1,1,3-tris[p-(2,3-   Glycidyl ethers
                                  epoxypropoxy)pheny
                                  l]propane.
67786-03-2.....................  2,2'-[[[2-           Glycidyl ethers
                                  (Oxiranylmethoxy)
                                  phenyl] methylene]
                                  bis (4,1-
                                  phenyleneoxymethyl
                                  ene)] bis-.
26619-69-2.....................  2H-2, 4a-            Glycidyl ethers
                                  Methanonaphthalene
                                  , 8,8a-
                                  epoxyoctahydro-
                                  1,1,5,5-
                                  tetramethyl-, (2S,
                                  4aR, 8R, 8aS) - (-
                                  ) -.
103490-06-8....................  Oxiranemethanamine,  Glycidyl ethers
                                  N,N'-[1,4-
                                  phenylenebis[(1-
                                  methylethylidene)-
                                  4,1-
                                  phenylene]]bis[N-
                                  (oxiranylmethyl)-.
28517-81-9.....................  Benzenesulfonic      Hydroxyamino
                                  acid, ((1-amino-     anthraquinones
                                  9,10-dihydro-4-
                                  hydroxy-9,10-dioxo-
                                  2-anthracenyl)oxy)
                                  (1,1-
                                  dimethylpropyl).
27177-08-8.....................  3,6,9,12,15,18,21,2  Polyethoxylated
                                  4,27-                nonylphenols
                                  Nonaoxanonacosan-1-
                                  ol, 29-
                                  (nonylphenoxy)-.
66197-78-2.....................  3,6,9,12,15,18,21,2  Polyethoxylated
                                  4-Octaoxahexacosan-  nonylphenols
                                  1-ol, 26-
                                  (nonylphenoxy)-,
                                  dihydrogen
                                  phosphate.
6262-21-1......................  3',4',5',6'-         Spiro[isobenzofura
                                  Tetrachlorofluores   n-1(3H),9'-
                                  cein.                [9H]xanthen]-3-
                                                       ones
17372-87-1.....................  2',4',5',7'-         Spiro[isobenzofura
                                  Tetrabromo-3',6'-    n-1(3H),9'-
                                  dihydroxyspiro[iso   [9H]xanthen]-3-
                                  benzofuran-          ones
                                  1(3H),9'-
                                  [9H]xanthen]-3-
                                  one, disodium salt.
24460-06-8.....................  Spiro                Spiro[isobenzofura
                                  [isobenzofuran-      n-1(3H),9'-
                                  1(3H),9'-[9H]        [9H]xanthen]-3-
                                  xanthen]-3-one, 2'-  ones
                                  amino-6'-
                                  (diethylamino)-.
69898-41-5.....................  Furo[3,4-b]pyridin-  Spiro[isobenzofura
                                  7(5H)-one, 5-[4-     n-1(3H),9'-
                                  (diethylamino)-2-    [9H]xanthen]-3-
                                  ethoxyphenyl]-5-(1-  ones
                                  ethyl-2-methyl-1H-
                                  indol-3-yl)-.
2712 -83-6.....................  Butyranilide,2,2,3,
                                  3,4,4,4-
                                  heptafluoro-
                                  2'hydroxy-4'-nitro-
 
5610-94-6......................  1-
                                  Naphthalenesulfoni
                                  c acid, 6-diazo-
                                  5,6-dihydro-5-oxo-
                                  , 4-benzoyl-1,2,3-
                                  benzenetriyl ester
39635-79-5.....................  Phenol, 4,4'-
                                  sulfonylbis [2,6-
                                  dibromo-
57000-78-9.....................  2-Butanone, 1-
                                  chloro-1-(4-
                                  chlorophenoxy)-3,3-
                                  dimethyl-
61219-95-2.....................  2,2-Dichloro-N-2-
                                  propenyl-N-[3-
                                  (trifluoromethyl)p
                                  henyl]acetamide
61792-00-5.....................  9,10-
                                  Anthracenedione,
                                  1,8-bis(2,4-
                                  dinitrophenoxy)-
                                  4,5-dinitro-
63467-15-2.....................  1(2H)-
                                  Quinolinepropanami
                                  de, 6-(2,2-
                                  dicyanoethenyl)-
                                  3,4-dihydro-
                                  2,2,4,7-
                                  tetramethyl-N-
                                  phenyl-
66332-96-5.....................  ,
                                  ,-
                                  Trifluoro-3'-
                                  isopropoxy-o-
                                  toluanalide
68318-35-4.....................  2,7-
                                  Naphthalenedisulfo
                                  nic acid, 4-amino-
                                  3-[[4'-[(2,4-
                                  dihydroxyphenyl)az
                                  o]-3,3'-
                                  dimethyl[1,1'-
                                  biphenyl]-4-
                                  yl]azo]-5-hydroxy-
                                  6-[(4-
                                  sulfophenyl)azo]-,
                                  trisodium salt
72850-64-7.....................  5-
                                  Thiazolecarboxylic
                                  acid, 2-chloro-4-
                                  (trifluoromethyl)-
                                  , phenylmethyl
                                  ester
93964-25-1.....................  11H-
                                  Benzo[a]carbazole-
                                  3-carboxamide, 2-
                                  hydroxy-N-(4-
                                  methoxy-2-
                                  methylphenyl)-,
                                  monosodium salt
97886-45-8.....................  3,5-
                                  Pyridinedicarbothi
                                  oic acid, 2-
                                  (difluoromethyl)-4-
                                  (2-methylpropyl)-6-
                                  (trifluoromethyl)-
                                  , S,S-dimethyl
                                  ester
------------------------------------------------------------------------


[[Page 10305]]

B. Information Solicitations: Perfluorinated Alcohols, Esters, Iodides, 
Acids, and Salts

    On May 25, 2000, the ITC delivered its 46\th\ Report to the EPA 
Administrator and solicited use, exposure, environmental fate, health 
effects, and ecological effects information on 50 perfluorinated 
chemicals (65 FR 75552, December 1, 2000) (FRL-6594-7) that were 
identified during the implementation of DEBITS. Since then the EPA has 
convened several public meetings to discuss chemicals containing 
perfluorooctyl sulfonates (PFOS) and proposed a significant new use 
rule (SNUR) under TSCA section 5(a)(2) for 90 chemical substances, 
including: Perfluorooctanesulfonic acid (PFOSA) and certain of its 
salts (PFOSS), perfluorooctanesulfonyl fluoride (PFOSF), certain higher 
and lower homologues of PFOSA and PFOSF, and certain other chemical 
substances, including polymers, that contain PFOSA and its homologues 
as substructures (65 FR 62319, October 18, 2000) (FRL-6745-5). All of 
these chemical substances were referred to collectively as PFOS in this 
proposed rule.
    The EPA and other U.S. Government organizations represented on the 
ITC are continuing to evaluate perfluorinated chemicals. Consequently, 
the ITC in cooperation with the EPA identified 17 additional 
perfluorinated chemicals, not named in the ITC's 46\th\ Report, the 
EPA's SNUR or the EPA's HPV Challenge, that are possible replacements 
for some uses of PFOS-containing chemicals. These 17 perfluorinated 
chemicals had production volumes greater than 10,000 pounds, but less 
than 1 million pounds (based on 1998 IUR, non-CBI data). The 17 
additional perfluorinated chemicals are listed in Tables 7-10.


                    Table 7.--Perfluoroalkyl Alcohols
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
865-86-1..........................  1-Dodecanol,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,12-heneicosafluoro-
39239-77-5........................  1-Tetradecanol,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,14-
                                     pentacosafluoro-
60699-51-6........................  1-Hexadecanol,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,15,15,16,16,
                                     16-nonacosafluoro-
65104-67-8........................  1-Octadecanol,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,15,15,16,16,
                                     17,17,18,18,18-tritriacontafluoro-
------------------------------------------------------------------------



                     Table 8.--Perfluoroalkyl Esters
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
17741-60-5........................  2-Propenoic acid,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,12-
                                     heneicosafluorododecyl ester
27905-45-9........................  2-Propenoic acid,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     0-heptadecafluorodecyl ester
34362-49-7........................  2-Propenoic acid,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,15,15,16,16,
                                     16-nonacosafluorohexadecyl ester
34395-24-9........................  2-Propenoic acid,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,14-
                                     pentacosafluorotetradecyl ester
65150-93-8........................  2-Propenoic acid,
                                     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,1
                                     1,11,12,12,13,13,14,14,15,15,16,16,
                                     17,17,18,18,18-
                                     tritriacontafluorooctadecyl ester
------------------------------------------------------------------------



                    Table 9.--Perfluoroalkyl Iodides
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
2043-54 -1........................  Dodecane,
                                     1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9
                                     ,9,10,10-heneicosafluoro-12-iodo-
2043 -57 -4.......................  Octane, 1,1,1,2,2,3,3,4,4,5,5,6,6-
                                     tridecafluoro-8-iodo-
30046 -31 -2......................  Tetradecane,
                                     1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9
                                     ,9,10,10,11,11,12,12-
                                     pentacosafluoro-14-iodo-
65104 -63 -4......................  Eicosane,
                                     1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9
                                     ,9,10,10,11,11,12,12,13,13,14,14,15
                                     ,15,16,16,17,17,18,18-
                                     heptatriacontafluoro-20-iodo-
65150 -94 -9......................  Octadecane,
                                     1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9
                                     ,9,10,10,11,11,12,12,13,13,14,14,15
                                     ,15,16,16-tritriacontafluoro-18-
                                     iodo-
65510 -55 -6......................  Hexadecane,
                                     1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9
                                     ,9,10,10,11,11,12,12,13,13,14,14-
                                     nonacosafluoro-16-iodo-
------------------------------------------------------------------------



                Table 10.--Perfluoroalkyl Acids and Salts
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
335-67-1..........................  Octanoic acid, pentadecafluoro
54950-05-9........................  Butanedioic acid, sulfo-, 1,4-
                                     bis(3,3,4,4,5,5,6,6,7,7,8,8,8,-
                                     tridecafluorooctyl)ester, sodium
                                     salt
------------------------------------------------------------------------



[[Page 10306]]

    The ITC needs use, exposure, health effects, ecological effects, 
and bioconcentration information for the 17 perfluorinated chemicals in 
Tables 7-10 to address the data needs of U.S. Government member 
organizations.

IV. Revisions to the TSCA Section 4(e) Priority Testing List

A. Chemicals Added to the Priority Testing List: Stannane, 
dimethylbis[(1-oxoneodecyl)oxy]-

    1. Recommendation. Stannane, dimethylbis[(1-oxoneodecyl)oxy]- (CAS 
No. 68928-76-7) is being recommended to obtain data on use, exposure, 
environmental fate, health effects, and ecological effects data.
    2. Rationale for recommendation. Stannane, dimethylbis[(1-
oxoneodecyl)oxy]- is a MPV chemical that is predicted to persist and 
bioconcentrate; the estimated BCF is 8,600. The 1998 IUR indicates that 
100,000 to 1,000,000 pounds of stannane, dimethylbis [(1-
oxoneodecyl)oxy]- were produced or imported in the United States but 
the ITC has no use and exposure information. A recent TSCA section 8(e) 
submission reported a rat oral LD50 of 894 milligram/
kilogram (mg/kg) body weight (Ref. 2, Crompton Corporation, 2001). 
Signs of toxicity, including neurotoxic effects, were observed in this 
rat oral gavage study. The ITC has no other effects data and no 
environmental fate data, including no data on hydrolysis rates or 
products.
    3. Supporting information. Organotin compounds as a broad class 
have an abundance of health and ecological effects data. Though the 
types of effects vary among different organotins, immunotoxicity, 
neurotoxicity and developmental and reproductive effects have been 
observed in mammalian studies. The ITC is aware that the Organotin 
Environmental Program (ORTEP) has proposed to conduct tests on several 
organotin compounds under the EPA's HPV Challenge. However, stannane, 
dimethylbis[(1-oxoneodecyl)oxy]-, a MPV chemical was not included in 
that program. As noted above, stannane, dimethylbis[(1-
oxoneodecyl)oxy]- has a rat oral LD50 of 894 mg/kg body 
weight. To establish the oral LD50, rats received single 
oral gavage doses of 592; 1,000; or 1,690 mg/kg Fomrez UL-28 (90.6% 
dimethylbis[(1-oxoneodecyl)oxy]-stannane). One of 10, 6/10, and 10/10 
rats died at 592; 1,000; and 1,690 mg/kg, respectively. Most of the 
animals exhibited hypoactivity, and abnormal excreta, along with 
impaired muscle coordination, tremors, and/or hypothermia in 17, 16, 
and 9 animals, respectively. Five of the 9 surviving animals at 592 mg/
kg appeared normal by day 12, while the remaining 4 animals exhibited 
hair loss, hypoactivity, impaired muscle coordination, partial eye 
closing, hypothermia, hyper-reactivity to touch, and/or dried red 
material around the nose at study termination. The 4 surviving animals 
at 1,000 mg/kg exhibited tremors, impaired muscle coordination, hyper-
reactivity to touch, and/or distended abdomen until study termination.
    4. Information needs. The ITC needs use, exposure, ecological 
effects, and environmental fate data and more health effects data. If 
the ITC does not receive voluntary information submissions to meet its 
data needs according to the procedures in VISP, the ITC may then 
request that EPA promulgate a TSCA section 8(d) HaSDR rule to determine 
if there are unpublished data to meet those needs.

B. Chemicals Removed From the Priority Testing List: Siloxanes

    To meet the data needs of the U.S. Government organizations 
represented on the ITC, 56 siloxanes were recommended for health 
effects testing in the ITC's 30\th\ Report (57 FR 30608, July 9, 1992) 
(FRL-4071-4). After this recommendation, the ITC's Siloxanes 
Subcommittee and the Silicones Environmental Health and Safety Council 
(SEHSC) established a Dialogue Group to develop health effects data. 
The health effects data are being developed under an April 9, 1996, 
Memorandum of Understanding (MOU) between EPA and the Dow Corning 
Corporation and a Product Stewardship Program between EPA and SEHSC. 
Since the establishment of this Dialogue Group, numerous activities 
have occurred resulting in the removal of 51 of the 56 siloxanes on the 
Priority Testing List (see the ITC's 37\th\, 38\th\, 39\th\, 40\th\, 
and 41\st\ Reports). During this reporting period, the SEHSC provided 
the ITC with a list of reports (health effects studies) that have been 
submitted to EPA since the implementation of the product stewardship 
program. The list includes reports on the 5 siloxanes being removed 
from the Priority Testing List. The list of reports, EPA's Document 
Control Number (DCN), and the key findings of these reports are 
available on the SEHSC's website (http://www.sehsc.com/). SEHSC will 
include study summaries of the listed reports on its website by April 
2002. Full copies of the listed reports are available from the EPA's 
Nonconfidential Information Center (NCIC) under docket control number 
OPTS-42071A. On its website, SEHSC also included a list of the 
publications that are available in the peer-reviewed literature on the 
health and safety data that have been developed under the siloxane 
product stewardship program. As a result of these activities the ITC is 
removing the 5 siloxanes from the Priority Testing List (Table 11).


    Table 11.--Siloxanes Being Removed From the Priority Testing List
------------------------------------------------------------------------
              CAS No.                           Chemical name
------------------------------------------------------------------------
                                        Cyclic Siloxanes
556-67-2..........................  Octamethylcyclotetrasiloxane (D4)
541-02-6..........................  Decamethylcyclopentasiloxane (D5)
540-97-6..........................  Dodecamethylcyclohexasiloxane (D6)
------------------------------------------------------------------------
                                        Linear Siloxanes
107-46-0..........................  Hexamethyldisiloxane (L2)
------------------------------------------------------------------------
                                        Polymers
63148-62-9........................  Dimethyl silicones and siloxanes
------------------------------------------------------------------------


[[Page 10307]]

V. References

    1. APERC. 2000. November 14, 2000, letter from Barbara S. Losey, 
Deputy Director, APERC to Dr. John D. Walker, Director, TSCA 
Interagency Testing Committee.
    2. Crompton Corporation. 2001. TSCA section 8(e) submission letter 
dated July 25, 2001. EPA Doc. No. 88-010000204. Fiche No. 8EHQ-0792-
606.

VI. The TSCA Interagency Testing Committee

    Statutory Organizations and Their Representatives

    Council on Environmental Quality
        Vacant

    Department of Commerce

          National Institute of Standards and Technology
            Robert Huie, Member
            Barbara C. Levin, Alternate

          National Oceanographic and Atmospheric Administration
            Thomas P. O'Connor, Member
            Teri Rowles, Alternate

    Environmental Protection Agency
        Paul Campanella, Member
        David R. Williams, Alternate

    National Cancer Institute
        Alan Poland, Member
        David Longfellow, Alternate

    National Institute of Environmental Health Sciences
        Scott Masten, Member, Chair
        William Eastin, Alternate

    National Institute for Occupational Safety and Health
        Mark Toraason, Member
        David Lynch, Alternate

    National Science Foundation
        A. Frederick Thompson, Member
        Marge Cavanaugh, Alternate

    Occupational Safety and Health Administration
        Val H. Schaeffer, Member, Vice Chair
        Lyn Penniman, Alternate

    Liaison Organizations and Their Representatives

    Agency for Toxic Substances and Disease Registry
        William Cibulas, Member
        Stephanie Miles-Richardson, Alternate

    Consumer Product Safety Commission
        Jacqueline Ferrante, Member
        Treye Thomas, Alternate

    Department of Agriculture
        Clifford P. Rice, Member
        Laura L. McConnell, Alternate

    Department of Defense
        Barbara Larcom, Member
        Kenneth Still, Alternate
        Jose Centeno, Alternate

    Department of the Interior
        Barnett A. Rattner, Member

    Food and Drug Administration
        David Hatten, Alternate

    National Library of Medicine
        Vera W. Hudson, Member

    National Toxicology Program
        NIEHS, FDA, and NIOSH Members

    Counsel
        Scott Sherlock, OPPT, EPA

    Technical Support Contractor
        Syracuse Research Corporation

    ITC Staff
        John D. Walker, Executive Director
        Norma S. L. Williams, Executive Assistant

TSCA Interagency Testing Committee, Office of Pollution Prevention and 
Toxics (7401), Environmental Protection Agency, 1200 Pennsylvania Ave., 
NW., Washington, DC 20460; telephone: (202) 564-7527; fax: (202) 564-
7528; e-mail address: [email protected]; url: http://www.epa.gov/opptintr/itc.

[FR Doc. 02-5317 Filed 3-5-02; 8:45 am]
BILLING CODE 6560-50-S