[Federal Register Volume 67, Number 40 (Thursday, February 28, 2002)]
[Notices]
[Pages 9306-9307]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-4832]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by agencies of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Production of Adeno-Associated Virus in Insect Cells

Robert M Kotin et al. (NHLBI)
Serial No. 09/986,618 filed 09 Nov 01
Licensing Contact: Susan Rucker; 301/496-7735 ext 245; e-mail: 
[email protected]

    The invention, described and claimed in this patent application, 
relates to the field of production of recombinant adeno-associated 
virus (rAAV). More particularly, the invention relates to systems for 
producing rAAV in a baculovirus-based system. The systems

[[Page 9307]]

for producing rAAV can use the AAV Rep protein and an AAV ITR or the 
insect counterpart thereof, NS-1 and a chimeric ITR derived from AAV 
but containing the NS-1 binding site and the NS1-nicking site. The 
invention provides for increased production of rAAV when compared to 
mammalian systems employing 293 cells which are typically used for rAAV 
production.
    This work has been published in part in C Ding et al., J. Virol. 
76(1): 338-45 (Jan. 2002).

Microbial Identification Databases

Jon G. Wilkes et al. (FDA)
Serial No. 09/975,530 filed 10 Oct 2001
Licensing Contact: Dale Berkley; 301/496-7735 ext. 223; e-mail: 
[email protected]

    The invention is a method for assembling a coherent database 
containing an essentially unlimited number of pyrolysis mass spectra to 
enable rapid chemotaxonomy of unknown microbial samples. The invention 
corrects for short and long-term drift of microbial pyrolysis mass 
spectra by using spectra of similar microbes as internal standards. The 
invention provides for the first time a practical way to assemble a 
coherent database containing an essentially unlimited number of 
pyrolysis mass spectra or other instrumental ``fingerprints'', where 
one or more is representative of each relevant strain, and 
representative of additional strains as they are added to the pool of 
microbial agents. Microorganisms can be identified using the invention 
from their fingerprint spectra regardless of the growth medium used to 
culture the bacteria. This is a result of the discovery that 
corrections made to the fingerprint spectrum of one type of bacterium 
to compensate for changes in growth medium may be applied successfully 
to metabolically similar bacteria. Fingerprint spectra to which the 
method of the invention may be applied include pyrolysis MALDI or other 
types of mass spectra, infrared spectra, chromatograms, NMR spectra and 
ion-mobility spectra. The present invention is especially useful for 
the rapid identification of microorganisms, including human pathogens.

    Dated: February 20, 2002.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 02-4832 Filed 2-27-02; 8:45 am]
BILLING CODE 4140-01-P