[Federal Register Volume 66, Number 194 (Friday, October 5, 2001)]
[Notices]
[Pages 51276-51284]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-25046]



[[Page 51275]]

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Part IV





Environmental Protection Agency





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Forty-Eighth Report of the TSCA Interagency Testing Committee to the 
Administrator, Receipt of Report and Request for Comments; Notice

  Federal Register / Vol. 66 , No. 194 / Friday October 5, 2001 / 
Notices  

[[Page 51276]]


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ENVIRONMENTAL PROTECTION AGENCY

[OPPTS-41056; FRL-6786-7]


Forty-Eighth Report of the TSCA Interagency Testing Committee to 
the Administrator; Receipt of Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing 
Committee (ITC) transmitted its Forty-Eighth Report to the 
Administrator of the EPA on May 15, 2001. In the 48\th\ ITC Report, 
which is included with this notice, the ITC adds 5 ``chlorinated 
trihalomethyl pyridines,'' 2 ``trihaloethylidene bisbenzenes,'' 3-
chlorotrifluralin, and 4 ``trichlorophenyldihydropyrazols'' to its 
Priority Testing List and solicits voluntary information for these 
chemicals under the ITC's Voluntary Information Submissions Policy 
(VISP). This action is part of the ITC's ongoing effort to evaluate 
chemicals with potential to persist and bioconcentrate, and with 
suspicions of toxicity and few data. In this Report, the ITC also 
removes 22 alkylphenols and ethoxylates, methylal, and ethyl silicate 
from its Priority Testing List and requests that EPA promulgate TSCA 
section 8(d) health and safety data reporting rules for 3-amino-5-
mercapto-1,2,4-triazole and glycoluril.

DATES: Comments, identified by docket control number OPPTS-41056, must 
be received on or before November 5, 2001.

ADDRESSES: Comments may be submitted by mail, electronically, or in 
person. Please follow the detailed instructions for each method as 
provided in Unit I. of the SUPPLEMENTARY INFORMATION. To ensure proper 
receipt by EPA, it is imperative that you identify docket control 
number OPPTS-41056 in the subject line on the first page of your 
response.

FOR FURTHER INFORMATION CONTACT: For general information contact: 
Barbara Cunningham, Acting Director, Environmental Assistance Division 
(7408), Office of Pollution Prevention and Toxics, Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; 
telephone numbers: (202) 554-1404; e-mail address: [email protected]. -
    For technical information contact: John D. Walker, ITC Executive 
Director (7401), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460; telephone number: (202) 564-7527; fax: 
(202) 564-7528; e-mail address: [email protected].

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?-

    This notice is directed to the public in general. It may, however, 
be of particular interest to you if you manufacture (defined by statute 
to include import) and/or process TSCA-covered chemicals and you may be 
identified by the North American Industrial Classification System 
(NAICS) codes 325 and 32411. Because this notice is directed to the 
general public and other entities may also be interested, the Agency 
has not attempted to describe all the specific entities that may be 
interested in this action. If you have any questions regarding the 
applicability of this action to a particular entity, consult the 
technical person listed under FOR FURTHER INFORMATION CONTACT.

B. How Can I Get Additional Information, Including Copies of this 
Document or Other Related Documents?-

    1. Electronically. You may obtain electronic copies of this 
document, and certain other related documents that might be available 
electronically, from the EPA Internet Home Page at http://www.epa.gov/. 
To access this document, on the Home Page select ``Laws and 
Regulations,'' ``Regulations and Proposed Rules,'' and then look up the 
entry for this document under the ``Federal Register--Environmental 
Documents.'' You can also go directly to the Federal Register listings 
at http://www.epa.gov/fedrgstr/.-
    You may also access additional information about the ITC and the 
TSCA testing program through the web site for the Office of Prevention, 
Pesticides and Toxic Substances (OPPTS) at http://www.epa.gov/opptsfrs/home/opptsim.htm/, or go directly to the ITC home page at http://www.epa.gov/opptintr/itc/.
    -2. In person. The Agency has established an official record for 
this action under docket control number OPPTS-41056. The official 
record consists of the documents specifically referenced in this 
action, any public comments received during an applicable comment 
period, and other information related to this action, including any 
information claimed as Confidential Business Information (CBI). This 
official record includes the documents that are physically located in 
the docket, as well as the documents that are referenced in those 
documents. The public version of the official record does not include 
any information claimed as CBI. The public version of the official 
record, which includes printed, paper versions of any electronic 
comments submitted during an applicable comment period, is available 
for inspection in the TSCA Nonconfidential Information Center, North 
East Mall Rm. B-607, Waterside Mall, 401 M St., SW., Washington, DC. 
The Center is open from noon to 4 p.m., Monday through Friday, 
excluding legal holidays. The telephone number for the Center is (202) 
260-7099.

C. How and to Whom Do I Submit Comments?-

    You may submit comments through the mail, in person, or 
electronically. To ensure proper receipt by EPA, it is imperative that 
you identify docket control number OPPTS-41056 in the subject line on 
the first page of your response. -
    1. By mail. Submit your comments to: Document Control Office 
(7407), Office of Pollution Prevention and Toxics (OPPT), Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460.-
    2. In person or by courier. Deliver your comments to: OPPT Document 
Control Office (DCO) in East Tower Rm. G-099, Waterside Mall, 401 M 
St., SW., Washington, DC. The DCO is open from 8 a.m. to 4 p.m., Monday 
through Friday, excluding legal holidays. The telephone number for the 
DCO is (202) 260-7093. -
    3. Electronically. You may submit your comments electronically by 
e-mail to: [email protected], or mail your computer disk to the address 
identified above. Do not submit any information electronically that you 
consider to be CBI. Electronic comments must be submitted as an ASCII 
file avoiding the use of special characters and any form of encryption. 
Comments and data will also be accepted on standard disks in 
WordPerfect 6.1/8.0 or ASCII file format. All comments in electronic 
form must be identified by docket control number OPPTS-41056. 
Electronic comments may also be filed online at many Federal Depository 
Libraries.

D. How Should I Handle CBI Information that I Want to Submit to the 
Agency?-

    Do not submit any information electronically that you consider to 
be CBI. You may claim information that you submit to EPA in response to 
this document as CBI by marking any part or all of that information as 
CBI. Information so marked will not be disclosed except in accordance 
with procedures set forth in 40 CFR part 2.

[[Page 51277]]

 In addition to one complete version of the comment that includes any 
information claimed as CBI, a copy of the comment that does not contain 
the information claimed as CBI must be submitted for inclusion in the 
public version of the official record. Information not marked 
confidential will be included in the public version of the official 
record without prior notice. If you have any questions about CBI or the 
procedures for claiming CBI, please consult the technical person listed 
under FOR FURTHER INFORMATION CONTACT.

E. What Should I Consider as I Prepare My Comments for EPA?-

    We invite you to provide your views and comments on the ITC's 
48\th\ Report. You may find the following suggestions helpful for 
preparing your comments:---
    1. Explain your views as clearly as possible.-
    2. Describe any assumptions that you used.-
    3. Provide copies of any technical information and/or data you used 
that support your views.-
    4. Provide specific examples to illustrate your concerns.-
    5. Offer alternatives for improvement. -
    6. To ensure proper receipt by EPA, be sure to identify the docket 
control number assigned to this action in the subject line on the first 
page of your response. You may also provide the name, date, and Federal 
Register citation.

II. Background-

    TSCA (15 U.S.C. 2601 et seq.) authorizes the Administrator of the 
EPA to promulgate regulations under section 4(a) of TSCA requiring 
testing of chemicals and chemical groups in order to develop data 
relevant to determining the risks that such chemicals and chemical 
groups may present to health or the environment. Section 4(e) of TSCA 
established the ITC to recommend chemicals and chemical groups to the 
Administrator of the EPA for priority testing consideration. Section 
4(e) of TSCA directs the ITC to revise the TSCA section 4(e)Priority 
Testing List at least every 6 months.

A. The 48\th\ ITC Report

    The 48\th\ ITC Report was transmitted to the EPA's Administrator on 
May 15, 2001, and is included in this notice.
    In the 48\th\ ITC Report, the ITC:-
    1. Adds 5 ``chlorinated trihalomethyl pyridines,'' 2 
``trihaloethylidene bisbenzenes,'' 3-chlorotrifluralin, and 4 
``trichlorophenyldihydropyrazols'' to its Priority Testing List and 
solicits voluntary information for these chemicals under the ITC's 
VISP. This action is part of the ITC's ongoing effort to evaluate 
chemicals with potential to persist and bioconcentrate, and with 
suspicions of toxicity and few data. -
    2. Removes 22 alkylphenols and ethoxylates, methylal, and ethyl 
silicate from its Priority Testing List.-
    3. Requests that EPA promulgate TSCA section 8(d) health and safety 
data reporting rules for 3-amino-5-mercapto-1,2,4-triazole and 
glycoluril.

B. Status of the Priority Testing List

    The current TSCA 4(e) Priority Testing List as of May 2001 can be 
found in Table 1 of the 48\th\ ITC's Report which is included in this 
notice.

List of Subjects-

    Environmental protection, Chemicals, Hazardous substances.

    Dated: September 26, 2001.
Charles M. Auer,
Director, Chemical Control Division, Office of Pollution Prevention and 
Toxics.

Forty-Eighth Report of the TSCA Interagency Testing Committee to 
the Administrator, U.S. Environmental Protection Agency

Table of Contents

-----------Summary

I. Background
II. TSCA Section 8 Reporting-
 A. TSCA Section 8 Reporting Rules-
 B. ITC's Use of TSCA Section 8 and Other Information-
 C. Promoting More Efficient Use of Information Submission Resources-
 D. Coordinating Information Requests-
 E. Requests to Promulgate TSCA Section 8(a) PAIR and Section 8(d) HaSD 
Reporting Rules
 III. ITC's Activities During this Reporting Period (November 2000 to 
April 2001)-
 IV. Revisions to the TSCA Section 4(e) Priority Testing List
 A. Chemicals Added to the Priority Testing List-
 1. Chlorinated trihalomethyl pyridines-
 2. Trihaloethylidene bisbenzenes-
 3. 3-Chlorotrifluralin
 4. Trichlorophenyldihydropyrazols--
 B. Chemicals Removed From the Priority Testing List-
 1. Alkylphenols and alkylphenol ethoxylates--
 2. Methylal--
 3. Ethyl silicate ---
 V. References
 VI. TSCA Interagency Testing Committee

SUMMARY

    This is the 48\th\ Report of the TSCA Interagency Testing Committee 
(ITC) to the Administrator of the U.S. Environmental Protection Agency 
(USEPA). In this Report, the ITC is adding 5 chlorinated trihalomethyl 
pyridines, 2 trihaloethylidene bisbenzenes, 3-chlorotrifluralin, and 4 
trichlorophenyldihydropyrazols to its Priority Testing List and 
soliciting voluntary information for these chemicals under the ITC's 
Voluntary Information Submissions Policy (VISP). This action is part of 
the ITC's ongoing effort to evaluate chemicals with suspicions of 
toxicity and few data and potential to persist and bioconcentrate. In 
this Report, the ITC is removing 22 alkylphenols and ethoxylates and 
methylal and ethyl silicate from its Priority Testing List. The ITC is 
removing 22 alkylphenols and ethoxylates from its Priority Testing List 
because domestic production or importation volumes were not reported to 
the USEPA in response to 1986, 1990, 1994, and 1998 TSCA section 8(a) 
Information Update Rules (IURs) and in response to the TSCA section 
8(a) Preliminary Assessment Information Reporting (PAIR) rule published 
in the Federal Register of July 5, 2000 (65 FR 41371) (FRL-6589-1). The 
ITC is removing methylal and ethyl silicate from its Priority Testing 
List because data are being developed under the USEPA's High Production 
Volume (HPV) Challenge Program. The revised TSCA section 4(e) Priority 
Testing List follows as Table 1.


                        Table 1.--The TSCA Section 4(e) Priority Testing List (May 2001)
----------------------------------------------------------------------------------------------------------------
               Report                         Date                  Chemical/group                Action
----------------------------------------------------------------------------------------------------------------
28.................................  May 1991..............  Chemicals with Low           Designated
                                                              Confidence Reference Dose
                                                              (RfD).
                                                               Acetone
                                                               Thiophenol
30.................................  May 1992..............  5 Siloxanes................  Recommended
31.................................  January 1993..........  13 Chemicals with            Designated
                                                              insufficient dermal
                                                              absorption rate data.

[[Page 51278]]

 
32.................................  May 1993..............  16 Chemicals with            Designated
                                                              insufficient dermal
                                                              absorption rate data.
35.................................  November 1994.........  4 Chemicals with             Designated
                                                              insufficient dermal
                                                              absorption rate data.
37.................................  November 1995.........  12 Alkylphenols and          Recommended
                                                              alkylphenol ethoxylates.
39.................................  November 1996.........  8 Nonylphenol ethoxylates..  Recommended
41.................................  November 1997.........  7 Alkylphenols and           Recommended
                                                              alkylphenol ethoxylates.
42.................................  May 1998..............  3-Amino-5-mercapto-1,2,4-    Recommended
                                                              triazole.
42.................................  May 1998..............  Glycoluril.................  Recommended
46.................................  May 2000..............  8 Nonylphenol                Recommended
                                                              polyethoxylate degradation
                                                              products.
47.................................  November 2000.........  37 Indium chemicals........  Recommended
47.................................  November 2000.........  Pentachlorothiophenol......  Recommended
47.................................  November 2000.........  Tetrachloropyrocatechol....  Recommended
47.................................  November 2000.........  p-Toluidine, 5-chloro-       Recommended
                                                              .alpha.,.alpha.,.alpha.-
                                                              trifluoro-2-nitro-N-phenyl.
47.................................  November 2000.........  Benzoic acid, 3-[2-chloro-4- Recommended
                                                               (trifluoromethyl)phenoxy]-
                                                              , 2-ethoxy-1-methyl-2-
                                                              oxoethyl ester.
47.................................  November 2000.........  3 Chloroalkenes............  Recommended
48.................................  May 2001..............  5 Chlorinated trihalomethyl  Recommended
                                                              pyridines.
48.................................  May 2001..............  2 Trihaloethylidene          Recommended
                                                              bisbenzenes.
48.................................  May 2001..............  3-Chlorotrifluralin........  Recommended
48.................................  May 2001..............  4                            Recommended
                                                              Trichlorophenyldihydropyra
                                                              zols.
----------------------------------------------------------------------------------------------------------------


I. Background---------

    -The ITC was established by section 4(e) of the Toxic Substances 
Control Act (TSCA) ``to make recommendations to the Administrator 
respecting the chemical substances and mixtures to which the 
Administrator should give priority consideration for the promulgation 
of a rule for testing under section 4(a).... At least every six 
months..., the Committee shall make such revisions to the Priority 
Testing List as it determines to be necessary and transmit them to the 
Administrator together with the Committee's reasons for the revisions'' 
(Public Law 94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 et seq.). 
Since its creation in 1976, the ITC has submitted 47 semi-annual (May 
and November) Reports to the EPA Administrator transmitting the 
Priority Testing List and its revisions. ITC Reports are available from 
the ITC's web site (http://www.epa.gov/opptintr/itc) within a few days 
of submission to the Administrator and from http://www.epa.gov/fedrgstr 
after publication in the Federal Register. The ITC meets monthly and 
produces its revisions to the Priority Testing List with administrative 
and technical support from the ITC Staff, ITC Members, and their U.S. 
Government organizations and contract support provided by EPA. ITC 
Members and Staff are listed at the end of this Report.

II. TSCA Section 8 Reporting

-A. TSCA Section 8 Reporting Rules

    Following receipt of the ITC's Report (and the revised Priority 
Testing List) by the USEPA Administrator, the USEPA's Office of 
Pollution Prevention and Toxics (OPPT) promulgates TSCA section 8(a) 
PAIR and TSCA section 8(d) Health and Safety Data (HaSD) reporting 
rules for chemicals added to the Priority Testing List. The PAIR rule 
requires producers and importers of CAS-numbered chemicals added to the 
Priority Testing List to submit production and exposure reports under 
TSCA section 8(a). The HaSD reporting rule requires producers, 
importers, and processors of all chemicals (including those with no CAS 
numbers) added to the Priority Testing List to submit unpublished 
health and safety studies under TSCA section 8(d) that must be in 
compliance with the revised HaSD reporting rule published in the 
Federal Register of April 1, 1998 (63 FR 15765) (FRL-5750-4). All 
submissions must be received by the USEPA within 90 days of the 
reporting rules' Federal Register publication date. The reporting rules 
are automatically promulgated by OPPT unless otherwise requested by the 
ITC. It is an ITC policy, for most chemicals that are added to the 
Priority Testing List, to delay automatic promulgation of HaSD 
reporting rules to allow voluntary submission of studies of specific 
interest (see Unit II.C. of this Report for further details).

-B. ITC's Use of TSCA Section 8 and Other Information

    The ITC reviews the TSCA section 8(a) PAIR reports, TSCA section 
8(d) HaSD reporting studies and ``other information'' that becomes 
available after the ITC adds chemicals to the Priority Testing List. 
``Other information'' includes TSCA section 4(a) and 4(d) studies, TSCA 
section 8(c) submissions, TSCA section 8(e) ``substantial risk'' 
notices, ``For Your Information'' (FYI) submissions, ITC voluntary 
submissions, unpublished data submitted to and from U.S. Government 
organizations represented on the ITC, published papers, as well as use, 
exposure, effects, and persistence data that are voluntarily submitted 
to the ITC by manufacturers, importers, processors, and users of 
chemicals recommended by the ITC. The ITC reviews this information and 
determines if data needs should be revised, if chemicals should be 
removed from the Priority Testing List, or if recommendations should be 
changed to designations.

C. Promoting More Efficient Use of Information Submission Resources

    To promote more efficient use of information submission resources, 
the ITC developed VISP. VISP provides examples of data needed by ITC 
Member U.S. Government organizations, examples of studies that should 
not be submitted, the milestones for submitting information, guidelines 
for using the TSCA Electronic HaSD Reporting Form, and instructions for 
electronically submitting full studies. The TSCA Electronic HaSD 
Reporting Form can be used to provide information electronically on ITC 
voluntary submissions, TSCA section 8(d) studies, FYI submissions, and 
TSCA section 8(e) studies. VISP is described in the ITC's 41\st\ Report 
published in the Federal Register of April 9, 1998 (63 FR 17658) (FRL-
5773-5) and is accessible through the world wide web (http://www.epa.gov/opptintr/itc/visp.htm ). To facilitate the implementation 
of VISP, the ITC developed the Voluntary Information Submissions 
Innovative Online Network (VISION). VISION is described in the ITC's 
42\nd\ Report

[[Page 51279]]

published in the Federal Register of August 7, 1998 (63 FR 42554) (FRL-
5797-8) and is accessible through the world wide web (http://www.epa.gov/opptintr/itc/vision.htm). VISION includes the VISP and 
links to the TSCA Electronic HaSD Reporting Form (http://www.epa.gov/opptintr/.er/hasd.htm) including revised section 3.2 of the TSCA 
Electronic HaSD Reporting Form to provide more use and exposure 
information (see the ITC's 46\th\ Report published in the Federal 
Register of December 1, 2000 (65 FR 75552) (FRL-6594-7) for details. -
    The ITC requests that chemical producers, importers, processors, 
and users provide information electronically via VISION on chemicals 
for which the ITC is soliciting voluntary information. To enhance 
visibility, the ITC will be adding all chemicals to the Priority 
Testing List for which it is soliciting voluntary information. If the 
ITC does not receive voluntary information submissions to meet its data 
needs according to the procedures in VISP, the ITC may then request 
that EPA promulgate the appropriate TSCA sections 8(a) and 8(d) 
reporting rules to determine if there are unpublished data to meet 
those needs. The ITC requests that those companies responding to a TSCA 
section 8(d) HaSD reporting rule provide data by using the TSCA 
Electronic HaSD Reporting Form. -

D. Coordinating Information Requests

    To avoid duplicate reporting, the ITC carefully coordinates its 
information solicitations and reporting requirements with other 
national and international testing programs, e.g., the National 
Toxicology Program, the Organization for Economic Cooperation and 
Development (OECD) Screening Information Data Set (SIDS) Program, and 
the USEPA's HPV Challenge Program. The ITC is currently focusing its 
efforts on persistent non-HPV chemicals that have exposure potential, 
but few, if any, publicly available ecological or health effects data. 
The ITC is working with the USEPA's workgroups, such as the Persistent 
Bioaccumulative Toxics (PBT), Endocrine Disruption, and 
perfluoroctylsulfonate chemicals workgroups to develop data that will 
complement the objectives of those programs.

E. Requests to Promulgate TSCA Section 8(a) PAIR and Section 8(d) HaSD 
Reporting Rules

    The ITC has not received any submissions on the chloroalkenes, 
chlorinated trihalomethyl pyridines, trihaloethylidene bisbenzenes, 
trifluralins and trichlorophenyldihydropyrazols in response to its 
solicitation for use and exposure information in the ITC's 45\th\ 
Report. Therefore, the ITC is asking the EPA to promulgate a TSCA 
section 8(a) PAIR rule for the 3 chloroalkenes added to the Priority 
Testing List in the ITC's 47\th\ Report published in the Federal 
Register of April 3, 2001 (66 FR 17768) (FRL-6763-6) and 5 chlorinated 
trihalomethyl pyridines, 2 trihaloethylidene bisbenzenes, 3-
chlorotrifluralin, and 4 trichlorophenyldihydropyrazols added to the 
Priority Testing List in this 48\th\ ITC Report. The PAIR data will 
provide production and exposure information and aid in the selection of 
chemicals for potential TSCA section 8(d) HaSD reporting rules. -
    The ITC is asking the USEPA not to promulgate TSCA section 8(d) 
HaSD reporting rules for the alkylphenols and alkylphenol ethoxylates 
that were added to the Priority Testing List in the ITC's 39\th\ Report 
published in the Federal Register of February 25, 1997 (62 FR 8578) 
(FRL-5580-9) and in the ITC's 41\st\ Report because of a need to 
further review the data. The TSCA section 8(d) HaSD reporting rule for 
methylal that was added to the Priority Testing List in the ITC's 
42\nd\ Report is no longer needed since this chemical is being removed 
from the Priority Testing List in this Report (see Unit IV.B.2. of this 
Report).-
    At this time, the ITC is requesting that EPA not promulgate TSCA 
section 8(d) HaSD reporting rules for the 5 chlorinated trihalomethyl 
pyridines, 2 trihaloethylidene bisbenzenes, 3-chlorotrifluralin, and 4 
trichlorophenyldihydropyrazols added to the Priority Testing List in 
this ITC Report, to allow producers, importers, processors, and users 
an opportunity to voluntarily provide the requested information (see 
Unit IV. of this Report). -
    After review of the information provided in the TSCA section 8(a) 
PAIR rule published in the Federal Register of July 24, 2000 (65 FR 
45535) (FRL-6589-1), the ITC is requesting that the USEPA promulgate 
TSCA section 8(d) HaSD reporting rules for 3-amino-5-mercapto-1,2,4-
triazole (CAS No. 16691-43-3) and glycoluril (CAS No. 496-46-8). These 
TSCA section 8(d) HaSD reporting rules will require the submission of 
pharmacokinetics, subchronic toxicity, immunotoxicity, genotoxicity, 
carcinogenicity, reproductive and developmental effects, and ecological 
effects studies. The chemical purity of 3-amino-5-mercapto-1,2,4-
triazole and glycoluril in these studies should exceed 90%. -

III. ITC's Activities During this Reporting Period (November 2000 
to April 2001)--

    In its 45\th\ and 46\th\ ITC Reports, the ITC discussed its 
strategies to screen and evaluate chemicals for persistence and 
bioconcentration potential. These strategies are referred to as 
Degradation Effects Bioconcentration Information Testing Strategies 
(DEBITS). DEBITS provides a means to prioritize chemicals based on 
degradation, ecological or human health effects, and bioconcentration 
information. In its 45\th\ ITC Report, the ITC added several chemicals 
to its web site to solicit measured bioconcentration data and use and 
exposure information. To avoid duplicate reporting requirements, the 
ITC is removing the USEPA's HPV Challenge Program chemicals (http://www.epa.gov/opptintr/chemrtk/hpvchmlt.htm) and European Union's HPVCs 
(http://ecb.ei.jrc.it/existing-chemicals/) from its web site. In its 
46\th\ ITC Report, the ITC initiated efforts to implement DEBITS by 
focusing its efforts on structural classes of chemicals from a subset 
of 42 moderate production volume (MPV) chemicals (production/
importation volumes between 100,000 and 1,000,000 pounds) with 
estimated or measured bioconcentration factors (BCFs) > 250 and about 
70 structurally related non-MPV chemicals (also with BCFs > 250). In 
its 47\th\ ITC Report, the ITC added more of these chemicals from its 
DEBITS prioritization to its Priority Testing List. Other chemical 
groups such as nitro musks, polycyclic musks, and tertiary butyl 
peroxyl chemicals were reviewed but not added to the Priority Testing 
List.-
    During this reporting period, the ITC continued to focus its 
efforts on structural classes of MPV chemicals by adding 5 chlorinated 
trihalomethyl pyridines, 2 trihaloethylidene bisbenzenes, 4 
trichlorophenyldihydropyrazols, and 3-chlorotrifluralin to its Priority 
Testing List and soliciting voluntary health and ecological effects 
information for these chemicals under the ITC's VISP. The ITC evaluated 
several chlorinated pyridines, and azo bis (alpha nitriles) and decided 
not to add them to the Priority Testing List at this time.

IV. Revisions to the TSCA Section 4(e) Priority Testing List

A. Chemicals Added to the Priority Testing List

    1. Chlorinated trihalomethyl pyridines--i. Recommendation. Five 
non-HPV chlorinated trihalomethyl pyridines are being added to the 
Priority Testing List to obtain information on

[[Page 51280]]

uses, exposures, environmental releases, pharmacokinetics, subchronic 
toxicity, mutagenicity, reproductive and developmental effects, 
carcinogenicity, and ecological effects as well as the percent by 
weight of any of the 5 unreacted chlorinated trihalomethyl pyridines in 
formulated products. The 5 non-HPV chlorinated trihalomethyl pyridines 
are 3,5-dichloro-2-(trichloromethyl)pyridine (CAS No. 1128-16-1), 
2,3,4,5-tetrachloro-6-(trichloromethyl)pyridine (CAS No. 1134-04-9), 
3,4,5-trichloro-2-(trichloromethyl)pyridine (CAS No. 1201-30-5), 2,6-
dichloro-3-(trichloromethyl)pyridine (CAS No. 55366-30-8), and 2,3-
dichloro-5-(trichloromethyl)pyridine (CAS No. 69045-84-7). See Table 2 
below.


                       Table 2.--Chlorinated Trihalomethyl Pyridines Identified by DEBITS
----------------------------------------------------------------------------------------------------------------
                                     Chlorinated
            CAS No.                 trihalomethyl             HPV                 BCF              Fish LC50
                                       pyridine
----------------------------------------------------------------------------------------------------------------
001128-16-1....................  3,5-Dichloro-2-      No................  238...............  3.5
                                  (trichloromethyl)p
                                  yridine.
001134-04-9....................  2,3,4,5-Tetrachloro- No................  2343..............  0.1
                                  6-
                                  (trichloromethyl)p
                                  yridine.
001201-30-5....................  3,4,5-Trichloro-2-   No................  747...............  2.7
                                  (trichloromethyl)p
                                  yridine.
001817-13-6....................  3,6-Dichloro-2-      Yes...............  238...............  3.5
                                  (trichloromethyl)p
                                  yridine.
001929-82-4....................  2-Chloro-6-          Yes...............  84................  9.3
                                  (trichloromethyl)p
                                  yridine.
055366-30-8....................  2,6-Dichloro-3-      No................  238...............  3.1
                                  (trichloromethyl)p
                                  yridine.
069045-78-9....................  2-Chloro-5-          Yes...............  76................  7.6
                                  (trichloromethyl)p
                                  yridine.
069045-83-6....................  2,3-Dichloro-5-      Yes...............  238...............  3.2
                                  (trichloromethyl)p
                                  yridine.
069045-84-7....................  2,3-Dichloro-5-      No................  45................  12.2
                                  (trifluoromethyl)p
                                  yridine.
----------------------------------------------------------------------------------------------------------------


    ii. Rationale for recommendation. The 5 non-HPV chlorinated 
trihalomethyl pyridines are predicted to persist in the environment. 
They present suspicions of toxicity based on fish LC50 
values and mutagenicity based on data from structurally related 
compounds. Several of these non-HPV chlorinated trihalomethyl pyridines 
are produced/imported in substantial amounts (>100,000 pounds) and have 
potential to bioconcentrate.--
    iii. Supporting information. The ITC used DEBITS to identify 9 
chlorinated trihalomethyl pyridines (Table 2 of this unit). Four of 
these chlorinated trihalomethyl pyridines are in the USEPA's HPV 
Challenge Program, including the registered pesticide, nitrapyrin (CAS 
No. 1929-82-4). The ITC is not soliciting information on the HPV 
chemicals but did review the available toxicity and ecological effects 
information on these compounds to better evaluate the data needs for 
the non-HPV chlorinated trihalomethyl pyridines. --
    The trichloro- and tetrachloro trichloromethyl pyridines have 
estimated bioconcentration factors (BCFs) > 250 while 2 of 3 dichloro 
trichloromethyl pyridines have estimated BCFs very close to this 
threshold (i.e., BCFs of 238). All five chloro trihalomethyl pyridines 
have fish LC50 values about 10 milligram/Liter (mg/L) or 
less, indicating that they have potential to cause acute effects in 
fish. The fish LC50 values are based on measured or 
estimated values for fathead minnows. The predicted mode of toxic 
action (based on fathead minnow models described by Russom et al., 
1997) for 4 of 5 chlorinated trihalomethyl pyridines is narcosis. The 
tetrachloro trichloromethyl pyridine (CAS No. 1134-04-9) with the 
lowest fish LC50 value and highest BCF is predicted to have 
a mode of toxic action based on uncoupling of oxidative 
phosphorylation.- -
    There were no health effects data available for the 5 chlorinated 
trihalomethyl pyridines being added to the Priority Testing List. 
However, there were some available health effects data for the two HPV 
monochloro substituted trichloromethyl pyridines (CAS Nos. 1929-82-4 
and 69045-78-9) and a HPV dichloro trichloromethyl pyridine (CAS No. 
69045-83-6). -
    Subchronic and mutagenicity data were available for 2-chloro-5-
(trichloromethyl)pyridine (CAS No. 69045-78-9). Mice exposed to 10 
parts per million (ppm) of 2-chloro-5-(trichloromethyl)pyridine died 
after 4 days. Histologic examination of these animals revealed hepatic 
necrosis and vacuolization. No treatment related effects were observed 
at 0, 0.1, or 1.0 ppm exposure levels (Dow Chemical Co., 1991). In a 
dermal irritation study with rats, a dose of 500 mg/(kilogram) kg/day 
[for 21 days (18 hours per day)] 2-chloro-5-(trichloromethyl)pyridine 
produced a well-defined systemic toxic response characterized by 
hepatic necrosis and a disturbance of lipid metabolism. As a result of 
topical irritation among the rats in the 100 mg/kg/day group, the no-
observed-adverse-effect-level (NOAEL) was 20 mg/kg/day (Hazelton 
Laboratories, 1992). In a number of mutagenicity test systems, 2-
chloro-5- (trichloromethyl)pyridine was found to be mutagenic 
(Confidential, 1984a; Confidential 1984b; and Confidential 1984c). -
    Subchronic data were available for 2,3-dichloro-5-
(trichloromethyl)pyridine (CAS No. 69045-83-6). Degenerative lesions 
occurred in the nasal turbinates of rats and mice exposed to 0.5 ppm 
2,3-dichloro-5-(trichloromethyl)pyridine for 2 weeks (Confidential, 
1986).-
    Numerous health effects data were available for 2-chloro-6-
(trichloromethyl)pyridine or nitrapyrin (CAS No. 1929-82-4). Nitrapyrin 
was well absorbed by dogs when administered using the oral route 
(Redemann et al., 1966). Oral administration of nitrapyrin at doses of 
30 to 50 mg/kg/day and greater in pregnant rats and rabbits caused 
maternal and fetal toxicity (Berdasco et al., 1988). Nitrapyrin is also 
reported to be mutagenic in the reverse mutation assay in Salmonella 
typhimurium under most conditions (Zeiger et al., 1988). Hepatotoxicity 
occurred in rats dermally exposed to 500 mg/kg/day of 2-chloro-5- 
(trichloromethyl)-pyridine for 3 weeks (Hazelton Laboratory, 1992). -
    iv. Information needs. -For the 5 non-HPV chlorinated trihalomethyl 
pyridines in Table 2 of this unit, the ITC needs:
    a. Use information, including percentages of production or 
importation that are associated with different uses;
    b. Identification of the chlorinated trihalomethyl pyridines that 
are intermediates and the final products in which they are contained;
    c. Weight percent of chlorinated trihalomethyl pyridines in 
commercial formulated products; and
    d. Pharmacokinetics, subchronic toxicity, mutagenicity, 
reproductive and developmental effects, carcinogenicity, and ecological 
effects data.

    2. Trihaloethylidene bisbenzenes--i. Recommendation. Two non-HPV 
trihaloethylidene bisbenzenes are being added to the Priority Testing 
List to obtain information on uses, exposures,

[[Page 51281]]

environmental releases, pharmacokinetics, subchronic toxicity, 
mutagenicity, reproductive and developmental effects, carcinogenicity, 
and ecological effects. The 2 non-HPV trihaloethylidene bisbenzenes are 
hexafluoroisopropylidenebis (4-hydroxybenzene) and benzene, 1,1'-
(2,2,2-trichloroethylidene)bis-. See Table 3 below.


      Table 3.--Trihaloethylidene Bisbenzenes Identified by DEBITS
------------------------------------------------------------------------
                                   Trihaloethylidene
            CAS No.                   bisbenzene               BCF
------------------------------------------------------------------------
000072-43-5...................  Methoxychlor (2,2-      8128
                                 bis(p-methoxyphenyl)-
                                 1,1,1-
                                 trichloroethane).
001478-61-1...................  Hexafluoroisopropylide  556
                                 nebis (4-
                                 hydroxybenzene).
002971-22-4...................  Benzene, 1,1'-(2,2,2-   1122
                                 trichloroethylidene)b
                                 is-.
------------------------------------------------------------------------


    -ii. Rationale for recommendation. The 2 non-HPV trihaloethylidene 
bisbenzenes have been produced/imported in substantial amounts 
(>100,000 pounds) and are predicted to persist and bioconcentrate in 
the environment. Benzene, 1,1'-(2,2,2-trichloroethylidene)bis- (CAS No. 
2971-22-4) is structurally related to the insecticide methoxychlor, 
which has estrogenic activity and has been shown to alter hormone 
levels, decrease fertility, damage reproductive organs, and retard 
reproductive development in experimental animals. -
    iii. Supporting information. The ITC used DEBITS to identify 3 
trihaloethylidene bisbenzenes (Table 3 of this unit). All are MPV 
chemicals that have estimated BCFs well over 250 (Table 3 of this 
unit). One of the trihaloethylidene bisbenzenes is the well studied 
insecticide, methoxychlor (CAS No. 72-43-5), that is not being added to 
the Priority Testing List but which is currently regulated by a number 
of international, Federal, and State agencies because of its potential 
to cause adverse effects in humans. Methoxychlor is included in the 
USEPA's Toxics Release Inventory (TRI) PBT rule published in the 
Federal Register of November 4, 1999 (64 FR 60194) (FRL-6097-7) and is 
a candidate for regulatory action under the USEPA's PBT Initiative. The 
Agency for Toxic Substances and Disease Registry (ATSDR) has recently 
completed a Toxicological Profile for methoxychlor which summarizes 
available health effects data (ATSDR, 2000). Among the effects that are 
relevant to predicting the effects of hexafluoroisopropylidenebis (4-
hydroxybenzene) and benzene, 1,1'-(2,2,2-trichloroethylidene)bis- are 
those related to alteration of hormone levels, including increasing 
levels of prolactin, follicle stimulating hormone (FSH), and thyroid 
stimulating hormone (TSH) in the pituitary of male rats (Goldman et al. 
1986; Gray et al. 1989). In addition to the ATSDR Toxicological Profile 
that summarizes the health effects of methoxychlor, a Pesticide 
Information Profile that summarizes the ecological effects of 
methoxychlor is available on the web (http://ace.orst.edu/cgi-bin/mfs/01/pips/methoxyc.htm). Methoxychlor is slightly toxic to bird species, 
with reported acute oral LD50 values of greater than 2,000 
mg/kg in the mallard duck, sharp-tailed grouse, and California quail 
(Hudson et al., 1984). In contrast, methoxychlor is highly toxic to 
fish; 96-hour LD50 values for the technical grade 90% pure 
chemical are less than 20 ug/L for cutthroat trout, atlantic salmon, 
brook trout, lake trout, northern pike, and large mouth bass (Johnson 
and Finley, 1980).-
    There are some health effects data for 
hexafluoroisopropylidenebis(4-hydroxybenzene) and benzene, 1,1'-(2,2,2-
trichloroethylidene)bis-. In an in vitro study evaluating endocrine 
disruption, hexafluoroisopropylidenebis(4-hydroxybenzene) was found to 
be estrogenic in MCF-7 cells, promoting cell proliferation and 
increasing protein synthesis (Olea-Serrano, 1998; Perez et al., 1998). 
Benzene, 1,1'-(2,2,2-trichloroethylidene)bis- had estrogenic activity 
at doses as low as 1 mg/rat (Bitman and Cecil, 1970). No other health 
or ecological effect studies were available for these two 
trihaloethylidene bisbenzenes.
    iv. Information needs. The ITC needs information on uses, 
exposures, environmental releases, pharmacokinetics, subchronic 
toxicity, mutagenicity, reproductive and developmental effects, 
carcinogenicity, and ecological effects.

    --3. 3-Chlorotrifluralin--i. Recommendation. 3-Chlorotrifluralin 
(CAS No. 29091-20-1) is being added to the Priority Testing List to 
obtain information on uses, exposures, environmental releases, 
pharmacokinetics, subchronic toxicity, mutagenicity, reproductive and 
developmental effects, carcinogenicity, and ecological effects. --
    ii. Rationale for Recommendation. 3-Chlorotrifluralin is a non-HPV 
chemical that has been produced/imported in substantial amounts 
(>100,000 pounds) and is predicted to persist and bioconcentrate in the 
environment. It is a chlorinated analog of the herbicide, trifluralin 
(CAS No. 1582-09-8). Trifluralin causes adverse effects in experimental 
animals and is considered to be a possible human carcinogen by the 
USEPA. 3-Chlorotrifluralin has limited toxicity data even though its 
potential to persist and bioconcentrate in the environment may be 
greater than trifluralin.-
    iii. Supporting Information. 3-Chlorotrifluralin meets the DEBITS 
criteria and has an estimated BCF of 7,700. There are no available 
subchronic toxicity studies or ecological effects data on this 
compound. The LD50 in mice was determined to be 2,744 mg/kg 
(Industrial Bio-Test Laboratories, 1992). The structurally related 
trifluralin caused adverse liver and kidney effects in rodents and dogs 
as a result of subchronic and chronic feeding studies. Trifluralin 
induced urinary tract tumors (renal pelvis carcinomas and urinary 
bladder papillomas) and thyroid tumors (adenomas/carcinomas combined) 
in one animal species (Fisher 344 rats) in one study (USEPA, 2000). 
Trifluralin is included in the USEPA's TRI PBT rule and is a candidate 
for regulatory action under the USEPA's PBT Program.--
    iv. Information Needs. The ITC needs information on uses, 
exposures, environmental releases, pharmacokinetics, subchronic 
toxicity, mutagenicity, reproductive and developmental effects, 
carcinogenicity, and ecological effects.

    --4. Trichlorophenyldihydropyrazols--i. Recommendation. Four 
trichlorophenyldihydropyrazols are being added to the Priority Testing 
List to obtain information on uses, exposures, environmental releases, 
pharmacokinetics, subchronic toxicity, mutagenicity, reproductive and 
developmental effects, carcinogenicity, and ecological effects (Table 4 
of this unit).


[[Page 51282]]



                          Table 4.--Trichlorophenyldihydropyrazols Identified by DEBITS
----------------------------------------------------------------------------------------------------------------
                 CAS No.                        Trichlorophenyldihydropyrazol                    BCF
----------------------------------------------------------------------------------------------------------------
030707-68-7.............................  3H-Pyrazol-3-one, 5-[(2-chloro-5-          2230
                                           nitrophenyl)amino]-2,4-dihydro-2-(2,4,6-
                                           trichlorophenyl)-.
040567-18-8.............................  Benzamide, 3-amino-N-[4,5-dihydro-5-oxo-1- 92
                                           (2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-
                                           .
053411-33-9.............................  3H-Pyrazol-3-one, 5-[(5-amino-2-           44
                                           chlorophenyl)amino]-2,4-dihydro-2-(2,4,6-
                                           trichlorophenyl)-.
063134-25-8.............................  Benzamide, N-[4,5-dihydro-5-oxo-1-(2,4,6-  338
                                           trichlorophenyl)-1H-pyrazol-3-yl]-3-
                                           nitro-.
----------------------------------------------------------------------------------------------------------------


    ii. Rationale for recommendation. The 4 
trichlorophenyldihydropyrazols are predicted to persist in the 
environment. Two of these trichlorophenyldihydropyrazols (CAS Nos. 
30707-68-7 and 63134-25-8) are produced/imported in substantial amounts 
(>100,000 pounds) and have potential to bioconcentrate.
    iii. Supporting information. Two of the four 
trichlorophenyldihydropyrazols have estimated BCFs >250 (Table 4 of 
this unit). The other two chemicals are structurally related but are 
predicted to have lower bioconcentration potential. There are no 
available health or ecological effects studies for any of the 
trichlorophenyldihydropyrazols.--
    iv. Information needs. The ITC needs information on uses, 
exposures, environmental releases, pharmacokinetics, subchronic 
toxicity, mutagenicity, reproductive and developmental effects, 
carcinogenicity, and ecological effects.

B. Chemicals Removed From the Priority Testing List--

    1. Alkylphenols and alkylphenol ethoxylates. In this Report, the 
ITC is removing 22 alkylphenols and alkylphenol ethoxylates that were 
added to the Priority Testing List in the ITC's 41\st\ Report published 
in the Federal Register of April 9, 1998 (63 FR 17658) ( FRL-5773-5). 
The 22 alkylphenols and alkylphenol ethoxylates are being removed from 
the Priority Testing List because:
    i. No domestic production or importation volumes were reported to 
the USEPA in response to 1986, 1990, 1994, and 1998 IURs (indicating 
that volumes were less than 10,000 pounds per site in 1985, 1989, 1993, 
and 1997) and
    ii. No domestic production or importation volumes were reported to 
the USEPA in response to the PAIR rule published in the Federal 
Register of July 5, 2000 (65 FR 41371) ( FRL-6589-1) (indicating that 
volumes were less than 1,000 pounds per site in 1999).
    The 22 alkylphenols and alkylphenol ethoxylates being removed from 
the Priority Testing List are listed in Table 5 of this unit.


 Table 5.-- Alkylphenols and Alkylphenol Ethoxylates Being Removed From
                        the Priority Testing List
------------------------------------------------------------------------
             CAS No.                              Chemical
------------------------------------------------------------------------
000136-81-2......................  Phenol, 2-pentyl-
002446-69-7-.....................  Phenol, 4-hexyl-
002589-78-8-.....................  Phenol, 4-hexadecyl-
003279-27-4-.....................  Phenol, 2-(1,1-dimethylpropyl)-
009004-87-9-.....................  Poly(oxy-1,2-ethanediyl), -
                                    (iso octylphenyl)--hydroxy-
 
009063-89-2-.....................  Poly(oxy-1,2-ethanediyl), -
                                    (octylphenyl)--hydroxy-
025401-86-9-.....................  Phenol, 2-hexadecyl-
025735-67-5-.....................  Phenol, 4-sec-pentyl-
026401-47-8-.....................  Poly(oxy-1,2-ethanediyl), -
                                    (4-dodecylphenyl)--hydroxy-
 
026401-74-1-.....................  Phenol, 2-sec-pentyl-
027157-66-0-.....................  Phenol, decyl-
059911-95-4-.....................  Poly(oxy-1,2-ethanediyl), -
                                    (4-hexadecylphenyl)--
                                    hydroxy-
061723-87-3-.....................  Poly(oxy-1,2-ethanediyl), -
                                    (tridecylphenyl)--hydroxy-
068081-86-7-.....................  Phenol, nonyl derivs.
068784-24-7-.....................  Phenol, C18-30-alkyl derivs.
068891-67-8-.....................  Phenol, polypropene derivs.
068954-70-1-.....................  Phenol, polyethylene derivs.
070682-80-3-.....................  Phenol, tetradecyl-
071902-25-5-.....................  Phenol, octenylated
084605-25-4-.....................  Phenol, 1-methylhexyl derivs.
091672-41-2-.....................  Phenol, 2-nonyl-, branched
112375-89-0-.....................  Phenol, poly(2,4,4-trimethylpentene)
                                    derivs.
------------------------------------------------------------------------


    2. Methylal. Methylal (CAS No. 109-87-5) was added to the Priority 
Testing List in the ITC's 42\nd\ Report and recommended for information 
reporting to meet U.S. Government data needs. In response to that 
recommendation, the USEPA added methylal to the PAIR rule published in 
the Federal Register of July 24, 2000 (65 FR 45535) (FRL-6589-1). The 
ITC reviewed the data submitted in response to the PAIR rule. These 
data indicated that in 1999, 10,000 to 500,000 pounds of methylal were 
produced under controlled release and enclosed conditions, involving 
<10 and 10-100 workers, respectively. Methylal's manufacture was 
associated with industrial products. The ITC is removing methylal from 
the Priority Testing List because it is being sponsored for testing 
under the USEPA's HPV Challenge Program. Test plans and data developed 
under the challenge program may be reviewed to determine if they meet 
the needs of the U.S. Government.

    --3. Ethyl silicate. Ethyl silicate (CAS No. 78-10-4) was also 
added to the Priority Testing List in the ITC's 42\nd\ Report and 
recommended for information reporting to meet U.S. Government data 
needs. In response to that recommendation, the USEPA added ethyl 
silicate to the PAIR rule published in the Federal Register of July 24, 
2000 (65 FR 45535) (FRL-6589-1) and the

[[Page 51283]]

ITC received voluntary use and toxicity data from the Silicones 
Environmental Health and Safety Council (SEHSC). Data submitted in 
response to the PAIR rule indicated that in 1999, 10,000 to 500,000 
pounds of ethyl silicate were produced under enclosed conditions, that 
10-100 workers were involved in the production of ethyl silicate under 
those conditions and that ethyl silicate's manufacture and customer 
uses were associated with industrial products. SEHSC's voluntary 
submissions confirmed that ethyl silicate is used as an industrial, not 
consumer chemical. Toxicity data voluntarily submitted by SEHSC 
indicated that:
    i. Ethyl silicate's rat oral LD50 was 5,920 mg/kg (Smyth 
et al., 1949);
    ii. No deaths occurred when rats, mice, guinea pigs, and rabbits 
were exposed to 50 and 88 ppm ethyl silicate for 90 days and the only 
significant observation was a depression in kidney weights in the mice 
exposed to 88 ppm ethyl silicate (Pozzani and Carpenter, 1951);
    iii. The mutagenic potential of ethyl silicate was evaluated using 
the Chinese Hamster Ovary (CHO), Sister Chromatid Exchange (SCE), and 
Unscheduled DNA Synthesis (UDS) assays; the only significant mutagenic 
effect was seen in the UDS assay (Slesinski et al., 1981).
 The ITC is removing ethyl silicate from the Priority Testing List 
because it is being sponsored for testing under the USEPA's HPV 
Challenge Program. Test plans and data developed under the challenge 
program may be reviewed to determine if they meet the needs of the U.S. 
Government.

V. References

    1. ATSDR. 2000. Toxicological Profile for Methoxychlor. Update-- 
DRAFT FOR PUBLIC COMMENT edition. Agency for Toxic Substances and 
Disease Registry, Atlanta, GA.
    2. Berdasco, N., Lomax, L., Zimmer, M., and Hanley, T. 1988. 
Teratologic evaluation of orally administered nitrapyrin in rats and 
rabbits. Fundamentals of Applied Toxicology. 11(3):464-471.
    3. Bitman, J. and Cecil, H.C. 1970. Estrogenic activity of DDT 
analogs and polychlorinated biphenyls. Journal of Agricultural Food 
Chemistry. 18:1108-12.
    4. Confidential. 1984a. Summary of results from several 
genotoxicity studies with 2- chloro-5-trichloromethyl pyridine; EPA 
Document No. 88-8500683; Fiche No. OTS0509740.
    5. Confidential. 1984b. The mutagenicity evaluation of 2-chloro-5-
trichloromethyl pyridine in the Ames test with cover letter dated 
121284; EPA Document No. 88-85704; Fiche No. OTS0509740.
    6. Confidential. 1984c. Substance H.109345: a cytogenetic study in 
human lymphocytes (in vitro) and an evaluation in the Salmonella 
mutagenicity assay with cover letter dated 122684; EPA Document No. 88-
8500713; Fiche No. OTS0509740.
    7. Confidential. 1986. Two-week inhalation toxicity study in 
Fischer 344 rats and B6C3F1 mice (company sanitized) with cover letter 
dated 101686; EPA Document No. FYI-OTS-1086-0473; Fiche No. 
OTS0000473_1.
    8. Dow Chemical Co. 1991. Initial submission: 2-chloro-5-
trichloromethyl pyridine: two-week inhalation toxicity study in b6c3f1 
mice (final report) with attachment and cover letter (sanitized). EPA 
Document No. 88-920000186S; Fiche No. OTS0534636.
    9. Goldman, J.M., Cooper, R.L., and Rehnberg, G.L., et al. 1986. 
Effects of low subchronic doses of methoxychlor on the rat 
hypothalamic-pituitary reproductive axis. Toxicology and Applied 
Pharmacology. 86:474-483.
    10. Gray, L.E., Otsby, J.S., and Ferrell, J.M., et al. 1989. A 
dose-response analysis of methoxychlor-induced alterations of 
reproductive development and function in the rat. Fundamentals of 
Applied Toxicology. 12:92-108.
    11. Hazelton Laboratories. 1992. Initial submission: three-week 
dermal toxicity study in the rat with cover letter. EPA Document No. 
88-920007444; Fiche No. OTS0545698.
    12. Hudson, R.H., Tucker, R.K., and Haegele, M.A. 1984. Handbook of 
Acute Toxicity of Pesticides to Wildlife, Resource Publication 153. 
U.S. Department of Interior, Fish and Wildlife Service, Washington, DC. 
pp. 6-54.
    13. Johnson, W.W. and Finley, M.T. 1980. Handbook of Acute Toxicity 
of Chemicals to Fish and Aquatic Invertebrates, Resource Publication 
137. U.S. Department of Interior, Fish and Wildlife Service, 
Washington, DC. pp. 6-56.
    14. Olea-Serrano, M.F., Pulgar, R., Perez, P., Metzler, M., 
Pedraza, V., and Olea, N. 1998. Bisphenols: in vitro effects. Hormonal 
Active Agents Food, Symposium. 1998:161-180.
    15. Perez, P., Pulgar, R., Olea-Serrano, F., Villalobos, M., Rivas, 
A., Metzler, M., Pedraza, V., and Olea, N. 1998. The estrogenicity of 
bisphenol A-related diphenylalkanes with various substituents at the 
central carbon and the hydroxy groups. Environmental Health 
Perspectives. 106(3):167-174.
    16. Pozzani, U.C. and Carpenter, C.P. 1951. Response of Rodents to 
Repeated Inhalation of Vapors of Tetraethyl Orthosilicate. Archives of 
Industrial Hygiene and Occupational Medicine. 4:465-468.
    17. Redemann, C., Williams, E., Clark, H., and Kaku, J. 1966. The 
excretion of n-6-chloropicolinoyl glycine by the dog fed 2-chloro-6-
(trichloromethyl)pyridine. Journal of Agricultural Food Chemistry. 
14(5):530-532.
    18. Russom, C.L., Bradbury S.P., Braiders S.J., Hammermeister D.E., 
and Drummond R.A. 1997. Predicting modes of toxic action from chemical 
structure: Acute toxicity in the fathead minnow (Pimephales Promelas). 
Environmental Toxicology and Chemistry. 16(5):948-967.
    19. Slesinski, R.S., Guzzie, P.J., Hengler, W.C., and Wagner, K.J. 
1981. TetraethylOrthosilicate-In Vitro Mutagenesis Studies-3-Test 
Battery. Export, PA: Bushy Run Research Center, Project Report 44-68, 
June 1981.
    20. Smyth, H.F., Jr., Carpenter, C.P., and Weil, C.S. 1949. Range-
Finding Toxicity Data, List III. Journal of Industrial Hygiene and 
Toxicology. 31:60-62.
    21. USEPA. 2000. Integrated Risk Information System (IRIS): 
Trifluralin, oral RfD last revised 7/89, cancer assessment updated 10/
93. Online chemical toxicity database, available at www.epa.gov/iris, 
accessed 12/00.
    22. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and 
Mortelmans, K. 1988. Salmonella mutagenicity tests: IV. Results from 
the testing of 300 chemical. Environmental Molecular Mutagenesis. 
11(s12):1-158.

VI. TSCA Interagency Testing Committee

    Statutory Organizations and Their Representatives

    Council on Environmental Quality
        Vacant

    Department of Commerce

          National Institute of Standards and Technology
            Robert Huie, Member
            Barbara C. Levin, Alternate

          National Oceanographic and Atmospheric Administration
            Vacant

    Environmental Protection Agency
        Paul Campanella, Member
        David R. Williams, Alternate

    National Cancer Institute
        Alan Poland, Member

    National Institute of Environmental Health Sciences
        Scott Masten, Member, Chair
        William Eastin, Alternate


[[Page 51284]]


    National Institute for Occupational Safety and Health
        Albert E. Munson, Member
        Mark Toraason, Alternate

    National Science Foundation
        A. Frederick Thompson, Member
        Marge Cavanaugh, Alternate

    Occupational Safety and Health Administration
        Val H. Schaeffer, Member, Vice Chair
        Lyn Penniman, Alternate

    Liaison Organizations and Their Representatives

    Agency for Toxic Substances and Disease Registry
        William Cibulas, Member
        Stephanie Miles-Richardson, Alternate

    Consumer Product Safety Commission
        Jacqueline Ferrante, Member
        Treye Thomas, Alternate

    Department of Agriculture
        Clifford P. Rice, Member
        Laurau L. McConnell, Alternate

    Department of Defense
        Barbara Larcom, Member
        Kenneth Still, Alternate
        Jose Centeno, Alternate

    Department of the Interior
        Barnett A. Rattner, Member

    Food and Drug Administration
        David Hatten, Alternate

    National Library of Medicine
        Vera W. Hudson, Member

    National Toxicology Program
        NIEHS, FDA, and NIOSH Members

    Counsel
        Scott Sherlock, OPPT, EPA

    Technical Support Contractor
        Syracuse Research Corporation

    ITC Staff
        John D. Walker, Executive Director
        Norma S. L. Williams, Executive Assistant

TSCA Interagency Testing Committee, Office of Pollution Prevention and 
Toxics (7401), Environmental Protection Agency, 1200 Pennsylvania Ave., 
NW., Washington, DC 20460; telephone: (202) 564-7527; fax: (202) 564-
7528; e-mail address: [email protected]; url: http://www.epa.gov/opptintr/itc.

[FR Doc. 01-25046 Filed 10-4-01; 8:45 am]
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