[Federal Register Volume 66, Number 176 (Tuesday, September 11, 2001)]
[Notices]
[Pages 47237-47238]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-22789]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Toxicology Program (NTP) Board of Scientific Counselors 
Technical Reports Review Subcommittee Meeting; Review of Draft NTP 
Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors Technical Reports 
Review Subcommittee on October 18, 2001 in the Rodbell Auditorium, Rall 
Building, South Campus, National Institute of Environmental Health 
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North 
Carolina. The meeting will begin at 8:30 a.m. on October 18, and is 
open to the public. The primary agenda topic is the peer review of 
draft Technical Reports of rodent toxicology and carcinogenesis studies 
conducted by the NTP.

Agenda

    Tentatively scheduled for review on October 18, are draft Technical 
Reports of three 2-year studies and a draft Toxicity Report of toxicity 
and metabolism studies. The reports are listed alphabetically in the 
attached table and the tentative order of review is given in the far 
right column.
    The agenda and roster of subcommittee members will be available 
prior to the meeting on the NTP web homepage at http://ntp-server.niehs.nih.gov and upon request to the Executive Secretary at the 
address given below. Following the meeting, summary minutes will be 
available electronically on the NTP web homepage and in hardcopy upon 
request to the Executive Secretary.
    Attendance at this meeting is limited only by the space available. 
Individuals who plan to attend and need special assistance are asked to 
notify the Executive Secretary in advance of the meeting.

Draft Reports Available for Public Review and Comment

    Approximately one month prior to the meeting, the draft reports 
will be available for public review, free of charge, through the 
Environmental Health Information Service (EHIS) at http://ehis.niehs.nih.gov. Printed copies can be obtained, as available, from: 
Central Data Management (CDM), NIEHS, P.O. Box 12233, MD E1-02, 
Research Triangle Park, NC 27709, T: 919-541-3419, Fax: 919-541-3687, 
e-mail: [email protected].
    The NTP Board of Scientific Counselors Technical Reports Review 
Subcommittee meeting is open to the public and public comment on any of 
the Technical Reports is welcome. Time will be provided at the meeting 
for public comment on each of the Reports under review. In order to 
facilitate planning for the meeting, persons requesting time for an 
oral presentation on a particular Report are asked to notify the 
Executive Secretary, Dr. Mary S. Wolfe, at P.O. Box 12233, MD A3-07, 
Research Triangle Park, NC 27709, T: 919-541-3971, Fax: 919-541-0295, 
e-mail: [email protected]. Persons registering to make comments are 
asked to provide, if possible, a written copy of their statement by 
October 11, to enable review by the Subcommittee and NTP staff prior to 
the meeting. Written statements can supplement and may expand the oral 
presentation. Each speaker is asked to provide his/her name, 
affiliation, mailing address, phone, fax, e-mail, and supporting 
organization (if any). At least seven minutes will be allotted to each 
speaker, and if time permits, may be extended to ten minutes. Each 
organization is allowed one time slot per Report being reviewed. 
Registration for making public comments will also be available on-site. 
If registering on-site to speak and reading comments from printed copy, 
the speaker is asked to provide 25 copies of the statement. These 
copies will be distributed to the Subcommittee and NTP staff and will 
supplement the record.
    Written comments, in lieu of an oral presentation, are also 
welcome. The comments should include name, affiliation, mailing 
address, phone, fax, e-mail, and sponsoring organization (if any) and 
preferably be received by October 11, to enable review by the 
Subcommittee and NTP staff prior to the meeting as well as to 
supplement the record.

Request for Additional Information

    The NTP would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing or planned studies as well as 
current production data, human exposure information, and use patterns 
for any of the chemicals listed in this announcement. Please forward 
this information to CDM at the address given above. CDM will forward 
the information to the appropriate staff scientist.

NTP Technical and Toxicity Report Series

    The NTP conducts toxicology and carcinogenesis studies of agents of 
public health concern. Any scientist, organization, or member of the 
public may nominate a chemical for NTP testing. Details about the 
nomination process are available on the NTP web site (http://ntp-server.niehs.nih.gov). The results of short-term rodent toxicology 
studies are published in the NTP Toxicity Report series. Longer-term 
studies, generally, two-year rodent studies, are published in the NTP 
Technical Report series. Study abstracts for all reports are available 
at the NTP web site under NTP Study Information. Hardcopies and PDF 
files of published reports can be obtained through subscription to the 
EHIS (http://ehis.niehs.nih.gov or 1-800-315-3010).

NTP Board of Scientific Counselors

    The Board is a technical advisory body composed of scientists from 
the public and private sectors who provide primary scientific oversight 
and peer review to the overall Program. Specifically, the Board advises 
the NTP on matters of scientific program content, both present and 
future, and conducts periodic review of the Program for the purposes of 
determining and advising on the scientific merit of its activities and 
their overall scientific quality. The Technical Reports Review 
Subcommittee of the Board provides scientific peer review of the 
findings and conclusions of NTP Technical Reports. The Report on 
Carcinogens Subcommittee of the Board provides scientific peer review 
of nominations to the Report on Carcinogens, a Congressionally mandated 
listing of agents known or reasonably anticipated to be human 
carcinogens.
    The Board's members are selected from recognized authorities 
knowledgeable in fields such as toxicology, pharmacology, pathology, 
biochemistry, epidemiology, risk

[[Page 47238]]

assessment, carcinogenesis, mutagenesis, molecular biology, behavioral 
and neurotoxicology, immunotoxicology, reproductive toxicology or 
teratology, and biostatistics. The NTP strives for equitable geographic 
distribution and minority and female representation on the Board.

    Dated:
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.

    Technical and Toxicity Reports Tentatively Scheduled for Review by the NTP Board of Scientific Counselors
                            Technical Reports Review Subcommittee on October 18, 2001
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                                                                                                          Review
     Chemical CAS number        Report number          Primary uses           Route & exposure levels     order
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Diazoaminobenzene 136-35-6...  TOX-73          Used as a laboratory         17-day dermal exposure            4
                                                reagent; occurs as a         toxicity study. Rats &
                                                contaminant in some          Mice: 12.5, 25, 50, 100,
                                                cosmetics.                   or 200 mg/kg. Intravenous,
                                                                             intragastric and dermal
                                                                             metabolism studies in rats
                                                                             and mice.
2,4-Hexadienal 142-83-6......  TR-509          Occurs naturally as a        Gavage (corn oil vehicle)         3
                                                peroxidation product of      Rats: 0, 22.5, 45, or 90
                                                fatty acids; used as a       mg/kg Mice: 30, 60 or 120
                                                flavoring agent and          mg/kg
                                                preservative.
Riddelliine 23246-96-0.......  TR-508          Plant alkaloid occurring in  Gavage (phosphate buffer          1
                                                a range of plants in         vehicle) Male Rats: mg/kg;
                                                western states.              Female Rats: 0.01, 0.033,
                                                                             0.1, 0.33, or 1 mg/kg Male
                                                                             Mice: 0.1, 0.3, 1, or 3 mg/
                                                                             kg; Female Mice: 3 mg/kg
Vanadium Pentoxide 1314-62-1.  TR-507          Used as a catalyst and in    Inhalation of particulates        2
                                                alloys; primary human        Rats: 0.5, 1, or 2 mg/m\3\
                                                exposure comes from          Mice: 1, 2, or 4 mg/m\3\
                                                cleaning oil-fired
                                                furnaces.
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[FR Doc. 01-22789 Filed 9-10-01; 8:45 am]
BILLING CODE 4140-01-P