[Federal Register Volume 66, Number 158 (Wednesday, August 15, 2001)]
[Notices]
[Page 42857]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-20507]


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ENVIRONMENTAL PROTECTION AGENCY

[FRL-7032-9]


Summary Report of the Technical Workshop on Issues Associated 
With Considering Developmental Changes in Behavior and Anatomy When 
Assessing Exposure to Children

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of availability of a final report.

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SUMMARY: The Environmental Protection Agency's (EPA) Risk Assessment 
Forum (RAF) announces the availability of a final report, Summary 
Report of the Technical Workshop on Issues Associated with Considering 
Developmental Changes in Behavior and Anatomy when Assessing Exposure 
to Children (EPA/630/R-00/005, December 2000). The report presents 
information and materials from a peer involvement workshop held by the 
RAF. Eastern Research Group, Inc., an EPA contractor, organized and 
convened the meeting on behalf of the RAF in Washington, DC on July 26 
and 27, 2000. The meeting discussions focused on how to consider age-
related changes in behavior and physical development when assessing 
childhood exposures to environmental contaminants. These discussions 
are part of EPA's ongoing efforts to improve the assessment of risk to 
children.

ADDRESSES: The document will be made available electronically through 
the Risk Assessment Forum's web site (www.epa.gov/ncea/raf/rafpub.htm). 
A limited number of paper copies will be available from the EPA's 
National Service Center for Environmental Publications (NSCEP), P.O. 
Box 42419, Cincinnati, OH 45242; telephone: 1-800-490-9198 or 513-489-
8190; facsimile: 513-489-8695. Please provide your name and mailing 
address and the title and EPA number of the requested publication.

FOR FURTHER INFORMATION CONTACT: Steven Knott, Risk Assessment Forum 
(8601D), U.S. Environmental Protection Agency, 1200 Pennsylvania 
Avenue, NW., Washington DC 20460; telephone: 202-564-3359; facsimile: 
202-565-0062; email: [email protected].

SUPPLEMENTARY INFORMATION: An Agency workgroup convened under the 
auspices of the RAF has been exploring children's exposure assessment 
issues. This workgroup has concluded that a major issue facing Agency 
assessors is how to consider age-related changes in behavior and 
physiology when preparing exposure assessments for children. Children's 
behavior changes over time in ways that can have an important impact on 
exposure. Further, children's physiology changes over time in ways that 
can impact both their exposures and their susceptibility to certain 
health effects. There are two aspects to these physiological changes. 
First, there are anatomical changes resulting from physical growth. 
Second, there are changes in pharmacokinetics and pharmacodynamics that 
affect the absorption, distribution, excretion and effects of 
environmental contaminants. The Agency is examining the 
pharmacokinetic/pharmacodynamic changes in children through other 
efforts and future meetings on this topic are anticipated. The July 
2000 workshop focused on incorporating age-related changes in behavior 
and anatomy into Agency exposure assessments.

    Dated: July 19, 2001.
Art Payne,
Acting Director, National Center for Environmental Assessment.
[FR Doc. 01-20507 Filed 8-14-01; 8:45 am]
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