[Federal Register Volume 66, Number 152 (Tuesday, August 7, 2001)]
[Notices]
[Page 41254]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-19642]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by agencies of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Amine Modified Random Primers for Microarray Detection

Dr. Charles Xiang and Dr. Michael J. Brownstein (NIMH), DHHS Reference 
No. E-098-01/0 filed 11 Apr 2001
    Licensing Contact: Uri Reichman; 301/496-7736 ext. 240; e-mail: 
[email protected].
    DNA Microarray technology has become one of the most important 
tools for high throughput studies in medical research, with 
applications in the areas of gene discovery, gene expression and 
mapping, and drug discovery. The technology requires the use of 
detection probes (cDNA probes, usually fluorescent) which are commonly 
made from single nucleotides using a template polynucleotide, such as 
mRNA. The standard methods of making cDNA probes suffer from problems 
related to reproducibility, and they generally result in poor 
incorporation of the fluorescent dye and in low sensitivity. The 
present invention relates to a new method for preparing cDNA probes. 
The new method overcomes the common problems exhibited by existing 
methods. The method utilizes amine modified random primers rather than 
single nucleotides, and results in highly efficient incorporation of 
the fluorescent dye in multiple sites in the probe. Coupling of the 
fluorescent dye to the amine residues is performed after the synthesis 
of the cDNA by reverse transcription. This novel procedure requires 
significantly less RNA than standard techniques. Licensees of the 
invention will be provided with primers and other reagents required to 
practice the invention.

Net-Trials--Clinical Trials Information System

Douglas Hageman, Dianne M. Reeves (NCI), DHHS Reference No. E-164-01/0
    Licensing Contact: Dale Berkley; 301/496-7735 ext. 223; e-mail: 
[email protected].
    The invention is a software-based application that supports data 
collection, reporting, validation and quality assurance for clinical 
data, where the data comprise clinical observations, patient histories, 
physical examinations and laboratory tests and procedures. This 
software is a Java based application with accompanying database that 
could be offered via an Internet browser to registered users. The 
invention is intended to offer health care sites and centers that are 
conducting clinical research an integrated software application for 
patient, protocol, and research data management in a single 
application.

Method to Fabricate Continuous Lengths of Helical Coiled Shape 
Memory Wire

Theodor Kolobow (NHLBI), DHHS Reference No. E-105-00/0 filed 29 Sep 
2000
    Licensing Contact: Dale Berkley; 301/496-7735 ext. 223; e-mail: 
[email protected].
    The invention is a method and apparatus for fabricating and storing 
continuous lengths of helical coil shaped memory wire for use in 
springs, endotracheal tubes, medical stents and as reinforcement for 
medical tubing (e.g. catheters). The helically coiled wire is 
continuously formed from a special nickel-titanium wire and spooled for 
storage in a straightened form. When the wire is later unspooled, it 
will snap back into the desired helical coil form.
    In one method of the invention, Nitinol wire is passed through a 
spring forming unit to curve the wire. The so formed coil is then 
loosely guided along a cylindrical mandrel, passed through a high 
temperature oven so that the helical coil shape will be memorized, and 
then uncoiled and stored in a straightened form. The method provides a 
very thin wire with great strength and integrity of shape that resists 
kinking or collapse in most medical applications.

    Dated: July 27, 2001.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 01-19642 Filed 8-6-01; 8:45 am]
BILLING CODE 4140-01-P