[Federal Register Volume 66, Number 133 (Wednesday, July 11, 2001)]
[Notices]
[Pages 36294-36295]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-17288]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Institute of Environmental Health Sciences (NIEHS); 
National Toxicology Program (NTP); Peer Review Panel for the Up-and-
Down Procedure (UDP): Notice of Meeting

Summary

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. Appendix 2), notice is hereby given of a public 
teleconference meeting of the Up-and-Down Procedure (UDP) independent 
scientific peer review panel (Panel). The teleconference is scheduled 
for Tuesday, August 21, 2001, from 10:00 a.m.-12:00 p.m. EDT. The 
agenda for this meeting will focus on a discussion of the following: 
(1) The revised draft Up-and-Down Procedure (UDP), modified in response 
to recommendations from the July 2000 Panel meeting; (2) a proposed 
procedure for calculating the confidence interval for the estimated 
LD50; and (3) a software program to aid in dose selection, test-
stopping decisions, calculation of an estimated LD50, and calculation 
of a confidence interval around the LD50.

[[Page 36295]]

    Following the Panel meeting, a final report of the Panel's findings 
and recommendations will be published and made available to the public 
through the NTP Interagency Center for the Evaluation of Alternative 
Toxicological Methods (NICEATM). In accordance with Public Law 106-545, 
the Interagency Coordinating Committee on the Validation of Alternative 
Methods (ICCVAM) will develop and forward test recommendations on the 
UDP to Federal agencies for their consideration. The ICCVAM 
recommendations will also be made available to the public through the 
NICEATM.
    Background, including the availability of review materials, can be 
found in previous Federal Register notices (see FR Volume 66, Number 
121, pages 33550-33552; FR Volume 65, Number 34, pages 8385-8386; and 
FR Volume 65, Number 106, pages 35109-35110). The Federal Register 
notice (Volume 66, Number 121) invites written public comments on the 
materials being discussed at the Panel meeting. Comments received by 
the August 6, 2001 deadline will be made available to the Panel prior 
to the August 21 teleconference.

Meeting information

    Panel members will participate in the meeting via teleconference. 
The teleconference will originate from Room 3162, 3rd Floor, NIEHS, 79 
T.W. Alexander Drive, Bldg. 4401, Research Triangle Park, NC and 
NICEATM staff will be on hand to coordinate the teleconference. The 
public is invited to attend with attendance limited only by the space 
available in Room 3162. To attend this meeting, please contact Ms. 
Loretta Frye, NICEATM, NIEHS, 79 Alexander Drive, Bldg. 4401, P.O. Box 
12233, EC-17, Research Triangle Park, NC 27709; telephone (919) 541-
3138; fax (919) 541-0947; or email [email protected]. Arrangements to 
attend the meeting, including the need for special accommodation, 
(e.g., wheelchair access), should be made with the NIEHS/NICEATM staff 
by 12:00 noon EDT on Tuesday, August 14, 2001.

Request for Public Comment

    While written public comments are requested and preferred, there 
will be an opportunity for oral public comments. For this 
teleconference meeting, oral comments by individual speakers will 
usually be limited to no more than three minutes per speaker. Persons 
registering to make oral comments are asked to provide their name, 
affiliation, mailing address, phone, fax, e-mail, and sponsoring 
organization. To facilitate planning for the meeting, persons 
interested in providing formal oral comments are asked to notify Ms. 
Loretta Frye (contact information provided above) in writing (email, 
fax, or mail) no later than 12:00 noon EDT on Tuesday, August 14, 2001. 
Persons registering to make oral comments are asked, if possible, to 
provide a copy of their statement to Ms. Loretta Frye by August 14, to 
enable review by the Panel and NICEATM staff prior to the meeting.

    Dated: July 3, 2001.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.
[FR Doc. 01-17288 Filed 7-10-01; 8:45 am]
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