[Federal Register Volume 66, Number 121 (Friday, June 22, 2001)]
[Notices]
[Page 33533]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-15734]


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DEPARTMENT OF DEFENSE

Department of the Army


Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Concerning Methods for Production of Antigens 
Under Control of Temperature-Regulated Promoters in Enteric Bacteria

AGENCY: U.S. Army Medical Research and Materiel Command, DoD.

ACTION: Notice.

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SUMMARY: In accordance with 37 CFR 404.6, announcement is made of the 
availability for licensing of U.S. Patent Serial No. 5,698,416 entitled 
``Methods for Production of Antigens Under Control of Temperature-
Regulated Promoters in Enteric Bacteria'' issued December 16, 1997. 
This patent application has been assigned to the United States 
Government as represented by the Secretary of the Army.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick, 
Maryland 21702-5012.

FOR FURTHER INFORMATION CONTACT: For patent issues, Ms. Elizabeth 
Arwine, Patent Attorney, (301) 619-7808. For licensing issues, Dr. Paul 
Mele, Office of Research & Technology Assessment, (301) 619-6664. Both 
at telefax (301) 619-5034.

SUPPLEMENTARY INFORMATION: Production of proteins in bacteria 
containing DNA sequences encoding proteins under the control of a 
temperature-regulated promoter is improved by growing the organisms at 
temperatures of less than 35  deg.C until the late logarithmic phase. 
Thereafter the temperature may be raised to 36  deg.C to 39  deg.C. 
Antigens produced by the method of invention may be used as vaccines, 
as means for measuring efficacy of vaccines, as probes to detect 
antigens from clinical samples and for biochemical characterizations of 
antigens.

Luz D. Ortiz,
Army Federal Register Liaison Officer.
[FR Doc. 01-15734 Filed 6-21-01; 8:45 am]
BILLING CODE 3710-08-M