[Federal Register Volume 66, Number 64 (Tuesday, April 3, 2001)]
[Notices]
[Pages 17724-17725]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 01-8092]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Toxicology Program (NTP) Board of Scientific Counselors 
Technical Reports Review Subcommittee Meeting; Review of Draft NTP 
Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors Technical Reports 
Review Subcommittee on May 3, 2001 in the Rodbell Auditorium, Rall 
Building, South Campus, National Institute of Environmental Health 
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North 
Carolina. The meeting will begin at 8:30 a.m. on May 3, and is open to 
the public. The primary agenda topic is the peer review of draft 
Technical Reports of rodent toxicology and carcinogenesis studies 
performed by the NTP.
    Tentatively scheduled for peer review on May 3, are draft Technical 
Reports of five 2-year studies, listed alphabetically in the attached 
table, along with supporting material. Studies were conducted using 
Fischer 344 rats and/or B6C3F1 mice. The tentative order of 
review is given in the far right column of the table.

Draft Reports Available for Public Review and Comment

    Approximately one month prior to the meeting, the draft reports 
will be available for public review on the internet, free of charge, 
through the Environmental Health Information Service (EHIS) at http://ehis.niehs.nih.gov. Printed copies can be obtained, as available, from: 
Central

[[Page 17725]]

Data Management (CDM), NIEHS, P.O. Box 12233, MD E1-02, Research 
Triangle Park, NC 27709, T: 919-541-3419, FAX: 919-541-3687, or e-mail: 
[email protected].
    The NTP Board of Scientific Counselors Technical Reports Review 
Subcommittee meeting is open to the public and public comment on any of 
the Technical Reports is welcome. Time will be provided at the meeting 
for public comment on each of the reports under review. In order to 
facilitate planning for the meeting, persons requesting time for an 
oral presentation on a particular Technical Report are asked to notify 
the Executive Secretary, Dr. Mary S. Wolfe, at P.O. Box 12233, MD A3-
07, Research Triangle Park, NC 27709, T: 919-541-3971, F: 919-541-0295, 
e-mail: [email protected]. Persons registering to make brief comments 
are asked to provide, if possible, a written copy of their statement by 
April 20, to enable review by the Subcommittee and staff prior to the 
meeting. Written statements can supplement and may expand the oral 
presentation. Each speaker is asked to provide his/her name, 
affiliation, mailing address, phone, fax, e-mail and supporting 
organization (if any). At least seven minutes will be allotted to each 
speaker, and if time permits, may be extended to 10 minutes. Each 
organization is allowed one time slot for each report being reviewed. 
Registration for making public comments will also be available on-site. 
If registering on-site to speak and reading oral comments from printed 
copy, the speaker is asked to bring 25 copies of the text. These copies 
will be distributed to the Chair and Subcommittee members and 
supplement the record.
    Written comments, in lieu of making oral comments, are also 
welcome. The comments should include name, affiliation, mailing 
address, phone, fax, e-mail and sponsoring organization (if any) and 
preferably be received by April 20, to enable review by the 
Subcommittee and staff prior to the meeting.

Request for Additional Information

    The NTP would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing or planned studies as well as 
current production data, human exposure information, and use patterns 
for any of the chemicals listed in this announcement. Please forward 
this information to CDM at the address given above. CDM will forward 
the information to the appropriate staff scientist.
    The agenda and a roster of subcommittee members will be available 
prior to the meeting on the NTP web homepage at http://ntp-server.niehs.nih.gov and upon request from the Executive Secretary. 
Following the meeting, summary minutes will be available on the NTP web 
homepage and upon request to Dr. Wolfe.

    Dated: March 23, 2001.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.

 Technical Reports Tentatively Scheduled for Review by the NTP Board of Scientific Counselors Technical Reports
                                       Review Subcommittee on May 3, 2001
----------------------------------------------------------------------------------------------------------------
                                                                                                         Review
       Chemical CAS number           Report No.           Primary uses        Route & exposure levels    order
----------------------------------------------------------------------------------------------------------------
Acrylonitrile 107-13-1..........  TR-506            Used in the production    Gavage (deionized water         3
                                                     of acrylic fibers,        vehicle).
                                                     elastomers, resins, and  Mice: 2.5, 10, or 20 mg/
                                                     a variety of chemical     kg.
                                                     or intermediates;
                                                     annual production is in
                                                     the millions of tons.
Citral 5392-40-5................  TR-505            Used in lemon flavoring   Microencapsulated               5
                                                     in foods and beverages    citral in feed Rats:
                                                     and as a lemon            0, 1000, 2000, or 4000
                                                     fragrance in              ppm.
                                                     detergents, perfumes,    Mice: 0, 500, 1000, or
                                                     and toiletries.           2000 ppm.
Methacrylonitrile 126-98-7......  TR-497            Used in the production    Gavage (deionized water         4
                                                     of polymers,              vehicle).
                                                     elastomers, and          Rats: 0, 3, 10, or 30
                                                     plastics including        mg/kg.
                                                     those used in beverage   Mice: 0, 1.5, 3, or 6
                                                     containers.               mg/kg.
o-Nitrotoluene 88-72-2..........  TR-504            Used in synthesis of      Feed...................         1
                                                     agricultural and rubber  Rats: 0, 625, 1250, or
                                                     chemicals and of a        2000 ppm;.
                                                     variety of dyes.         Male rats: 2000 or 5000
                                                                               ppm (stop study).
                                                                              Mice: 0, 1250, 2500, or
                                                                               5000 ppm.
p-Nitrotoluene 99-99-0..........  TR-498            Used in synthesis of      Feed...................         2
                                                     agricultural and rubber  Rats & Mice:...........
                                                     chemicals and of a       0, 1250, 2500, or 5000
                                                     variety of dyes.          ppm.
----------------------------------------------------------------------------------------------------------------

[FR Doc. 01-8092 Filed 4-2-01; 8:45 am]
BILLING CODE 4140-01-P