[Federal Register Volume 65, Number 163 (Tuesday, August 22, 2000)]
[Notices]
[Page 51002]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 00-21368]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by agencies of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by contacting Peter A. 
Soukas, J.D., at the Office of Technology Transfer, National Institutes 
of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 
20852-3804; telephone: 301/496-7056 ext. 268; fax: 301/402-0220; e-
mail: [email protected]. A signed Confidential Disclosure Agreement 
will be required to receive copies of the patent applications.

Cloned Genome of Infectious Hepatitis C Virus of Genotype 2a and 
Uses Thereof

Jens Bukh, Masayuki Yanagi, Robert H. Purcell, Suzanne U. Emerson 
(NIAID)
DHHS Reference No. E-100-99/0
Filed 04 Jun 1999

    The current invention provides a nucleic acid sequence comprising 
the genome of infectious hepatitis C viruses (HCV) of genotype 2a. The 
encoded polyprotein differs from those of the infectious clones of 
genotypes 1a and 1b (PHS Invention Number E-050-98/0) by approximately 
thirty (30) percent. It covers the use of this sequence and 
polypeptides encoded by all or part of the sequence, in the development 
of vaccines and diagnostic assays for HCV and the development of 
screening assays for the identification of antiviral agents for HCV. 
Additional information can be found in Yanagi et al. (1999), Virology 
262, 250-263.

HCV/BVDV Chimeric Genomes and Uses Thereof

Jae-Hwan Nam, Jens Bukh, Robert H. Purcell, Suzanne U. Emerson (NIAID)
DHHS Reference No. E-102-99/0
Filed 04 June 1999

    The current invention provides nucleic acid sequences comprising 
chimeric viral genome of hepatitis C Virus (HCV) and bovine viral 
diarrhea viruses (BVDV). The chimeric viruses are produced by replacing 
the structural region or a structural gene of an infectious BVDV clone 
with the corresponding region or gene of an infectious HCV. It covers 
the use of these sequences and polypeptides encoded by all or part of 
the sequences in the development of vaccines and diagnostic assays for 
HCV and the development of screening assays for the identification of 
antiviral agents for HCV.

Infectious cDNA Clone of GB Virus B and Uses Thereof

Jens Bukh, Masayuki Yanagi, Robert H. Purcell, Suzanne U. Emerson 
(NIAID)
DHHS Reference No. E-173-99/0
Filed 04 Jun 1999

    The current invention provides nucleic acid sequences comprising 
the genomes of infectious GB virus B, the most closely related member 
of the Flaviviridae to hepatitis C virus (HCV). It also covers chimeric 
GBVB-HCV sequences and polypeptides for use in the development of 
vaccines and diagnostic assays for HCV and the development of screening 
assays for the identification of antiviral agents for HCV. Additional 
information can be found in Bukh et al. (1999), Virology 262, 470-478.

    Dated: August 14, 2000.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 00-21368 Filed 8-21-00; 8:45 am]
BILLING CODE 4140-01-P