[Federal Register Volume 65, Number 14 (Friday, January 21, 2000)]
[Notices]
[Page 3467]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 00-1425]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY:  National Institutes of Health, Public Health Service, DHHS.

ACTION:  Notice.

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SUMMARY:  The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally funded research and development.

ADDRESSES:  Licensing information and a copy of the U.S. patent 
application referenced below may be obtained by contacting J.E. Fahner-
Vihtelic at the Office of Technology Transfer, National Institutes of 
Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852-
3804; Telephone: 301/496-7735 ext. 270; Fax: 301/402-0220; E-mail; 
[email protected]. A signed Confidential Disclosure Agreement is required 
to receive a copy of any patent application.

Artificial Salivary Gland

Bruce J. Baum et al. (NIDCR)
Serial No. 60/121,335
Filed 24 Feb 1999

    The present application describes an artificial fluid secreting 
prosthetic device for non-invasive insertion and methods of using this 
device. Specifically, compositions and methods based on the discovery 
of an artificial fluid secreting prosthesis are disclosed in this 
application. Currently, there is no conventional effective treatment 
for salivary gland hypofunction. And although the transplantation of 
mammalian salivary glands has also been tried, this option has not 
proven desirable due to lack of sufficient donor supplies. To date, the 
inventors have performed experiments that have demonstrated: (1) 
Subjects having irradiated salivary gland cells can be induced to 
secrete fluid subsequent to transfer of a gene; (2) heterologous genes 
can be transferred to salivary gland cells; and (3) an artificial gland 
has been designed having a support, an attachment surface joined to the 
support, and a monolayer of allogenic cells, engineered to secrete ions 
and water unidirectionally, joined to the attachment surface.

    Dated: January 11, 2000.
Jack Spiegel, Ph.D.,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer.
[FR Doc. 00-1425 Filed 1-20-00;8:45am]
BILLING CODE 4140-01-M