[Federal Register Volume 63, Number 189 (Wednesday, September 30, 1998)]
[Notices]
[Pages 52282-52283]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-26187]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP) Board of Scientific Counselors'
Meeting; Review of Draft NTP Technical Reports
Pursuant to Public law 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors' Technical Reports
Review Subcommittee on October 30, 1998, in the Conference Center,
Building 101, South Campus, National Institute of Environmental Health
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North
Carolina. The meeting will begin at 9:00 a.m. on October 30, and is
open to the public. The agenda topic is the peer review of draft
Technical Reports of long-term toxicology and carcinogenesis studies
from the National Toxicology Program.
Tentatively scheduled to be peer reviewed on October 30 are draft
Technical Reports of five two-year studies, listed alphabetically,
along with supporting information in the attached table. The draft
Report on triethanolamine had been peer reviewed previously but is
being returned for rereview as this was the first study in which
infection of B6C3F1 mice with Halicobacter hepaticus was
discovered. All studies were done using Fischer 344 rats and
B6C3F1 mice. The order of review is given in the far right
column of the table. By September 30, 1998, full copies of these draft
reports will be available for free on the Internet for public review
and comment through the Environmental Health Information Service (EHIS)
at http://ehis.niehs.nih.gov. Printed copies can be obtained, as
available, from: Central Data Management, MD E1-02, P.O. Box 12233,
Research Triangle Park, NC 27709 (919/541-3419), FAX (919/541-3687);
email: [email protected].
Public comment on any of the Technical Reports is welcome. Persons
wanting to make a formal presentation regarding a particular Technical
Report must notify the Executive Secretary by telephone at 919/541-
3971, by FAX at 919/541-0295, by mail, or by email at
[email protected]., by no later than October 27, 1998, and, if
possible, provide a written copy in advance of the meeting so copies
can be made and distributed to all Subcommittee members and staff, and
made available at the meeting for attendees. Written statements could
supplement and may expand on the oral presentation. Oral presentations
should be limited to no more than five minutes.
The Program would welcome receiving toxicology and carcinogenesis
information from completed, ongoing, or planned studies by others, as
well as current production data, human exposure information, and use
patterns for any of the chemicals listed in this announcement. Please
contact Central Data Management at the address given above, and they
will relay the information to the appropriate staff scientist.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,
Research Triangle Park, North Carolina 27709 will furnish agenda and a
roster of Subcommittee members prior to the meeting. Summary minutes
subsequent to the meeting will be available upon request to Central
Data Management.
Dated: September 21, 1998.
Kenneth Olden,
Director, National Toxicology Program.
Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the NTP Board of
Scientific Counselor's Technical Reports Review Subcommittee
[October 30, 1998]
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Technical report Review
Chemical CAS No. No. Primary uses Route/exposure levels order
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Ethylene Glycol Monobutyl Ether TR-484............. Solvent for mineral Inhalation (air): 3
111-76-2. oils, in spray Rats: 0, 31, 62.5, or
lacquers, varnish 125 ppm; Mice: 0,
removers, metal 62.5, 125, or 250 ppm
cleaners. (50/sex/species/
group).
Glutaraldehyde 111-30-8........ TR-490............. Disinfectant and Inhalation (air): 5
sterilizing agent; Rats: 0, 250, 500, or
Embalming fluid; 750 ppm; Mice: 0,
chemical intermediate 62.5, 125, or 250 ppb
for adhesives, (50/sex/species/
electrical products, group).
tanning soft leathers;
in photographic
developing, dental
materials.
Methyleugenol 93-15-2.......... TR-491............. Insect attractant; Gavage 2
major constituent of (methylcellulose):
clove oil, used Rats & Mice: 0, 37,
extensively in 75, or 150 mg/kg (50/
perfumes & flavorings. sex/species/group).
[[Page 52283]]
Oxymetholone 434-07-1.......... TR-485............. Maintain a positive Gavage 4
nitrogen balance; to (methylcellulose);
promote weight gain in Rats only: Males: 0,
Cachexia, debilitating 3, 30, or 150 mg/kg;
diseases, serious Females: 0, 3, 30, or
infections, burns, 100 mg/kg.
trauma and surgery;
treatment of anemias.
Triethanolamine 102-71-6 TR-449............. Intermediate in the Topical (acetone): 1
(Reconsideration and manufacture of Male Rats: 0, 32, 63,
discussion of Helicobacter surfactants, textile or 125 mg/kg; Female
issue). specialties, waxes, Rats: 0, 63, 125, or
polishes, herbicides, 250 mg/kg; Male Mice:
petroleum 0, 200, 630, or 2000
demulsifiers, toilet mg/kg; Female Mice:
goods, cement 0, 100, 300, or 1000
additives, cutting mg/kg (60/group).
oils, in making
mineral & vegetable
oil emulsions,
solvent, pharmaceutics
aid (alkalizer).
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By September 30, 1998, full copies of these draft reports will be
available for free on the Internet for public review and comment
through the Environmental Health Information Service (EHIS) at http://
ehis.niehs.nih.gov. Printed copies can be obtained by contacting
Central Data Management by phone at 919-541-3418; fax: 919-541-3687; or
email: [email protected].
[FR Doc. 98-26187 Filed 9-29-98; 8:45 am]
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