[Federal Register Volume 63, Number 136 (Thursday, July 16, 1998)]
[Notices]
[Pages 38405-38407]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-18936]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention


Government-Owned Inventions; Availability for Licensing

AGENCY: Centers for Disease Control and Prevention (CDC), Department of 
Health and Human Services (HHS).

ACTION: Notice.

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    The inventions named in this notice are owned by agencies of the 
United States Government and are available for licensing in the United 
States (U.S.) in accordance with 35 U.S.C. 207 to achieve expeditious 
commercialization of results of federally funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for U.S. companies and may also be 
available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to Thomas E. 
O'Toole, M.P.H., Licensing and Marketing Specialist, Technology 
Transfer Office, Centers for Disease Control and Prevention (CDC), 
Mailstop

[[Page 38406]]

E-67, 1600 Clifton Rd., NE., Atlanta, GA 30333, telephone (404) 639-
6270; facsimile (404) 639-6266. A signed Confidential Disclosure 
Agreement will be required to receive copies of the patent 
applications.

Detection and Identification of Non-polio Enteroviruses

Kilpatrick, David R.
Filed 2 October 96
Serial No. 60/027, 353 (ref# I-001-96)

    This invention allows the diagnosis, detection, and differentiation 
of clinical paralysis cases due to polioviruses. A new and novel method 
for designing polymerase chain reaction (PCR) primes was developed to 
differentiate between the three poliovirus serotypes. This method has 
been further developed to produce PCR primers capable of 
differentiating the 60+ serotypes of nonpolio enterviruses.

Generation of Viral Transfectants Using Recombinant DNA-Derived 
Nucleocapsid Proteins

Shaw, Michael W.
Filed 1 May 96
Serial No. 60/017,907 (CDC Ref# I-002-96)

    This invention provides a method of producing viral transfectants 
that eliminates the need for purified RNP complexes or for purified 
viral RNA polymerases. The methods of this invention thus dramatically 
simplify the preparation of viral transfectants. The development of 
reverse genetics for influenza viruses has allowed the direct 
manipulation of virion gene products and the creation of entirely new 
recombinant viruses not seen in nature.

Nucleic Acid Assay for the Detection and Differentiation of Three 
Chlamydia Species

Messemer, Trudy
Filed 5 September 96
Serial No. 60/025, 509 (Ref# I-006-96)

    This invention provides a novel assay for easily and readily 
detecting three important Chlamydia sp., i.e., C. trachormatis, C. 
psittaci, and C. pneumoniae. These three species may be detected and 
differentiated in the same sample aliquot at the same time through the 
use of amplification primers targeted to the 16s rRNA gene specific for 
each of the species. Additionally, even though multiple targets are 
used, the assay described is highly sensitive and specific 
consistently.

Inhibitors of Casein Kinase II (Protein Kinase CK2) Inhibit HIV-1 
Replication

Critchfield, William
Filed 16 January 98
Serial No. (Ref# I-012-96)

    This invention provides compositions and methods which are 
effective in inhibiting the activity of specific cellular components 
associated with viral replication, specifically protein kinase enzymes 
such as casein kinases. These compositions are easily administered by 
oral, subcutaneous and intravenous routes, and can be given in dosages 
that are safe, and provide inhibition of viral replication. The present 
invention provides a method of treating mammalian diseases mediated by 
viral infection by administering a composition comprising an anti-viral 
compound in a dosage sufficient to inhibit transcription and 
translation of viral genomes thereby preventing the propagation of 
viral particles.

DNA Polymerase From Treponema Pallidum

Steiner, Bret Martain
Filed 10 June 97
Serial No. 08/872, 094 (Ref# I-013-96)

    This invention provides the nucleic acid and amino acid sequences 
of the DNA polymerase I region of the Treponema pallidum genome and 
sequences of nucleic acid molecules that selectively hybridize with 
nucleic acid molecules encoding the DNA polymerase I enzyme from 
Treponema pallidum or certain complementary sequences that are 
described. The nucleic acid molecules are useful for the production of 
recombinant DNA polymerase I enzyme or as probes to detect the presence 
of T. pallidum. The nucleic acid and amino acid sequences are also 
useful as laboratory research tools to study the organism and the 
disease and to develop therapies and treatments for syphilis.

Nucleic Acids for Detection Aspergillus Species

Morrison, Christine
Filed 2 May 97
Serial No. 60/045, 400 (Ref# I-016-96)

    The present invention relates to nucleic acids for detecting 
Aspergillus species. Unique internal transcribed spacer 2 coding 
regions permit the development of probes specific for five different 
species, A. flavus, A. fumigatus, A. niger, A. terreus, and A. 
nidulans. The invention thereby provides methods for the species-
specific detection and diagnosis of Aspergillus infection in a subject.

Nucleic Acids of the M Antigen Gene of Histoplasma Capsulatum, 
Isolated and Recombinantly-Produced Antigens, Vaccine and 
Antibodies, Methods and Kits for Detecting Histoplasmosis

Lott, Timothy J.
Filed 30 April 98
Serial No. 60/083,676 CDC Ref# I-002-97

    This invention relates to nucleic acids (DNAs) relating to the M 
antigen gene of Histoplasma capsulatum; to vectors and host expression 
systems containing these nucleic acids; to nucleic acids (RNAs) which 
encode the M antigen of H. capsulatum; to isolated and recombinantly-
produced antigens encoded by these nucleic acids; to antibodies 
produced against these antigens; to methods and kits for detecting 
histoplasmosis using these nucleic acids, antigens and antibodies; and 
to vaccines for treatment or prevention of histoplasmosis.

Dust Detector Tube

Volkwein, Jon C
Filed 3 July 97
Serial No. 60/052, 619 (Ref# I-004-97)

    The present invention relates to an apparatus for real time dust 
dosimetry using the sampling pump having inlet port coupled to the dust 
detecting device or tube for detecting dust mass exposure using 
differential pressure measurements. The tube is elongated with the 
collection filter positioned therein for trapping dust mass. The dust 
detecting device coupled to the pump draws the flow of gas there 
through and traps selected dust mass at the collection filter. 
Differential pressure between the pump side of the collection filter 
and the atmosphere is indicative of the cumulative dust mass trapped.

Isocyanate Derivatizing Agent and Methods of Production and Use

Streicher, Robert P.
Filed 13 May 98
Serial No. 60/085,260 (CDC Ref# I-005-97)

    This invention relates to a derivatizing agent and method for 
detecting and quantifying isocyanate contamination in an environmental 
sample. A novel isocyanate derivatizing agent, useful for the 
determination of isocyanates in an environmental sample, is provided. A 
method for producing this agent and a method for measuring the total 
level of isocyanate in an environmental sample are also provided.

Rapid and Sensitive Method for Detecting Histoplasma Capsulatum

Schafer, Millie P.
Filed 21 April 98
Serial No. 60/082,477 (CDC Ref# I-006-97)

    This invention relates to detecting a pathogenic fungus, 
Histoplasma capsulatum, using oligonucleotide probes specific for H. 
capsulatum to

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amplify H. capsulatum DNA by means of the polymerase chain reaction. 
Test samples may originate from the environment where H. capsulatum are 
found, or from clinical samples obtained from the patients.

New Retrovirus Isolated From Humans

Sandstrom, Paul A.
Filed 3 February 97
Serial No. 08/798, 071 (Ref# I-012-97)

    This invention comprises a spumavirus isolate of human origin that 
has been definitively isolated from a human with no apparent disease. 
This novel spumavirus has been maintained through tissue culture cells 
where it causes characteristic vacuolation of the cells. The spumavirus 
also has a reagent for the immunological screening of such viruses. The 
spumavirus can also serve as a vector in gene therapy because the virus 
appears to cause no disease in humans and is not transmitted to other 
humans. Additionally, the spumavirus can be used as a reagent in 
pathogenicity studies of these and related viruses. Finally, the 
sequences of the spumavirus can be used as probes to detect virus in 
biological samples.

Hand Wipe Disclosing Method for the Presence of Lead

Esswein, Eric
Filed 11 June 97
Serial No. (Ref# I-014-97)

    A method for the detection of lead in surfaces using a handwipe 
system and chemical test which includes either rhodizonate or sulfide 
ions. This invention is especially useful in detecting the presence of 
lead on skin and assessing the effectiveness of hand washing in removal 
of lead from the skin of exposed individuals. This invention is also 
especially useful in field evaluation for the presence of lead, and the 
effectiveness of its subsequent removal.

Epitope Peptides Immunogenic Against Streptococcus Pneumoniae

Carlone, George
Filed 2 March 98
Serial No. 60/076, 565 (Ref# I-017-97)

    This invention describes novel immunogenic peptides obtained from a 
random library by selection for high affinity binding to monoclonal 
antibodies specific for Psa A epitopes. In addition, the peptides of 
the invention have the capability if serving as immunogens in a 
subject, thereby effectively eliciting the production of antibodies by 
the subject and additionally conferring protective immunity against 
infection by S. pneumoniae on the subject. The invention also relates 
to a selection method employed to obtain such peptides.

Instrumented Cable; Wire for Monitoring Bolts

Martain, Lewis A.
Filed 27 February 98
Serial No. 69/076, 138 (Ref# I-023-97)

    This invention provides an apparatus for providing support to a 
structure, and for measuring stress placed on the apparatus when 
present in the structure. The stress placed upon the apparatus can be 
measured at more than one location along the length of the apparatus, 
and the apparatus is spinnable into a rock mass without damaging said 
stress measuring devices.

Remote Monitoring Safety System

Marshall, Thomas E.
Filed 9 December 97
Serial No. (CDC Ref# I-024-97)

    This invention relates to a roof monitoring safety system in which 
a single point or multipule points in a single bore hole can be 
measured to detect movement or sag in the roof strata of an underground 
mine. Movement of the rock strata overlying the mine is measured 
directly by use of one or more potentiometers connected via cables to 
the rock strata at different locations in a bore hole in the roof 
strata.

Method for Developing Degenerate PCR Primers

Kilpatrick, David R.
Filed 15 April 98
Serial No. 60/081,944 (CDC Ref# I-031-97)

    The method of this invention provides degenerate primers for the 
amplification and subsequent detection of virtually all genes that 
encode an amino acid sequence. The degenerate primers are effective for 
detection of any gene which lies within a coding region that results in 
the production of a protein. Examples of genes that can be detected 
include those where the sequence of the specific target gene is 
structural, nonstructural, or enzymatic. The method provides highly 
specific primers which are effective for substantial amplification of a 
target sequence even where the target nucleic acid sequence is unknown.

Oligonucleotide Probes for Detecting Enterbacteriaceae and 
Quinolone-Resistant Enterobacteriaceae

Tenover, Fred C.
Filed 1 April 98
Serial No. (Ref# I-003-98)

    This invention provides a simple, rapid, and useful method for 
differentiating Enterobacteriaceae species and determining their 
quinolone-resistance status. This invention also provides material and 
methods to apply the species-specific probes to isolated DNA from host 
samples for an in vitro diagnosis of Enterobacteiaceae infection.

Method for the Determination of Hexavalent Chromium Using 
Ultrasonication and Strong Anion Exchange Solid Phase Extraction

Wang, Jin
Filed 27 February 98
Serial No. 60/076,137 (CDC Ref# I-010-98)

    This invention relates to a method for the determination of 
hexavalent chromium. Based on the chemical properties of chromium 
species in aqueous solutions, a simple, fast, sensitive, and economical 
field method has been developed and evaluated for the determination of 
hexavalent chromium in environmental and workplace air samples.

Intrinsically-safe Roof Hazard Alert Module

Mayercheck, William D.
Filed 30 April 98
Serial No. 60/083,677 (CDC Ref# I-012-98)

    The invention relates to an intrinsically-safe roof hazard warning 
device designed to be attached to the roof of a mine to indicate 
unsupported roof conditions or other unsafe conditions. The device of 
this invention is especially useful in underground mining operations in 
order to discourage miners from going into unsupported mine roof areas 
by rendering the attendant hazard more evident, directing the miner's 
attention to an appropriate warning message on the module, and thus 
avoiding the hazard beyond the device. The warning device of this 
invention is intrinsically-safe, self-contained, simple to use, 
inexpensive to build and operate, portable, light weight, compact, and 
low-profile. These features make it useful in short-term or temporary 
hazardous situations where the installation of complex or bulky warning 
systems may not be warranted or justified.

    Dated: July 10, 1998.
Joseph R. Carter,
Acting Associate Director for Management and Operations, Centers for 
Disease Control and Prevention (CDC).
[FR Doc. 98-18936 Filed 7-15-98; 8:45 am]
BILLING CODE 4163-18-P