[Federal Register Volume 63, Number 93 (Thursday, May 14, 1998)]
[Notices]
[Pages 26818-26820]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-12779]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Toxicology Program; Availability of the Report on 
Carcinogens, Eighth Edition

Background

    The National Toxicology Program (NTP) announces the availability of 
the Report on Carcinogens, Eighth Edition.

[[Page 26819]]

    The Report on Carcinogens (RoC) is a Congressionally-mandated 
listing of known human carcinogens and reasonably anticipated human 
carcinogens and its preparation is delegated to the National Toxicology 
Program by the Secretary, Department of Health and Human Services 
(HHS). Section 301(b)(4) of the Public Health Service Act, as amended, 
provides that the Secretary, (HHS), shall publish a report which 
contains a list of all substances (1) which either are known to be 
human carcinogens or may reasonably be anticipated to be human 
carcinogens; and (2) to which a significant number of persons residing 
in the United States (US) are exposed. The law also states that the 
reports should provide available information on the nature of 
exposures, the estimated number of persons exposed and the extent to 
which the implementation of Federal regulations decreases the risk to 
public health from exposure to these chemicals.
    The new entries for the 8th RoC have undergone a multiphased peer 
review process involving two Federal scientific review groups and one 
non-government, scientific peer review body (a subcommittee of the NTP 
Board of Scientific Counselors) which met in an open, public meeting 
that included a public comment session. All data relevant to the 
criteria for inclusion of candidate agents, substances or mixtures in 
the RoC have been evaluated by the three scientific review committees.
    In the 8th RoC, the NTP is adding 14 agents, substances or mixtures 
to the existing list. In addition, thiotepa, which is currently listed 
in previous Reports on Carcinogens as reasonably anticipated to be a 
human carcinogen is moved to the known human carcinogen list. These 
agents, substances or mixtures are provided in the following table with 
their Chemical Abstracts Services (CAS) Registry numbers and listing.
    Hard copies of the 8th RoC, or the 8th RoC Summary (which contains 
the same information that is in the full Report with the exception of 
specific information on regulations promulgated by regulatory health 
agencies) can be obtained by contacting the NIEHS Environmental Health 
Information Service, ATTN: Order Processing, P.O. Box 12510, Research 
Triangle Park, NC 27709-2510, fax number (919) 541-0763, email: 
[email protected]. The 8th RoC Summary is also available on the 
internet and can be accessed from the NIEHS Environmental Health 
Information Service Home Page at: http:///ehis.niehs.nih.gov/ or from 
the NTP Home Page at: http://ntp-server.niehs.nih.gov//.
    Questions or comments concerning the 8th RoC should be directed to: 
Dr. C.W. Jameson, National Toxicology Program, Report on Carcinogens, 
MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709; phone: 
(919) 541-4096, fax: (919) 541-2242, email: [email protected].
Kenneth Olden,
Director, National Toxicology Program.

      Summary for Agents, Substances or Mixtures Newly Listed in the Report on Carcinogens, Eighth Edition      
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        Chemical/CAS number                            Primary uses                         Newly listed as     
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AZACITIDINE/320-67-2...............  Used as a cytostatic agent in the treatment of   Reasonably Anticipated to 
                                      acute leukemia.                                  be a Human Carcinogen    
p-CHLORO-o-TOLUIDINE and its HCl     Used to produce azo dyes for cotton, silk        Reasonably Anticipated to 
 salt/95-69-2.                        acetate and nylon and as intermediate in         be a Human Carcinogen.   
                                      production of Pigment Red 7 and Pigment Yellow                            
                                      49. Also an impurity in and a metabolite of                               
                                      the pesticide chlordimeform.                                              
CHLOROZOTOCIN/54749-90-5...........  Used as a cytostatic agent in the treatment of   Reasonably Anticipated to 
                                      cancers of the stomach, large intestine          be a Human Carcinogen.   
                                      pancreas and lung; melanoma; and multiple                                 
                                      myeloma.                                                                  
CYCLOSPORIN/59865-13-3.............  Used as an immunosuppressive agent in the        Known to be a Human       
                                      prevention and treatment of graft-vs-host        Carcinogen.              
                                      reactions in bone marrow transplantation and                              
                                      for the prevention of rejection of kidney,                                
                                      heart, and liver transplants.                                             
DANTHRON/(1,8-                       Used as a laxative and as an intermediate in     Reasonably Anticipated to 
 Dihydroxyanthraquinone) 117-10-2.    the manufacture of dyes.                         be a Human Carcinogen    
1,6-DINITROPYRENE/42397-64-8.......  Not used commercially, detected in ambient       Reasonably Anticipated to 
                                      atmospheric samples and as a constituent of      be a Human Carcinogen    
                                      diesel exhaust.                                                           
1,8-DINITROPYRENE/42397-65-9.......  Not used commercially, detected in ambient       Reasonably Anticipated to 
                                      atmospheric samples and as a constituent of      be a Human Carcinogen    
                                      diesel exhaust.                                                           
DISPERSE BLUE 1/(1,4,5,8-            Used as an anthraquinone based dyestuff in hair  Reasonably Anticipated to 
 Tetraaminoanthraquinone) 2475-45-8.  color formulations and in coloring fabrics and   be a Human Carcinogen    
                                      plastics.                                                                 
FURAN/100-00-9.....................  Used as an intermediate in the synthesis and     Reasonably Anticipated to 
                                      production of other organic compounds.           be a Human Carcinogen    
O-NITROANISOLE/91-23-6.............  Used a a precursor in the synthesis of o-        Reasonably Anticipated to 
                                      anisidine which is used in the manufacture of    be a Human Carcinogen.   
                                      over 100 azo dyes.                                                        
6-NITROCHRYSENE/7495-02-8..........  Not used commercially, detected in ambient       Reasonably Anticipated to 
                                      atmospheric samples.                             be a Human Carcinogen.   
1-NITROPYRENE/5522-43-0............  Not used commercially, detected in ambient       Reasonably Anticipated to 
                                      atmospheric samples and as a constituent of      be a Human Carcinogen.   
                                      diesel and gasoline engine exhaust.                                       
4-NITROPYRENE/57835-92-4...........  Not used commercially, detected in ambient       Reasonably Anticipated to 
                                      atmospheric samples.                             be a Human Carcinogen.   
THIOTEPA/52-24-4...................  Used as a cytostatic agent in the treatment of   Known to be a Human       
                                      lymphomas and a variety of solid tumors, such    Carcinogen.              
                                      as breast and ovary. It has also been used at                             
                                      high doses in combination chemotherapy with                               
                                      cyclophosphamide in patients with refractory                              
                                      malignancies treated with autologous bone                                 
                                      transplantation.                                                          

[[Page 26820]]

                                                                                                                
1,2,3-TRICHLOROPROPANE/96-18-4.....  Used as a polymer crosslinking agent, paint and  Reasonably Anticipated to 
                                      varnish remover, solvent and degreasing agent.   be a Human Carcinogen.   
                                      It has been found as an impurity in certain                               
                                      nematicides and soil fumigants and has been                               
                                      detected in drinking and ground water in                                  
                                      various parts of the United States.                                       
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[FR Doc. 98-12779 Filed 5-13-98; 8:45 am]
BILLING CODE 4140-01-M