[Federal Register Volume 63, Number 5 (Thursday, January 8, 1998)]
[Notices]
[Pages 1118-1119]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-456]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institute of Environmental Health Sciences National
Toxicology Program; Announcement of Nominated Chemicals Under
Consideration for Toxicological Studies by the National Toxicology
Program (NTP)--Recommendations by the Interagency Committee for
Chemical Evaluation and Coordination (ICCEC)--Request for Comments
Background
As part of an effort to earlier inform and obtain public input into
the selection of chemicals for evaluation, the National Toxicology
Program (NTP) routinely seeks public input on (1) chemicals nominated
to the Program for toxicological studies, and (2) the testing
recommendations made by the Interagency Committee for Chemical
Evaluation and Coordination (ICCEC).
[[Page 1119]]
Summaries of the ICCEC's recommendations and public comments received
are next presented to the NTP Board of Scientific Counselors for their
review and comment in an open public session. ICCEC recommendations,
Board recommendations, and public comments are incorporated into
recommendations that are then submitted to the NTP Executive Committee.
The Executive Committee reviews and approves action to move forward to
test, defer, or delete each of the nominated chemicals, classes or
mixtures for the various types of study, and recommends priorities.
Request for Comment
Interested parties are encouraged to comment and provide
information on chemicals under consideration for study listed in the
Table. The Program would welcome receiving toxicology and
carcinogenesis information from completed, ongoing, or planned studies
by others, as well as current production data, human exposure
information, use patterns, and environmental occurrence for any of the
chemicals listed in this announcement. To provide comments or
information, please contact Dr. William Eastin at the address given
below within 60 days of the appearance of this announcement.
At their meeting on December 11, 1997, the ICCEC reviewed and
recommended 9 chemicals or chemical classes for metabolism, toxicity,
or carcinogenicity studies. It was also recommended that testing not be
performed on one chemical, trans--1,4-dichloro-2-butene (CAS Number
110-57-6), because industry studies showed it to be a potent
carcinogen. Chemicals with CAS numbers, nomination source, types of
studies under consideration, and other information are given in the
Table.
Contact may be made by mail to: Dr. William Eastin, NIEHS/NTP, P.O.
Box 12233, Research Triangle Park, North Carolina 27709; by telephone
at (919) 541-7941; by FAX at (919) 541-3687; or by email at
[email protected].
Dated: January 5, 1998.
Kenneth Olden,
Director, National Toxicology Program.
Attachment
Attachment
Chemicals Recommended for Study by the NTP Interagency Committee for Chemical Evaluation and Coordination
(ICCEC) on December 11, 1997
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Testing
Chemical [CAS No.] Nomination source recommendations Study rationale/remarks
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2-Acetylpyridine [1122-62-9]........ NCI --Cardinogenicity..... --Potential for human
exposure.
--Suspicion of
carcinogenicity.
2-Chloropyridine [109-09-1]......... NCI --Dermal --Increasing production.
carcinogenicity in --Occupational and
transgenic mice. environmental exposure.
Comfrey [72698-57-8]................ NIEHS --Carcinogenicity;.... --Extensive use as a herbal
Symphytine [22571-95-5]......... --Reproductive and supplement and medicinal.
developmental --Contains pyrrolizidine
toxicity. alkaloids including
symphytine.
Glycoluril [496-46-8]............... NCI --In vitro and in vivo --Moderate production.
nitrosation studies. --Potential human exposure.
--Potential to form
nitrosamides.
Goldenseal.......................... NIEHS --Carcinogenicity..... --Extensive use as a herbal
Berberine [2086-83-1]........... --Reproductive and supplement and medicinal.
Hydrastine [118-08-1]........... developmental --Contains active alkaloids
toxicity. berberine and hydrastine.
4-Methoxy-N-methyl-1,8-naphthalimide NCI --Chemical disposition --Occupational exposure.
[3271-05-4]. --Extensive consumer
exposure.
Myristicin [607-91-0]............... NCI --Genetic toxicity;... --Widespread natural
--Metabolism;......... product.
--Carcinogenicity in --Extensive consumer
transgenic animals. exposure.
--Similarity to known
carcinogen safrole.
7-2H-Naphthol[1,2-d]triazol-2-yl)-3- NCI --Chemical disposition --Moderate production.
phenylcoumarine [333-62-8]. --Extensive occupational
and consumer exposure.
Saw Palmetto -Sitosterol NIEHS --Carcinogenicity;.... --Widely used herbal remedy
[83-46-5]. --Multigeneration for benign prostate
reproductive toxicity. hyperplasia.
--Contains active
sitosterols.
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[FR Doc. 98-456 Filed 1-7-98; 8:45 am]
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