[Federal Register Volume 63, Number 5 (Thursday, January 8, 1998)]
[Notices]
[Pages 1118-1119]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-456]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Institute of Environmental Health Sciences National 
Toxicology Program; Announcement of Nominated Chemicals Under 
Consideration for Toxicological Studies by the National Toxicology 
Program (NTP)--Recommendations by the Interagency Committee for 
Chemical Evaluation and Coordination (ICCEC)--Request for Comments

Background

    As part of an effort to earlier inform and obtain public input into 
the selection of chemicals for evaluation, the National Toxicology 
Program (NTP) routinely seeks public input on (1) chemicals nominated 
to the Program for toxicological studies, and (2) the testing 
recommendations made by the Interagency Committee for Chemical 
Evaluation and Coordination (ICCEC).

[[Page 1119]]

Summaries of the ICCEC's recommendations and public comments received 
are next presented to the NTP Board of Scientific Counselors for their 
review and comment in an open public session. ICCEC recommendations, 
Board recommendations, and public comments are incorporated into 
recommendations that are then submitted to the NTP Executive Committee. 
The Executive Committee reviews and approves action to move forward to 
test, defer, or delete each of the nominated chemicals, classes or 
mixtures for the various types of study, and recommends priorities.

Request for Comment

    Interested parties are encouraged to comment and provide 
information on chemicals under consideration for study listed in the 
Table. The Program would welcome receiving toxicology and 
carcinogenesis information from completed, ongoing, or planned studies 
by others, as well as current production data, human exposure 
information, use patterns, and environmental occurrence for any of the 
chemicals listed in this announcement. To provide comments or 
information, please contact Dr. William Eastin at the address given 
below within 60 days of the appearance of this announcement.
    At their meeting on December 11, 1997, the ICCEC reviewed and 
recommended 9 chemicals or chemical classes for metabolism, toxicity, 
or carcinogenicity studies. It was also recommended that testing not be 
performed on one chemical, trans--1,4-dichloro-2-butene (CAS Number 
110-57-6), because industry studies showed it to be a potent 
carcinogen. Chemicals with CAS numbers, nomination source, types of 
studies under consideration, and other information are given in the 
Table.
    Contact may be made by mail to: Dr. William Eastin, NIEHS/NTP, P.O. 
Box 12233, Research Triangle Park, North Carolina 27709; by telephone 
at (919) 541-7941; by FAX at (919) 541-3687; or by email at 
[email protected].

    Dated: January 5, 1998.
Kenneth Olden,
Director, National Toxicology Program.

Attachment

Attachment

    Chemicals Recommended for Study by the NTP Interagency Committee for Chemical Evaluation and Coordination   
                                          (ICCEC) on December 11, 1997                                          
----------------------------------------------------------------------------------------------------------------
                                                                     Testing                                    
         Chemical [CAS No.]             Nomination source        recommendations       Study rationale/remarks  
----------------------------------------------------------------------------------------------------------------
2-Acetylpyridine [1122-62-9]........  NCI                    --Cardinogenicity.....  --Potential for human      
                                                                                      exposure.                 
                                                                                     --Suspicion of             
                                                                                      carcinogenicity.          
2-Chloropyridine [109-09-1].........  NCI                    --Dermal                --Increasing production.   
                                                              carcinogenicity in     --Occupational and         
                                                              transgenic mice.        environmental exposure.   
Comfrey [72698-57-8]................  NIEHS                  --Carcinogenicity;....  --Extensive use as a herbal
    Symphytine [22571-95-5].........                         --Reproductive and       supplement and medicinal. 
                                                              developmental          --Contains pyrrolizidine   
                                                              toxicity.               alkaloids including       
                                                                                      symphytine.               
Glycoluril [496-46-8]...............  NCI                    --In vitro and in vivo  --Moderate production.     
                                                              nitrosation studies.   --Potential human exposure.
                                                                                     --Potential to form        
                                                                                      nitrosamides.             
Goldenseal..........................  NIEHS                  --Carcinogenicity.....  --Extensive use as a herbal
    Berberine [2086-83-1]...........                         --Reproductive and       supplement and medicinal. 
    Hydrastine [118-08-1]...........                          developmental          --Contains active alkaloids
                                                              toxicity.               berberine and hydrastine. 
4-Methoxy-N-methyl-1,8-naphthalimide  NCI                    --Chemical disposition  --Occupational exposure.   
 [3271-05-4].                                                                        --Extensive consumer       
                                                                                      exposure.                 
Myristicin [607-91-0]...............  NCI                    --Genetic toxicity;...  --Widespread natural       
                                                             --Metabolism;.........   product.                  
                                                             --Carcinogenicity in    --Extensive consumer       
                                                              transgenic animals.     exposure.                 
                                                                                     --Similarity to known      
                                                                                      carcinogen safrole.       
7-2H-Naphthol[1,2-d]triazol-2-yl)-3-  NCI                    --Chemical disposition  --Moderate production.     
 phenylcoumarine [333-62-8].                                                         --Extensive occupational   
                                                                                      and consumer exposure.    
Saw Palmetto -Sitosterol     NIEHS                  --Carcinogenicity;....  --Widely used herbal remedy
 [83-46-5].                                                  --Multigeneration        for benign prostate       
                                                              reproductive toxicity.  hyperplasia.              
                                                                                     --Contains active          
                                                                                      sitosterols.              
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[FR Doc. 98-456 Filed 1-7-98; 8:45 am]
BILLING CODE 4140-01-M