[Federal Register Volume 62, Number 176 (Thursday, September 11, 1997)]
[Notices]
[Pages 47821-47822]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-24048]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institute of Environmental Health Sciences; National
Toxiology Program Request for Comments on Chemicals Nominated to the
National Toxicology Program (NTP) for Toxicological Studies--
Recommendations by the Interagency Committee for Chemical Evaluations
and Coordination (ICCEC) for Study, No Studies, or Deferral To Obtain
Further Supporting Information
Background
As part of an effort to earlier inform and obtain public input into
the selection of chemicals for evaluation, the National Toxicology
Program (NPT) routinely seeks public input on (1) chemicals nominated
to the Program for toxicological studies, and (2) the testing
recommendations made by the Interagency Committee for Chemical
Evaluation and Coordination (ICCEC). Summaries of the ICCEC's
recommendations and public comments received on the nominated chemicals
are next presented to the NTP Board of Scientific Counselors for their
review and comment in an open, public session. ICCEC recommendations,
Board recommendations, and public comments are incorporated into
recommendations that are then submitted to the NTP Executive Committee.
The Executive Committee reviews and approves action to move forward to
test, defer, or delete each of the nominated chemicals for the various
types of study, and recommends priorities.
Request for Comment
Interested parties are encouraged to comment and provide
information on the chemicals listed below. The Program would welcome
receiving toxicology and carcinogenesis information from completed or
ongoing studies, and information on planned studies, as well as current
production data, human exposure information, use patterns, and
environmental occurrence for any of the chemicals listed in this
announcement. To provide comments or information, please contact Dr.
William Eastin at the address given below within 60 days of the
appearance of this announcement.
At its meeting on August 15, 1997, the ICCEC reviewed and
recommended 4 chemicals or substances for toxicity and/or
carcinogenicity studies, recommended that no studies be performed on 5
chemicals, and deferred 4 chemicals pending receipt of test data
[[Page 47822]]
from other agencies, and additional information on production,
exposure, and use patterns. Chemicals with CAS numbers, nomination
source, types of studies recommended, and other supporting information,
are given in the following tables.
Comments may be forwarded by mail to: Dr. William Eastin, NIEHS/
NTP, P.O. Box 12233, Research Triangle Park, North Carolina 27709; by
telephone at (919) 541-7941; by FAX at (919) 541-4714; or by email at
[email protected].
Dated: August 29, 1997.
Kenneth Olden,
Director, National Toxicology Program.
Chemicals Nominated to the NTP for Study and Testing;
Recommendations Made by the ICCEC on August 15, 1997
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Rationale; other
Chemical CASRIN Nomin. by Recommended for info.
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Chemicals Recommended for Testing
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Asphalt fumes................. 8052-42-4 NIOSH; Calif..... --28-day toxicological --high exposure
assessment. --lack of adequate
--plumonary function short term toxicity
and irritation. information
biomarkers of exposure --need to identify
--biomarkers of
exposure
Luminol (o-Aminophthalic 521-31-3 private indiv., --toxicity............ --widespread use and
hydrazide). NIOSH. --carcinogenicity..... potential for
in vivo genetic exposure
toxicity.
Orthanilic acid............... 88-21-1 NIEHS............ --short-term toxicity --high production
studies. --very little
toxicology data
available
Phenothiazine................. 92-84-2 NIEHS............ --carciogenicity...... --high production and
exposure
--no carcinogencity
data available
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Chemicals for Which No Testing is Recommended
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Dicyclopentadiene............. 77-73-6 NCI.............. --reproductive --no adverse effects
toxicity. seen in teratology
--carcinogenicity..... tests
--not mutagenic in
Salmonella
--low potential for
human exposure
C.I. Direct Black 80.......... 8003-69-8 NCI.............. --carcingoenicity by --dermal absorption
dermal route. too low (1.3%) to
support a study
Ethyl cyanoacrylate........... 7085-85-0 NCI.............. --reproductive and --stable aerosol
developmental cannot be generated
toxicity. --rapidly polymerizes
neurotoxicity......... in presence of
--carcinogenicity..... atmospheric moisture
Isoamyl acetate............... 123-92-2 NIEHS............ --toxicity............ --rapdily hydrolyzed
--neurotoxicity....... in blood to isoamyl
--carcinogenicity..... alcohol, which has
been studied, and
acetic acid
2,4,6-Tribromophenol.......... 118-79-6 HIEHS............ --carcinogenicity..... --low production and
exposure
--little chance for
bioaccumulation
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Chemicals Deferred for Additional Information
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3-Amino-5-mercapto-1,2,4- 16691-43-3 NIEHS............ --toxicity; --high production
triazole. carcinogenicity. --suspect chemical
structure
Diethylamine.................. 109-89-7 NIEHS............ --toxicity; --high production and
carcinogenicity. exposure
--very little
toxicology data
available
--not mutagenic in
Salmonella
Isopropylamine................ 75-31-0 NIEHS............ --toxicity; --high production and
carcinogenicity. exposure
--very little
toxicology data
available
--not mutagenic in
Salmonella
Triethylamine................. 121-44-8 UAW; NIEHS....... --carcinogenicity..... --high production and
exposure
--not mutagenic in
Salmonella
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[FR Doc. 97-24048 Filed 9-10-97; 8:45 am]
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