[Federal Register Volume 62, Number 176 (Thursday, September 11, 1997)]
[Notices]
[Pages 47821-47822]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-24048]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Institute of Environmental Health Sciences; National 
Toxiology Program Request for Comments on Chemicals Nominated to the 
National Toxicology Program (NTP) for Toxicological Studies--
Recommendations by the Interagency Committee for Chemical Evaluations 
and Coordination (ICCEC) for Study, No Studies, or Deferral To Obtain 
Further Supporting Information

Background

    As part of an effort to earlier inform and obtain public input into 
the selection of chemicals for evaluation, the National Toxicology 
Program (NPT) routinely seeks public input on (1) chemicals nominated 
to the Program for toxicological studies, and (2) the testing 
recommendations made by the Interagency Committee for Chemical 
Evaluation and Coordination (ICCEC). Summaries of the ICCEC's 
recommendations and public comments received on the nominated chemicals 
are next presented to the NTP Board of Scientific Counselors for their 
review and comment in an open, public session. ICCEC recommendations, 
Board recommendations, and public comments are incorporated into 
recommendations that are then submitted to the NTP Executive Committee. 
The Executive Committee reviews and approves action to move forward to 
test, defer, or delete each of the nominated chemicals for the various 
types of study, and recommends priorities.

Request for Comment

    Interested parties are encouraged to comment and provide 
information on the chemicals listed below. The Program would welcome 
receiving toxicology and carcinogenesis information from completed or 
ongoing studies, and information on planned studies, as well as current 
production data, human exposure information, use patterns, and 
environmental occurrence for any of the chemicals listed in this 
announcement. To provide comments or information, please contact Dr. 
William Eastin at the address given below within 60 days of the 
appearance of this announcement.
    At its meeting on August 15, 1997, the ICCEC reviewed and 
recommended 4 chemicals or substances for toxicity and/or 
carcinogenicity studies, recommended that no studies be performed on 5 
chemicals, and deferred 4 chemicals pending receipt of test data

[[Page 47822]]

from other agencies, and additional information on production, 
exposure, and use patterns. Chemicals with CAS numbers, nomination 
source, types of studies recommended, and other supporting information, 
are given in the following tables.
    Comments may be forwarded by mail to: Dr. William Eastin, NIEHS/
NTP, P.O. Box 12233, Research Triangle Park, North Carolina 27709; by 
telephone at (919) 541-7941; by FAX at (919) 541-4714; or by email at 
[email protected].

    Dated: August 29, 1997.
Kenneth Olden,
Director, National Toxicology Program.

Chemicals Nominated to the NTP for Study and Testing; 
Recommendations Made by the ICCEC on August 15, 1997

----------------------------------------------------------------------------------------------------------------
                                                                                              Rationale; other  
           Chemical                 CASRIN          Nomin. by          Recommended for             info.        
----------------------------------------------------------------------------------------------------------------
                                        Chemicals Recommended for Testing                                       
----------------------------------------------------------------------------------------------------------------
Asphalt fumes.................       8052-42-4  NIOSH; Calif.....  --28-day toxicological  --high exposure      
                                                                    assessment.            --lack of adequate   
                                                                   --plumonary function     short term toxicity 
                                                                    and irritation.         information         
                                                                   biomarkers of exposure  --need to identify   
                                                                                           --biomarkers of      
                                                                                            exposure            
Luminol (o-Aminophthalic              521-31-3  private indiv.,    --toxicity............  --widespread use and 
 hydrazide).                                     NIOSH.            --carcinogenicity.....   potential for       
                                                                   in vivo genetic          exposure            
                                                                    toxicity.                                   
Orthanilic acid...............         88-21-1  NIEHS............  --short-term toxicity   --high production    
                                                                    studies.               --very little        
                                                                                            toxicology data     
                                                                                            available           
Phenothiazine.................         92-84-2  NIEHS............  --carciogenicity......  --high production and
                                                                                            exposure            
                                                                                           --no carcinogencity  
                                                                                            data available      
----------------------------------------------------------------------------------------------------------------
                                  Chemicals for Which No Testing is Recommended                                 
----------------------------------------------------------------------------------------------------------------
Dicyclopentadiene.............         77-73-6  NCI..............  --reproductive          --no adverse effects 
                                                                    toxicity.               seen in teratology  
                                                                   --carcinogenicity.....   tests               
                                                                                           --not mutagenic in   
                                                                                            Salmonella          
                                                                                           --low potential for  
                                                                                            human exposure      
C.I. Direct Black 80..........       8003-69-8  NCI..............  --carcingoenicity by    --dermal absorption  
                                                                    dermal route.           too low (1.3%) to   
                                                                                            support a study     
Ethyl cyanoacrylate...........       7085-85-0  NCI..............  --reproductive and      --stable aerosol     
                                                                    developmental           cannot be generated 
                                                                    toxicity.              --rapidly polymerizes
                                                                   neurotoxicity.........   in presence of      
                                                                   --carcinogenicity.....   atmospheric moisture
Isoamyl acetate...............        123-92-2  NIEHS............  --toxicity............  --rapdily hydrolyzed 
                                                                   --neurotoxicity.......   in blood to isoamyl 
                                                                   --carcinogenicity.....   alcohol, which has  
                                                                                            been studied, and   
                                                                                            acetic acid         
2,4,6-Tribromophenol..........        118-79-6  HIEHS............  --carcinogenicity.....  --low production and 
                                                                                            exposure            
                                                                                           --little chance for  
                                                                                            bioaccumulation     
----------------------------------------------------------------------------------------------------------------
                                  Chemicals Deferred for Additional Information                                 
----------------------------------------------------------------------------------------------------------------
3-Amino-5-mercapto-1,2,4-           16691-43-3  NIEHS............  --toxicity;             --high production    
 triazole.                                                          carcinogenicity.       --suspect chemical   
                                                                                            structure           
Diethylamine..................        109-89-7  NIEHS............  --toxicity;             --high production and
                                                                    carcinogenicity.        exposure            
                                                                                           --very little        
                                                                                            toxicology data     
                                                                                            available           
                                                                                           --not mutagenic in   
                                                                                            Salmonella          
Isopropylamine................         75-31-0  NIEHS............  --toxicity;             --high production and
                                                                    carcinogenicity.        exposure            
                                                                                           --very little        
                                                                                            toxicology data     
                                                                                            available           
                                                                                           --not mutagenic in   
                                                                                            Salmonella          
Triethylamine.................        121-44-8  UAW; NIEHS.......  --carcinogenicity.....  --high production and
                                                                                            exposure            
                                                                                           --not mutagenic in   
                                                                                            Salmonella          
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[FR Doc. 97-24048 Filed 9-10-97; 8:45 am]
BILLING CODE 4140-01-M