[Federal Register Volume 62, Number 76 (Monday, April 21, 1997)]
[Notices]
[Pages 19348-19349]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-10180]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


National Institute of Environmental Health Sciences; National 
Toxicology Program; Announcement of Nominated Chemicals Approved and 
Under Consideration for Toxicological Studies by the National 
Toxicology Program (NTP)--Request for Comments

    As part of an effort to earlier inform and obtain public input into 
the selection of chemicals for evaluation, the National Toxicology 
Program (NTP) routinely announces in the Federal Register chemicals 
nominated to the Program, recommended for toxicological studies by the 
Interagency Committee for Chemical Evaluation and Coordination (ICCEC), 
and approved for study by the NTP Executive Committee. This 
announcement will allow interested parties to comment and provide 
information on chemicals under consideration for study. The Program 
would welcome receiving toxicology and carcinogenesis information from 
completed, ongoing, or planned studies by others, as well as current 
production data, human exposure information, use patterns, and 
environmental occurrence for any of the chemicals listed in this 
announcement. To provide comments or information, please contact Dr. 
William Eastin at the address given below within 60 days of the 
appearance of this announcement.
    At their meeting on February 7, 1997, the ICCEC reviewed and 
recommended twelve chemicals or chemical classes for metabolism, 
toxicity, or carcinogenicity studies. On February 27, 1997, the NTP 
Executive Committee reviewed and approved the recommendations of the 
ICCEC. Chemicals with CAS numbers, nomination source, types of studies 
under consideration, and other supporting information are given in the 
table. Contact may be made by mail to: Dr. William Eastin, NIEHS/NTP, 
P. O. Box 12233, Research Triangle Park, North Carolina 27709; by 
telephone at (919) 541-7941; by FAX at (919) 541-4714; or by email at 
[email protected].

    Dated: April 10, 1997.
Kenneth Olden,
Director, National Institute of Environmental Health Sciences and 
National Toxicology Program.

                              Attachment--Chemicals Approved for Study by the NTP Executive Committee on February 27, 1997                              
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         Chemical (CAS number)                           Nomination source                     Testing recommendations        Study rationale remarks   
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Bromodichloroacetic Acid (71333-14-7).  EPA...............................................  Carcinogenicity;               Water disinfectant byproduct,
                                                                                             Reproductive, neurotoxicity    part of a class study.      
                                                                                             screen; Genetic toxicity.                                  
2-Butyne-1,4-diol (110-65-6)..........  NIEHS.............................................  Short and long-term toxicity;  Industrial intermediate,     
                                                                                             reproductive, neurotoxicity    stabilizer, corrosion       
                                                                                             screen; metabolism;            inhibitor.                  
                                                                                             mechanistic studies.                                       
                                                                                                                             Coordinate with EPA the    
                                                                                                                            testing planned through OECD-
                                                                                                                            SIDS.                       
Dibromoacetonitrile (3252-42-5).......  EPA...............................................  Carcinogenicity;               Water disinfectant byproduct,
                                                                                             Reproductive, neurotoxicity    part of a class study.      
                                                                                             screen; in vivo micronucelus.                              
trans-1,4-Dichloro-2-butene (110-57-6)  NIEHS.............................................  Carcinogenicity; Short-term    High production volume.      
                                                                                             toxicity.                                                  
                                                                                                                             Chemical intermediate.     
                                                                                                                             Human exposure not well    
                                                                                                                            defined.                    
                                                                                                                             Extensive toxicity and     
                                                                                                                            carcinogenesis data received
                                                                                                                            from industry may lead to   
                                                                                                                            deferral.                   
Ethyl Bromoacetate (105-36-2).........  NCI...............................................  Metabolism studies...........  May hydrolyze to bromoacetic 
                                                                                                                            acid.                       

[[Page 19349]]

                                                                                                                                                        
                                                                                                                             Odorant in toxic gases.    
                                                                                                                             Chemical intermediate.     
-Hydroxy Acids (and their      FDA...............................................  Phototoxicity; Chronic         FDA's FY 1997 priority       
 salts).                                                                                     toxicity.                      nomination.                 
Glycolic Acid (79-14-1)...............  ..................................................  .............................  Skin care product uses.      
Lactic Acid (50-21-5).................  ..................................................  .............................  Class study.                 
Methyl Isobutyl Ketone (108-10-1).....  NCI...............................................  Carcinogenicity..............  High production volume.      
                                                                                                                             Environmental exposure.    
Methylamine (74-89-5).................  NCI; Private individual...........................  Pharmacokinetics.............  Component of many foods.     
-Myrcene (123-35-3)..........  NIEHS.............................................  Metabolism studies; Consider   May be metabolized to a      
                                                                                             for carcinogenicity.           diepoxide.                  
                                                                                                                             High production and high   
                                                                                                                            level of natural exposure.  
Octachloronaphthalene (2234-13-1).....  NCI...............................................  Liver P450 enzyme induction;   Potential to bioaccumulate   
                                                                                             Estrogenic activity.           and enter food chain as     
                                                                                                                            component of halowaxes.     
Propargyl Alcohol (107-19-7)..........  NCI...............................................  Subchronic toxicity..........  High production and human    
                                                                                                                            exposure.                   
Sodium Thioglycolate (367-51-1).......  NCI...............................................  Reproductive toxicity........  High production and          
                                                                                                                            occupational and human      
                                                                                                                            exposure in hair care       
                                                                                                                            products.                   
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[FR Doc. 97-10180 Filed 4-18-97; 8:45 am]
BILLING CODE 4140-01-M