[Federal Register Volume 62, Number 43 (Wednesday, March 5, 1997)]
[Notices]
[Page 10063]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-5322]



[[Page 10063]]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health


Advertisement of an Opportunity To Investigate the Effect of 
Nitroxide Compounds on Diseases Relating to Stresses of Aging

AGENCY: National Institute on Aging, NIH.

ACTION: Advertisement of an opportunity.

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SUMMARY: The National Institute on Aging is seeking a Cooperative 
Research and Development Agreement (CRADA) with a pharmaceutical 
company to investigate the effect of nitroxide compounds on diseases 
related to the stresses of aging.
    The Collaborator must be able to collaborate with NIA staff to 
explore the effect nitroxides have on diseases of aging. The 
Collaborator must have a demonstrated record of success in privately 
producing nitroxide compounds suitable for pharmaceutical application, 
as well as a reputation for excellence in research.
    The term of the CRADA will be up to five (5) years.

DATES: Interested parties should notify this office in writing of their 
intent to file a formal proposal no later than May 5, 1997. Formal 
proposals must be submitted to this office no later than June 3, 1997.

ADDRESSES: Inquiries and proposals regarding this opportunity should be 
addressed to Bruce D. Goldstein, J.D., (Tel. #301-496-0477, FAX # 301-
402-2177), Office of Technology Development, National Center Institute, 
Executive Plaza South, Suite 450, 6120 Executive Blvd. MSC 7182, 
Bethesda, Maryland, 20892.

SUPPLEMENTARY INFORMATION: A CRADA is the anticipated joint agreement 
to be entered into by NIA pursuant to the Federal Technology Transfer 
Act of 1986, as amended by the National Technology Transfer Act (Pub. 
L. #104-1993 (1996)) and by Executive Order 12591 of October 10, 1987. 
NIA is presently exploring the protective effects of nitroxide 
compounds on oxyradical-induced oxidative stress, to the extent such 
stresses are related to diseases of aging.
     Under the present proposal, the goal of the CRADA will be 
research into, and development of, the following technology:
     Assessment of the qualitative and quantitative influence 
nitroxide compounds have on various aspects of the aging process.
     Development of new nitroxide compounds having in vivo 
inhibitive effect on the formation of oxyradicals.
     Development of new nitroxide compounds that enhance 
neuronal function and performance of aged animals.

Party Contributions

    The role of NIA includes the following:
    (1) Provide staff, expertise, & materials for the development of 
the desired compounds;
    (2) Evaluate the work product of Collaborator to ensure progress 
toward meeting the CRADA goals; and
    (3) Provide work space, expertise, and equipment for production of 
any prototypes developed.
    The role of the successful Collaborator will include the following:
    (1) Provide expertise on biological aging mechanisms and assistance 
in the development of nitroxide compounds likely to have therapeutic 
value;
    (2) Provide funding, as necessary, in support of production and 
dissemination of the desired compounds; and
    (3) Provide resources and expertise to market any products 
developed.

Selection Criteria

    Proposals submitted for consideration should fully address each of 
the following qualifications:
    (1) Expertise:
    (A) Demonstrated expertise in developing and producing nitroxide 
compounds;
    B. Demonstrated expertise on biological aging mechanisms;
    C. Demonstrated ability to secure national and international 
marketing and distribution of nitroxide compounds;
    D. Demonstrated expertise in overseeing all aspects of product 
development; and
    E. Demonstrated intellectual ability to participate in the research 
and commercial ability to guide development of the results into a 
viable product line.
    (2) Physical Resources:
    A. An established headquarters with offices, space, and equipment;
    B. Access to the organization during business hours by telephone, 
mail, e-mail, the Internet, and other evolving technologies; and
    C. Sufficient financial resources to support the current activities 
of the CRADA to meet the needs of NIA.

    Dated: February 18, 1997.
Thomas D. Mays,
Director, Office of Technology Development, NCI, NIH.
[FR Doc. 97-5322 Filed 3-4-97; 8:45 am]
BILLING CODE 4140-01-M