[Federal Register Volume 61, Number 242 (Monday, December 16, 1996)]
[Notices]
[Page 66055]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-31777]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Toxicology Program; Availability of Technical Report on 
Toxicology and Carcinogenesis Studies of 1-Amino-2,4-
Dibromoanthraquinone

    The HHS' National Toxicology Program announces the availability of 
the NTP Technical Report on the toxicology and carcinogenesis studies 
of 1-amino-2,4-dibromoanthraquinone. This chemical is an anthraquinone-
derived vat dye, a member of a class of insoluble dyes that are 
impregnated into textile fibers.
    Toxicology and carcinogenicity studies were conducted by 
administering 1-amino-2,4-dibromoanthraquinone to groups of 70 F344/N 
rats of each sex at 0; 5,000; or 10,000 ppm in feed for 104 weeks. In 
addition, groups of 50 F344/N rats of each sex were given 2,000 ppm for 
104 weeks. Groups of 60 B6C3F1 mice of each sex were given 0, 
10,000, or 20,000 ppm in feed for 104 weeks.
    Under the conditions of these 2-year feed studies, there was clear 
evidence of carcinogenic activity \1\ of 1-amino-2,4-
dibromoanthraquinone in male and female F344/N rats based on increased 
incidences of neoplasms in the liver, large intestine, kidney, and 
urinary bladder. There was clear evidence of carcinogenic activity of 
1-amino-2,4-dibromoanthraquinone in male and female B6C3F1 mice 
based on increased incidences of neoplasms in the liver, forestomach, 
and lung.
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    \1\ The NTP uses five categories of evidence of carcinogenic 
activity observed in each animal study: two categories for positive 
results (``clear evidence'' and ``some evidence''), one category for 
uncertain findings (``equivocal evidence''), one category for 
studies that cannot be evaluated because of major flaws 
(``inadequate study'').
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    Questions or comments about the Technical Report should be directed 
to Central Data Management at P.O. Box 12233, Research Triangle Park, 
NC 27709 or telephone (919) 541-3419.
    Copies of Toxicology and Carcinogenesis Studies of 1-Amino-2,4-
Dibromoanthraquinone (CAS No. 81-49-2) (TR-383) are available without 
charge from Central Data Management, NIEHS, MD E1-02, P.O. Box 12233, 
Research Triangle Park, NC 27709; telephone (919) 541-3419.

    Dated: November 13, 1996.
Samuel H. Wilson,
Deputy Director, NIEHS.
[FR Doc. 96-31777 Filed 12-13-96; 8:45 am]
BILLING CODE 4140-01-M