[Federal Register Volume 61, Number 223 (Monday, November 18, 1996)]
[Notices]
[Pages 58698-58699]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-29465]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institute of Environmental Health Sciences; National 
Toxicology Program (NTP) Board of Scientific Counselors' Meeting; 
Review of Draft NTP Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors' Technical Reports 
Review Subcommittee on December 11 and 12, 1996, in the Conference 
Center, Building 101, South Campus, National Institute of Environmental 
Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, 
North Carolina. The meeting will begin at 8:30 a.m. both days and is 
open to the public. The agenda topic is the peer review of draft 
Technical Reports of long-term toxicology and carcinogenesis studies 
from the National Toxicology Program.
    Tentatively scheduled to be peer reviewed on December 11-12 are 
draft Technical Reports of 10 two-year studies, listed alphabetically, 
along with supporting information in the attached table. All studies 
were done using Fischer 344 rats and B6C3F1 mice. The order of 
review is given in the far right column of the table. Copies of the 
draft Reports may be obtained, as available, from: Central Data 
Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 
(919/541-3419).
    Persons wanting to make a formal presentation regarding a 
particular Technical Report must notify the Executive Secretary by 
telephone, by FAX, or by mail no later than December 6, 1996, and 
provide a written copy in advance of the meeting so copies can be made 
and distributed to all Subcommittee members and staff and make 
available at the meeting for attendees. Written statements should 
supplement and may expand on the oral presentation. Oral presentations 
should be limited to no more than five minutes.
    The program would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing, or planned studies by others, as 
well as current production data, human exposure information, and use 
patterns for any of the chemicals listed in this announcement. Please 
contact Central Data Management at the address given above, and they 
will relay the information to the appropriate staff scientist.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, 
Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; 
FAX 919/541-0295) will furnish agenda and a roster of Subcommittee 
members prior to the meeting. Summary minutes subsequent to the meeting 
will be available upon request to Central Data Management.

    Dated: November 11, 1996.
Kenneth Olden,
Director, National Toxicology Program.

  Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the Board of Scientific 
                     Counselor's Technical Reports Review Subcommittee, December 11-12, 1996                    
----------------------------------------------------------------------------------------------------------------
                                      Technical report                            Route exposure        Review  
         Chemical CAS No.                   No.              Primary uses             levels            order   
----------------------------------------------------------------------------------------------------------------
3'-AZIDO-3'-deoxythymidine (AZT)    TR-469               Pyrimidine            Gavage 5%                       2
 30516-87-1 and.                                          nucleoside analog     Methylcellulose):               
                                                          with antiviral        Mice only: 0, 30,               
                                                          activity used in      60, OR 120 MG/KG;               
                                                          the treatment of      50/SEX.                         
                                                          AIDS (Merck 1989).                                    
INTERFERON AD+ AZT (AIDS            ...................  Used in the           Subcutaneous Inj.+               
 INITIATIVE).                                             experimental          Gavage (.5%                     
                                                          treatment of AIDS.    Methylcellulose):               
                                                                                DUAL ROUTES WITH                
                                                                                BOTH COMPOUNDS:                 
                                                                                AZT: 0, 30, 60, OR              
                                                                                120 (GAV) MG/KG;                
                                                                                IFN: 500 OR 5000                
                                                                                UNITS 3X/WEEK.                  
CHLOROPRENE 126-99-8..............  TR-467               Monomer for neoprene  Inhalation (Air):               4
                                                          elastomers;           Rats & Mice: 0,                 
                                                          industrial rubber     12.8, 32.0, OR 80.0             
                                                          products; component   PPM; 50/SEX/SPECIES/            
                                                          of laboratory         GROUP.                          
                                                          adhesives in food                                     
                                                          packaging.                                            

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COBALT SULFATE HEPTAHYDRATE 10026-  TR-471               Drying agent for      Inhalation (Air):               3
 24-1.                                                    varnishes and inks;   Rats & Mice; 0,                 
                                                          component of          0.3, 1.0, OR 3.0 MG/            
                                                          electroplating        M3; 50/SEX/SPECIES/             
                                                          solutions.            GROUP.                          
ETHLYBENZENE 100-41-4.............  TR-466               Manufacture of        Inhalation (Air)                6
                                                          synthetic rubber.     Rats & Mice: 0, 75,             
                                                          Solvent. Fuel         250, 750 PPM (50/               
                                                          additive. Chemical    SEX/SPECIES/GROUP).             
                                                          intermediate.                                         
ISOBUTYRALDEHYDE 78-84-2..........  TR-472               Synthesis of          Inhalation (Air)               10
                                                          pantothenic acid,     Rats & Mice: 0,                 
                                                          cellulose esters,     500, 1000, OR 2000              
                                                          perfumes, flavors,    PPM (50/SEX/SPECIES/            
                                                          and gasoline          GROUP).                         
                                                          additives. Chemical                                   
                                                          intermediate.                                         
OXAZEPAM 604-75-1.................  TR-468               Tranquilizer........  Dosed-Feed (NIH-07):            1
                                                                                Rats only: 0, 625,              
                                                                                1250, 2500, 5000,               
                                                                                OR 10000 PPM; 50/               
                                                                                SEX/GROUP.                      
POLYVINYL ALCOHOL 9002-89-5.......  TR-474               PVA film for          Intravaginal                    8
                                                          intravaginal          (Deionized Water):              
                                                          administration of     Mice only: 25% PVA,             
                                                          spermicides.          VEHICLE, UNTREATED;             
                                                          Textile warp sizing   100/GROUP.                      
                                                          and finishing,                                        
                                                          adhesives.                                            
                                                          Pesticides. Pigment                                   
                                                          in TV picture tubes.                                  
PRIMIDONE (PRIMACLONE) 125-33-7...  TR-476               Prophylactic          Dosed-Feed (NIH-07              9
                                                          management of         Mice: 0, 0.03,                  
                                                          partial grand mal     0.06, OR 0.13% Rats             
                                                          and psychomotor       & Mice: 0, 0.06,                
                                                          seizures that are     0.13, OR 0.25% (50/             
                                                          refractory to other   SEX/SPECIES).                   
                                                          antiepileptic drugs.                                  
TETRAHYDROFURAN 109-99-9..........  TR-475               Reaction medium for   Inhalation (Air)                7
                                                          grignard and metal    Rats & Mice: 0,                 
                                                          hydride reactions.    200, 600, OR 1800               
                                                          Packaging             PPM (50/SEX/SPECIES/            
                                                          fabrication.          GROUP).                         
                                                          Solvent for resins                                    
                                                          and plastics.                                         
                                                          Chemical                                              
                                                          intermediate.                                         
THEOPHYLLINE 58-55-9..............  TR-473               Diuretic, cardiac     Gavage (Corn Oil):              5
                                                          stimulant, smooth     Rats: 0, 7.5, 25,               
                                                          muscle relaxant,      OR 75 MG/KG; 50/                
                                                          antiasthmatic,        GROUP Female Mice:              
                                                          occurs naturally in   0, 7.5, 25, OR 75               
                                                          tea (Merck 1989).     MG/KG; 50/GROUP                 
                                                                                Male Mice: 0, 15,               
                                                                                50, OR 150 MG/KG;               
                                                                                50/GROUP.                       
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[FR Doc. 96-29465 Filed 11-15-96; 8:45 am]
BILLING CODE 4140-01-M