[Federal Register Volume 61, Number 127 (Monday, July 1, 1996)]
[Notices]
[Page 33937]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-16720]



[[Page 33937]]

National Institutes of Health


Proposed Collection, Comment Request; ``Alcoholism Prevalence and 
Gene/Environment Interactions in Native America Tribes (a 10 Tribe 
Study)'' and ``A Native American Tribe With Low Alcoholism Prevalence: 
Transmission Analysis, Linkage Analysis and Gene/Environment 
Interactions (a 1 Tribe Study)''

SUMMARY: In compliance with Section 3506 (c) (2) (A) of the Paperwork 
Reduction Act of 1995, which provides for an opportunity for public 
comment on proposed data collection projects, the National Institute on 
Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health 
(NIH) will publish periodic summaries of proposed projects to be 
submitted to the Office of Management and Budget (OMB) for review and 
approval.

PROPOSED COLLECTION: The Laboratory of Neurogenetics (LN), Division of 
Intramural Clinical and Biological Research, NIAAA, intends to conduct 
the study for ``Alcoholism Prevalence and Gene/Environment Interactions 
in Native American Tribes (a 10 tribe study)'' and ``A Native American 
Tribe with Low Alcoholism Prevalence: Transmission Analysis, Linkage 
and Gene/Environment Intersactions (a 1 tribe study).''
    The LN is authorized by Section 452 of Part G of Title IV of the 
Public Health Service Act (42 USC 288) as amended by the NIH 
Revitalization Act of 1993 (Pub. Law 103-43). The information proposed 
for collection in both studies will be used by the NIAAA to define the 
prevalence in alcoholism and associated problems in tribes in which the 
rates of alcoholism have been reported to be widely divergent. 
Additional information will be collected on severe trauma and stress, 
alcohol availability and socioeconomic factors to identify how these 
variables interact with hereditary factors in the development of 
alcoholis and related problems. In the single tribe study, a large 
pedigree (or a few large pedigrees) will be constructed in order to 
address issues of transmission of alcoholism vulnerability, linkage to 
chromosomally mapped DNA markers, and the issues of mutations in 
candidate genes.
    The annual burden estimates are as follows:

----------------------------------------------------------------------------------------------------------------
                                                               Responses                                        
               Type and number of respondents                     per         Total        Hours     Total hours
                                                               respondent   responses                           
----------------------------------------------------------------------------------------------------------------
Clients 3300................................................            1         3300          6.0       19,800
----------------------------------------------------------------------------------------------------------------

Total Number of Respondents: 3,300 (1,100 per year)
Total Number of Responses: 3,300 (1,100 per year)
Total Hours: 19,800 (6,600 per year)

REQUEST FOR COMMENTS: Comments are invited on: (a) whether the proposed 
collection is necessary, including whether the information has 
practical use; (b) ways to enhance the clarity, quality, and use of the 
information to be collected; (c) the accuracy of the agency estimate of 
burden of the proposed collection; and (d) ways to minimize the 
collection burden of the respondents. Send written comments to Ms. 
Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural 
Clinical and Biological Research, NIAAA, NIH, DANAC4 (Flow Labs), 12501 
Washington Ave., Rockville, Maryland 20852.

FOR FURTHER INFORMATION :To request more information on the proposed 
project or to obtain a copy of the data collection plans, contact Ms. 
Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural 
Clinical and Biological Research, NIAAA, DANAC4 (Flow Labs), 12501 
Washington Ave., Rockville, Maryland 20852, or call non-toll-free 
number (301) 443-5781.

COMMENTS DUE DATE: Comments regarding this information collection are 
best assured of having their full effect if received on or before 
August 30, 1996.

    Dated: June 20, 1996.
Martin K. Trustry,
Executive Officer, NIAAA.
[FR Doc. 96-16720 Filed 6-28-96; 8:45 am]
BILLING CODE 4140-01-M