[Federal Register Volume 61, Number 85 (Wednesday, May 1, 1996)]
[Notices]
[Page 19306]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-10835]



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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Toxicology Program; Availability of Technical Report on 
Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol

    The HHS' National Toxicology Program announces the availability of 
the NTP Technical Report on the toxicology and carcinogenesis studies 
of o-benzyl-p-chlorophenol. o-Benzyl-p-chlorophenol, an aryl halide, is 
a broad spectrum germicide used in disinfectant solutions and soap 
formulations in United States hospitals and households. Human exposure 
to o-benzyl-p-chlorophenol occurs by absorption through the skin and 
mucous membranes and by ingestion.
    Toxicology and carcinogenicity studies were conducted by dermal 
administration of o-benzyl-p-chlorophenol to groups of 50 Swiss (CD-
1) mice of each sex to study its effect as an initiator, 
promoter, and complete carcinogen.
    Under the conditions of the 1-year mouse skin initiation/promotion 
study in Swiss (CD-1) mice, o-benzyl-p-chlorophenol was a 
cutaneous irritant and a weak skin tumor promoter relative to strong 
promoters such as 12-O-tetradecanoylphorbol-13-acetate. o-Benzyl-p-
chlorophenol had no activity as an initiator or as a complete 
carcinogen.\1\

    \1\ The NTP uses five categories of evidence of carcinogenic 
activity observed in each animal study: two categories for positive 
results (``clear evidence'' and ``some evidence''), one category for 
uncertain findings (``equivocal evidence''), one category for no 
observable effect (``no evidence''), and one category for studies 
that cannot be evaluated because of major flaws (``inadequate 
study'').
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    Questions or comments about the Technical Report should be directed 
to Central Data Management at P.O. Box 12233, Research Triangle Park, 
NC 27709 or telephone (919) 541-3419.

    Copies of Toxicology and Carcinogenesis Studies of o-Benzyl-p-
Chlorophenol (CAS No. 120-32-1) TR-444) are available without charge 
from Central Data Management, NIEHS, MD E1-02, P.O. Box 12233, Research 
Triangle Park, NC 27709; telephone (919) 541-3419.

    Dated March 27, 1996.

Kenneth Olden,

Director, National Toxicology Program.

[FR Doc. 96-10835 Filed 4-30-96; 8:45 am]

BILLING CODE 4140-01-M