[Federal Register Volume 61, Number 26 (Wednesday, February 7, 1996)]
[Notices]
[Pages 4630-4631]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-2635]



=======================================================================
-----------------------------------------------------------------------

DEPARTMENT OF ENERGY

Office of Energy Research


Energy Research Financial Assistance Program Notice 96-08: Human 
Genome Program; Technological Advances

AGENCY: U.S. Department of Energy (DOE).

ACTION: Notice inviting grant applications.

-----------------------------------------------------------------------

[[Page 4631]]


SUMMARY: The Office of Health and Environmental Research (OHER) of the 
Office of Energy Research (ER), U.S. Department of Energy, hereby 
announces its interest in receiving grant applications in support of 
the DOE Human Genome Program (HGP). This program is a coordinated, 
multidisciplinary, goal-oriented research effort to obtain a detailed 
understanding of the human genome at the molecular level. The objective 
of this notice is to promote substantive improvements in high-
throughput, integrated approaches to large-scale human genome 
sequencing and its analysis. The solicited topics are: (1) Supportive 
instrumentation and automation systems; (2) assembly of multi-megabase 
scale, ordered and sequence-ready DNA clones; (3) informatics for the 
rapid assembly, analysis, and annotation of data from high-throughput 
sequencing; and (4) informatics for facile submission, retrieval, and 
visualization of data for single or multiple related databases, 
specifically including the Genome Data Base and the Genome Sequence 
Data Base. Applicants must address clearly how the proposed work will 
help achieve the sequencing goals of the HGP. Collaborative, 
multidisciplinary efforts are specifically encouraged.

DATES: Potential applicants are strongly encouraged to submit a brief 
preapplication. All preapplications, referencing Program Notice 96-08, 
should be received by DOE by 4:30 p.m. E.S.T., March 28, 1996. A 
response discussing the potential program relevance of a formal 
application generally will be communicated to the applicant within 30 
days of receipt. The deadline for receipt of formal applications 
submitted in response to this notice must be received by 4:30 p.m., 
E.D.T., July 11, 1996, in order to be accepted for merit review in 
September 1996 and to permit timely consideration for awards in fiscal 
year 1997.

ADDRESSES: All preapplications, referencing Program Notice 96-08, 
should be sent to Ms. Joanne Corcoran, U.S. Department of Energy, 
Office of Health and Environmental Research, ER-72, 19901 Germantown 
Road, Germantown, MD 20874-1290.
    After receiving notification from DOE concerning successful 
preapplications, applicants may prepare formal applications and send 
them to: U.S. Department of Energy, Office of Energy Research, Grants 
and Contracts Division, ER-64, 19901 Germantown Road, Germantown, MD 
20874-1290, ATTN: Program Notice 96-08. The above address for formal 
applications also must be used when submitting formal applications by 
U.S. Postal Service Express Mail, any commercial mail delivery service, 
or when handcarried by the applicant.

FOR FURTHER INFORMATION CONTACT: Dr. Gerald Goldstein, if referencing 
topic (1); Dr. Marvin Stodolsky, if referencing topic (2); and Dr. Jay 
Snoddy, if referencing topics (3) or (4) at the U.S. Department of 
Energy, Office of Health and Environmental Research, ER-72, 19901 
Germantown Road, Germantown, MD 20874-1290, by telephone (301) 903-
6488, by facsimile (301) 903-8521, or preferably by E-mail, 
[email protected]. General HGP information can also be 
obtained on the World Wide Web (WWW) Internet browsers at: http://
www.er.doe.gov/production/oher/hug____top.html, http://www.ornl.gov/
techresources/human____genome/home.html, and sites linked to these WWW 
pages. The 5-year goals of the U.S. HGP are published in the journal, 
Science, volume 262, pages 43-46.

SUPPLEMENTARY INFORMATION: The brief preapplication, in accordance with 
10 CFR 600.10(d)(2), should consist of two to three pages of narrative 
describing the research objectives and methods of accomplishment. The 
preapplications will be reviewed for relevance to the notice, and 
further instructions will be provided with the response. 
Preapplications determined by staff of the Office of Health and 
Environmental Research to be insufficiently directed at the goals of 
this notice will be returned without further review to the applicant. 
Telephone and FAX numbers are required parts of the preapplication, and 
electronic mail addresses are desirable.
    It is anticipated that approximately $2,000,000 will be available 
for grant awards in this area during FY 1997, contingent upon 
availability of appropriated funds. Multiple year funding of grant 
awards is expected, and is also contingent upon availability of funds, 
progress of the research, and continuing program need. Projected awards 
will be in the range of $50,000 per year up to $1,000,000 per year with 
terms of 2 to 3 years.
    Information on the development and submission of applications, 
eligibility, limitations, evaluation, selection process, and other 
policies and procedures may be found in 10 CFR Part 605, and in the 
Application Guide for the Office of Energy Research Financial 
Assistance Program. The Application Guide is available from the U.S. 
Department of Energy, Office of Health and Environmental Research, 
Health Effects and Life Sciences Research Division, ER-72, 19901 
Germantown Road, Germantown, MD 20874-1290. Telephone requests may be 
made by calling (301) 903-6488. Internet requests can be made to: 
[email protected]. Electronic access to ER's Financial 
Assistance Guide is possible via the Internet using the following E-
mail address: http://www.er.doe.gov
    The Office of Energy Research, as part of its grant regulations, 
requires at 10 CFR 605.11(b) that a grantee funded by ER and performing 
research involving recombinant DNA molecules and/or organisms and 
viruses containing recombinant DNA molecules shall comply with the 
National Institutes of Health ``Guidelines for Research Involving 
Recombinant DNA Molecules'' (59 FR 34496, July 5, 1994) or such later 
revision of those guidelines as may be published in the Federal 
Register.
    The Catalog of Federal Domestic Assistance Number for this program 
is 81.049, and the solicitation control number is ERFAP 10 CFR part 
605.

    Issued in Washington, DC, on January 24, 1996.
John Rodney Clark,
Associate Director for Resource Management, Office of Energy Research.
[FR Doc. 96-2635 Filed 2-6-96; 8:45 am]
BILLING CODE 6450-01-P