[Federal Register Volume 60, Number 232 (Monday, December 4, 1995)]
[Notices]
[Page 62083]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-29413]



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DEPARTMENT OF DEFENSE

Availability for Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application Concerning a Bacterial Delivery 
System

AGENCY: U.S. Army Medical Research and Materiel Command, DOD.

ACTION: Notice.

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SUMMARY: In accordance with 37 CFR 404.6, announcement is made of the 
availability of U.S. Patent Application Serial No. 08/523,855 entitled 
``Bacterial Delivery System'' and filed September 6, 1995. This patent 
has been assigned to the United States Government as represented by the 
Secretary of the Army.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
ATTN: Staff Judge Advocate, Fort Detrick, Frederick, Maryland 21702-
5012.

FOR FURTHER INFORMATION CONTACT:
Mr. John F. Moran, Patent Attorney, (301) 619-2065 or telefax (301) 
619-7714.

SUPPLEMENTARY INFORMATION: This invention describes a bacterial 
delivery system for the delivery of DNA and antigens to cells. Said 
system consists of an attenuated bacterial vector which enters 
mammalian cells and ruptures, thus delivering functional plasmid DNA 
and antigens into the cell cytoplasm. This Shigella vector was designed 
to deliver DNA to colonic surfaces, thus opening the possibility of 
oral and other mucosal DNA immunization and gene therapy strategies. 
The attentuated Shigella is also useful as a vaccine for reducing 
disease symptoms caused by Shigella.
Gregory D. Showalter,
Army Federal Register Liaison Officer.
[FR Doc. 95-29413 Filed 12-1-95; 8:45 am]
BILLING CODE 3710-08-M