[Federal Register Volume 60, Number 220 (Wednesday, November 15, 1995)]
[Notices]
[Pages 57451-57452]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-28209]



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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service


National Toxicology Program (NTP) Board of Scientific Counselors' 
Meeting; Review of Draft NTP Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors Technical Reports 
Review Subcommittee on December 5, 1995, in the Conference Center, 
Building 101, South Campus, National Institute of Environmental Health 
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North 
Carolina. The meeting will begin at 8:30 a.m. and is open to the 
public. The agenda topic is the peer review of draft Technical Reports 
of long-term toxicology and carcinogenesis studies from the National 
Toxicology Program.
    Tentatively scheduled to be peer reviewed on December 5 are draft 
Technical Reports of six two-year studies, listed alphabetically, along 
with supporting information in the attached table. All studies were 
done using Fischer 344 rats and B6C3F1 mice. The order of review 
is given in the far right column of the table. Copies of the draft 
Reports may be obtained, as available, from: Central Data Management, 
MD A0-01, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-
3419).
    Persons wanting to make a formal presentation regarding a 
particular Technical Report must notify the Executive Secretary by 
telephone, by FAX, or by mail no later than November 30, 1995, and 
provide a written copy in advance of the meeting so copies can be made 
and distributed to all Subcommittee members and staff and made 
available at the meeting for attendees. Written statements should 
supplement and may expand on the oral presentation. Oral presentations 
should be limited to no more than five minutes.
    The program would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing, or planned studies by others, as 
well as current production data, human exposure information, and use 
patterns for any of the chemicals listed in this announcement. Please 
contact Central Data Management at the address given above, and they 
will relay the information to the appropriate staff scientist.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, 
Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; 
FAX 919/541-0719) will furnish agenda and a roster of Subcommittee 
members prior to the meeting. Summary minutes subsequent to the meeting 
will be available upon request to Central Data Management.

    Dated: November 3, 1995.
Kenneth Olden,
Director, National Toxicology Program.

  Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the Board of Scientific 
                                Counselors' Technical Reports Review Subcommittee                               
                                               [December 5, 1995]                                               
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                                   Technical Report                                                      Review 
        Chemical CAS No.                 No.               Primary Uses        Route/Exposure Levels     Order  
----------------------------------------------------------------------------------------------------------------
D & C Yellow No. 11, 8003-22-3..  TR-463             Color additive used in   Dosed-Feed (NIH-07):             4
                                                      cosmetic and             Rats: 0, 0.05, 0.17,             
                                                      externally applied to    OR 0.5%; 60/GROUP.               
                                                      drugs. Contaminant of                                     
                                                      D&C Yellow 10, a                                          
                                                      compound which FDA is                                     
                                                      currently considering                                     
                                                      for approval for                                          
                                                      contact lenses.                                           
Molybdenum Trioxide, 1313-27-5..  TR-462             In manufacture of        Inhalation (AIR): Rats           6
                                                      molybdenum metals;       & Mice: 10, 30, OR 100           
                                                      corrosion inhibitor;     MG/M3; 50/SEX/SPECIES/           
                                                      catalyst; chemical       GROUP.                           
                                                      analysis reagent;                                         
                                                      alloying agent in                                         
                                                      steel; agricultural                                       
                                                      chemical; component of                                    
                                                      ceramics, enamel &                                        
                                                      pigments.                                                 

[[Page 57452]]
                                                                                                                
Nitromethane, 75-52-5...........  TR-461             Fuel additive and        Inhalation (AIR): Rats:          5
                                                      propellant. Cellulosic   0, 94, 188, OR 375               
                                                      compound solvent.        PPM; 50/GROUP. Mice:             
                                                      Intermediate for nitro   0,188, 375, OR 750               
                                                      and amino alcohols.      PPM; 50/GROUP.                   
Phenolphthalein, 77-09-8........  TR-465             Laboratory reagent.      Dosed-Feed (NIH-07):             2
                                                      Dyes. Cathartic drug     Rats: 0, 1.2, 2.5, OR            
                                                      in laxatives.            5%; Mice 0, 0.3, 0.6,            
                                                                               OR 1.2% (50/SEX/                 
                                                                               SPECIES/GROUP).                  
Sodium Xylene Sulfonate, 1300-72- TR-464             Hydrotrope in liquid     Topical (ETHANOL):               3
 7.                                                   detergents, shampoos,    Rats: 0, 60, 120, OR             
                                                      degreasing compounds.    240 MG/KG Mice: 0,               
                                                      Used in textile,         182, 364, OR 727 MG/KG           
                                                      paper, and leather       (50/SEX/GROUP.                   
                                                      industries.                                               
Tetrafluoroethylene, 116-14-3...  TR-450             Monomer for              Inhalation (AIR): Mice           1
                                                      polytetrafluoroethylen   & Female Rats: 0, 312,           
                                                      e polymers.              625, OR 1250; Male               
                                                      Preparation of           Rats: 0, 156, 312, OR            
                                                      propellants for food     625 PPM; 50/GROUP.               
                                                      product aerosols.                                         
                                                      Chemical intermediate.                                    
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[FR Doc. 95-28209 Filed 11-14-95; 8:45 am]
BILLING CODE 4140-01-P-M