[Federal Register Volume 60, Number 209 (Monday, October 30, 1995)]
[Notices]
[Pages 55272-55273]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-26824]



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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency For Toxic Substances and Disease Registry
[ATSDR-102]

Availability of Draft Toxicological Profiles
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice of availability.

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SUMMARY: The Comprehensive Environmental Response, Compensation, and 
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments 
and Reauthorization Act of 1986 (SARA) (42 U.S.C. 9604(i)(3)) directs 
the Administrator of ATSDR to prepare toxicological profiles of 
priority hazardous substances and to revise and republish each 
toxicological profile as necessary. This notice announces the 
availability of eight updated drafts and three new draft toxicological 
profiles prepared by ATSDR for review and comment.

DATES: Comments on these draft toxicological profiles must be received 
on or before February 20, 1996. Comments received after the close of 
the public comment period will be considered at the discretion of ATSDR 
based upon what is deemed to be in the best interest of the general 
public.

ADDRESSES: Requests for copies of the draft toxicological profiles or 
comments regarding the draft toxicological profiles should be sent to 
the attention of Ms. Kim E. Jenkins, Division of Toxicology, Agency for 
Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333.
    Requests for the draft toxicological profiles must be in writing. 
Please specify the profiled hazardous substance(s) you wish to receive. 
ATSDR reserves the right to provide only one copy of each profile 
requested, free of charge. In case of extended distribution delays, 
requestors will be notified.
    Written comments and other data submitted in response to this 
notice and the draft toxicological profiles should bear the docket 
control number ATSDR-102. Send one copy of all comments and three 
copies of all supporting documents to the Division of Toxicology at the 
above address by the end of the comment period. All written comments 
and draft profiles will be available for public inspection at the 
ATSDR, Building 4, Executive Park Drive, Atlanta, Georgia (not a 
mailing address), from 8:00 a.m. until 4:30 p.m., Monday through 
Friday, except for legal holidays. Because all public comments 
regarding ATSDR toxicological profiles are available for public 
inspection, no confidential business information should be submitted in 
response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Kim E. Jenkins, Division of 
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop 
E-29, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (404) 
639-6357.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental 
Response, Compensation, and Liability Act (CERCLA or Superfund) (42 
U.S.C. 9601 et seq.) by establishing certain responsibilities for the 
ATSDR and the Environmental Protection Agency (EPA) with regard to 
hazardous substances which are most commonly found at 

[[Page 55273]]
facilities on the CERCLA National Priorities List (NPL). Among these 
statutory provisions is that the Administrator of ATSDR prepare 
toxicological profiles for substances included on the priority lists of 
hazardous substances. These lists identified 275 hazardous substances 
that ATSDR and EPA determined pose the most significant potential 
threat to human health. The availability of the revised priority list 
of 275 hazardous substances was announced in the Federal Register on 
February 28, 1994 (59 FR 9486). For prior versions of the list of 
substances see Federal Register notices dated April 17, 1987 (52 FR 
12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); 
October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); and 
October 28, 1992 (57 FR 48801). CERCLA also requires ATSDR to assure 
the initiation of a research program to fill data needs associated with 
the substances.
    Section 104(i)(3) of CERCLA [42 U.S.C. 9604(i)(3)] outlines the 
content of these profiles. Each profile is required to include an 
examination, summary and interpretation of available toxicological 
information and epidemiologic evaluations. This information and these 
data are to be used to ascertain the levels of significant human 
exposure for the substance and the associated health effects. The 
profiles must also include a determination of whether adequate 
information on the health effects of each substance is available or in 
the process of development. When adequate information is not available, 
ATSDR, in cooperation with the National Toxicology Program (NTP), is 
required to assure the initiation of research to determine these health 
effects.
    Although key studies for each of the substances were considered 
during the profile development process, this Federal Register notice is 
to solicit any additional studies, particularly unpublished data and 
ongoing studies, for possible addition to the profiles now or in the 
future.
    The following draft toxicological profiles are expected to be 
available to the public on or about October 17, 1995.

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         Document                Hazardous substance           CAS No.  
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1........................  Benzene........................   000071-43-2
2........................  Chlorfenvinfos.................      470-90-6
3........................  Chloroform.....................   000067-66-3
4........................  Chlorpyrifos...................   002921-88-2
5........................  Cyanide........................   000057-12-5
                           Ammonium Thiocyanate...........   001762-95-4
                           Cyanazine......................   021725-46-2
                           Hydrogen Cyanide...............   000074-90-8
                           Sodium Cyanide.................   000143-33-9
                           Thiocyanate....................   000302-04-5
                           Potassium Cyanide..............      151-50-8
                           Calcium Cyanide................      592-01-8
                           Copper(I) Cyanide..............      544-92-3
                           Potassium Silver Cyanide.......      506-61-6
                           Cyanogen.......................      460-19-5
                           Cyanogen Chloride..............      506-77-4
6........................  Dichlorvos.....................       62-73-7
7........................  Nickel.........................   007440-02-0
                           Nickel Chloride................   007718-54-9
                           Nickel Oxide...................     1313-99-1
                           Nickel Sulfate.................     7786-81-4
                           Nickel Subsulfide..............    12035-72-2
                           Nickel Acetate.................      373-02-4
                           Nickel Nitrate.................    13138-45-9
8........................  Polychlorinated Biphenyls......   001336-36-3
                           Aroclor 1016...................   012674-11-2
                           Aroclor 1221...................   011104-28-2
                           Aroclor 1232...................   011141-16-5
                           Aroclor 1242...................   053469-21-9
                           Aroclor 1248...................   012672-29-6
                           Aroclor 1254...................   011097-69-1
                           Aroclor 1260...................   011096-82-5
                           Aroclor 1262...................    37324-23-5
                           Aroclor 1268...................    11100-14-4
9........................  Tetrachloroethylene............   000127-18-4
10.......................  Trichloroethylene..............   000079-01-6
11.......................  Vinyl Chloride.................   000075-01-4
------------------------------------------------------------------------

    All profiles issued as ``Drafts for Public Comment'' represent the 
agency's best efforts to provide important toxicological information on 
priority hazardous substances in compliance with the substantive and 
procedural requirements of Section 104(i)(3) of CERCLA, as amended. As 
in the past, we are seeking public comments and additional information 
which may be used to supplement these profiles. ATSDR remains committed 
to providing a public comment period for these documents as a means to 
best serve public health and our clients.

    Dated: October 24, 1995.
Claire V. Broome,
Deputy Administrator, Agency for Toxic Substances and Disease Registry.
[FR Doc. 95-26824 Filed 10-27-95; 8:45 am]
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