[Federal Register Volume 60, Number 130 (Friday, July 7, 1995)]
[Notices]
[Page 35412]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-16673]



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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Toxicology Program; Availability of Technical Report on 
Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid

    The HHS' National Toxicology Program announces the availability of 
the NTP Technical Report on the toxicology and carcinogenesis studies 
of p-nitrobenzoic acid, which is used in organic synthesis and as an 
intermediate in the manufacture of pesticides, dyes, explosives, and 
industrial solvents.
    Toxicology and carcinogenicity studies were conducted by 
administering p-nitrobenzoic acid in feed to groups of 60 male and 
female F344/N rats at doses 0, 1,250, 2,500, or 5,000 ppm for 2 years 
and 60 male and female B6C3F1 mice at doses 0, 1,250, 2,500, or 
5,000 ppm for 2 years.
    Under the conditions of these 2-year feed studies, there was no 
evidence of carcinogenic activity 1 of p-nitrobenzoic acid in male 
F344/N rats exposed to 1,250, 2,500, or 5,000 ppm. There was some 
evidence of carcinogenic activity of p-nitrobenzoic acid in female 
F344/N rats based on increases in the incidences of clitoral gland 
adenoma and of clitoral gland adenoma or carcinoma (combined). There 
was no evidence of carcinogenic activity of p-nitrobenzoic acid in male 
or female B6C3F1 mice exposed to 1,250, 2,500, or 5,000 ppm.

    \1\ The NTP uses five categories of evidence of carcinogenic 
activity observed in each animal study: two categories for positive 
results (``clear evidence'' and ``some evidence''), one category for 
uncertain findings (``equivocal evidence''), one category for no 
observable effect (``no evidence''), and one category for studies 
that cannot be evaluated because of major flaws (``inadequate 
study'').
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    There were chemical-related decreases in the incidences of 
mononuclear cell leukemia in exposed male and female rats. p-
Nitrobenzoic acid caused mild hematologic toxicity in female rats.
    Questions or comments about the Technical Report should be directed 
to Central Data Management at P.O. Box 12233, Research Triangle Park, 
NC 27709 or telephone (919) 541-3419.
    Copies of Toxicology and Carcinogenesis Studies of p-Nitrobenzoic 
Acid (CAS No. 62-23-7) (TR-442) are available without charge from 
Central Data Management, NIEHS, MD A0-01, P.O. Box 12233, Research 
Triangle Park, NC 27709; telephone (919) 541-3419.

    Dated: May 30, 1995.
Kenneth Olden,
Director National Toxicology Program.
[FR Doc. 95-16673 Filed 7-6-95; 8:45 am]
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