[Federal Register Volume 60, Number 54 (Tuesday, March 21, 1995)]
[Notices]
[Pages 14955-14956]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-6854]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institute of Environmental Health Sciences: Opportunity
for a Cooperative Research and Development Agreement (CRADA) and/or
Licensing Opportunity for Preparative Two Dimensional Gel
Electrophoresis System
AGENCY: National Institute of Environmental Health Sciences, National
Institutes of Health, PHS, DHHS.
ACTION: Notice.
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SUMMARY: The National Institutes of Health (NIH) is seeking CRADA
partners and/or licensees for the further development, evaluation, and
commercialization of a Preparative Two Dimensional Gel Electrophoresis
System (U.S. Patent Application Serial No. 08/243,643, filed May 16,
1994) for protein analysis and characterization. The National Institute
of Environmental Health Sciences has also determined that the developed
technology can be utilized in other scientific areas. The invention
claimed in the above-referenced patent application is available for
either further development under a CRADA and/or exclusive or non-
exclusive licensing (in accordance with 35 U.S.C 207 and 37 CFR part
404) for the applications described below under Supplementary
Information.
ADDRESSES: CRADA proposals and questions about this opportunity may be
addressed to Dr. B. Alex Merrick, NIEHS, Mail Drop D4-03, P.O. Box
12233, Research Triangle Park, NC 27709 (Telephone: 919/541-1531; Fax:
919/541-4704; Email: [email protected]). CRADA proposals must be
received by the date specified below.
Licensing proposals and questions about this opportunity should be
addressed to: David Sadowski, Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Rockville, MD 20852
(Telephone: 301/496-7735 ext. 288; Fax: 301/402-0220).
Information on the patent application and pertinent information not
yet publicly described can be obtained under a Confidential Disclosure
Agreement. Respondees interested in licensing the invention(s) will be
required to submit an Application for License to Public Health Service
Inventions. Respondees interested in submitting a CRADA proposal should
be aware that it may be necessary to secure a license to the above
patent rights in order to commercialize products arising from a CRADA
agreement.
DATES: Capability statements/CRADA proposals must be received by NIH on
or before May 22, 1995. There is no [[Page 14956]] deadline by which
license applications must be received.
SUPPLEMENTARY INFORMATION:
The National Institute of Environmental Health Sciences has
developed procedures and a prototype device for isolation of proteins
from complex mixtures for protein sequencing. The system serves as a
one-step purification method for isolation of biologically relevant
proteins affected by disease or experimental treatment and has been
described in Electrophoresis 15,535-545,1994. The system includes a
preparative isoelectric focusing device for separation of proteins by
charge, a glass mold for preparative polyacrylamide gel separation by
mass and a protocol for use.
The commercial advantage of the Preparative Two Dimensional Gel
Electrophoresis system is to separate and isolate sufficient amounts of
individual protein for sequencing in a powerful one-step purification
method. The Preparative Two Dimensional Gel Electrophoresis system can
resolve individual proteins by charge and mass from up to 1 to 2 mg of
unpurified starting material from protein mixtures. Current devices for
two dimensional gel electrophoresis are generally for analytical scale
work and are not physically or procedurally adapted to accommodate
preparative sample loads. Although other preparative electrophoresis
devices do exist, they separate by either mass or charge alone and
function as stand-alone units without ready integration into additional
systems for resolution of individual proteins.
The developed technology has applications for protein sequencing,
protein immunization for antibody production, immunostaining and other
modes of protein characterization. Although the system has been tested
and is operational, some refinements in protein resolution are still
possible which may involve procedural, reagent or equipment
modifications.
The CRADA awardees will have an option to negotiate for an
exclusive license to market and commercialize any new technology
developed within the scope of the CRADA research plan for the
Preparative Two Dimensional Gel Electrophoresis System. This CRADA may
be directed toward the co-development of improved preparative
electrophoresis equipment and pertinent procedures.
Roles of NIEHS
1. Provide design and specifications of an operating prototype
device, provide a protocol for prototype operation, provide user
expertise, and assist in beta testing.
2. Work cooperatively with the company(s) to determine the market
potential for the Preparative Two Dimensional Gel Electrophoresis
system and to refine the prototype system.
Roles of the CRADA Partner
1. Provide expertise in application and commercial-oriented
separation systems.
2. Develop plan for production, testing and commercialization of
Preparative Two Dimensional Gel Electrophoresis system.
Selection criteria for choosing the CRADA partner(s) will include,
but will not be limited to the following:
1. Experience in manufacturing electrophoresis devices or related
separation technologies.
2. Capability to develop, implement and manage the product
commercialization so as to ensure the dissemination of the
technology(s) to research or health care services.
3. Ability to cost share for production and testing of a
preparative two-dimensional gel electrophoresis device.
Dated: March 13, 1995.
Barbara M. McGarey,
Deputy Director, Office of Technology Transfer.
[FR Doc. 95-6854 Filed 3-20-95; 8:45 am]
BILLING CODE 4140-01-P