[Federal Register Volume 59, Number 249 (Thursday, December 29, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-32117]


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[Federal Register: December 29, 1994]


_______________________________________________________________________

Part X





Environmental Protection Agency





_______________________________________________________________________




Thirty-Fifth Report of the TSCA Interagency Testing Committee to the 
Administrator Receipt of Report, Request for Comments, Solicitation of 
Interested Parties in Developing Testing Consent Agreement; Notice
ENVIRONMENTAL PROTECTION AGENCY

[OPPTS-41042; FRL-4923-2]

 
Thirty-Fifth Report of the TSCA Interagency Testing Committee to 
the Administrator Receipt of Report, Request for Comments, Solicitation 
of Interested Parties in Developing Testing Consent Agreement

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The TSCA Interagency Testing Committee (ITC), established 
under section 4(e) of the Toxic Substances Control Act (TSCA), 
transmitted its Thirty-Fifth Report to the Administrator of EPA on 
November 3, 1994. As noted in this Report, which is included with this 
notice, the ITC revised the Priority Testing List by designating a 
group of 25 chemicals to the List for priority consideration by the 
Administrator for promulgation of test rules under section 4(a) of the 
Act. These chemicals are designated for response within 12 months. 
Therefore, in response to the ITC's designation, EPA will either 
initiate rulemaking under section 4(a) of TSCA, enter into a testing 
consent agreement, or publish a Federal Register notice explaining the 
reasons for not initiating such rulemaking within 12 months. The ITC 
also removed 110 of 123 previously recommended chemicals from the List. 
The ITC removed 28 of 43 isocyanates, 27 of 89 aldehydes, 25 of 26 
sulfones, 7 of 11 cyanoacrylates, 4 of 14 diaryl ethers and 19 of 35 
chemicals originally recommended for subchronic (90-day) toxicity 
testing. The ITC's reasons for removing these chemicals from the List 
are listed in the Thirty-Fifth Report. There are no recommended with 
intent-to-designate or recommended chemicals or chemical groups in the 
Thirty-Fifth Report. EPA invites interested persons to submit written 
comments on the Report.
    In addition, EPA is soliciting interested parties for participation 
in or monitoring of a TSCA section 4 testing consent agreement 
development process for the chemicals that were designated for dermal 
absorption testing. EPA is also inviting manufacturers and/or 
processors of chemical substances who wish to participate in testing 
negotiations for the chemicals designated for dermal absorption testing 
to develop and submit testing agreement proposals to EPA.

DATES: Written comments on the Thirty-Fifth ITC Report should be 
submitted by January 30, 1995. Written testing proposals must be 
received by February 27, 1995. Written notice of interest in being 
designated an ``interested party'' to the development or monitoring of 
a consent agreement for the chemicals designated for dermal absorption 
testing must be received by February 27, 1995. Those submitting written 
testing proposals will be considered ``interested parties'' and do not 
have to submit separate written notice. EPA will contact all 
``interested parties'' and advise them of meeting dates.

ADDRESSES: Send six copies of written submissions to: TSCA 
Nonconfidential Information Center (7407), Office of Pollution 
Prevention and Toxics, Environmental Protection Agency, Rm. B-607 NEM, 
401 M St., SW., Washington, DC 20460. Submissions should bear the 
document control number (OPPTS-41042; FRL-4923-2).
    The public record supporting this action, including comments, is 
available for public inspection in Rm. B-607 NEM at the address noted 
above from 12 noon to 4 p.m., Monday through Friday, except legal 
holidays.
FOR FURTHER INFORMATION CONTACT: Susan B. Hazen, Director, 
Environmental Assistance Division (7408), Office of Pollution 
Prevention and Toxics, Environmental Protection Agency, 401 M St., SW., 
Rm. E-543B, Washington, DC 20460, (202) 554-1404, TDD (202) 554-0551.

SUPPLEMENTARY INFORMATION: EPA has received the TSCA Interagency 
Testing Committee's Thirty-Fifth Report to the Administrator.

I. Background

    TSCA (Pub. L. 94-469, 90 Stat. 2003 et seq; 15 U.S.C. 260l et seq.) 
authorizes the Administrator of EPA to promulgate regulations under 
section 4(a) requiring testing of chemicals and chemical groups in 
order to develop data relevant to determining the risks that such 
chemicals and chemical groups may present to health or the environment. 
Section 4(e) of TSCA established the Interagency Testing Committee to 
recommend chemicals and chemical groups to the Administrator of EPA for 
priority testing consideration. Section 4(e) directs the ITC to revise 
the TSCA section 4(e) Priority Testing List at least every 6 months. 
The most recent revisions to this List are included in the ITC's 
Thirty-Fifth Report. The Report was received by the Administrator on 
November 3, 1994, and is included in this Notice. The Report designates 
a group of 25 chemicals, and removes 110 of 123 previously recommended 
chemicals from the TSCA section 4(e) Priority Testing List.

II. Written and Oral Comments

    EPA invites interested persons to submit detailed comments on the 
ITC's Report. All submissions should bear the identifying docket number 
(OPPTS-41042).
    EPA invites interested persons to submit detailed comments on the 
ITC's new recommendations. The Agency is interested in receiving 
information concerning additional or ongoing health and safety studies 
on the subject chemicals as well as information relating to the human 
and environmental exposure to these chemicals.
    A notice will be published at a later date in the Federal Register 
adding certain of the substances recommended in the ITC's Thirty-Fifth 
Report to the TSCA section 8(d) Health and Safety Data Reporting Rule 
(40 CFR part 716), which requires the reporting of unpublished health 
and safety studies on the listed chemicals. That notice will also add 
the chemicals to the TSCA section 8(a) Preliminary Assessment 
Information Rule (40 CFR part 712). The section 8(a) rule requires the 
reporting of production volume, use, exposure, and release information 
on the listed chemicals.

III. Status of List

    The ITC's Thirty-Fifth Report notes the designation of 25 chemicals 
and the removal of 110 chemicals from the Priority Testing List. The 
current TSCA section 4(e) Priority Testing List contains 13 chemicals 
and 12 chemical groups, with 3 chemical groups and 3 chemicals 
designated for testing.

IV. Testing Consent Agreements

    1. Solicitation of interested parties. EPA's procedures for 
requiring the testing of chemical substances under section 4 of TSCA 
include the adoption of enforceable consent agreements and the 
promulgation of test rules. These processes are found at 40 CFR 790.20. 
EPA has on numerous occasions been approached by chemical companies 
interested in negotiating consent agreements for testing ITC chemicals 
or chemical groups. As a result of these requests, EPA is now inviting 
persons interested in participating in or monitoring negotiations on 
the chemical designated in the Thirty-Fifth ITC Report to notify EPA in 
writing. Those who respond to this solicitation by the deadline 
established in this notice will have the status of ``interested 
parties'' and will be afforded opportunities to participate in the 
negotiation process. These ``interested parties'' will not incur any 
obligations by being designated ``interested parties.''
    2. Solicitation of testing proposals for consent agreement 
negotiations. EPA is also now soliciting testing proposals for a 
consent agreement to perform dermal absorption testing on the 25 
chemicals designated in the Thirty-Fifth Report. While solicitation is 
separate from the solicitation of interested parties made for the 24 
substances designated in the Thirty-First ITC Report published May 5, 
1993 (58 FR 26898), and the 34 substances designated in the Thirty-
Second Report published July 16, 1993 (58 FR 38490), EPA expects that 
any testing consent agreement adopted for this effort, as well as the 
testing method referenced, will be substantially similar. (Note: Two of 
these chemicals were removed in the Thirty-Fourth Report). Following 
publication of this notice, manufacturers and/or processors have 60 
days to develop and submit testing proposals for any of the chemical 
substances designated in the Thirty-Fifth Report that they wish EPA to 
consider as candidates for consent agreement negotiations.
    Federal scientists from a number of the ITC's statutory and liaison 
organizations, including the Consumer Product Safety Commission, 
Environmental Protection Agency, Food and Drug Administration, National 
Institute of Occupational Safety and Health, and Occupational Safety 
and Health Administration, have developed a proposed test protocol that 
will provide data needed by several U.S. Government Organizations 
represented on the ITC. This proposed protocol is entitled ``Protocol 
for in vitro Percutaneous Absorption Studies'' and is available to the 
public through the TSCA Nonconfidential Information Center and the 
Environmental Assistance Division listed above. This document should be 
reviewed before submitting any testing proposals in response to this 
notice.
    Comments on the proposed protocol that were submitted in response 
to the Thirty-First ITC Report (Docket OPPTS 41038) and the Thirty-
Second ITC Report (Docket OPPTS 41039) will be incorporated in the 
docket for this notice and need not be resubmitted.
    For additional technical information on this testing protocol 
contact Dr. John D. Walker, Executive Director, TSCA Interagency 
Testing Committee, (202) 260-1820.
    All testing proposals submitted should describe the testing to be 
performed and explain any deviations from the test protocol that are 
necessary to assure the development of reliable percutaneous absorption 
data.
    EPA will review the submissions and select the most promising 
submissions as candidates for negotiation. Submissions that fully 
address the ITC's concerns will have a higher chance of success than 
those that do not fully address all data needs.
    3. Negotiation of testing program and development of a testing 
consent agreement. EPA will follow the negotiation procedures under 40 
CFR 790.22, and to the extent feasible, the timetable outlined in 40 
CFR part 790, appendix A to subpart B.
    For additional information about process or negotiations contact 
Frank Kover, Chief, Chemical Testing and Information Branch, (202) 260-
8130.
    Authority: 15 U.S.C. 2603.

    Dated: December 20, 1994.

Charles M. Auer,

Director, Chemical Control Division, Office of Pollution Prevention and 
Toxics.

Administrator, U.S. Environmental Protection Agency

SUMMARY: This is the 35th Report of the TSCA Interagency Testing 
Committee (ITC) to the Administrator of the U.S. Environmental 
Protection Agency (EPA). In this Report, the ITC is revising its TSCA 
section 4(e) Priority Testing List by designating a group of 25 
chemicals for dermal absorption testing because they are of regulatory 
interest to the Occupational Safety and Health Administration (OSHA). 
The ITC is also revising its List by removing recommended chemicals, 
including 28 of 43 isocyanates, 27 of 89 aldehydes, 25 of 26 sulfones, 
7 of 11 cyanoacrylates, 4 of 14 diaryl ethers and 19 of 35 chemicals 
originally recommended for subchronic (90-day) toxicity testing.

I. Background

    The TSCA Interagency Testing Committee (ITC) was established by 
section 4(e) of the Toxic Substances Control Act (TSCA) ``to make 
recommendations to the Administrator respecting the chemical substances 
and mixtures to which the Administrator should give priority 
consideration for the promulgation of a rule for testing under section 
4(a).... At least every 6 months..., the Committee shall make such 
revisions in the List as it determines to be necessary and to transmit 
them to the Administrator together with the Committee's reasons for the 
revisions'' (Public Law 94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 
et seq.). Since its creation in 1976, the ITC has submitted 34 semi-
annual Reports to the EPA Administrator transmitting the Priority 
Testing List and its revisions. These Reports have been published in 
the Federal Register and are available from the ITC. The ITC meets 
monthly and produces its revisions with the help of staff and technical 
contract support provided by EPA. ITC membership and support personnel 
are listed at the end of this Report.
    Following receipt of the ITC's Report and the addition of chemicals 
to the Priority Testing List, the EPA's Office of Pollution Prevention 
and Toxics adds new chemicals from the List to TSCA section 8(a) and 
8(d) rules that require manufacturers, processors, and/or distributors 
of these chemicals to submit TSCA section 8(a) production and exposure 
data and TSCA section 8(d) health and safety studies, within 60 days of 
the rule's effective date. The submissions are indexed and maintained 
by EPA. The ITC reviews the section 8(a) and 8(d) information and other 
available data on chemicals and chemical groups (e.g., TSCA section 
8(e) ``substantial risk'' studies, ``For Your Information'' (FYI) 
submissions to EPA, and published papers) to determine if revisions to 
the List are necessary. Revisions can include changing a recommendation 
to a designation for action by the Administrator within 12 months, 
modifying the recommended testing, or removing the chemical or chemical 
group from the List.

II. Revisions to the TSCA Section 4(e) Priority Testing List

    The ITC's revisions to its TSCA Section 4(e) Priority Testing List 
are summarized in Table 1.

  Table 1.--Chemicals Designated or Removed From the TSCA Section 4(e)  
                          Priority Testing List                         
------------------------------------------------------------------------
         Chemical/Group                       Action               Date 
------------------------------------------------------------------------
25 Chemicals with insufficient   Designate for Dermal Absorption   11/94
 dermal absorption data.          Testing                               
                                                                        
28 Isocyanates.................  Remove Previously Recommended     11/94
                                  Chemicals                             
                                                                        
25 Sulfones....................  Remove Previously Recommended     11/94
                                  Chemicals                             
                                                                        
18 Chemicals with insufficient   Remove Previously Recommended     11/94
 subchronic (90-day) toxicity     Chemicals                             
 data.                                                                  
                                                                        
27 Aldehydes...................  Remove Previously Recommended     11/94
                                  Chemicals                             
                                                                        
7 Cyanoacrylates...............  Remove Previously Recommended     11/94
                                  Chemicals                             
                                                                        
4 Diaryl ethers................  Remove Previously Recommended     11/94
                                  Chemicals                             
------------------------------------------------------------------------

III. Rationale for the Revisions

A. ITC's Activities During this Reporting Period

    During the 6 months covered by this Report, May through October 
1994, the ITC reviewed dermal absorption data for 63 chemicals with 
dermal LD50 values and 1989 production volumes greater than 1 
million pounds. The ITC also reviewed the TSCA section 8(a) and section 
8(d) submissions and other available data for 43 isocyanates that were 
recommended in the ITC's 26th Report (55 FR 23050, June 5, 1990) as 
well as 26 sulfones and 35 chemicals with insufficient subchronic (90-
day) toxicity data that were recommended in the ITC's 27th Report (56 
FR 9534, March 6, 1991). In addition, the ITC reviewed the production 
volume data obtained under the 1990 TSCA Inventory Update Rule and TSCA 
section 8(a) Preliminary Assessment Information Reporting rules for 89 
aldehydes that were recommended in the ITC's 27th Report, 11 
cyanoacrylates that were recommended in the ITC's 28th Report (56 FR 
41212, August 19, 1991) and 14 diaryl ethers that were recommended in 
the ITC's 29th Report (56 FR 67424, December 30, 1991). Based on these 
reviews, the ITC decided which chemicals in these groups to designate 
for testing, to retain on the Priority Testing List or to remove from 
the List.

B. Specific Rationales

    1. Designated chemicals--a. Chemicals with insufficient dermal 
absorption data. OSHA previously established Permissible Exposure 
Limits (PELs) for chemical substances and mixtures to limit workers' 
exposure to industrial chemicals. In general, PELs are based on 
inhalation of airborne dusts and vapors. In those cases where chemical 
absorption through the skin could be harmful, the chemicals with PELs 
are assigned skin notations. OSHA needs quantitative measures of dermal 
absorption to evaluate potential hazards to workers.
    In September 1991, OSHA nominated chemical substances and mixtures 
with PELs to the ITC to assess the availability of dermal absorption 
data. OSHA requested that ITC use its TSCA section 4(e) statutory 
authority to designate chemicals with insufficient dermal absorption 
data for priority testing consideration. As described in previous ITC 
reports, the chemicals were organized into groups to facilitate review. 
In its 31st report, the ITC designated a group of 24 chemicals for 
dermal absorption testing for which no dermal toxicity or absorption 
data could be located in the publicly available literature. In its 32nd 
report, the ITC designated a group of 34 chemicals for dermal 
absorption testing because existing dermal toxicity and absorption data 
were insufficient for OSHA's needs. In the 34th report, the ITC removed 
two of the previously designated chemicals from the Priority Testing 
List because dermal absorption data to meet OSHA's needs were obtained.
    Over the past year, the ITC began to review a group of 429 
chemicals that have rabbit dermal LD50 values in RTECS. Relevant 
information regarding dermal absorption, production volume, exposure 
and use, health effects and physicochemical properties were evaluated. 
The ITC reviewed 63 of these chemicals, all of which had 1989 
production volumes greater than 1 million pounds, and is designating 25 
chemicals determined to have insufficient dermal absorption data to 
meet OSHA's needs in the following Table 2. The ITC is continuing to 
review the remaining chemicals.

  Table 2.--Chemicals With Insufficient Dermal Absorption Data That Are 
             Being Designated for Dermal Absorption Testing             
------------------------------------------------------------------------
              CAS No.                           Chemical Name           
------------------------------------------------------------------------
75-05-8............................  Acetonitrile                       
75-12-7............................  Formamide                          
75-35-4............................  Vinylidene chloride                
77-73-6............................  Dicyclopentadiene                  
78-59-1............................  Isophorone                         
78-83-1............................  Isobutyl alcohol                   
78-87-5............................  Propylene dichloride               
91-20-3............................  Naphthalene                        
92-52-4............................  Biphenyl                           
95-50-1............................  o-Dichlorobenzene                  
96-18-4............................  1,2,3-Trichloropropane             
98-29-3............................  t-Butylcatechol                    
99-08-1............................  m-Nitrotoluene                     
99-99-0............................  p-Nitrotoluene                     
106-46-7...........................  p-Dichlorobenzene                  
107-06-2...........................  Ethylene dichloride                
108-93-0...........................  Cyclohexanol                       
108-94-1...........................  Cyclohexanone                      
110-12-3...........................  Methyl isoamyl ketone              
120-80-9...........................  Catechol                           
121-69-7...........................  Dimethylaniline                    
123-42-2...........................  Diacetone alcohol                  
127-19-5...........................  Dimethyl acetamide                 
542-92-7...........................  Cyclopentadiene                    
34590-94-8.........................  Dipropylene glycol methyl ether    
------------------------------------------------------------------------

    2. Removal of chemicals from the Priority Testing List--a. 
Previously recommended chemicals for which production volume and 
exposure data and health and safety studies have been reviewed. For 
three previously recommended chemical groups (isocyanates, sulfones and 
chemicals with insufficient subchronic (90-day) toxicity data), the ITC 
reviewed the 1989 production volume data that were submitted in 
response to EPA's September 27, 1990, TSCA section 8(a) Partial 
Inventory Update Rule (55 FR 39586). In addition, the ITC reviewed the 
production and exposure data and health and safety studies that were 
submitted in response to EPA's September 28, 1990, TSCA section 8(a) 
Preliminary Assessment Information Reporting (PAIR) Rule and TSCA 
section 8(d) Health and Safety Data Reporting Rule for isocyanates (55 
FR 39586) and EPA's August 29, 1991, PAIR and Health and Safety Data 
Reporting Rule for sulfones and chemicals with insufficient subchronic 
(90-day) toxicity data (56 FR 42688). For these chemical groups, the 
ITC also requested, received and reviewed, use and exposure data from 
several companies, studies that have been published since the ITC 
recommended these chemicals for testing, TSCA section 8(e) and FYI 
studies, unpublished data from tests conducted by the U.S. Government 
organizations represented on the ITC and data from the 1981-1983 
National Occupational Exposure Survey (NOES). After reviewing these 
data and considering the data needs of U.S. Government organizations 
represented on the ITC, the ITC decided which chemicals in these groups 
should be removed from the Priority Testing List. The chemicals in 
these groups that were removed from the List and the rationales for 
removing them are described below.
    1. Isocyanates. The ITC transmitted its 26th Report to the EPA 
Administrator on May 8, 1990, and recommended a group of 43 isocyanates 
for physical and chemical property testing in response to a nomination 
from the EPA to support its TSCA New Chemicals Program. (55 FR 23050, 
June 5, 1990). The ITC is removing 27 isocyanates from the Priority 
Testing List because annual production volumes were less than 1 million 
pounds or there appeared to be low potential for exposure. The ITC is 
also removing methyl isocyanate from the List because its physical and 
chemical properties appear to be well characterized. The 28 isocyanates 
that ITC is removing from the List are included in the following Table 
3.

      Table 3.--Isocyanates removed from the Priority Testing List      
------------------------------------------------------------------------
              CAS No.                           Chemical Name           
------------------------------------------------------------------------
91-97-4............................  4,4'-Diisocyanato-3,3'-            
                                      dimethylbiphenyl                  
100-28-7...........................  p-Nitrophenyl isocyanate           
104-49-4...........................  p-Phenylene diisocyanate           
109-90-0...........................  Ethyl isocyanate                   
110-78-1...........................  n-Propyl isocyanate                
112-96-9...........................  Octadecyl isocyanate               
123-61-5...........................  1,3-Diisocyanatobenzene            
614-68-6...........................  1-Isocyanato-2-methylbenzene       
622-58-2...........................  1-Isocyanato-4-methylbenzene       
624-83-9...........................  Methyl isocyanate                  
1476-23-9..........................  3-Isocyanato-1-propene             
2422-91-5..........................  1,1',1''-Methylidynetris(4-        
                                      isocyanatobenzene)                
2493-02-9..........................  1-Bromo-4-isocyanatobenzene        
2909-38-8..........................  1-Chloro-3-isocyanatobenzene       
2949-22-6..........................  Ethyl isocyanatoacetate            
4151-5.............................  1-3-Tris(4-isocyanatophenyl)       
                                      thiophosphate                     
10031-75-1.........................  Diphenylmethylene diisocyanate     
15646-96-5.........................  1,6-Diisocyanato-2,4,4-            
                                      trimethylhexane                   
16938-22-0.........................  1,6-Diisocyanato-2,2,4-            
                                      trimethylhexane                   
25854-16-4.........................  Bis(isocyanatomethyl)benzene       
26603-40-7.........................  1,3,5-Tris(3-                      
                                      isocyanatomethylphenyl)-1,3,5-    
                                      triazine-2,4,6(1H,3H,5H)-trione   
26747-90-0.........................  Toluene diisocyanate dimer         
28178-42-9.........................  2,6-Diisopropylphenyl isocyanate   
28556-81-2.........................  2-Isocyanato-1,3-dimethylbenzene   
30674-80-7.........................  2-Isocyanatoethyl methacrylate     
34893-92-0.........................  3,5-Dichlorophenyl isocyanate      
68239-06-5.........................  2-Heptyl-3,4-bis(9-isocyanatononyl)-
                                      1-pentylcyclohexane               
73597-26-9.........................  Isophorone diisocyanate,           
                                      hydroxyethyl methacrylate adduct  
------------------------------------------------------------------------

    2. Sulfones. In its 27th Report, the ITC recommended a group of 26 
sulfones for physical and chemical property testing to estimate whether 
occupational exposures or environmental releases were likely to occur 
(56 FR 9534, March 6, 1991). This recommendation was based on the 
results of the ITC's 6th Scoring Exercise and the use of the ITC's 
Substructure-based Computerized Chemical Selection Expert System 
(SuCCSES) to identify chemical groups with common chemical 
substructures, common exposure or adverse effects potentials and common 
data insufficiencies. The Scoring Exercise and SuCCSES have been 
previously described by Walker and Brink (Ref. 1) and Walker (Refs. 2 
and 3). SuCCSES was used to identify sulfones with insufficient 
physical/chemical properties. Based on a review of the data and other 
considerations, the ITC is removing 25 sulfones from the Priority 
Testing List that are listed in the following Table 4.

       Table 4.-- Sulfones Removed from the Priority Testing List       
------------------------------------------------------------------------
              CAS No.                           Chemical Name           
------------------------------------------------------------------------
Sulfones removed because there                                          
 appeared to be low exposure                                            
 potential based on annual                                              
 production volume and NOES data:                                       
  67-71-0..........................  Dimethylsulfone                    
  80-08-0..........................  4,4'-Diaminodiphenyl sulfone       
  98-30-6..........................  2-Amino-4-(methylsulfonyl)phenol   
  127-63-9.........................  Diphenylsulfone                    
  2580-77-0........................  2,2'-Sulfonyl bisethanol           
  3278-22-6........................  1,1'-[Methylene                    
                                      bis(sulfonyl)]bisethene           
  5246-57-1........................  2-[(3-Aminophenyl)sulfonyl]-ethanol
  16588-67-3.......................  3-[N-Ethyl-4-[[6-(methylsulfonyl)-2-
                                      benzothiazolyl]azo]-m-toluidino]- 
                                      propionitrile                     
  17557-67-4.......................  6-Methylsulfonyl)-2-               
                                      benzothiazolamine                 
  17601-96-6.......................  2-Amino-4-[(2-                     
                                      hydroxyethyl)sulfonyl]phenol      
  17688-68-5.......................  4-Phenylthiomorpholine, 1,1-dioxide
  17741-62-7.......................  4-[4-[(2,6-Dichloro-4-             
                                      nitrophenyl)azo]phenyl]-          
                                      thiomorpholine, 1,1-dioxide-      
  20018-09-1.......................  1-(Diiodomethyl)sulfonyl-4-methyl  
                                      benzene                           
  26750-50-5.......................  1,1'-[Oxybis(methylenesulfonyl)]   
                                      bisethene                         
  36724-43-3.......................  2,2'-[Oxybis(methylenesulfonyl)]   
                                      bisethanol                        
  41123-59-5.......................  1,1'-[Methylenebis(sulfonyl)] bis-2-
                                      chloroethane                      
  41123-69-7.......................  2,2'-[Methylenebis(sulfonyl)]      
                                      bisethanol                        
  41687-30-3.......................  2-[(3-Nitrophenyl)sulfonyl] ethanol
  52218-35-6.......................  2-[(6-Amino-2-                     
                                      naphthalenyl)sulfonyl] ethanol    
  53061-10-2.......................  1,1'-[Oxybis(methylenesulfonyl)]   
                                      bis-2-chloroethane                
  63134-33-8.......................  4-[[4-(Phenylmethoxy)phenyl]-      
                                      sulfonyl] phenol                  
Sulfones removed because testing                                        
 recommendations are currently a                                        
 lower priority than others:                                            
  77-79-2..........................  Sulfolene                          
  80-09-1..........................  Bisphenol S                        
  126-33-0.........................  Sulfolane                          
18760-44-6.........................  3-(Decyloxy)tetrahydrothiophene 1,1-
                                      dioxide                           
------------------------------------------------------------------------

    3. Chemicals previously recommended for subchronic (90-day) 
toxicity testing. On May 17, 1987, the ITC convened a public meeting to 
discuss the results of the its 6th Scoring Exercise, development of 
SuCCSES and a list of 166 substantially produced chemicals (i.e., 
chemicals with 1985 production volumes > 1 million pounds) that were 
coded in SuCCSES for exposure and adverse effects potentials. Based on 
a review of available data, the ITC recommended a group of 35 chemicals 
in its 27th Report that did not have 90-day subchronic toxicity test 
data (56 FR 9534, March 6, 1991). Based on a review of the data 
submitted to EPA and other considerations, the ITC is removing 18 
chemicals from the Priority Testing List that are listed in the 
following Table 5.

   Table 5.--Chemicals Previously Recommended for Subchronic (90-day)   
         Toxicity Testing Removed from the Priority Testing List        
------------------------------------------------------------------------
              CAS No.                           Chemical Name           
------------------------------------------------------------------------
Chemicals removed because there                                         
 appeared to be low exposure                                            
 potential based on annual                                              
 production volume and use data:                                        
  84-51-5..........................  2-Ethylanthraquinone               
  87-02-5..........................  7-Amino-4-hydroxy-2-               
                                      naphthalenesulfonic acid          
  95-32-9..........................  2-(4-Morpholinyldithio)-           
                                      benzothiazole                     
  98-48-6..........................  1,3-Benzenedisulfonic Acid         
  99-63-8..........................  Isophthaloyl chloride              
  100-20-9.........................  Terephthaloyl chloride             
  106-31-0.........................  Butyric anhydride                  
  116-81-4.........................  Bromamine acid                     
  123-62-6.........................  Propanoic anhydride                
  616-21-7.........................  1,2-Dichlorobutane                 
  760-23-6.........................  3,4-Dichlorobutene                 
  1111-78-0........................  Ammonium carbamate                 
Chemicals removed because Screening                                     
 Information Data Set dossiers have                                     
 been developed and the need for 90-                                    
 day subchronic toxicity tests will                                     
 be considered by representatives                                       
 from OECD countries that review                                        
 these dossiers:                                                        
  92-70-6..........................  3-Hydroxy-2-naphthoic acid         
  102-01-2.........................  Acetoacetanilide                   
Chemicals removed because                                               
 subchronic (90-day) toxicity                                           
 testing recommendations are                                            
 currently a lower priority than                                        
 other:                                                                 
  123-54-6.........................  2,4-Pentanedione                   
  311-89-7.........................  Perfluorotributylamine             
  355-42-0.........................  Perfluoro-N-hexane                 
  1047-16-1........................  Quinacridone                       
------------------------------------------------------------------------

    b. Previously recommended chemicals for which production volume 
data have been reviewed. For three previously recommended chemical 
groups (aldehydes, cyanoacrylates and diaryl ethers), the ITC reviewed 
the 1989 production volume data that were submitted in response to 
EPA's September 27, 1990, TSCA section 8(a) Partial Inventory Update 
Rule (55 FR 39586). In addition, the ITC reviewed the production and 
exposure data that were submitted in response to EPA's August 29, 1991 
PAIR rule for aldehydes (56 FR 42688), to EPA's December 27, 1993 PAIR 
rule for cyanoacrylates (58 FR 68317) and to EPA's March 12, 1993 PAIR 
rule for diaryl ethers (58 FR 13556). After reviewing these data, the 
ITC decided to remove chemicals in these groups from the Priority 
Testing List that had production volumes less than 10,000 pounds per 
year.
    1. Aldehydes. The ITC submitted its 27th Report to the EPA 
Administrator on November 19, 1990, and recommended a group of 89 
aldehydes for aquatic toxicity testing in response to a nomination from 
the EPA to support its TSCA New Chemicals Program (56 FR 9534, March 6, 
1991). Based on a review of production volume data, the ITC is removing 
27 aldehydes from the Priority Testing List. These aldehydes are listed 
in the following Table 6.

       Table 6.--Aldehydes removed from the Priority Testing List       
------------------------------------------------------------------------
              CAS No.                           Chemical Name           
------------------------------------------------------------------------
66-77-3............................  1-Naphthalenecarboxaldehyde        
78-85-3............................  2-Methyl-2-Propenal                
93-53-8............................  Methyl-benzeneacetaldehyde
95-01-2............................  2,4-Dihydroxybenzaldehyde          
97-51-8............................  2-Hydroxy-5-nitrobenzaldehyde      
98-03-3............................  2-Thiophenecarboxaldehyde          
99-72-9............................  4-Methylbenzeneacetaldehyde        
106-26-3...........................  3,7-Dimethyl-2,6-Octadienal, (Z)-  
106-72-9...........................  2,6-Dimethyl-5-heptenal            
123-08-0...........................  4-Hydroxybenzaldehyde              
135-02-4...........................  2-Methoxybenzaldehyde              
141-27-5...........................  3,7-Dimethyl-2,6-octadienal, (E)-  
143-14-6...........................  9-Undecenal                        
455-19-6...........................  4-(Trifluoromethyl)benzaldehyde    
505-57-7...........................  2-Hexenal                          
552-89-6...........................  2-Nitrobenzaldehyde                
1121-60-4..........................  2-Pyridinecarboxaldehyde           
1200-14-2..........................  4-Butylbenzaldehyde                
1334-78-7..........................  Methylbenzaldehyde                 
1423-46-7..........................  2,4,6-Trimethyl-3-cyclohexene-1-   
                                      carboxaldehyde                    
5435-64-3..........................  3,5,5-Trimethylhexanal             
5780-07-4..........................  7-Methoxy-1,3-benzodioxole-5-      
                                      carboxaldehyde                    
5949-05-3..........................  3,7-Dimethyl-6-Octenal, (S)-       
5988-91-0..........................  3,7-dimethyloctanal                
10031-82-0.........................  4-Ethoxybenzaldehyde               
28602-27-9.........................  (Dimethylamino)benzaldehyde        
37677-14-8.........................  4-4-Methyl-3-pentenyl)-3-          
                                      cyclohexene-1-carboxaldehyde      
------------------------------------------------------------------------

    2. Cyanoacrylates. In its 28th Report, the ITC recommended a group 
of 11 cyanoacrylates for physical and chemical property testing. The 
ITC's recommendation was based on concerns and uncertainties related to 
production and use, potential exposures and releases from production, 
processing and use (56 FR 41212, August 19, 1991). Based on a review of 
production volume data, the ITC is removing 7 cyanoacrylates from the 
Priority Testing List. These cyanoacrylates are listed in the following 
Table 7.

     Table 7.--Cyanoacrylates Removed from the Priority Testing List    
------------------------------------------------------------------------
           CAS No.                           Chemical Name              
------------------------------------------------------------------------
1069-55-2...................  2-Propenoic acid, 2-cyano-, isobutyl ester
                               (isobutyl cyanoacrylate)                 
6606-65-1...................  2-Propenoic acid, 2-cyano-, butyl ester   
                               (butyl cyanoacrylate)                    
7324-02-9...................  2-Propenoic acid, 2-cyano-, 2-propenyl    
                               ester (allyl cyanoacrylate)              
10586-17-1..................  2-Propenoic acid, 2-cyano-, 1-methylethyl 
                               ester (isopropyl cyanoacrylate)          
21982-43-4..................  2-Propenoic acid, 2-cyano-, ethoxy ethyl  
                               ester (ethoxy ethyl cyanoacrylate)       
23023-91-8..................  2-Propenoic acid, 2-cyano-, 2,2,2-        
                               trifluomethyl ester (2,2,2-              
                               trifluoromethyl cyanoacrylate)           
27816-23-5..................  2-Propenoic acid, 2-cyano-, methyoxy ethyl
                               ester (methoxy ethyl cyanoacrylate)      
------------------------------------------------------------------------

    3. Diaryl ethers. In its 29th Report, the ITC recommended a group 
of 14 alkyl, bromo, chloro, or hydroxy-methyl diaryl ethers for 
physical chemical property, biodegradation rate, health effects and 
ecological effects screening tests (56 FR 67424, December 30, 1991). 
This recommendation was based on an analysis of data in SuCCSES that 
was compiled during the ITC's 6th Scoring Exercise. Based on a review 
of production volume data, the ITC is removing 4 diaryl ethers from the 
Priority Testing List. These diaryl ethers are listed in the following 
Table 8.

     Table 8.--Diaryl Ethers Removed from the Priority Testing List     
------------------------------------------------------------------------
                CAS No.                           Chemical Name         
------------------------------------------------------------------------
3061-36-7.............................  1,4-Diphenoxybenzene            
50789-44-1............................  3-Phenoxybenzene methanol       
                                         acetate                        
61702-88-3............................  1,1'-Oxybis(1,1,3,3-            
                                         tetramethylbutyl)benzene       
69834-19-1............................  1,1'-Oxybisdodecylbenzene       
------------------------------------------------------------------------

References

    (1) Walker, J.D. and Brink, R.H. ``New Cost-Effective, 
Computerized Approaches to Selecting Chemicals for Priority Testing 
Consideration,'' In: Aquatic Toxicology and Environmental Fate: 
Eleventh Volume, ASTM STP 1007, G. W. Suter, II and M.A. Lewis, 
Eds., American Society for Testing and Materials, Philadelphia, PA, 
pp. 507-536 (1989).
    (2) Walker, J.D. ``Chemical Selection by the TSCA Interagency 
Testing Committee: Use of Computerized Substructure Searching to 
Identify Chemical Groups for Health Effects, Chemical Fate and 
Ecological Effects Testing,'' Science of the Total Environment: Vol. 
109/110, pp. 691-700 (1991).
    (3) Walker, J.D. ``The TSCA Interagency Testing Committee, 1977 
to 1992: Creation, Structure, Functions and Contributions,'' In: 
Environmental Toxicology and Risk Assessment: Second Volume, ASTM 
STP 1216, J.W. Gorsuch, F.J. Dwyer, C.G. Ingersoll and T.W. LaPoint, 
Eds., American Society for Testing and Materials, Philadelphia, PA, 
pp. 451-509 (1993).

IV. The TSCA Section 4(e) Revised Priority Testing List

    The revised TSCA section 4(e) Priority Testing List follows.

       The TSCA Section 4(e) Priority Testing List (November 1994)      
------------------------------------------------------------------------
     Report             Date          Chemical/Group          Action    
------------------------------------------------------------------------
23..............  November 1988    Butyraldehyde         Recommended    
23..............  November 1988    Tetrakis(2-           Recommended    
                                    chloroethyl)ethylen   with intent-to-
                                    e diphosphate         designate     
                                   Tris(1,3-dichloro-2-                 
                                    propyl) phosphate                   
                                   Tris(1-chloro-2-                     
                                    propyl) phosphate                   
                                   Tris(2-chloro-1-                     
                                    propyl) phosphate                   
                                   Tris(2-chloroethyl)-                 
                                    phosphate                           
26..............  May 1990         15 Isocyanates        Recommended    
                                                          with intent-to-
                                                          designate     
27..............  November 1990    62 Aldehydes          Recommended    
                                                          with intent-to-
                                                          designate     
27..............  November 1990    Sulfonyl bis(4-       Recommended    
                                    chlorobenzene)                      
27..............  November 1990    17 Chemicals with     Recommended    
                                    insufficient                        
                                    subchronic (90-day)                 
                                    toxicity data                       
28..............  May 1991         Acetone               Designated     
28..............  May 1991         Thiophenol            Designated     
28..............  May 1991         m-Dinitrobenzene      Recommended    
28..............  May 1991         14 Cyanoacrylates     Recommended    
29..............  November 1991    10 Alkyl-, bromo-,    Recommended    
                                    chloro-,                            
                                    hydroxymethyl                       
                                    diaryl ethers                       
30..............  May 1992         56 Siloxanes          Recommended    
30..............  May 1992         25 Chloroalkyl        Recommended    
                                    phosphates                          
31..............  January 1993     24 Chemicals with no  Designated     
                                    dermal toxicity                     
                                    data                                
31..............  January 1993     13 Propylene glycol   Recommended    
                                    ethers and esters                   
31..............  January 1993     32 Methyl ethylene    Recommended    
                                    glycol ethers and                   
                                    esters                              
32..............  May 1993         32 Chemicals with     Designated     
                                    insufficient dermal                 
                                    absorption data                     
34..............  May 1994         White phosphorus      Designated     
34..............  May 1994         Ethyl tert-butyl      Recommended    
                                    ether                               
34..............  May 1994         Tert-amyl methyl      Recommended    
                                    ether                               
35..............  November 1994    25 Chemicals with     Designated     
                                    insufficient dermal                 
                                    absorption data                     
------------------------------------------------------------------------

TSCA Interagency Testing Committee

    Statutory Organizations and Their Representatives

    Council on Environmental Quality
        Elisabeth Blaug, Member

     Department of Commerce
        Edward White, Member
        Willie E. May, Alternate

     Environmental Protection Agency
        David R. Williams, Member
        Lois Dicker, Alternate

    National Cancer Institute
        Harry Seigried, Member
        Richard Adamson, Alternate

    National Institute of Environmental Health Sciences
        Errol Zeiger, Member, Vice Chair
        H.B. Matthews, Alternate

    National Institute for Occupational Safety and Health
        Henryka Nagy, Member
        David A. Dankovic, Alternate

    National Science Foundation
        Linda Duguay, Member

    Occupational Safety and Health Administration
        Christine Whittaker, Member, Chair

    Liaison Organizations and Their Representatives
    Agency for Toxic Substances and Disease Registry
        William Cibulas, Member

    Consumer Product Safety Commission
        Val Schaeffer, Member
        Lakshmi C. Mishra, Alternate

    Department of Agriculture
        Donald Derr, Member
        Clifford Rice, Alternate

    Department of Defense
        David A. Macys, Member
        James N. McDougal, Alternate

    Department of the Interior
        Barnett A. Rattner, Member

    Food and Drug Administration
        Edwin J. Matthews, Member
        Raju Kammula, Alternate

    National Library of Medicine
        Vera Hudson, Member

    National Toxicology Program
        Victor A. Fung, Member

    Counsel
        Mary Ellen Levine, Office of General Counsel, EPA

    Technical Support Contractor
        Syracuse Research Corporation

    ITC Staff
         John D. Walker, Executive Director
        Norma S.L. Williams, Executive Assistant, TSCA Interagency 
Testing Committee U.S. EPA/OPPT (MC 7401) 401 M Street, S.W. 
Washington, D.C. 20460 Phone (202) 260-1825 Fax (202) 260-7895 
Internet [email protected]
[FR Doc. 94-32117 Filed 12-28-94; 8:45 am]
BILLING CODE 6560-50-F