[Federal Register Volume 59, Number 232 (Monday, December 5, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-29765]
[[Page Unknown]]
[Federal Register: December 5, 1994]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
Centers for Disease Control and Prevention; Statement of
Organization, Functions, and Delegations of Authority
Part H, Chapter HC (Centers for Disease Control and Prevention) of
the Statement of Organization, Functions, and Delegations of Authority
of the Department of Health and Human Services (45 FR 67772-67776,
dated October 14, 1980, and corrected at 45 FR 69296, October 20, 1980,
as amended most recently at 59 FR 47146, dated September 14, 1994) is
amended to establish the Health Effects Laboratory Division, National
Institute for Occupational Safety and Health at Morgantown, West
Virginia.
Section HC-B, Organization and Functions, is hereby amended as
follows:
After the functional statement for the Office of Extramural
Coordination and Special Projects (HCC13), insert the following:
Health Effects Laboratory Division (HCC3)
(1) Provides new focused research capabilities in mechanisms of
occupational disease and identifies causative substances and early
indicators (biomarkers) of response to chemical, biological, and
physical substances which will be directed at prevention and control of
occupational disease and integrated into the filed research and
services programs in NIOSH; (2) develops new state-of-the-art research
techniques in physiology, human and animal cellular and molecular
pathology; (3) develops new state-of-the-art research techniques in the
areas of biochemistry, immunotoxicology, pharmacology, molecular and
cellular biology, genetic toxicology, and imaging; (4) provides new
research to develop and improve methods for environmental measurement
of aerosols; (5) develops and evaluates (including development of
performance criteria) intelligent, real-time personal and area direct
reading instruments for chemical, biological and physical agents; (6)
develops and improves techniques for measuring exposures and human
responses to workplace exposures; (7) develops new research techniques
in the areas of aeromicrobiology, particle characterization, molecular
characterization, micro-sensors, advanced sampling and instrumentation,
electronic monitoring, electrical and mechanical engineering; (8)
develops new methodologies for exposure modeling of current and past
exposures for use in applied research; (9) provides new research
capabilities for developing and establishing engineering solutions for
the control of occupational diseases and for utilizing engineering
techniques to solve problems; (10) develops new research techniques in
the areas of computerized workplace simulations and mathematical
models; (11) provides environmental and biological laboratory services
for all field and laboratory programs in NIOSH; (12) develops and
evaluates effective communication strategies for promoting health
education to communicate risk and prevention recommendations to those
at risk and form coalitions to advocate prevention activities.
Toxicology and Molecular Biology Branch (HCC32)
(1) Provides focused research in workplace exposure and identifies
causative substances and biomarkers of response to chemical,
biological, and physical substances; (2) develops laboratory techniques
or modifications that could be useful for population-based or large
environmental testing; (3) develops molecular programs to examine the
toxic effects of workplace exposures/agents on human, animal, and
cellular systems; (4) defines the levels and circumstances of exposures
that lead to development of pre- and post-toxic biomarkers, toxic
responses, repair of damage or alleviation of damage, mechanisms of
toxicity, and recommendations for prevention and control of toxic
exposures; (5) develops integrated research programs in areas including
cell to cell communication, cellular interaction, genome activations,
responses to and production/release of cellular signals; and mechanisms
of control, blockage, and homeostasis of cellular systems, broadly
interpreted with respect to environmental and occupational agents; (6)
studies microbial cellular components and production and release of
exotoxins and mycotoxins in context with the holistic human and animal
response, including targets such as the lung, skin, and nervous system;
(7) provides support to the Division on state-of-the-art research in
the areas of toxicology, molecular and cellular biology.
Pathology and Physiological Research Branch (HCC33)
(1) Provides research into new ways to identify disease mechanisms,
develops pre-disease early warning systems, identifies methods for
repair or resolution of disease, and develops and applies new imaging
techniques; (2) examines in an applied and preventive research mode the
effects of workplace exposures on human and animal body functions and
cellular response-receptors in the development of disease/disfunction,
mechanism of action, early functional markers of detection, and
recommendations for prevention and control/intervention; (3) provides
advice and collaborative service for NIOSH investigators interested in
physiological/pharmacological effects of workplace exposures on field-
based and animal/cellular systems; (4) examines the alteration of
function based on pre-existing disease, induced-disease, or cellular/
organ structural impairment in the context of responses to occupational
exposures, both actual and laboratory-generated; (5) assists HELD and
other NIOSH divisions by providing animal exposure and pathological
support in the development, use, and evaluation of exposure systems
that mimic the occupational situation, reach the target organ, and
results in sensitive models of change, structural or functional; (6)
provides animal pathology support to researchers through the
development of sensitive animal-specific tools, molecular probes, or
recognition techniques that can be modified or used for animal models
of occupational disease/exposure.
Exposure Assessment Branch (HCC34)
(1) Provides research methods for the Division to develop and
improve methods for environmental measurement of aerosols; (2) develops
and evaluates real-time personal and area direct reading instruments
for chemical, biological, and physical agents; (3) develops techniques
for measuring human responses to workplace exposures; (4) provides new
research techniques in the areas of aeromicrobiology, particle
characterization, molecular characterization, micro sensors, advanced
sampling and instrumentation, electronic monitoring, and electrical and
mechanical engineering; (5) coordinates with other NIOSH laboratory-
based research (particularly the toxicology and molecular biology
research), as well as NIOSH field studies and health hazard evaluations
to advance exposure assessment methods; (6) develops new methodologies
for exposure modeling of current and past exposure for use in applied
research (epidemological and molecular epidemiological studies).
Engineering and Control Technology Branch (HCC35)
(1) Provides research capabilities for developing and establishing
engineering solutions for the control of occupational disease; (2)
coordinates with the Exposure Assessment Branch to develop engineering
techniques to solve problems in measuring and monitoring programs; (3)
develops and utilizes techniques in computerized workplace simulations
and mathematical models; (4) develops passive protection devices and
systems for preventing or minimizing worker exposure to hazardous
chemical, biological, and physical substances; (5) develops
sophisticated personal protective equipment to provide workers with
information about their working environment.
Analytical Services Branch (HCC36)
(1) Provides environmental and biological analytical laboratory
services such as immunotoxical, pharmacological, molecular and cellular
biological analysis, identification, qualification, and other requested
characterizations for all NIOSH research and service programs; (2)
provides analytical services such as multi-chemical mixture analysis,
particle size analysis, component identification, quantification, and
other requested characterization; (3) develops state-of-the-art
analytical methods for the evaluation and control of newly identified
workplace hazards and exposures that could lead to occupational
disease.
Biostatistics Branch (HCC37)
(1) Provides experimental design and support of laboratory-based
research to address the statistical aspects of projects in the Division
and throughout the Institute; (2) verifies the statistical quality,
both in the design and analysis phase of all experimental research in
the Institute; (3) develops and directs the application of new
statistical methods as well as the design and analysis of field
research projects for the Institute; (4) develops computerized methods
for independent research initiatives in statistical methods to advance
basic research in experimental and observational studies; (5)
collaborates in the design of laboratory and field research studies,
providing consultation through the course of the research on
computerized methods of data collection and interpretation of results.
Health Communication Research Branch (HCC38)
(1) Designs, implements, and evaluations effective communication
strategies for the Division using expertise in health education, and
communication; (2) develops messages, materials, and methods to clearly
and effectively communicate risks and prevention recommendation to
those at risk and those that can most effectively implement or promote
prevention activities; (3) evaluates the effectiveness of the
Division's health communication to determine the impact and
contribution to prevention of workplace injury and disease; (4)
coordinates with others in the field of health communication to form
coalitions to advocate prevention activities.
Effective Date: November 18, 1994.
David Satcher,
Director, Centers for Disease Control and Prevention.
[FR Doc. 94-29765 Filed 12-2-94; 8:45 am]
BILLING CODE 4160-18-M