[Federal Register Volume 59, Number 210 (Tuesday, November 1, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-26973]


[[Page Unknown]]

[Federal Register: November 1, 1994]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES
 

National Toxicology Program; National Toxicology Program (NTP) 
Board of Scientific Counselors' Meeting; Review of Draft NTP Technical 
Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors' Technical Reports 
Review Subcommittee on November 29, 1994, in the Conference Center, 
Building 101, South Campus, National Institute of Environmental Health 
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North 
Carolina. The meeting will begin at 8:30 a.m. and is open to the 
public. The primary agenda topic is the peer review of draft Technical 
Reports of long-term toxicology and carcinogenesis studies from the 
National Toxicology Program. Additionally, the draft Technical Report 
of the short-term toxicity study on 1-nitropyrene will be reviewed. 
This is the first NTP short-term report where the conclusion has been 
drawn that the chemical is a likely carcinogen in the absence of 
neoplasms in an NTP study.
    Tentatively scheduled to be peer reviewed on November 29 are draft 
Technical Reports of six two-year studies, listed alphabetically, along 
with supporting information in the attached table. Similar information 
is given for the short-term report on 1-nitropyrene. All studies were 
done using Fischer 344 rats and B6C3F1 mice, while one two-year 
study also employed Sencar mice. The order of review is given in the 
far right column of the table. Copies of the draft Reports may be 
obtained, as available, from: Central Data Management, MD A0-01, P.O. 
Box 12233, Research Triangle Park, NC 27709 (919/541-3419).
    Persons wanting to make a formal presentation regarding a 
particular Technical Report must notify the Executive Secretary by 
telephone, by FAX, or by mail no later than November 22, 1994, and 
provide a written copy in advance of the meeting so copies can be made 
and distributed to all Subcommittee members and staff and made 
available at the meeting for attendees. Oral presentations should 
supplement and not just repeat the written statement. Presentations 
should be limited to no more than five minutes.
    The program would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing, or planned studies by others, as 
well as current production data, human exposure information, and use 
patterns on any of the chemicals listed in this announcement. Please 
contact Central Data Management at the address given above, and they 
will relay the information to the appropriate staff scientist.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, 
Research Triangle Park, North Carolina 27709 (telephone 919/541-3491; 
FAX 919/541-2260) will furnish a roster of Subcommittee members prior 
to the meeting. Summary minutes subsequent to the meeting will be 
available upon request.

Attachment

    Dated: October 26, 1994.
Richard A. Griesemer,
Deputy Director, National Toxicology Program.

      Summary Data for Technical Reports Scheduled for Review at the Meeting of the NTP Board of Scientific     
                                Counselors' Technical Reports Review Subcommittee                               
                                               [November 29, 1994]                                              
----------------------------------------------------------------------------------------------------------------
                    Project leader/                                                                             
 Chemical/CAS No.   technical report       Primary uses       Route/exposure levels  Study laboratory    Review 
                          No.                                                                            order  
----------------------------------------------------------------------------------------------------------------
                                                LONG-TERM STUDIES                                               
----------------------------------------------------------------------------------------------------------------
2,2-Bis            Dr. J. Dunnick,    Flame retardant for     Dosed-Feed (NIH-07):   Southern                  5
 (bromomethyl)-1,   919-541-4811; TR-  epoxy, polyester, and   R: 0, 2500, 5000, or   Research                  
 3-Propanediol;     452.               urethane forms.         10000 PPM; 70/group    Institute.                
 3296-90-0.                            Chemical intermediate.  M: 0, 312, 625, or                               
                                                               1250 PPM; 60/group.                              
Isobutyl nitrite;  Dr. K. Abdo, 919-  Industrial              Inhalation (air):      IIT Research              1
 542-56-3.          541-7819; TR-448.  intermediate in         R&M: 0, 37, 75, or     Institute.                
                                       chemical synthesis.     150 PPM.                                         
                                       (TDB).                                                                   
Nickel (II)        Dr. J. Dunnick,    Chemical intermediate   Inhalation (air): R:   Lovelace Inhal            3
 oxide; 1313-99-1.  919-541-4811; TR-  for stainless and       0, .62, 1.25, or 2.5   Tox Res Inst              
                    451.               alloy steels.           M: 0, 1.25, 2.5, or    (DOE).                    
                                       Catalysts. Electrical   5.0 mg/m3; 50/group.                             
                                       devices. Thermister                                                      
                                       material.                                                                
Nickel sulfate     Dr. J. Dunnick,    Nickel plating.         Inhalation (air): R:   Lovelace Inhal            4
 hexahydrate,       919-541-4811, TR-  Blackening zinc and     0, 0.125, 0.25, or     Tox Res Inst              
 10101-97-0.        454.               brass. Mordant in       0.5 M: 0, .25, .5,     (DOE).                    
                                       dyeing.                 or 1.0 mg/m3; 50/                                
                                                               group.                                           
Nickel             Dr. J. Dunnick,    Major component in      Inhalation (air): R:   Lovelace Inhal            2
 subsulfide;        919-541-4811; TR-  nickel refinery flue    0, 0.075, or 0.15 M:   Tox Res Inst              
 12035-72-2.        453.               dust. Not used          0, 0.6, or 1.2 mg/     (DOE).                    
                                       commercially in U.S.    m3; 50/group.                                    
Triethanolamine;   Dr. J. Bucher,     Intermediate in manuf.  Topical (acetone):     Battelle                  6
 102-71-6.          919-541-4532; TR-  surfactants, textile    MR: 0, 32, 63, or      Columbus                  
                    449.               specialties, waxes,     125; FR: 0, 63, 125    Laboratory.               
                                       polishes, herbicides,   or 250; MM: 0, 200,                              
                                       petroleum               630, or 2000; FM: 0.                             
                                       demulsifiers, toilet                                                     
                                       goods.                                                                   
Triethanolamine;   Dr. J. Bucher,     Intermediate in manuf.  Topical (acetone):     Battelle                  6
 102-71-6.          919-541-4532; TR-  surfactants, textile    MR: 0, 32, 63, or      Columbus                  
                    449.               specialties, waxes,     125; FR: 0, 63, 125,   Laboratory.               
                                       polishes, herbicides,   or 250; MM: 0, 200,                              
                                       petroleum               630, or 2000; FM: 0,                             
                                       demulsifiers, toilet    100, 300, or 1000 mg/                            
                                       goods, cement           kg; 60/group.                                    
                                       additives, cutting                                                       
                                       oils, in making                                                          
                                       mineral and veg. oil                                                     
                                       emulsions, solvent,                                                      
                                       pharmaceutic aid                                                         
                                       (alkalizer) (Merck                                                       
                                       1989).                                                                   
----------------------------------------------------------------------------------------------------------------
                                            SHORT-TERM TOXICITY STUDY                                           
----------------------------------------------------------------------------------------------------------------
1-Nitropyrene;     Dr. P. Chan, 919-  Byproduct of            Inhalation (air): R:   Battelle                  7
 5522-43-0.         541-7561; TOX-34.  combustion primary      0, 0.5, 2.0, 8.0,      Northwest                 
                                       nitrated PAH emitted    20.0, or 50.0 mg/m3    Laboratory.               
                                       in diesel engine        12/s/group (core); 5/                            
                                       exhaust.                s/group for lung                                 
                                                               burden.                                          
----------------------------------------------------------------------------------------------------------------
R=Rats.                                                                                                         
M=Mice.                                                                                                         

[FR Doc. 94-26973 Filed 10-31-94; 8:45 am]
BILLING CODE 4140-01-M